Linkage disequilibrium and gene mapping: An empirical least-squares approach

American Journal of Human Genetics

Volumn 62, Issue 1, 1998, Pages 159-170

  Lazzeroni, Laura C ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CYSTIC FIBROSIS; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE MAPPING; HUMAN; PARAMETER; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 0031939968     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301678     Document Type: Article

References (19)

1. Akaike H (1974) A new look at statistical model identification. IEEE Trans Automatic Control AU-19:716-723
2. Bengtsson BO, Thomson G (1981) Measuring the strength of associations between HLA antigens and diseases. Tissue Antigens 18:356-363
3. Devlin B, Risch N (1995) A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 29: 311-322
4. Devlin B, Risch N, Roeder K (1996) Disequilibrium mapping: composite likelihood for pairwise disequilibrium. Genomics 36:1-16
5. Efron B (1979) Bootstrap methods: another look at the jack-knife. Ann Stat 7:1-26
6. Efron B, Tibshirani R (1993) An introduction to the bootstrap. Chapman & Hall, New York
7. Goddard KAB, Yu C-E, Oshima J, Miki T, Nakura J, Piussan C, Martin GM, et al (1996) Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers. Am J Hum Genet 58: 1286-1302
8. Hästbacka J, de la Chapelle A, Mahtani MM, Clines G, Reeve-Daly MP, Daly M, Hamilton BA, et al (1994) The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell 78:1073-1087
9. Hill WG, Weir BS (1994) Maximum-likelihood estimation of gene location by linkage disequilibrium. Am J Hum Genet 54:705-714
10. Jorde LB (1995) Linkage disequilibrium as a gene mapping tool. Am J Hum Genet 56:11-14
11. Kaplan NL, Hill WG, Weir BS (1995) Likelihood methods for locating disease genes in nonequilibrium populations. Am J Hum Genet 56:18-32
12. Kerem B, Rommens JM, Buchanan JA, Markiewicz D, Cox TK, Chakravarti A, Buchwald M, et al (1989) Identification of the cystic fibrosis gene: genetic analysis. Science 245: 1073-1080
13. Lazzeroni LC, Lange K. A conditional inference framework for extending the transmission/disequilibrium test. Hum Hered (in press)
14. Lehesjoki AE, Koskiniemi M, Norio R, Tirrito S, Sistonen P, Lander E, de la Chapelle A (1993) Localization of the EPM1 gene for progressive myoclonus epilepsy on chromosome 21: linkage disequilibrium allows high resolution mapping. Hum Mol Genet 2:1229-1234
15. Ott J (1991) Analysis of human genetic linkage. Johns Hopkins University Press, Baltimore
16. Ramsay M, Williamson R, Estivill X, Wainwright BJ, Ho MF, Halford S, Kere J, et al (1993) Haplotype analysis to determine the position of a mutation among closely linked DNA markers. Hum Mol Genet 2:1007-1014
17. Seber GAF, Wild CJ (1989) Nonlinear regression. John Wiley, New York
18. Terwilliger JD (1995) A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 56: 777-787
19. Xiong M, Guo S-W (1997) Fine-scale genetic mapping based on linkage disequilibrium: theory and applications. Am J Hum Genet 60:1513-1531