Immunobiology of interleukin-12

Immunologic Research

Volumn 17, Issue 1-2, 1998, Pages 269-278

  Trinchieri, Giorgio ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

Antigen presenting cells; Immune regulation; Immune response to infection; Inflammation; Interleukin 12; Phagocytic cells; T helper cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12;

ANTIGEN PRESENTING CELL; BACTERICIDAL ACTIVITY; HELPER CELL; IMMUNOBIOLOGY; NATURAL KILLER CELL; PHAGOCYTE; PRIORITY JOURNAL; REVIEW;

EID: 0031918989     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786451     Document Type: Review

References (94)

1. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, et al.: Identification and purification of Natural Killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989;170:827-846.
2. Stern AS, Podlaski FJ, Hulmes JD, Pan YE, Quinn PM, Wolitzky AG, et al.: Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 1990;87:6808-6812.
3. Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, et al.: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and Natural Killer cells. J Immunol 1991;146:3074-3081.
4. Merberg DM, Wolf SF, Clark SC: Sequence similarity between NKSF and the IL-6/G-CSF family. Immunol Today 1992;13:77,78.
5. Johnson LL, Gibson GW, Sayles PC: CR3-dependent resistance to acute Toxoplasma gondii infection in mice. Infect Immun 1996; 64:1998-2003.
6. Chua AO, Chizzonite R, Desai BB, Truitt TP, Nunes P, Minetti LJ, et al.: Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol 1994;153:128-136.
7. Chua AO, Wilkinson VL, Presky DH, Gubler U: Cloning and characterization of a mouse IL-12 receptor-β component. J Immunol 1995;155:4286-4294.
8. Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, et al.: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA 1996;93:14.002-14,007.
9. Zou J, Presky DH, Wu CY, Gubler U: Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta 1 and beta 2 JAK. J Biol Chem 1997;272:6073-6077.
10. Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE, Jr, et al.: Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 1995;181:1755-1762.
11. Bacon CM, Petricoin EF, III, Ortaldo JR, Rees RC, Larner AC, Johnston JA, et al.: IL-12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci USA 1995;92:7307-7311.
12. Cho SS, Bacon CM, Sudarshan C, Rees RC, Finbloom D, Pine R, et al.: Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J Immunol 1996;157:4781-4789.
13. Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, et al.: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996; 382:171-174.
14. Desai BB, Quinn PM, Wolitzky AG, Mongini PKA, Chizzonite R, Gately MK: The IL-12 receptor. II. Distribution and regulation of receptor expression. J Immunol 1992;148:3125-3132.
15. Wu CY, Warrier RR, Carvajal DM, Chua AO, Minetti LJ, Chizzonite R, et al.: Biological function and distribution of human interleukin-12 receptor beta chain. Eur J Immunol 1996;26:345-350.
16. Szabo SJ, Dighe AS, Gubler U, Murphy KM: Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper (Th1) and Th2 cells. J Exp Med 1997;185:817-824.
17. Rogge L, Barberis-Maino L, Biffi M, Passini N, Presky DH, Gubler U, Sinigaglia F: Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 1997;185:825-831.
18. Jones D, Elloso MM, Showe L, Williams D, Trinchieri G, Scott P: Differential regulation of both the IL-12 receptor β1 and β2 subunits during the innate immune response to Leishmania major. 1997, submitted.
19. D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste-Amezaga M, et al.: Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J Exp Med 1992;176:1387-1398.
20. Trinchieri G: Interleukin 12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T helper cells type 1 and cytotoxic lymphocytes. Blood 1994; 84:4008-4027.
21. Cassatella MA, Meda L, Gasperini S, D'Andrea A, Ma X, Trinchieri G: Interleukin-12 production by human polymorphonuclear leukocytes. Eur J Immunol 1995;25:1-5.
22. Kubin M, Chow JM, Trinchieri G: Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 1994;83:1847-1855.
23. Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospísil M, Young HA, et al.: Induction of IFN-γ production by NK cell stimulatory factor (NKSF): Characterization of the responder cells and synergy with other inducers. J Exp Med 1991;173:869-879.
24. Manetti R, Parronchi P, Giudizi MG, Piccinni M-P, Maggi E, Trinchieri G, et al.: Natural killer cell stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J Exp Med 1993;177:1199-1204.
25. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G: Interleukin-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/interleukin-12 synthesis in accessory cells. J Exp Med 1993;178:1041-1048.
26. Kubin M, Kamoun M, Trinchieri G: Interleukin-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp Med 1994;180:211-222.
27. Murphy EE, Terres G, Macatonia SE, Hsieh C, Mattson J, Lanier L, et al.: B7 and IL-12 cooperate for proliferation and IFN-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med 1994;180:223-231.
28. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trinchieri G: Stimulatory and inhibitory effects of IL-4 and IL-13 on production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and TNF-α production. J Exp Med 1995;181:537-546.
29. Kang K, Kubin M, Cooper KD, Lessin SR, Trinchieri G, Rook AH: IL-12 synthesis by human Langerhans cells. J Immunol 1996;156: 1402-1407.
30. Kanangat S, Nair S, Babu JS, Rouse BT: Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens. J Leukocyte Biol 1995;57:310-316.
31. Macatonia SE, Hosken NA, Litton M, Vieira P, Hsieh C, Culpepper JA, et al.: Dendritic cells produce IL-12 and direct the development of Th 1 cells from naive CD4+ T-cells. J Immunol 1995;154:5071-5079.
32. Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, et al.: Interleukin-12 is produced by dendritic cells and mediates Th1 development as well as IFN-γ production by Th1 cells. Eur J Immunol 1996;26:659-668.
33. Germann T, Gately MK, Schoenhaut DS, Lohoff M, Mattner F, Fischer S, et al.: Interleukin-12/T-cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur J Immunol 1993;23:1762-1770.
34. Shu U, Kiniwa M, Wu CY, Maliszewski C, Vezzio N, Hakimi J, et al.: Activated T-cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur J Immunol 1995;25:1125-1128.
35. Kennedy MK, Picha KS, Fanslow WC, Grabstein KH, Alderson MR, Clifford KN, et al.: CD40/CD40 ligand interactions are required for T-cell-dependent production of interleukin-12 by mouse macrophages. Eur J Immunol 1996;26: 370-378.
36. Maruo S, Oh-Hora M, Ahn H, Ono S, Wysocka M, Kaneko Y, et al.: B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T-cell/APC interactions. J Immunol 1997;158:120-126.
37. Hodge-Dufour J, Noble PW, Horton MR, Bao C, Wysocka M, Burdick MD, et al.: Induction of IL-12 and chemokines by hyaluronan requires adhesion dependent priming of resident but not elicited macrophages. J Immunol 1997;159:2492-2500.
38. Ma X, Chow JM, Gri G, Carra G, Gerosa F, Wolf SF, et al.: The interleukin-12 p40 gene promoter is primed by interferon-γ in monocytic cells. J Exp Med 1996;183: 147-157.
39. Murphy KM, Szabo SJ, Cleveland MG, Jacobson NG, Gubler U, Magram J, et al.: Regulation of the IL-12 p40 gene and IL-12 receptor signaling pathway in T-cell development. Meeting abstract: IL-12 in infection, prospects for prophylactic and therapeutic intervention, Bethesda, MD, May 15-17, 1995.
40. Hayes MP, Wang J, Norcross MA: Regulation of interleukin-12 expression in human monocytes: selective priming by IFN-γ of LPS-inducible p35 and p40 genes. Blood 1995;86:646-650.
41. Jacobsen SE, Veiby OP, Smeland EB: Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells. J Exp Med 1993;178:413-418.
42. Ploemacher RE, van Soest PL, Voorwinden H, Boudewijn A: Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture. Leukemia 1993;7:1381-1388.
43. Bellone G, Trinchieri G: Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis. J Immunol 1994;153:930-937.
44. Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A: Interleukin-12 is required for the T-lymphocyte independent induction of interferon-γ by an intracellular parasite and induces resistance in T-deficient hosts. Proc Natl Acad Sci USA 1993;90:6115-6119.
45. Hunter CA, Chizzonite R, Remington JS: IL-1β is required for IL-12 to induce production of IFN-γ by NK cells. A role for IL-1β in the T cell-independent mechanism of resistance against intracellular pathogens. J Immunol 1995;155: 4347-4354.
46. Chan SH, Kobayashi M, Santoli D, Perussia B, Trinchieri G: Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12): Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J Immunol 1992;148:92-98.
47. Gazzinelli RT, Wysocka M, Hayashi S, Denkers EY, Hieny S, Caspar P, et al.: Parasite induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 1994;153:2533-2543.
48. Taga T, Kishimoto T: Cytokine receptors and signal transduction. FASEB J 1993;7:3387-3396.
49. Tripp CS, Wolf SF, Unanue ER: Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA 1993;90:3725-3729.
50. Perussia B, Chan S, D'Andrea A, Tsuji K, Santoli D, Pospisil M, et al: Natural killer cell stimulatory factor or IL-12 has differential effects on the proliferation of TCRαβ+,TCRγδ+ T lymphocytes and NK cells. J Immunol 1992; 149:3495-3502.
51. Gately MK, Wolitzky AG, Quinn PM, Chizzonite R: Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol 1992;143:127-142.
52. Chehimi J, Starr S, Frank I, Rengaraju M, Jackson SJ, Lianes C, et al.: Natural killer cell stimulatory factor (NKSF) increases the cytotoxic activity of NK cells from both healthy donors and HIV-infected patients. J Exp Med 1992;175:789-796.
53. Chehimi J, Valiante NM, D'Andrea A, Rengaraju M, Rosado Z, Kobayashi M, et al.: Enhancing effect of natural killer cell stimulatory factor (NKSF/IL-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur J Immunol 1993;23:1826-1830.
54. Bloom ET, Horvath JA: Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T-cell activity. Implications for the age-related decline in CTL. J Immunol 1994;152:4242-4254.
55. H1 cells. Immunol Today 1993;14: 335-338.
56. + T-cells occurs through macrophage production of IL-12. Science 1993;260:547-549.
57. Tripp CS, Gately MK, Hakimi J, Ling P, Unanue ER: Neutralization of IL-12 decreases resistance to Listeria in SCID and CB-17 mice. J Immunol 1994;152:1883-1887.
58. Ploemacher RE, van Soest PL, Boudewijn A, Neben S: Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia 1993;7:1374-1380.
59. Vieira LQ, Hondowicz BD, Afonso LCC, Wysocka M, Trinchieri G, Scott P: Infection with Leishmania major induces interleukin-12 production in vivo. Immunol Lett 1994;40:157-161.
60. Gerosa F, Paganin C, Peritt D, Paiola F, Scupoli MT, Aste-Amezaga M, et al.: Interleukin-12 primes human CD4and CD8 T-cell clones for high production of both interferon-γ and interleukin-10. J Exp Med 1996;183:2559-2569.
61. Manetti R, Gerosa F, Giudizi MG, Biagiotti R, Parronchi P, Piccinni M, et al.: Interleukin-12 induces stable priming for interferon-γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J ExpMed 1994;179:1273-1283.
62. + T lymphocytes. J Immunol 1995;155:111-117.
63. Wu CY, Demeure CE, Gately M, Podlaski F, Yssel H, Kiniwa M, Delespesse G: In vitro maturation of human neonatal CD4 T lymphocytes: I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12. J Immunol 1994;152:1141-1153.
64. Macatonia SE, Hsieh C, Murphy KM, O'Garra A: Dendritic cells and macrophages are required for Th1 development of CD4+ T-cells from αβ-TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int Immunol 1993;5:1119-1128.
65. Seder RA, Gazzinelli R, Sher A, Paul WE: IL-12 acts directly on CD4+ T-cells to enhance priming for IFNγ production and diminishes IL-4 inhibition of such priming. Proc Natl Acad Sci USA 1993;90:10,188-10,192.
66. Schmitt E, Hoehn P, Germann T, Rüde E: Differential effects of interleukin-12 on the development of naive mouse CD4+ T-cells. Eur J Immunol 1994;24:343-347.
67. Kennedy MK, Picha KS, Shanebeck KD, Anderson DM, Grabstein KH: Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur J Immunol 1994;24:2271-2278.
68. DeKruyff RH, Fang Y, Wolf SF, Umetsu DT: IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T-cells through an effect on antigen-presenting cells. J Immunol 1995;154:2578-2587.
69. Schmitt E, Hoehn P, Huels C, Goedert S, Palm N, Rüde E, et al.: T helper type 1 development of naive CD4+ T-cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-α. Eur J Immunol 1994;24:793-798.
70. Trinchieri G, Peritt D, Gerosa F: Acute induction and priming for cytokine production in lymphocytes. Cytokine Growth Factor Rev 1996;7:123-132.
71. Wysocka M, Kubin M, Vieira LQ, Ozmen L, Garotta G, Scott P, et al.: Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol 1995;25:672-676.
72. Heinzel FP, Rerko RM, Ling P, Hakimi J, Schoenhaut DS: Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect Immun 1994;62: 4244-4249.
73. Afonso LCC, Scharton TM, Vieira LQ, Wysocka M, Trinchieri G, Scott P: The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994 ;263:235-237.
74. Miller MA, Skeen MJ, Ziegler HK: Nonviable bacterial antigens administered with IL-12 generate antigen-specific T-cell responses and protective immunity against Listeria monocytogenes. J Immunol 1995;155:4817-4828.
75. Wynn TA, Jankovic D, Hieny S, Cheever AW, Sher A: IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases Thelper 2 cytokine expression, IgE production, and tissue eosinophilia. J Immunol 1995;154: 4701-4709.
76. Wynn TA, Cheever AW, Jankovic D, Poindexter RW, Caspar P, Lewis FA, et al.: An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 1995;376:594-596.
77. Finkelman FD, Madden KB, Cheever AW, Katona IM, Morris SC, Gately MK, et al.: Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med 1994;179:1563-1572.
78. Pearlman E, Heinzel FP, Hazlett FE Jr, Kazura JW: IL-12 modulation of T helper responses to the filarial Helminth, Brugia malayi. J Immunol 1995;154:4658-4664.
79. Tang YW, Graham BS: Interleukin-12 treatment during immunization elicits a T helper cell type 1-like immune response in mice challenged with respiratory syncytial virus and improves vaccine immunogenicity. J Infect Dis 1995;172:734-738.
80. Schijns VE, Haagmans BL, Horzinek MC: IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-γ-receptor-deficient mice. J Immunol 1995;155:2525-2532.
81. Car BD, Eng VM, Schnyder B, LeHir M, Shakhov AN, Woerly G, et al.: Role of interferon-γ in IL-12-induced pathology in mice. Am J Pathol 1995;147:1693-1707.
82. Neta R, Stiefel SM, Finkelman F, Herrmann S, Ali N: IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation. J Immunol 1994;153:4230-4237.
83. Gately MK, Warrier RR, Honasoge S, Carvajal DM, Faherty DA, Connaughton SE, et al.: Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int Immunol 1994;6:157-167.
84. Ozmen L, Pericin M, Hakimi J, Chizzonite RA, Wysocka M, Trinchieri G, et al.: IL-12, IFN-γand TNF-α are the key cytokines of the generalized Shwartzman reaction. J Exp Med 1994;180:907-916.
85. Karp CL, Wysocka M, Wahl LM, Ahearn JM, Cuomo PJ, Sherry B, et al.: Mechanism of suppression of cell-mediated immunity by measles virus. Science 1996;273:228-231.
86. Chehimi J, Starr S, Frank I, D'Andrea A, Ma X, MacGregor RR, et al.: Impaired interleukin-12 production in human immunodeficiency virus-infected patients. J Exp Med 1994;179:1361-1366.
87. Gazzinelli RT, Bala S, Stevens R, Baseler M, Wahl L, Kovacs J, et al.: HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines. J Immunol 1995;155:1565-1574.
88. Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M, et al.: Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993;178:1223-1230.
89. Coughlin CM, Wysocka M, Kurzawa HL, Lee WMF, Trinchieri G, Eck SL: B7-1 and IL-12 synergistically induce effective antitumor immunity. Cancer Res 1995;55: 4980-4987.
90. Brunda MJ, Luistro L, Hendrzak JA, Fountoulakis M, Garotta G, Gately MK: Role of interferon-γ in mediating the antitumor efficacy of interleukin-12. J Immunother Emphasis Tumor Immunol 1995;17: 71-77.
91. Voest EE, Kenyon BM, O'Reilly MS, Truitt G, D'Amato RJ, Folkman J: Inhibition of angiogenesis in vivo by interleukin 12. JNCI 1995;87:581-586.
92. Sgadari C, Angiolillo AL, Tosato G: Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10. Blood 1996;87:3877-3882.
93. Gavett SH, O'Hearn DJ, Li X, Huang SK, Finkelman FD, Wills-Karp M: Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995;182:1527-1536.
94. Trembleau S, Germann T, Gately MK, Adorini L: The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol Today 1995;16:383-386.