Scaffold proteins in mammalian MAP kinase cascades

Journal of Biochemistry

Volumn 135, Issue 6, 2004, Pages 657-661

  Yoshioka, Katsuji ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

ERK; JNK; Kinesin; p38; Signal transduction

Indexed keywords

ACTIN BINDING PROTEIN; BETA ARRESTIN; BINDING PROTEIN; FILAMIN; G PROTEIN COUPLED RECEPTOR; KINESIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN JIP1; PROTEIN JIP2; PROTEIN JLP; PROTEIN JSAP1; PROTEIN KSR; PROTEIN MP1; PROTEIN POSH; SCAFFOLD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME REGULATION; MAMMAL; NONHUMAN; PROTEIN LOCALIZATION; SHORT SURVEY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEAR MATRIX-ASSOCIATED PROTEINS;

MAMMALIA;

EID: 3142590478     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvh079     Document Type: Short Survey

References (55)

1. Widmann, C., Gibson, S., Jarpe, M.B., and Johnson, G.L. (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79, 143-180
2. Chang, L. and Karin, M. (2001) Mammalian MAP kinase signaling cascades. Nature 410, 37-40
3. Kyriakis, J.M. and Avruch, J. (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81, 807-869
4. Ichijo, H. (1999) From receptors to stress-activated MAP kinases. Oncogene 18, 6087-6093
5. Schaeffer, H. and Weber, M.J. (1999) Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell. Biol. 19, 2435-2444
6. Morrison, D.K. and Davis, R.J. (2003) Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell. Dev. Biol. 19, 91-118
7. Whitmarsh, A.J., Cavanagh, J., Tournier, C., Yasuda, J., and Davis, R.J. (1998) A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281, 1671-1674
8. Dickens, M., Rogers, J.S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J.R., Greenberg, M.E., Sawyers, C.L., and Davis, R.J. (1997) A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277, 693-696
9. Levchenko, A., Bruck, J., and Sternberg, P.W. (2000) Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl Acad. Sci. USA 97, 5818-5823
10. Haefliger, J.A., Tawadros, T., Meylan, L., Gurun, S.L., Roehrich, M.E., Martin, D., Thorens, B., and Waeber, G. (2003) The scaffold protein IB1/JIP-1 is crucial mediator of cytokine-induced apoptosis in pancreatic β cells. J. Cell Sci. 116, 1463-1469
11. Willoughby, E.A., Perkins, G.R., Collins, M.K., and Whitmarsh, A.J. (2003) The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK. J. Biol. Chem. 278, 10731-10736
12. Whitmarsh, A.J., Kuan, C.Y., Kennedy, N.J., Kelkar, N., Haydar, T.F., Mordes, J.P., Apple, M., Rossini, A.A., Jones, S.N., Flavell, R.A., Rakic, P., and Davis, R.J. (2001) Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 15, 2421-2432
13. Thompson, N.A., Haefliger, J.A., Senn, A., Tawadros, T., Magara, F., Ledermann, B., Nicod, P., and Waeber, G. (2001) Islet-brain1/JNK-interacting protein-1 is required for early embryogenesis in mice. J. Biol. Chem. 276, 27745-27748
14. Yasuda, J., Whitmarsh, A.J., Cavanagh, J., Sharma, M., and Davis, R.J. (1999) The JIP group of mitogen-activated protein kinase scaffold proteins. Mol. Cell. Biol. 19, 7245-7254
15. Negri, S., Oberson, A., Steinmann, M., Sauser, C., Nicod, P., Waeber, G., Schorderet, D.F., and Bonny, C. (2000) cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. Genomics 64, 324-330
16. Schoorlemmer, J. and Goldfarb, M. (2002) Fibroblast growth factor homologous factors and islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. J. Biol. Chem. 277, 49111-49119
17. Buchsbaum, R.J., Connolly, B.A., and Feig, L.A. (2002) Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. Mol. Cell. Biol. 22, 4073-4085
18. Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., and Yamamoto, K. (1999) JSAP1, a novel Jun N-terminal protein kinase (JNK)-binding protein that functions as a scaffold factor in the JNK signaling pathway. Mol. Cell. Biol. 19, 7539-7548
19. Kelkar, N., Gupta, S., Dickens, M., and Davis, R.J. (2000) Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol. Cell. Biol. 20, 1030-1043
20. Akechi, M., Ito, M., Uemura, K., Takamatsu, N., Yamashita, S., Uchiyama, K., Yoshioka, K., and Shiba, T. (2001) Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system. Neurosci. Res. 39, 391-400
21. Matsuura, H., Nishitoh, H., Takeda, K., Matsuzaka, A., Amagasa, T., Ito, M., Yoshioka, K., and Ichijo, H. (2002) Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. J. Biol. Chem. 277, 40703-40709
22. Matsuguchi, T., Matsuda, A., Sugimoto, K., Nagai, Y., and Yoshikai, Y. (2003) JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. EMBO J. 22, 4455-4464
23. 2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways. J. Biol. Chem. 275, 39815-39818
24. Kelkar, N., Delmotte, M.H., Weston, C.R., Barrett, T., Sheppard, B.J., Flavell, R.A., and Davis, R.J. (2003) Morpho-genesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc. Natl Acad. Sci. USA 100, 9843-9848
25. Xu, P., Yoshioka, K., Yoshimura, D., Tominaga, Y., Nishioka, T., Ito, M., and Nakabeppu, Y. (2003) In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis. J. Biol. Chem. 278, 48422-48433
26. Lee, C.M., Onésime, D., Reddy, C.D., Dhanasekaran, N., and Reddy, E.P. (2002) JLP: A scaffolding protein that tethers JNK/ p38MAPK signaling modules and transcription factors. Proc. Natl Acad. Sci. USA 99, 14189-14194
27. Morrison, D.K. (2001) KSR: a MAPK scaffold of the Ras pathway? J. Cell Sci. 114, 1609-1612
28. Ohmachi, M., Rocheleau, C.E., Church, D., Lambie, E., Schedl, T., and Sundaram, M.V. (2002) C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required fot MPK-1 ERK phosphorylation. Curr. Biol. 12, 427-433
29. Roy, F., Laberge, G., Douziech, M., Ferland-McCollough, D., and Therrien, M. (2001) KSR is a scaffold required for activation of the ERK/MAPK module. Genes Dev. 16, 427-438
30. Nguyen, A., Burack, W.R., Stock, J.L., Kortum, R., Chaika, O.V., Afkarian, M., Muller, W.J., Murphy, K.M., Morrison, D.K., Lewis, R.E., McNeish, J., and Shaw, A.S. (2002) Kinase suppressor of Ras (KSR) is a scaffold protein which facilitates mitogen-activated protein kinase activation in vivo. Mol. Cell. Biol. 22, 3035-3045
31. Schaeffer, H.J., Catling, A.D., Eblen, S.T., Collier, L.S., Krauss, A., and Weber, M.J. (1998) MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281, 1668-1671
32. Tapon, N., Nagata, K., Lamarche, N., and Hall, A. (1998) A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NK-κB signaling pathways. EMBO J. 17, 1395-1404
33. Xu, Z., Kukekov, N.V., and Greene, L.A. (2003) POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22, 252-261
34. Luttrell, L.M. and Lefkowitz, R.J. (2002) The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 115, 455-465
35. DeFea, K.A., Zalevsky, J., Thoma, M.S., Déry, O., Mullins, R.D., and Bunnett, N.W. (2000) β-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 148, 1267-1281
36. Luttrell, L.M., Roudabush, F.L., Choy, E.W., Miller, W.E., Field, M.E., Pierce, K.L., and Lefkowitz, R.J. (2001) Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds. Proc. Natl Acad. Sci. USA 98, 2449-2454
37. McDonald, P.H., Chow, C.W., Miller, W.E., Laporte, S.A., Field, M.E., Lin, F.T., Davis, R.J., and Lefkowitz, R.J. (2000) β-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science 290, 1574-1577
38. Marti, A., Luo, Z., Cunningham, C., Ohta, Y., Hartwig, J., Stossel, T.P., Kyriakis, J.M., and Avruch, J. (1997) Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-α activation of SAPK in melanoma cells. J. Biol. Chem. 272, 2620-2628
39. Zama, T., Aoki, R., Kamimoto, T., Inoue, K., Ikeda, Y., and Hagiwara, M. (2002) Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. J. Biol. Chem. 277, 23919-23926
40. Uhlik, M.T., Abell, A.N., Johnson, N.L., Sun, W., Cuevas, B.D., Lobel-Rice, K.E., Horne, E.A., Dell'Acqua, M.L., and Johnson, G.L. (2003) Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat. Cell Biol. 5, 1104-1110
41. Park, S.H., Zarrinpar, A., and Lim, W.A. (2003) Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299, 1061-1064
42. Nihalani, D., Wong, H.N., and Holzman, L.B. (2003) Requirement of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation. J. Biol. Chem. 278, 28694-28702
43. Kim, A.H., Yano, H., Cho, H., Meyer, D., Monks, B., Margolis, B., Birnbaum, M.J., and Chao, M.V. (2002) Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35, 697-709
44. Figueroa, C., Tarras, S., Taylor, J., and Vojtek, A.B. (2003) Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. J. Biol. Chem. 278, 47922-47927
45. Verhey, K.J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B.J., Rapoport, T.A., and Margolis, B. (2001) Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J. Cell Biol. 152, 959-970
46. Taru, H., Kirino, Y., and Suzuki, T. (2002) Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J. Biol. Chem. 277, 27567-27574
47. Inomata, H., Nakamura, Y., Hayakawa, A., Takata, H., Suzuki, T., Miyazawa, K., and Kitamura, N. (2003) J. Biol. Chem. 278, 22946-22955
48. Matsuda, S., Matsuda, Y., and D'Adamio, L. (2003) Amyloid β protein precursor (AβPP), but not AβPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J. Biol. Chem. 278, 38601-38606
49. Bowman, A.B., Kamal, A., Ritchings, B.W., Philp, A.V., McGrail, M., Gindhart, J.G., and Goldstein, L.S.B. (2000) Kinesin-dependent axonal transport is mediated by the Sunday driver (SYD) protein. Cell 103, 583-594
50. Byrd, D.T., Kawasaki, M., Walcoff, M., Hisamoto, N., Matsumoto, K., and Jin, Y. (2001) UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. Neuron 32, 787-800
51. Setou, M., Seog, D.H., Tanaka, Y., Kanai, Y., Takei, Y., Kawagishi, M., and Hirokawa, N. (2002) Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature 417, 83-87
52. Müller, J., Ory, S., Copeland, T., Piwnica-Worms, H., and Morrison, D.K. (2001) C-TAK regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol. Cell 8, 983-993
53. Ory, S., Zhou, M., Conrads, T.P., Veenstra, T.D., and Morrison, D.K. (2003) Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites. Curr. Biol. 13, 1356-1364
54. Ge, L., Ly, Y., Hollenberg, M., and DeFea, K. (2003) A β-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278, 34418-34426
55. Teis, D., Wunderlich, W., and Huber, L.A. (2002) Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 3, 803-814