Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor γ

Journal of Biological Chemistry

Volumn 281, Issue 37, 2006, Pages 26943-26950

  Winn, Robert A ^a,b,c   Van Scoyk, Michelle ^b   Hammond, Mandy ^b   Rodriguez, Karen ^b   Crossno Jr , Joseph T ^a,b   Heasley, Lynn E ^b   Nemenoff, Raphael A ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; EPITAXIAL GROWTH; MUTAGENESIS; PROTEINS; TUMORS;

ANTI-TUMORIGENIC EFFECTS; EPITHELIAL DIFFERENTIATION; LUNG TUMORIGENESIS; NON-SMALL CELL LUNG CANCER (NSCLC) CELL LINES;

DISEASE CONTROL;

FRIZZLED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 7; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN WNT 7A; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CADHERINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; HUMANS; LUNG NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASE 7; ORGANOPHOSPHORUS COMPOUNDS; PPAR GAMMA; PROTO-ONCOGENE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROTRANSMITTER; WNT PROTEINS;

EID: 33748754006     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604145200     Document Type: Article

References (38)

1. Polakis, P. (2000) Genes Dev. 14, 1837-1851
2. Tamai, K., Semenov, M., Kato, Y., Spokony, R., Liu, C., Katsuyama, Y., Hess, F., Saint-Jeannet, J. P., and He, X. (2000) Nature 407, 530-535
3. Gonzalez-Sancho, J. M., Brennan, K. R., Castelo-Soccio, L. A., and Brown, A. M. (2004) Mol. Cell. Biol. 24, 4757-4768
4. Karim, R., Tse, G., Putti, T., Scolyer, R., and Lee, S. (2004) Pathology 36, 120-128
5. Mazieres, J., He, B., You, L., Xu, Z., and Jablons, D. M. (2005) Cancer Lett. 222, 1-10
6. Winn, R. A., Marek, L., Han, S. Y., Rodriguez, K., Rodriguez, N., Hammond, M., Van Scoyk, M., Acosta, H., Mirus, J., Barry, N., Bren-Mattison, Y., Van Raay, T. J., Nemenoff, R. A., and Heasley, L. E. (2005) J. Biol. Chem. 280, 19625-19634
7. Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., and Wahli, W. (2006) Prog. Lipid Res. 45, 120-159
8. Michalik, L., Desvergne, B., and Wahli, W. (2004) Nat. Rev. Cancer 4, 61-70
9. Kinzler, K. W., and Vogelstein, B. (1996) Cell 87, 159-170
10. Sarraf, P., Mueller, E., Smith, W. M., Wright, H. M., Kum, J. B., Aaltonen, L. A., de la Chapelle, A., Spiegelman, B. M., and Eng, C. (1999) Mol. Cell 3, 799-804
11. Chang, T. H., and Szabo, E. (2000) Cancer Res. 60, 1129-1138
12. Tsubouchi, Y., Sano, H., Kawahito, Y., Mukai, S., Yamada, R., Kohno, M., Inoue, K., Hla, T., and Kondo, M. (2000) Biochem. Biophys. Res. Commun. 270, 400-405
13. Sasaki, H., Tanahashi, M., Yukiue, H., Moiriyama, S., Kobayashi, Y., Nakashima, Y., Kaji, M., Kiriyama, M., Fukai, I., Yamakawa, Y., and Fujii, Y. (2002) Lung Cancer 36, 71-76
14. Wick, M., Hurteau, G., Dessev, C., Chan, D., Geraci, M. W., Winn, R. A., Heasley, L. E., and Nemenoff, R. A. (2002) Mol. Pharmacol. 62, 1207-1214
15. Bren-Mattison, Y., Van Putten, V., Chan, D., Winn, R., Geraci, M. W., and Nemenoff, R. A. (2005) Oncogene 24, 1412-1422
16. Winn, R. A., Bremnes, R. M., Bemis, L., Franklin, W. A., Miller, Y. E., Cool, C., and Heasley, L. E. (2002) Oncogene 21, 7497-7506
17. He, T. C., Chan, T. A., Vogelstein, B., and Kinzler, K. W. (1999) Cell 99, 335-345
18. Akaike, M., Che, W., Marmarosh, N. L., Ohta, S., Osawa, M., Ding, B., Berk, B. C., Yan, C., and Abe, J. (2004) Mol. Cell. Biol. 24, 8691-8704
19. Cameron, S. J., Malik, S., Akaike, M., Lerner-Marmarosh, N., Yan, C., Lee, J. D., Abe, J., and Yang, J. (2003) J. Biol. Chem. 278, 18682-18688
20. Kamakura, S., Moriguchi, T., and Nishida, E. (1999) J. Biol. Chem. 274, 26563-26571
21. Mody, N., Leitch, J., Armstrong, C., Dixon, J., and Cohen, P. (2001) FEBS Lett. 502, 21-24
22. Perissi, V., Aggarwal, A., Glass, C. K., Rose, D. W., and Rosenfeld, M. G. (2004) Cell 116, 511-526
23. Rieusset, J., Touri, F., Michalik, L., Escher, P., Desvergne, B., Niesor, E., and Wahli, W. (2002) Mol. Endocrinol. 16, 2628-2644
24. Santini, E., Fallahi, P., Ferrari, S. M., Masoni, A., Antonelli, A., and Ferrannini, E. (2004) Diabetes 53, Suppl. 3, S79-S83
25. Thiery, J. P. (2002) Nat. Rev. Cancer 2, 442-454
26. Thiery, J. P. (2003) Curr. Opin. Cell Biol. 15, 740-746
27. Hajra, K. M., Chen, D. Y., and Fearon, E. R. (2002) Cancer Res. 62, 1613-1618
28. Jansson, E. A., Are, A., Greicius, G., Kuo, I. C., Kelly, D., Arulampalam, V., and Pettersson, S. (2005) Proc. Natl. Acad. Sci. U. S. A.
29. Kirikoshi, H., and Katoh, M. (2002) Int. J. Oncol. 21, 895-900
30. Calvo, R., West, J., Franklin, W., Erickson, P., Bemis, L., Li, E., Helfrich, B., Bunn, P., Roche, J., Brambilla, E., Rosell, R., Gemmill, R. M., and Drabkin, H. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 12776-12781
31. Demetri, G. D., Fletcher, C. D., Mueller, E., Sarraf, P., Naujoks, R., Campbell, N., Spiegelman, B. M., and Singer, S. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3951-3956
32. Nemenoff, R. A., and Winn, R. A. (2005) Eur. J. Cancer 41, 2561-2568
33. Fukuhara, S., Marinissen, M. J., Chiariello, M., and Gutkind, J. S. (2000) J. Biol. Chem. 275, 21730-21736
34. Hayashi, M., and Lee, J. D. (2004) J. Mol. Med. 82, 800-808
35. Gelman, L., Michalik, L., Desvergne, B., and Wahli, W. (2005) Curr. Opin. Cell Biol. 17, 216-222
36. Hu, E., Kim, J. B., Sarraf, P., and Spiegelman, B. M. g. (1996) Science 274, 2100-2103
37. Shao, D., Rangwala, S. M., Bailey, S. T., Krakow, S. L., Reginato, M. J., and Lazar, M. A. (1998) Nature 396, 377-380
38. Yu, C., Markan, K., Temple, K. A., Deplewski, D., Brady, M. J., and Cohen, R. N. (2005) J. Biol. Chem. 280, 13600-13605