Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation

Journal of Biological Chemistry

Volumn 281, Issue 37, 2006, Pages 27613-27620

  Vaidehi, Nagarajan ^b,d   Schlyer, Sabine ^a   Trabanino, Rene J ^b   Floriano, Wely B ^b   Abrol, Ravinder ^b   Sharma, Shantanu ^b   Kochanny, Monica ^a   Koovakat, Sunil ^a   Dunning, Laura ^a   Liang, Meina ^a   Fox, James M ^c   De Mendonça, Filipa Lopes ^c   Pease, James E ^c   Goddard III, William A ^b   Horuk, Richard ^a  

^a BAYER AG   (Germany)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; IMMUNOLOGY; PROTEINS; STRUCTURAL ANALYSIS; VIRUSES;

COMPUTATIONAL METHOD; G PROTEIN-COUPLED RECEPTORS (GPCR); MUTANTS; THREE-DIMENSIONAL STRUCTURE;

DRUG DOSAGE;

1 [5 CHLORO 2 [2 [4 (4 FLUOROBENZYL) 2 METHYL 1 PIPERAZINYL] 2 OXOETHOXY]PHENYL]UREA; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR1;

ARTICLE; BINDING SITE; CHEMOTAXIS; CORRELATION ANALYSIS; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN CELL; LIGAND BINDING; MATHEMATICAL MODEL; POINT MUTATION; PREDICTION; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ANIMALS; BINDING SITES; CHEMOTAXIS; EPITOPES; HUMANS; MICE; MODELS, MOLECULAR; MUTATION; PHENYLUREA COMPOUNDS; PIPERIDINES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CHEMOKINE; SOFTWARE; TYROSINE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33748747498     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601389200     Document Type: Article

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