Ecotin modulates thrombin activity through exosite-2 interactions

International Journal of Biochemistry and Cell Biology

Volumn 38, Issue 11, 2006, Pages 1893-1900

  Castro, Helena C ^a,b   Monteiro, Robson Q ^b   Assafim, Mariane ^b   Loureiro, Natália I V ^a   Craik, Charles ^c   Zingali, Russolina B ^b  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Allosteric changes; Anion binding exosite; Ecotin; Thrombin

Indexed keywords

ANTITHROMBIN; BACTERIAL PROTEIN; ECOTIN; FIBRINOGEN; HEPARIN; SERINE PROTEINASE INHIBITOR; THROMBIN; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; ECO PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; PERIPLASMIC PROTEIN; SERINE PROTEINASE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; BLOOD CLOTTING; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME STRUCTURE; FLUORESCENCE ANALYSIS; GEL FILTRATION CHROMATOGRAPHY; IC 50; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; STOICHIOMETRY; THROMBOCYTE AGGREGATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; HUMAN; METABOLISM; PROTEIN CONFORMATION; SPECTROFLUOROMETRY;

ESCHERICHIA COLI; MAMMALIA;

BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI PROTEINS; HUMANS; PERIPLASMIC PROTEINS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPECTROMETRY, FLUORESCENCE; THROMBIN;

EID: 33748658787     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2006.05.001     Document Type: Article

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