-
1
-
-
0019739066
-
Alpha 2-macroglobulin
-
Barrett, A. J. (1981). Alpha 2-macroglobulin. Methods Enzymol. 80 Pt C, 737-754.
-
(1981)
Methods Enzymol.
, vol.80
, Issue.PART C
, pp. 737-754
-
-
Barrett, A.J.1
-
2
-
-
0026530977
-
Natural protein proteinase inhibitors and their interaction with proteinase
-
Bode, W. & Huber, R. (1992). Natural protein proteinase inhibitors and their interaction with proteinase. Eur. J. Biochem. 204 (2), 433-451.
-
(1992)
Eur. J. Biochem.
, vol.204
, Issue.2
, pp. 433-451
-
-
Bode, W.1
Huber, R.2
-
3
-
-
0021112585
-
Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases
-
Chung, C. H., Ives, H. E., Almeda, S. & Goldberg, A. L. (1983). Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases. J. Biol. Chem, 258(18), 11032-11038.
-
(1983)
J. Biol. Chem
, vol.258
, Issue.18
, pp. 11032-11038
-
-
Chung, C.H.1
Ives, H.E.2
Almeda, S.3
Goldberg, A.L.4
-
4
-
-
46149129351
-
InsightII
-
Dayringer, H. E., Tramontano, A., Sprang, S. R. & Fletterick, R. J. (1986). InsightII. Mol. Graph. 4, 82-87.
-
(1986)
Mol. Graph.
, vol.4
, pp. 82-87
-
-
Dayringer, H.E.1
Tramontano, A.2
Sprang, S.R.3
Fletterick, R.J.4
-
5
-
-
0028853810
-
Divining the serpin inhibition mechanism: A suicide substrate 'spring'?
-
Engh, R. A., Huber, R., Bode, W. & Schulze, A. J. (1995). Divining the serpin inhibition mechanism: a suicide substrate 'spring'? Trends Biotechnol. 13(12), 503-510.
-
(1995)
Trends Biotechnol.
, vol.13
, Issue.12
, pp. 503-510
-
-
Engh, R.A.1
Huber, R.2
Bode, W.3
Schulze, A.J.4
-
6
-
-
0024393375
-
Introduction of a cysteine protease active site into trypsin
-
Higaki, J. N., Evnin, L. B. & Craik, C. S. (1989). Introduction of a cysteine protease active site into trypsin. Biochemistry, 28(24), 9256-9263.
-
(1989)
Biochemistry
, vol.28
, Issue.24
, pp. 9256-9263
-
-
Higaki, J.N.1
Evnin, L.B.2
Craik, C.S.3
-
7
-
-
0027218342
-
Molecular recognition in biological systems: From activation to inhibition
-
Kossiakoff, A. A., Hynes, T. & de Vos, A. (1993). Molecular recognition in biological systems: from activation to inhibition. Biochem. Soc. Trans. 21(Pt 3), 614-618.
-
(1993)
Biochem. Soc. Trans.
, vol.21
, Issue.3 PART
, pp. 614-618
-
-
Kossiakoff, A.A.1
Hynes, T.2
De Vos, A.3
-
8
-
-
2642699794
-
Rapid and efficient site-specific mutagenesis without phenotypic selection
-
Kunkel, T. A. (1985). Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl Acad. Sci. USA, 82(2), 488-492.
-
(1985)
Proc. Natl Acad. Sci. USA
, vol.82
, Issue.2
, pp. 488-492
-
-
Kunkel, T.A.1
-
9
-
-
0018873523
-
Protein inhibitions of proteinases
-
Laskowski, M. J. & Kato, I. (1980). Protein inhibitions of proteinases. Annu. Rev. Biochem. 49(593), 593-626.
-
(1980)
Annu. Rev. Biochem.
, vol.49
, Issue.593
, pp. 593-626
-
-
Laskowski, M.J.1
Kato, I.2
-
10
-
-
0015222647
-
The interpretation of protein structures: Estimation of static accessibility
-
Lee, B. & Richards, F. M. (1971). The interpretation of protein structures: estimation of static accessibility. J. Mol. Biol. 55(3), 379-400.
-
(1971)
J. Mol. Biol.
, vol.55
, Issue.3
, pp. 379-400
-
-
Lee, B.1
Richards, F.M.2
-
11
-
-
0031581824
-
Binding of amino acid side-chains to S1 cavities of serine proteinases
-
Lu, W., Apostol, I., Qasim, M. A., Warne, N., Wynn, R., Zhang, W. L., Anderson, S., Chiang, Y. W., Ogin, E., Rothberg, I., Ryan, K. & Laskowski, M., Jr (1997). Binding of amino acid side-chains to S1 cavities of serine proteinases. J. Mol. Biol. 266(2), 441-461.
-
(1997)
J. Mol. Biol.
, vol.266
, Issue.2
, pp. 441-461
-
-
Lu, W.1
Apostol, I.2
Qasim, M.A.3
Warne, N.4
Wynn, R.5
Zhang, W.L.6
Anderson, S.7
Chiang, Y.W.8
Ogin, E.9
Rothberg, I.10
Ryan, K.11
Laskowski Jr., M.12
-
12
-
-
0026410233
-
Expression of the protease inhibitor ecotin and its co-crystallization with trypsin
-
McGrath, M. E., Erpel, Y., Browner, M. F. & Fletterick, R. J. (1991a). Expression of the protease inhibitor ecotin and its co-crystallization with trypsin. J. Mol. Biol. 222(2), 139-142.
-
(1991)
J. Mol. Biol.
, vol.222
, Issue.2
, pp. 139-142
-
-
McGrath, M.E.1
Erpel, Y.2
Browner, M.F.3
Fletterick, R.J.4
-
13
-
-
0025865926
-
The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli
-
McGrath, M. E., Hines, W. M., Sakanari, J. A., Fletterick, R. J. & Craik, C. S. (1991b). The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli. J. Biol. Chem. 266(10), 6620-6625.
-
(1991)
J. Biol. Chem.
, vol.266
, Issue.10
, pp. 6620-6625
-
-
McGrath, M.E.1
Hines, W.M.2
Sakanari, J.A.3
Fletterick, R.J.4
Craik, C.S.5
-
14
-
-
0028266885
-
Macromolecular chelation as an improved mechanism of protease inhibition: Structure of the ecotin-trypsin complex
-
McGrath, M. E., Erpel, T., Bystroff, C. & Fletterick, R. J. (1994). Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex. EMBO J. 13(7), 1502-1507.
-
(1994)
EMBO J.
, vol.13
, Issue.7
, pp. 1502-1507
-
-
McGrath, M.E.1
Erpel, T.2
Bystroff, C.3
Fletterick, R.J.4
-
15
-
-
0014454095
-
Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors
-
Morrison, J. F. (1969). Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors. Biochim. Biophys. Acta, 185(2), 269-286.
-
(1969)
Biochim. Biophys. Acta
, vol.185
, Issue.2
, pp. 269-286
-
-
Morrison, J.F.1
-
16
-
-
0028288397
-
Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis
-
Pal, G., Sprengel, G., Patthy, A. & Graf, L. (1994). Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis. FEBS Letters, 342(1), 57-60.
-
(1994)
FEBS Letters
, vol.342
, Issue.1
, pp. 57-60
-
-
Pal, G.1
Sprengel, G.2
Patthy, A.3
Graf, L.4
-
17
-
-
0040031788
-
Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis
-
Pal, G., Szilagyi, L. & Graf, L. (1996). Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis. FEBS Letters, 385(3), 165-170.
-
(1996)
FEBS Letters
, vol.385
, Issue.3
, pp. 165-170
-
-
Pal, G.1
Szilagyi, L.2
Graf, L.3
-
18
-
-
0031024397
-
Interscaffolding additivity. Association of P1 variants of eglin c and of turkey ovomucoid third domain with serine proteinases
-
Qasim, M. A., Ganz, P. J., Saunders, C. W., Bateman, K. S., James, M. N. & Laskowski, M., Jr (1997). Interscaffolding additivity. Association of P1 variants of eglin c and of turkey ovomucoid third domain with serine proteinases. Biochemistry, 36(7), 1598-1607.
-
(1997)
Biochemistry
, vol.36
, Issue.7
, pp. 1598-1607
-
-
Qasim, M.A.1
Ganz, P.J.2
Saunders, C.W.3
Bateman, K.S.4
James, M.N.5
Laskowski Jr., M.6
-
19
-
-
0025329390
-
The structure of a complex recombinant hirudin and human alpha-thrombin
-
Rydel, T. J., Ravichandran, K. G., Tulinsky, A., Bode, W., Huber, R., Roitsch, C. & Fenton, J. W. d. (1990). The structure of a complex recombinant hirudin and human alpha-thrombin. Science, 249(4966), 277-280.
-
(1990)
Science
, vol.249
, Issue.4966
, pp. 277-280
-
-
Rydel, T.J.1
Ravichandran, K.G.2
Tulinsky, A.3
Bode, W.4
Huber, R.5
Roitsch, C.6
Fenton, J.W.D.7
-
20
-
-
0014211618
-
On the size of the active site in proteases. I. Papain
-
Schechter, I. & Berger, A. (1967). On the size of the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27, 159.
-
(1967)
Biochem. Biophys. Res. Commun.
, vol.27
, pp. 159
-
-
Schechter, I.1
Berger, A.2
-
21
-
-
0028780764
-
The P1 reactive site methionine residue of ecotin is not crucial for its specificity on target proteases. A potent inhibitor of pancreatic serine proteases from Escherichia coli
-
Seong, I. S., Lee, H. R., Seol, J. H., Park, S. K., Lee, C. S., Suh, S. W., Hong, Y. M., Kang, M. S., Ha, D. B. & Chung, C. H. (1994). The P1 reactive site methionine residue of ecotin is not crucial for its specificity on target proteases. A potent inhibitor of pancreatic serine proteases from Escherichia coli. J. Biol. Chem. 269(34), 21915-21918.
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.34
, pp. 21915-21918
-
-
Seong, I.S.1
Lee, H.R.2
Seol, J.H.3
Park, S.K.4
Lee, C.S.5
Suh, S.W.6
Hong, Y.M.7
Kang, M.S.8
Ha, D.B.9
Chung, C.H.10
-
22
-
-
0028269445
-
Ecotin is a potent anticoagulant and reversible tight-binding inhibitor of factor Xa
-
Seymour, J. L., Lindquist, R. N., Dennis, M. S., Moffat, B., Yansura, D., Reilly, D., Wessinger, M. E. & Lazarus, R. A. (1994). Ecotin is a potent anticoagulant and reversible tight-binding inhibitor of factor Xa. Biochemistry, 33(13), 3949-3958.
-
(1994)
Biochemistry
, vol.33
, Issue.13
, pp. 3949-3958
-
-
Seymour, J.L.1
Lindquist, R.N.2
Dennis, M.S.3
Moffat, B.4
Yansura, D.5
Reilly, D.6
Wessinger, M.E.7
Lazarus, R.A.8
-
23
-
-
0025812630
-
Refined crystal structure of the complex of subtilisin BPN' and Streptomyces subtilisin inhibitor at 1.8 Å resolution
-
Takeuchi, Y., Satow, T., Nakamura, K. T. & Mitsui, Y. (1991). Refined crystal structure of the complex of subtilisin BPN' and Streptomyces subtilisin inhibitor at 1.8 Å resolution. J. Mol. Biol. 221(1), 309-325.
-
(1991)
J. Mol. Biol.
, vol.221
, Issue.1
, pp. 309-325
-
-
Takeuchi, Y.1
Satow, T.2
Nakamura, K.T.3
Mitsui, Y.4
-
24
-
-
0028784163
-
Two heads are better than one: Crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin
-
van de Locht, A., Lamba, D., Bauer, M., Huber, R., Friedrich, T., Kroger, B., Hoffken, W. & Bode, W. (1995). Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J. 14(21), 5149-5157.
-
(1995)
EMBO J.
, vol.14
, Issue.21
, pp. 5149-5157
-
-
Locht, A.1
Lamba, D.2
Bauer, M.3
Huber, R.4
Friedrich, T.5
Kroger, B.6
Hoffken, W.7
Bode, W.8
-
25
-
-
0029957955
-
The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
-
van de Locht, A., Stubbs, M. T., Bode, W., Friedrich, T., Bollschweiler, C., Hoffken, W. & Huber, R. (1996). The ornithodorin-thrombin crystal structure, a key to the TAP enigma? EMBO J. 15(22), 6011-6017.
-
(1996)
EMBO J.
, vol.15
, Issue.22
, pp. 6011-6017
-
-
Locht, A.1
Stubbs, M.T.2
Bode, W.3
Friedrich, T.4
Bollschweiler, C.5
Hoffken, W.6
Huber, R.7
-
26
-
-
0029020237
-
Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin
-
Wang, C. I., Yang, Q. & Craik, C. S. (1995). Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin. J. Biol. Chem. 270(20), 12250-12256.
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.20
, pp. 12250-12256
-
-
Wang, C.I.1
Yang, Q.2
Craik, C.S.3
-
27
-
-
0025082684
-
Additivity of mutational effects in proteins
-
Wells, J. A. (1990). Additivity of mutational effects in proteins. Biochemistry, 29(37), 8509-8517.
-
(1990)
Biochemistry
, vol.29
, Issue.37
, pp. 8509-8517
-
-
Wells, J.A.1
-
28
-
-
0030050701
-
Binding in the growth hormone receptor complex
-
Wells, J. A. (1996). Binding in the growth hormone receptor complex. Proc. Natl Acad. Sci USA, 93(1), 1-6.
-
(1996)
Proc. Natl Acad. Sci USA
, vol.93
, Issue.1
, pp. 1-6
-
-
Wells, J.A.1
-
29
-
-
0023394374
-
Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering
-
Wells, J. A., Cunningham, B. C., Graycar, T. P. & Estell, D. A. (1987). Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering. Proc. Natl Acad. Sci. USA, 84(15), 5167-5171.
-
(1987)
Proc. Natl Acad. Sci. USA
, vol.84
, Issue.15
, pp. 5167-5171
-
-
Wells, J.A.1
Cunningham, B.C.2
Graycar, T.P.3
Estell, D.A.4
-
30
-
-
0032546736
-
Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator
-
Yang, S. Q. & Craik, C. S. (1998). Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator. J. Mol. Biol. 279, 1001-1011.
-
(1998)
J. Mol. Biol.
, vol.279
, pp. 1001-1011
-
-
Yang, S.Q.1
Craik, C.S.2
|