Sequence determinants of function and evolution in serine proteases

Trends in Cardiovascular Medicine

Volumn 10, Issue 4, 2000, Pages 171-176

  Krem, Maxwell M ^a   Rose, Thierry ^a   Di Cera, Enrico ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; ANCROD; APOLIPOPROTEIN A; AZUROCIDIN; BATROXOBIN; BLOOD CLOTTING FACTOR 9; BRACHYURIN; CALDECRIN; CATHEPSIN G; CHYMASE; CHYMOTRYPSIN; COMPLEMENT; COMPLEMENT COMPONENT C2; COMPLEMENT FACTOR D; COMPLEMENT FACTOR I; EPITOPE; FIBRINOGEN; GRANZYME A; GRANZYME B; GRANZYME D; GRANZYME F; HOUSE DUST ALLERGEN; HYPODERMIN; KALLIKREIN; LEUKOCYTE ELASTASE; MEPRIN; MYELOBLASTIN; NERVE GROWTH FACTOR; NEUROENDOCRINE SPECIFIC PROTEIN; NEUROPSIN; PLASMIN; PLASMINOGEN; PROSTATE SPECIFIC ANTIGEN; PROTEIN C; PROTEINASE; PROTHROMBIN; SCATTER FACTOR; SERINE PROTEINASE; THROMBIN; TRYPTASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BINDING SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; EVOLUTION; HUMAN; KRINGLE DOMAIN; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ANIMALS; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, PROTEIN; SERINE ENDOPEPTIDASES;

EID: 0034470147     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(00)00068-2     Document Type: Review

References (52)

1. A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection
2. The Drosophila stubble-stubbloid gene encodes an apparent transmembrane serine-protease required for epithelial morphogenesis
3. Introduction; tissue kallikrein and its relatives
4. Monocyte chemotaxis; stimulation by specific exosite region in thrombin
5. Isolation and sequence of a rat chymotrypsin B gene
6. Horseshoe crab coagulogen is an invertebrate protein with a nerve growth factor-like domain
7. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
8. Thrombin-induced chemotaxis and aggregation of neutrophils
9. Exon and domain evolution in the proenzymes of blood coagulation and fibrinolysis
10. The molecular evolution of genes and proteins; a tale of two serines
11. The role of easter, an apparent serine protease, in organizing the dorsal-ventral axis of the Drosophila embryo
12. Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
13. Thrombin, a survival factor for cultured myoblasts
14. Residue 225 determines the Na+-induced allosteric regulation of catalytic activity in serine proteases
15. Molecular mechanisms of thrombin function
16. Prothrombin messenger-RNA is expressed by cells of the nervous-system
17. Signaling pathways involved in thrombin-induced cell protection
18. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities
19. Reconstructing the evolution of vertebrate blood coagulation from a consideration of the amino acid sequences of clotting proteins
20. Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates
21. Evolution of the complement system
22. Molecular characterization of five serine protease genes cloned from Anopheles gambiae hemolymph
23. Converting trypsin to chymotrypsin; the role of surface loops
24. The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis
25. Genes for mast-cell serine protease and their molecular evolution
26. Divergent evolutionary histories of kringle and protease domains in serine proteases; a typical example of domain evolution
27. Signaling mechanisms in the antimicrobial host defense of Drosophila.
28. Structure and evolution of the bovine prothrombin gene
29. Protease-activated receptor 3 is a second thrombin receptor in humans
30. New types of clotting factors and defense molecules found in horseshoe crab hemolymph; their structures and functions
31. Conserved water molecules in the specificity pocket of serine proteases and the molecular mechanism of Na+ binding
32. The C-terminal sequence encodes function in serine proteases
33. Convergent evolution of apolipoprotein(a) in primates and hedgehog
34. Conservation and variability in the structures of serine proteinases of the chymotrypsin family
35. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila.
36. A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
37. Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene
38. The role of hemolymph coagulation in innate immunity
39. Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules
40. Evolution of blood coagulation and fibrinolysis
41. Evolutionary families of peptidases
42. The molecular evolution of the vertebrate trypsinogens
43. Evolutionary divergence and conservation of trypsin
44. Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteases
45. Inhibition of thrombin-induced neuronal cell death by recombinant thrombomodulin and E5510, a synthetic thrombin receptor signaling inhibitor
46. Mutational analysis of the Drosophila snake protease; an essential role for domains within the proenzyme polypeptide-chain
47. Ontogeny of neuropsin messenger-RNA expression in the mouse brain
48. The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system
49. Recent evolutionary divergence of plasma prekallikrein and factor XI
50. Molecular-cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
51. Plasticity-related serine proteases in the brain
52. Prothrombin promotes the invasiveness of melanoma cells by a different mechanism from thrombin