The Asp272-Glu282 region of platelet glycoprotein IBα interacts with the heparin-binding site of α-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III

Journal of Biological Chemistry

Volumn 275, Issue 6, 2000, Pages 3887-3895

  De Cristofaro, Raimondo ^a,c   De Candia, Erica ^a   Rutella, Sergio ^a   Weitz, Jeffrey I ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b MCMASTER UNIVERSITY   (Canada)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; ASPARTIC ACID; CARBOXYPEPTIDASE C; GLUTAMIC ACID; GLYCOPROTEIN IB; HEPARIN; SNAKE VENOM; THROMBIN; CALCIUM; CARBOXYPEPTIDASE; FIBRINOGEN; METALLOPROTEINASE; MOCARHAGIN; PEPTIDE FRAGMENT; PPGB PROTEIN, HUMAN; SINGLE STRANDED DNA; SODIUM CHLORIDE; THROMBIN RECEPTOR;

ARTICLE; BINDING SITE; ENZYME INHIBITION; HUMAN; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; THROMBOCYTE AGGREGATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; KINETICS; METABOLISM; PROTEIN BINDING;

ANTITHROMBIN III; BINDING SITES; CALCIUM; CARBOXYPEPTIDASE C; CARBOXYPEPTIDASES; COBRA VENOMS; DNA, SINGLE-STRANDED; FIBRINOGEN; HEPARIN; HUMANS; KINETICS; METALLOENDOPEPTIDASES; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN BINDING; SODIUM CHLORIDE; THROMBIN;

EID: 0034635224     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.6.3887     Document Type: Article

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