Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 36, 2006, Pages 13451-13456

  Tran, Elise H ^a   Azuma, Yasu Taka ^b   Chen, Manchuan ^a   Weston, Claire ^c   Davis, Roger J ^c   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Osaka Prefecture University   (Japan)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

C Jun N terminal kinase; Experimental autoimmune encephelomyelitis; Innate immunity; Macrophages

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INACTIVATION; ENZYME REGULATION; FEMALE; GENE LOSS; IMMUNE RESPONSE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TARGET ORGAN;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNITY; BRAIN; CROSSES, GENETIC; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FREUND'S ADJUVANT; IMMUNITY, NATURAL; INTERLEUKIN-10; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 8; MYELIN-ASSOCIATED GLYCOPROTEIN; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

ANIMALIA;

EID: 33748629409     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601155103     Document Type: Article

References (42)

1. Buljevac, D., Flach, H.Z., Hop, W. C. J., Hijdra, D., Laman, J. D., Savelkoul, H. F. J., van der Meche, F. G. A., van Doorn, P. A. & Hintzen, R. Q. (2002) Brain 125, 952-960.
2. Kerfoot, S. M., Long, E. M., Hickey, M. J., Andonegui, G., Lapointe, B. M., Zanardo, R. C. O., Bonder, C., James, W. G., Robbins, S. M. & Kubes, P. (2004) J. Immunol. 173, 7070-7077.
3. Goverman, J., Woods, A., Larson, L., Weiner, L. P., Hood, L. & Zaller, D. M. (1993) Cell 72, 551-560.
4. Weston, C.R. & Davis, R. J. (2002) Curr. Opin. Genet. Dev. 12, 14-21.
5. Yang, D.D., Kuan, C. Y., Whitmarsh, A. J., Rincon, M., Zheng, T.S., Davis, R. J., Rakic, P. & Flavell, R. A. (1997) Nature 389, 865-870.
6. Sabapathy, K., Hochedlinger, K., Nam, S. Y., Bauer, A., Karin, M. & Wagner, E. F. (2004) Mol. Cell 15, 713-725.
7. Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C. Z., Uysal, K. T., Maeda, K., Karin, M. & Hotamisligil, G. S. (2002) Nature 420, 333-336.
8. David, J. P., Sabapathy, K., Hoffmann, O., Idarraga, M. H. & Wagner, E. F. (2002) J. Cell Sci. 115, 4317-4325.
9. Sabapathy, K., Kallunki, T., David, J. P., Graef, I., Karin, M. & Wagner, E. F. (2001) J. Exp. Med. 193, 317-328.
10. Gao, M., Labuda, T., Xia, Y., Gallagher, E., Fang, D., Liu, Y. C. & Karin, M. (2004) Science 306, 271-275.
11. Dong, C., Yang, D. D., Wysk, M., Whitmarsh, A. J., Davis, R. J. & Flavell, R. A. (1998) Science 282, 2092-2095.
12. Conze, D., Krahl, T., Kennedy, N., Weiss, L., Lumsden, J., Hess, P., Flavell, R. A., Le Gros, G., Davis, R. J. & Rincon, M. (2002) J. Exp. Med. 195, 811-823.
13. Arbour, N., Naniche, D., Homann, D., Davis, R. J., Flavell, R. A. & Oldstone, M. B. A. (2002) J. Exp. Med. 195, 801-810.
14. Jaeschke, A., Rincon, M., Doran, B., Reilly, J., Neuberg, D., Greiner, D. L., Shultz, L. D., Rossini, A. A., Flavell, R. A. & Davis, R. J. (2005) Proc. Natl. Acad. Sci. USA 102, 6931-6935.
15. Constant, S. L., Dong, C., Yang, D. D., Wysk, M., Davis, R. J. & Flavell, R. A. (2000) J. Immunol. 165, 2671-2676.
16. Akira, S. & Takeda, K. (2004) Nat. Rev. Immunol. 4, 499-511.
17. Moon, Y. & Pestka, J. J. (2002) Toxicol Sci. 69, 373-382.
18. Hacker, H., Mischak, H., Hacker, G., Eser, S., Prenzelm, N., Ullrichm, A. & Wagner, H. (1999) EMBO J. 18, 6973-6982.
19. Foster, G. H. & Tesh, V. L. (2002) J. Leukocyte Biol. 71, 107-114.
20. Palaszynski, K. M., Loo, K. K., Ashouri, J. F., Liu, H. B. & Voskuhl, R. R. (2004) J. Neuroimmunol. 146, 144-152.
21. Papenfuss, T. L., Rogers, C. J., Gienapp, I., Yurrita, M., McClain, M., Damico, N., Valo, J., Song, F. & Whitacre, C. C. (2004) J. Neuroimmunol. 150, 59-69.
22. Nicolson, K., Freland, S., Weir, C., Delahunt, B., Flavell, R. A. & Backstrom, B. T. (2002) Int. Immunol. 14, 849-856.
23. Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Derijard, B. & Davis, R. J. (1996) EMBO J. 15, 2760-2770.
24. Zamvil, S. S. & Steinman, L. (1990) Annu. Rev. Immunol. 8, 579-621.
25. Hofstetter, H. H., Karulin, A. Y., Forsthuber, T. G., Ott, P. A., Tary-Lehmann, M. & Lehmann, P. V. (2005) J. Neuroimmunol. 170, 105-114.
26. Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A. & Cua, D. J. (2005) J. Exp. Med. 201, 233-240.
27. Kolls, J. K. & Linden, A. (2004) Immunity 21, 467-476.
28. Ndhlovu, L. C., Ishii, N., Murata, K., Sato, T. & Sugamura, K. (2001) J. Immunol. 167, 2991-2999.
29. Disis, M. L., Bernhard, H., Shiota, F. M., Hand, S. L., Gralow, J. R., Huseby, E. S., Gillis, S. & Cheever, M. A. (1996) Blood 88, 202-210.
30. Munn, D. H. & Mellor, A. L. (2003) Curr. Pharm. Des. 9, 257-265.
31. Moore, K. W., de Waal Malefyt, R., Coffman, R. L. & O'Garra, A. (2001) Annu. Rev. Immunol. 19, 683-765.
32. Greter, M., Heppner, F. L., Lemos, M. P., Odermatt, B. M., Goebels, N., Laufer, T., Noelle, R. J. & Becher, B. (2005) Nat. Med. 11, 328-334.
33. Flügel, A., Berkowicz, T., Ritter, T., Labeur, M., Jenne, D. E., Li, Z., Ellwart, J. W., Willem, M., Lassmann, H. & Wekerle, H. (2001) Immunity 14, 547-560.
34. Kohm, A. P., Carpentier, P. A., Anger, H. A. & Miller, S. D. (2002) J. Immunol. 169, 4712-4716.
35. Heppner, F. L., Greter, M., Marino, D., Falsig, J., Raivich, G., Hovelmeyer, N., Waisman, A., Rulicke, T., Prinz, M., Priller, J., et al. (2005) 11, 146-152.
36. Schwandner, R., Yamaguchi, K. & Cao, Z. (2000) J. Exp. Med. 191, 1233-1240.
37. Olsen, J. K. & Miller, S. D. (2004) J. Immunol. 173, 3916-3924.
38. Prinz, M., Garbe, F., Schmidt, H., Mildner, A., Gutcher, I., Wolter, K., Piesche, M., Schroers, R., Weiss, E., Kirschning, C. J., et al. (2006) J. Clin. Invest. 116, 456-464.
39. Namer, I. J. & Steibel, J. (2000) J. Neuroimmunol. 103, 63-68.
40. Matthys, P., Vermeire, K. & Billiau, A. (2001) Trends Immunol. 22, 367-371.
41. Zekki, H., Feinstein, D. L. & Rivest, S. (2002) Brain Pathol. 12, 308-319.
42. Tran, E. H., Prince, E. N. & Owens, T. (2000) J. Immunol. 164, 2759-2768.