Ras: The stress and the strain

Journal of Molecular and Cellular Cardiology

Volumn 41, Issue 4, 2006, Pages 595-600

  Clerk, Angela ^a   Sugden, Peter H ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCINEURIN; G PROTEIN COUPLED RECEPTOR; GLUTATHIONE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

AMINO ACID SEQUENCE; CELL DEATH; CELL PROTECTION; CONFORMATIONAL TRANSITION; EDITORIAL; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART HYPERTROPHY; HUMAN; MOLECULAR INTERACTION; MUSCLE STRAIN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRESS STRAIN RELATIONSHIP;

ANIMALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTATHIONE; HUMANS; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; MODELS, MOLECULAR; OXIDATIVE STRESS; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; STRESS, MECHANICAL;

EID: 33748613778     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2006.06.075     Document Type: Editorial

References (49)

1. Sugden P.H., and Clerk A. Cellular mechanisms of cardiac hypertrophy. J. Mol. Med. 76 (1998) 725-746
2. Wilkins B.J., and Molkentin J.D. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem. Biophys. Res. Commun. 322 (2004) 1178-1191
3. Matsui T., and Rosenzweig A. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J. Mol. Cell Cardiol. 38 (2005) 63-71
4. Wollert K.C., and Chien K.R. Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development. J. Mol. Med. 75 (1997) 492-501
5. Aikawa R., Komuro I., Yamazaki T., Zou Y., Kudoh S., Tanaka M., et al. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J. Clin. Invest. 100 (1997) 1813-1821
6. Clerk A., Fuller S.J., Michael A., and Sugden P.H. Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) by oxidative and other stresses. J. Biol. Chem. 273 (1998) 7228-7234
7. Clerk A., Michael A., and Sugden P.H. Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes. Biochem. J. 333 (1998) 581-589
8. + exchange in neonatal rat cardiac myocytes. Circ. Res. 82 (1998) 1053-1062
9. Pham F.H., Sugden P.H., and Clerk A. Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circ. Res. 86 (2000) 1252-1258
10. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103 (2000) 211-225
11. Downward J. Ras signalling and apoptosis. Curr. Opin. Genet. Dev. 8 (1998) 49-54
12. Feig L.A., Urano T., and Cantor S. Evidence for a Ras/Ral signaling cascade. Trends Biochem. Sci. 21 (1996) 438-441
13. Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81 (2001) 807-869
14. Clerk A., and Sugden P.H. Small guanine nucleotide-binding proteins and myocardial hypertrophy. Circ. Res. 86 (2000) 1019-1023
15. Sawyer D.B., Siwik D.A., Xiao L., Pimentel D.R., Singh K., and Colucci W.S. Role of oxidative stress in myocardial hypertrophy and failure. J. Mol. Cell. Cardiol. 34 (2002) 379-388
16. Pimentel D.R., Amin J.K., Xiao L., Miller T., Viereck J., Oliver-Krasinski J., et al. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ. Res. 89 (2001) 453-460
17. D.R. Pimentel, T. Adachi, Y. Ido, T. Heibeck, B. Jiang, Y. Lee, A. Melendez, R.A. Cohen, W.S. Colucci, Strain-simulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation. J. Mol. Cell Cardiol. (in press). doi:10.1016/j.yjmcc.2006.05.009
18. Cherfils J., and Chardin P. GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem. Sci. 24 (1999) 306-311
19. Bernards A., and Settleman J. GAPs in growth factor signalling. Growth Factors 23 (2005) 143-149
20. Sprang S.R. G protein mechanisms: insights from structural analysis. Annu. Rev. Biochem. 66 (1997) 639-678
21. Yan J., Roy S., Apolloni A., Lane A., and Hancock J.F. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J. Biol. Chem. 273 (1998) 24052-24056
22. Paduch M., Jeleń F., and Otlewski J. Structure of small G proteins and their regulators. Acta Biochim. Pol. 48 (2001) 829-850
23. Feig L.A. Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases. Nat. Cell Biol. 1 (1999) E25-E27
24. Berthiaume L.G. Insider information: how palmitoylation of Ras makes it a signaling double agent. Sci. STKE 2002 152 (2002) E41
25. Winter-Vann A.M., and Casey P.J. Post-prenylation-processing enzymes as new targets in oncogenesis. Nat. Rev., Cancer 5 (2005) 405-412
26. Der C.J., and Cox A.D. Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity. Cancer Cells 3 (1991) 331-340
27. Wellbrock C., Karasarides M., and Marais R. The RAF proteins take centre stage. Nat. Rev. Mol. Cell Biol. 5 (2004) 875-885
28. Sadoshima J., and Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J. 12 (1993) 1681-1692
29. 2. Role in cell survival following oxidant injury. J. Biol. Chem. 271 (1996) 4138-4142
30. Wung B.S., Cheng J.J., Chao Y.J., Hsieh H.J., and Wang D.L. Modulation of Ras/Raf/extracellularsignal-regulated kinase pathway by reactive oxygen species is involved in cyclic strain-induced early growth response-1 gene expression in endothelial cells. Circ. Res. 84 (1999) 804-812
31. Salmeen A., and Barford D. Functions and mechanisms of redox regulation of cysteine-based phosphatases. Antioxid. Redox Signal. 7 (2005) 560-577
32. Rao G.N. Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinase group of mitogen-activated protein kinases. Oncogene 13 (1996) 713-719
33. Ras S-nitrosylation and kinetics of nitric oxide-mediated guanine nucleotide exchange. Biochemistry 43 (2004) 2314-2322
34. Heo J., and Campbell S.L. Superoxide anion radical modulates the activity of Ras and Ras-related GTPases by a radical mechanism similar to that of nitric oxide. J. Biol. Chem. 280 (2005) 12435-12438
35. ras interaction. J. Biol. Chem. 272 (1997) 4323-4326
36. Ghezzi P. Regulation of protein function by glutathionylation. Free Radical Res. 39 (2005) 573-580
37. Adachi T., Pimentel D.R., Heibeck T., Hou X., Lee Y.J., Jiang B., et al. S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J. Biol. Chem. 279 (2004) 29857-29862
38. Clerk A., Aggeli I.-K., Stathopoulou K., and Sugden P.H. Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinase in neonatal cardiomyocytes. Cell. Signal. 18 (2006) 225-235
39. Clavreul N., Adachi T., Pimental D.R., Ido Y., Schöneich C., and Cohen R.A. S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells. FASEB J. 20 (2006) 518-520
40. Fiske C.H. The nature of the depressor substance of the blood. Proc. Natl. Acad. Sci. U. S. A. 20 (1934) 25-27
41. Lander H.M., Sehajpal P.K., and Novogrodsky A. Nitric oxide signaling: a possible role for G proteins. J. Immunol. 151 (1993) 7182-7187
42. Taylor S.J., and Shalloway D. Cell cycle-dependent activation of Ras. Curr. Biol. 6 (1996) 1621-1627
43. de Rooij J., and Bos J.L. Minimal Ras binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14 (1997) 623-625
44. Mott H.R., Carpenter J.W., and Campbell S.L. Structural and functional analysis of a mutant Ras protein that is insensitive to nitric oxide activation. Biochemistry 36 (1997) 3640-3644
45. Bogoyevitch M.A., Marshall C.J., and Sugden P.H. Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes. J. Biol. Chem. 270 (1995) 26303-26310
46. Chiloeches A., Paterson H.F., Marais R., Clerk A., Marshall C.J., and Sugden P.H. Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the ERK cascade by phorbol ester is mediated by Ras. J. Biol. Chem. 274 (1999) 19762-19770
47. Farooq A., and Zhou M.M. Structure and regulation of MAPK phosphatases. Cell. Signal. 16 (2004) 769-779
48. Pai E.F., Krengel U., Petsko G.A., Goody R.S., Kabsch W., and Wittinghofer A. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution: implications for the mechanism of GTP hydrolysis. EMBO J. 9 (1990) 2351-2359
49. Chen J., Anderson J.B., DeWeese-Scott C., Fedorova N.D., Geer L.Y., He S., et al. MMDP: entrez's 3D-structure database. Nucleic Acids Res. 31 (2003) 474-477