-
1
-
-
0025010979
-
The GTPase superfamily: A conserved switch for diverse cell functions
-
Bourne, H.R., Sanders, D.A. & McCormick, F. (1990) The GTPase superfamily: A conserved switch for diverse cell functions. Nature 348, 125-132.
-
(1990)
Nature
, vol.348
, pp. 125-132
-
-
Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
-
2
-
-
0026026818
-
The GTPase superfamily: A conserved structure and molecular mechanism
-
Bourne, H.R., Sanders, D.A. & McCormick, F. (1991) The GTPase superfamily: A conserved structure and molecular mechanism. Nature 349, 117-127.
-
(1991)
Nature
, vol.349
, pp. 117-127
-
-
Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
-
3
-
-
0035135929
-
Small GTP-binding proteins
-
Takai, Y., Sasaki, T. & Matozaki, T. (2001) Small GTP-binding proteins. Physiol Rev. 81, 153-208.
-
(2001)
Physiol Rev.
, vol.81
, pp. 153-208
-
-
Takai, Y.1
Sasaki, T.2
Matozaki, T.3
-
4
-
-
0025908897
-
The ras protein family: Evolutionary tree and role of conserved amino acids
-
Valencia, A., Chardin, P., Wittinghofer, A. & Sander, C. (1991) The ras protein family: Evolutionary tree and role of conserved amino acids. Biochemistry 30, 4637-4648.
-
(1991)
Biochemistry
, vol.30
, pp. 4637-4648
-
-
Valencia, A.1
Chardin, P.2
Wittinghofer, A.3
Sander, C.4
-
5
-
-
0012698942
-
p21ras is modified by a farnesyl isopre noid
-
Casey, P.J., Solski, P.A., Der, C.J. & Buss, J.E. (1989) p21ras is modified by a farnesyl isopre noid. Proc. Natl. Acad. Sci. U.S.A. 86, 8323-8327.
-
(1989)
Proc. Natl. Acad. Sci. U.S.A.
, vol.86
, pp. 8323-8327
-
-
Casey, P.J.1
Solski, P.A.2
Der, C.J.3
Buss, J.E.4
-
6
-
-
0025254314
-
RAS2 protein of Saccharomyces cerevisiae undergoes removal of methionine at N terminus and removal of three amino acids at C terminus
-
Fujiyama, A. & Tamanoi, F. (1990) RAS2 protein of Saccharomyces cerevisiae undergoes removal of methionine at N terminus and removal of three amino acids at C terminus. J. Biol. Chem. 265, 3362-3368.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 3362-3368
-
-
Fujiyama, A.1
Tamanoi, F.2
-
7
-
-
0024465343
-
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis
-
Gutierrez, L., Magee, A.I., Marshall, C.J. & Hancock, J.F. (1989) Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis. EMBO J. 8, 1093-1098.
-
(1989)
EMBO J.
, vol.8
, pp. 1093-1098
-
-
Gutierrez, L.1
Magee, A.I.2
Marshall, C.J.3
Hancock, J.F.4
-
8
-
-
0024316475
-
Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans
-
Schafer, W.R., Kim, R., Sterne, R., Thorner, J., Kim, S.H. & Rine, J. (1989) Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science 245, 379-385.
-
(1989)
Science
, vol.245
, pp. 379-385
-
-
Schafer, W.R.1
Kim, R.2
Sterne, R.3
Thorner, J.4
Kim, S.H.5
Rine, J.6
-
9
-
-
0024406286
-
All ras proteins are polyisoprenylated but only some are palmitoylated
-
Hancock, J.F., Magee, A.I., Childs, J.E. & Marshall, C.J. (1989) All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57, 1167-1177.
-
(1989)
Cell
, vol.57
, pp. 1167-1177
-
-
Hancock, J.F.1
Magee, A.I.2
Childs, J.E.3
Marshall, C.J.4
-
10
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
Kohl, N.E., Orner, C.A., Conner, M.W., Anthony, N.J., Davide, J.P., deSolms, S.J., Giuliani, E.A., Gomez, R.P., Graham, S.L., Hamilton, K. et al. (1995) Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat. Med. 1, 792-797.
-
(1995)
Nat. Med.
, vol.1
, pp. 792-797
-
-
Kohl, N.E.1
Orner, C.A.2
Conner, M.W.3
Anthony, N.J.4
Davide, J.P.5
DeSolms, S.J.6
Giuliani, E.A.7
Gomez, R.P.8
Graham, S.L.9
Hamilton, K.10
-
11
-
-
0345482977
-
GTP-binding domain: Three consensus sequence elements with distinct spacing
-
Dever, T.E., Glynias, M.J. & Merrick, W.C. (1987) GTP-binding domain: Three consensus sequence elements with distinct spacing. Proc. Natl. Acad. Sci. U.S.A. 84, 1814-1818.
-
(1987)
Proc. Natl. Acad. Sci. U.S.A.
, vol.84
, pp. 1814-1818
-
-
Dever, T.E.1
Glynias, M.J.2
Merrick, W.C.3
-
12
-
-
0022394955
-
Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins
-
Jurnak, F. (1985) Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins. Science 230, 32-36.
-
(1985)
Science
, vol.230
, pp. 32-36
-
-
Jurnak, F.1
-
13
-
-
0022124319
-
Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. Coli as studied by X-ray crystallography
-
la Cour, T.F., Nyborg, J., Thirup, S. & Clark, B.F. (1985) Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography. EMBO J. 4, 2385-2388.
-
(1985)
EMBO J.
, vol.4
, pp. 2385-2388
-
-
La Cour, T.F.1
Nyborg, J.2
Thirup, S.3
Clark, B.F.4
-
14
-
-
0023062991
-
G proteins: Transducers of receptor-generated signals
-
Gilman, A.G. (1987) G proteins: Transducers of receptor-generated signals. Annu. Rev. Biochem. 56, 615-649.
-
(1987)
Annu. Rev. Biochem.
, vol.56
, pp. 615-649
-
-
Gilman, A.G.1
-
15
-
-
0001607723
-
Distantly related sequences in the alpha-and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
-
Walker, J.E., Saraste, M., Runswick, M.J. & Gay, N.J. (1982) Distantly related sequences in the alpha-and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1, 945-951.
-
(1982)
EMBO J.
, vol.1
, pp. 945-951
-
-
Walker, J.E.1
Saraste, M.2
Runswick, M.J.3
Gay, N.J.4
-
16
-
-
0030920782
-
G protein mechanisms: Insights from structural analysis
-
Sprang, S.R. (1997) G protein mechanisms: Insights from structural analysis. Annu. Rev. Biochem. 66, 639-678.
-
(1997)
Annu. Rev. Biochem.
, vol.66
, pp. 639-678
-
-
Sprang, S.R.1
-
17
-
-
0035942247
-
Dynamic properties of the Ras switch I region and its importance for binding to effectors
-
Spoerner, M., Herrmann, C., Vetter, I.R., Kalbitzer, H.R. & Wittinghofer, A. (2001) Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc. Natl. Acad. Sci. U.S.A. 98, 4944-4949.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 4944-4949
-
-
Spoerner, M.1
Herrmann, C.2
Vetter, I.R.3
Kalbitzer, H.R.4
Wittinghofer, A.5
-
18
-
-
0029665424
-
Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP
-
Geyer, M., Schweins, T., Herrmann, C., Prisner, T., Wittinghofer, A. & Kalbitzer, H.R. (1996) Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP. Biochemistry 35, 10308-10320.
-
(1996)
Biochemistry
, vol.35
, pp. 10308-10320
-
-
Geyer, M.1
Schweins, T.2
Herrmann, C.3
Prisner, T.4
Wittinghofer, A.5
Kalbitzer, H.R.6
-
19
-
-
0032552972
-
The role of ligand binding in the kinetic folding mechanism of human p21(H-ras) protein
-
Zhang, J. & Matthews, C.R. (1998) The role of ligand binding in the kinetic folding mechanism of human p21(H-ras) protein. Biochemistry 37, 14891-14899.
-
(1998)
Biochemistry
, vol.37
, pp. 14891-14899
-
-
Zhang, J.1
Matthews, C.R.2
-
20
-
-
0032552966
-
Ligand binding is the principal determinant of stability for the p21(H)-ras protein
-
Zhang, J. & Matthews, C.R. (1998) Ligand binding is the principal determinant of stability for the p21(H)-ras protein. Biochemistry 37, 14881-14890.
-
(1998)
Biochemistry
, vol.37
, pp. 14881-14890
-
-
Zhang, J.1
Matthews, C.R.2
-
21
-
-
0032540249
-
Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue
-
Ihara, K., Muraguchi, S., Kato, M., Shimizu, T., Shirakawa, M., Kuroda, S., Kaibuchi, K. & Hakoshima, T. (1998) Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue. J. Biol. Chem. 273, 9656-9666.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9656-9666
-
-
Ihara, K.1
Muraguchi, S.2
Kato, M.3
Shimizu, T.4
Shirakawa, M.5
Kuroda, S.6
Kaibuchi, K.7
Hakoshima, T.8
-
22
-
-
0028556994
-
Structure of the human ADP-ribosylation factor 1 complexed with GDP
-
Amor, J.C., Harrison, D.H., Kahn, R.A. & Ringe, D. (1994) Structure of the human ADP-ribosylation factor 1 complexed with GDP. Nature 372, 704-708.
-
(1994)
Nature
, vol.372
, pp. 704-708
-
-
Amor, J.C.1
Harrison, D.H.2
Kahn, R.A.3
Ringe, D.4
-
23
-
-
0028929866
-
Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form
-
Scheffzek, K., Klebe, C., Fritz-Wolf, K., Kabsch, W. & Wittinghofer, A. (1995) Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form. Nature 374, 378-381.
-
(1995)
Nature
, vol.374
, pp. 378-381
-
-
Scheffzek, K.1
Klebe, C.2
Fritz-Wolf, K.3
Kabsch, W.4
Wittinghofer, A.5
-
24
-
-
0029958571
-
The GTP binding motif: Variations on a theme
-
Kjeldgaard, M., Nyborg, J. & Clark, B.F.C. (1996) The GTP binding motif: Variations on a theme. FASEB J. 10, 1347-1368.
-
(1996)
FASEB J.
, vol.10
, pp. 1347-1368
-
-
Kjeldgaard, M.1
Nyborg, J.2
Clark, B.F.C.3
-
25
-
-
0027404091
-
(2+)-binding site of the guanine nucleotide-binding protein p21H-ras
-
(2+)-binding site of the guanine nucleotide-binding protein p21H-ras. J. Biol. Chem. 268, 923-929.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 923-929
-
-
John, J.1
Rensland, H.2
Schlichting, I.3
Vetter, I.4
Borasio, G.D.5
Goody, R.S.6
Wittinghofer, A.7
-
26
-
-
0030772378
-
The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek, K., Ahmadian, M.R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F. & Wittinghofer, A. (1997) The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277, 333-338.
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kabsch, W.3
Wiesmüller, L.4
Lautwein, A.5
Schmitz, F.6
Wittinghofer, A.7
-
27
-
-
0031226057
-
Crystal structure of RhoA-GDP and its functional implications
-
Wei, Y., Zhang, Y., Liu, X., Minor, W., Nakamoto, R.K., Somlyo, A.V., Somlyo, A.P. & Derewenda, Z.S. (1997) Crystal structure of RhoA-GDP and its functional implications. Nat. Struct. Biol. 4, 699-703.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 699-703
-
-
Wei, Y.1
Zhang, Y.2
Liu, X.3
Minor, W.4
Nakamoto, R.K.5
Somlyo, A.V.6
Somlyo, A.P.7
Derewenda, Z.S.8
-
29
-
-
0025337447
-
Kinetics of interaction of nucleotides with nucleotide-free H-ras p21
-
John, J., Sohmen, R., Feuerstein, J., Linke, R., Wittinghofer, A. & Goody, R.S. (1990) Kinetics of interaction of nucleotides with nucleotide-free H-ras p21. Biochemistry 29, 6058-6065.
-
(1990)
Biochemistry
, vol.29
, pp. 6058-6065
-
-
John, J.1
Sohmen, R.2
Feuerstein, J.3
Linke, R.4
Wittinghofer, A.5
Goody, R.S.6
-
30
-
-
0028988578
-
Interactions between the amino-and carboxyl-terminal regions of G alpha subunits: Analysis of mutated G alpha o/G alpha i2 chimeras
-
Denker, B.M., Boutin, P.M. & Neer, E.J. (1995) Interactions between the amino-and carboxyl-terminal regions of G alpha subunits: Analysis of mutated G alpha o/G alpha i2 chimeras. Biochemistry 34, 5544-5553.
-
(1995)
Biochemistry
, vol.34
, pp. 5544-5553
-
-
Denker, B.M.1
Boutin, P.M.2
Neer, E.J.3
-
31
-
-
0028960178
-
Switching nucleotide specificity of Ha-Ras p21 by a single amino acid substitution at aspartate 119
-
Zhong, J.M., Chen-Hwang, M.C. & Hwang, Y.W. (1995) Switching nucleotide specificity of Ha-Ras p21 by a single amino acid substitution at aspartate 119. J. Biol Chem. 270, 10002-10007.
-
(1995)
J. Biol Chem.
, vol.270
, pp. 10002-10007
-
-
Zhong, J.M.1
Chen-Hwang, M.C.2
Hwang, Y.W.3
-
32
-
-
0030046054
-
Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides
-
Schmidt, G., Lenzen, C., Simon, I., Deuter, R., Cool, R.H., Goody, R.S. & Wittinghofer, A. (1996) Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides. Oncogene 12, 87-96.
-
(1996)
Oncogene
, vol.12
, pp. 87-96
-
-
Schmidt, G.1
Lenzen, C.2
Simon, I.3
Deuter, R.4
Cool, R.H.5
Goody, R.S.6
Wittinghofer, A.7
-
33
-
-
0028064521
-
Elongation factor Tu D138N, a mutant with modified substrate specificity, as a tool to study energy consumption in protein biosynthesis
-
Weijland, A., Parlato, G. & Parmeggiani, A. (1994) Elongation factor Tu D138N, a mutant with modified substrate specificity, as a tool to study energy consumption in protein biosynthesis. Biochemistry 33, 10711-10717.
-
(1994)
Biochemistry
, vol.33
, pp. 10711-10717
-
-
Weijland, A.1
Parlato, G.2
Parmeggiani, A.3
-
34
-
-
0028868377
-
X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp
-
Scheidig, A.J., Franken, S.M., Corrie, J.E., Reid, G.P., Wittinghofer, A., Pai, E.F. & Goody, R.S. (1995) X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J. Mol. Biol. 253, 132-150.
-
(1995)
J. Mol. Biol.
, vol.253
, pp. 132-150
-
-
Scheidig, A.J.1
Franken, S.M.2
Corrie, J.E.3
Reid, G.P.4
Wittinghofer, A.5
Pai, E.F.6
Goody, R.S.7
-
36
-
-
0028314516
-
Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: An experimental and theoretical study
-
Frech, M., Darden, T.A., Pedersen, L.G., Foley, C.K., Charifson, P.S., Anderson, M.W. & Wittinghofer, A. (1994) Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: An experimental and theoretical study. Biochemistry 33, 3237-3244.
-
(1994)
Biochemistry
, vol.33
, pp. 3237-3244
-
-
Frech, M.1
Darden, T.A.2
Pedersen, L.G.3
Foley, C.K.4
Charifson, P.S.5
Anderson, M.W.6
Wittinghofer, A.7
-
37
-
-
0028925947
-
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins
-
Schweins, T., Geyer, M., Scheffzek, K., Warshel, A., Kalbitzer, H.R. & Wittinghofer, A. (1995) Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nat. Struct. Biol. 2, 36-44.
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 36-44
-
-
Schweins, T.1
Geyer, M.2
Scheffzek, K.3
Warshel, A.4
Kalbitzer, H.R.5
Wittinghofer, A.6
-
39
-
-
0035282079
-
Substrate assisted catalysis - Application to G proteins
-
Kosloff, M. & Selinger, Z. (2001) Substrate assisted catalysis - application to G proteins. Trends Biochem. Sci. 26, 161-166.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 161-166
-
-
Kosloff, M.1
Selinger, Z.2
-
40
-
-
0029843561
-
Mechanistic analysis of the relationships in p21ras and related systems
-
Schweins, T. & Warshel, A. (1996) Mechanistic analysis of the relationships in p21ras and related systems. Biochemistry 35, 14232-14243.
-
(1996)
Biochemistry
, vol.35
, pp. 14232-14243
-
-
Schweins, T.1
Warshel, A.2
-
41
-
-
0029781354
-
Ras-catalyzed hydrolysis of GTP: A new perspective from model studies
-
Maegley, K.A., Admiral, S.J., Herschlag, D. (1996) Ras-catalyzed hydrolysis of GTP: A new perspective from model studies. Proc. Natl. Acad. Sci. U.S.A. 94, 8160-8166.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 8160-8166
-
-
Maegley, K.A.1
Admiral, S.J.2
Herschlag, D.3
-
43
-
-
0035933139
-
The arginine finger of RasGAP helps Gin-61 align the nucleophilic water in GAP-stimulate hydrolysis of GTP
-
Resat, H., Straatsma, T.P., Dixon, D.A. & Miller, J.H. (2001) The arginine finger of RasGAP helps Gin-61 align the nucleophilic water in GAP-stimulate hydrolysis of GTP. Proc. Natl. Acad. Sci. U.S.A. 98, 6033-6038.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 6033-6038
-
-
Resat, H.1
Straatsma, T.P.2
Dixon, D.A.3
Miller, J.H.4
-
46
-
-
0035852966
-
Ras catalyzes GTP hydrolysis by shifting negative charges from gamma-to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy
-
Allin, C. & Gerwert, K. (2001) Ras catalyzes GTP hydrolysis by shifting negative charges from gamma-to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy. Biochemistry 40, 3037-3046.
-
(2001)
Biochemistry
, vol.40
, pp. 3037-3046
-
-
Allin, C.1
Gerwert, K.2
-
48
-
-
0029593456
-
i alpha 1 beta 1 gamma 2
-
i alpha 1 beta 1 gamma 2. Cell 83, 1047-1058.
-
(1995)
Cell
, vol.83
, pp. 1047-1058
-
-
Wall, M.A.1
Coleman, D.E.2
Lee, E.3
Iniguez-Lluhi, J.A.4
Posner, B.A.5
Gilman, A.G.6
Sprang, S.R.7
-
49
-
-
0032589269
-
Effectors for the Rho GTPases
-
Aspenstrom, P. (1999) Effectors for the Rho GTPases. Curr. Opin. Cell. Biol. 11, 95-102.
-
(1999)
Curr. Opin. Cell. Biol.
, vol.11
, pp. 95-102
-
-
Aspenstrom, P.1
-
50
-
-
0033563754
-
Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA
-
Maesaki, R., Shimizu, T., Ihara, K., Kuroda, S., Kaibuchi, K. & Hakoshima, T. (1999) Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA. J. Struct. Biol. 126, 166-170.
-
(1999)
J. Struct. Biol.
, vol.126
, pp. 166-170
-
-
Maesaki, R.1
Shimizu, T.2
Ihara, K.3
Kuroda, S.4
Kaibuchi, K.5
Hakoshima, T.6
-
51
-
-
0028963150
-
Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change
-
Sung, Y.J., Carter, M., Zhong, J.M. & Hwang, Y.W. (1995) Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change. Biochemistry 34, 3470-3477.
-
(1995)
Biochemistry
, vol.34
, pp. 3470-3477
-
-
Sung, Y.J.1
Carter, M.2
Zhong, J.M.3
Hwang, Y.W.4
-
52
-
-
0033580833
-
Effector recognition by the small GTP-binding proteins Ras and Ral
-
Bauer, B., Mirey, G., Vetter, I.R., Garcia-Ranea, J.A., Valencia, A., Wittinghofer, A., Camonis, J.H. & Cool, R.H. (1999) Effector recognition by the small GTP-binding proteins Ras and Ral. J. Biol. Chem. 274, 17763-17770.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17763-17770
-
-
Bauer, B.1
Mirey, G.2
Vetter, I.R.3
Garcia-Ranea, J.A.4
Valencia, A.5
Wittinghofer, A.6
Camonis, J.H.7
Cool, R.H.8
-
53
-
-
0029913467
-
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor
-
Herrmann, C., Horn, G., Spaargaren, M. & Wittinghofer, A. (1996) Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J. Biol. Chem. 271, 6794-6800.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 6794-6800
-
-
Herrmann, C.1
Horn, G.2
Spaargaren, M.3
Wittinghofer, A.4
-
54
-
-
0029745645
-
Ras/Rap effector specificity determined by charge reversal
-
Nassar, N., Horn, G., Herrmann, C., Block, C., Janknecht, R. & Wittinghofer, A. (1996) Ras/Rap effector specificity determined by charge reversal. Nat. Struct. Biol. 3, 723-729.
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 723-729
-
-
Nassar, N.1
Horn, G.2
Herrmann, C.3
Block, C.4
Janknecht, R.5
Wittinghofer, A.6
-
55
-
-
0031228462
-
Structure of the Ras-binding domain of Ral guanine-nucleotide exchange factor: Implications for Ras binding and signaling
-
Geyer, M., Herrmann, C., Wohlgemuth, S., Wittinghofer, A. & Kalbitzer, H.R. (1997) Structure of the Ras-binding domain of Ral guanine-nucleotide exchange factor: Implications for Ras binding and signaling. Nat. Struct. Biol. 4, 694-699.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 694-699
-
-
Geyer, M.1
Herrmann, C.2
Wohlgemuth, S.3
Wittinghofer, A.4
Kalbitzer, H.R.5
-
56
-
-
0033635157
-
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma
-
Pacold, M.E., Suire, S., Perisic, O., Lara-Gonzalez, S., Davis, C.T., Walker, E.H., Hawkins, P.T., Stephens, L., Eccleston, J.F. & Williams, R.L. (2000) Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell 103, 931-943.
-
(2000)
Cell
, vol.103
, pp. 931-943
-
-
Pacold, M.E.1
Suire, S.2
Perisic, O.3
Lara-Gonzalez, S.4
Davis, C.T.5
Walker, E.H.6
Hawkins, P.T.7
Stephens, L.8
Eccleston, J.F.9
Williams, R.L.10
-
57
-
-
0029107760
-
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue
-
Nassar, N., Horn, G., Herrmann, C., Scherer, A., McCormick, F. & Wittinghofer, A. (1995) The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature 375, 554-560.
-
(1995)
Nature
, vol.375
, pp. 554-560
-
-
Nassar, N.1
Horn, G.2
Herrmann, C.3
Scherer, A.4
McCormick, F.5
Wittinghofer, A.6
-
58
-
-
0029757119
-
The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site
-
Mott, H.R., Carpenter, J.W., Zhong, S., Ghosh, S., Bell, R.M., Campbell, S.L. (1996) The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site. Proc. Natl. Acad. Sci. U.S.A. 93, 8312-8317.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 8312-8317
-
-
Mott, H.R.1
Carpenter, J.W.2
Zhong, S.3
Ghosh, S.4
Bell, R.M.5
Campbell, S.L.6
-
59
-
-
0028073606
-
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation
-
Freed, E., Symons, M., MacDonald, S.G., McCormick, F. & Ruggieri, R. (1994) Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science 265, 1713-1716.
-
(1994)
Science
, vol.265
, pp. 1713-1716
-
-
Freed, E.1
Symons, M.2
MacDonald, S.G.3
McCormick, F.4
Ruggieri, R.5
-
60
-
-
0029584327
-
KSR, a novel protein kinase required for RAS signal transduction
-
Therrien, M., Chang, H.C., Solomon, N.M., Karim, F.D., Wassarman, D.A. & Rubin, G.M. (1995) KSR, a novel protein kinase required for RAS signal transduction. Cell 83, 879-888.
-
(1995)
Cell
, vol.83
, pp. 879-888
-
-
Therrien, M.1
Chang, H.C.2
Solomon, N.M.3
Karim, F.D.4
Wassarman, D.A.5
Rubin, G.M.6
-
61
-
-
0029850713
-
KSR modulates signal propagation within the MAPK cascade
-
Therrien, M., Michaud, N.R., Rubin, G.M. & Morrison, D.K. (1996) KSR modulates signal propagation within the MAPK cascade. Genes Dev. 10, 2684-2695.
-
(1996)
Genes Dev.
, vol.10
, pp. 2684-2695
-
-
Therrien, M.1
Michaud, N.R.2
Rubin, G.M.3
Morrison, D.K.4
-
62
-
-
0032582663
-
CNK, a RAF-binding multidomain protein required for RAS signaling
-
Therrien, M., Wong, A.M. & Rubin, G.M. (1998) CNK, a RAF-binding multidomain protein required for RAS signaling. Cell 95, 343-353.
-
(1998)
Cell
, vol.95
, pp. 343-353
-
-
Therrien, M.1
Wong, A.M.2
Rubin, G.M.3
-
63
-
-
0034213327
-
Rho GTPases and their effector proteins
-
Bishop, A.L. & Hall, A. (2000) Rho GTPases and their effector proteins. Biochem. J. 348, 241-255.
-
(2000)
Biochem. J.
, vol.348
, pp. 241-255
-
-
Bishop, A.L.1
Hall, A.2
-
64
-
-
0032541650
-
Increasing complexity of Ras signaling
-
Campbell, S.L., Khosravi-Far, R., Rossman, K.L., Clark, G.J. & Der, C.J. (1998) Increasing complexity of Ras signaling. Oncogene 17, 1395-1413.
-
(1998)
Oncogene
, vol.17
, pp. 1395-1413
-
-
Campbell, S.L.1
Khosravi-Far, R.2
Rossman, K.L.3
Clark, G.J.4
Der, C.J.5
-
65
-
-
0034644537
-
Ras and Rho GTPases: A family reunion
-
Bar-Sagi, D. & Hall, A. (2000) Ras and Rho GTPases: A family reunion. Cell 103, 227-238.
-
(2000)
Cell
, vol.103
, pp. 227-238
-
-
Bar-Sagi, D.1
Hall, A.2
-
66
-
-
0029944499
-
Structure and mutational analysis of Rab GDP-dissociation inhibitor
-
Schalk, I., Zeng, K., Wu, S.K., Stura, E.A., Matteson, J., Huang, M., Tandon, A., Wilson, I.A. & Balch, W.E. (1996) Structure and mutational analysis of Rab GDP-dissociation inhibitor. Nature 381, 42-48.
-
(1996)
Nature
, vol.381
, pp. 42-48
-
-
Schalk, I.1
Zeng, K.2
Wu, S.K.3
Stura, E.A.4
Matteson, J.5
Huang, M.6
Tandon, A.7
Wilson, I.A.8
Balch, W.E.9
-
67
-
-
0030992879
-
C-terminal binding domain of RhoGDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases
-
Gosser, Y.Q., Nomanbhoy, T.K., Aghazadeh, B., Manor, D., Combs, C., Cerione, R.A. & Rosen, M.K. (1997) C-terminal binding domain of RhoGDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases. Nature 387, 814-819.
-
(1997)
Nature
, vol.387
, pp. 814-819
-
-
Gosser, Y.Q.1
Nomanbhoy, T.K.2
Aghazadeh, B.3
Manor, D.4
Combs, C.5
Cerione, R.A.6
Rosen, M.K.7
-
68
-
-
0343750716
-
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI
-
Scheffzek, K., Stephan, I., Jensen, O.N., Illenberger, D. & Gierschik, P. (2000) The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat. Struct. Biol. 7, 122-126.
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 122-126
-
-
Scheffzek, K.1
Stephan, I.2
Jensen, O.N.3
Illenberger, D.4
Gierschik, P.5
-
69
-
-
0031570337
-
A modulator of rho family G proteins, RhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
-
Keep, N.H., Barnes, M., Barsukov, I., Badii, R., Lian, L.Y., Segal, A.W., Moody, P.C.E. & Roberts, G.C.K. (1997) A modulator of rho family G proteins, RhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. Structure 5, 623-633.
-
(1997)
Structure
, vol.5
, pp. 623-633
-
-
Keep, N.H.1
Barnes, M.2
Barsukov, I.3
Badii, R.4
Lian, L.Y.5
Segal, A.W.6
Moody, P.C.E.7
Roberts, G.C.K.8
-
70
-
-
0034650210
-
Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1
-
Lian, L.Y., Barsukov, I., Golovanov, A.P., Hawkins, D.I., Badii, R., Sze, K.H., Keep, N.H., Bokoch, G.M. & Roberts, G.C. (2000) Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1. Structure Fold. Des. 8, 47-55.
-
(2000)
Structure Fold. Des.
, vol.8
, pp. 47-55
-
-
Lian, L.Y.1
Barsukov, I.2
Golovanov, A.P.3
Hawkins, D.I.4
Badii, R.5
Sze, K.H.6
Keep, N.H.7
Bokoch, G.M.8
Roberts, G.C.9
-
71
-
-
13044304207
-
How RhoGDI binds Rho
-
Longenecker, K., Read, P., Derewenda, U., Dauter, Z., Liu, X., Garrard, S., Walker, L., Somlyo, A.V., Nakamoto, R.K., Somlyo, A.P. & Derewenda, Z.S. (1999) How RhoGDI binds Rho. Acta Crystallogr. D Biol. Crystallogr. 55, 1503-1515.
-
(1999)
Acta Crystallogr. D Biol. Crystallogr.
, vol.55
, pp. 1503-1515
-
-
Longenecker, K.1
Read, P.2
Derewenda, U.3
Dauter, Z.4
Liu, X.5
Garrard, S.6
Walker, L.7
Somlyo, A.V.8
Nakamoto, R.K.9
Somlyo, A.P.10
Derewenda, Z.S.11
-
72
-
-
0029951250
-
Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor
-
Danley, D.E., Chuang, T.H. & Bokoch, G.M. (1996) Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor. J. Immunol. 157, 500-503.
-
(1996)
J. Immunol.
, vol.157
, pp. 500-503
-
-
Danley, D.E.1
Chuang, T.H.2
Bokoch, G.M.3
-
73
-
-
0030001665
-
Characterization of the interaction between RhoGDI and Cdc42Hs using fluorescence spectroscopy
-
Nomanbhoy, T.K. & Cerione, R. (1996) Characterization of the interaction between RhoGDI and Cdc42Hs using fluorescence spectroscopy. J. Biol. Chem. 271, 10004-10009.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10004-10009
-
-
Nomanbhoy, T.K.1
Cerione, R.2
-
74
-
-
0029829561
-
Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras
-
Scheffzek, K., Lautwein, A., Kabsch, W., Ahmadian, M.R. & Wittinghofer, A. (1996) Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature 384, 591-596.
-
(1996)
Nature
, vol.384
, pp. 591-596
-
-
Scheffzek, K.1
Lautwein, A.2
Kabsch, W.3
Ahmadian, M.R.4
Wittinghofer, A.5
-
75
-
-
0030716497
-
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition state analog
-
Rittinger, K., Walker, P.A., Eccleston, J.F., Smerdon, S.J. & Gambin, S.J. (1997) Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition state analog. Nature 389, 758-762.
-
(1997)
Nature
, vol.389
, pp. 758-762
-
-
Rittinger, K.1
Walker, P.A.2
Eccleston, J.F.3
Smerdon, S.J.4
Gambin, S.J.5
-
76
-
-
18144437689
-
The structure of the GTPase-activating domain form p50rhoGAP
-
Barrett, T., Xiao, B., Dodson, E.J., Ludbrook, S.B., Nurmahomed, K., Ganbin, S.J., Smerdon, S.J. & Eccleston, J.F. (1997) The structure of the GTPase-activating domain form p50rhoGAP. Nature 385, 458-461.
-
(1997)
Nature
, vol.385
, pp. 458-461
-
-
Barrett, T.1
Xiao, B.2
Dodson, E.J.3
Ludbrook, S.B.4
Nurmahomed, K.5
Ganbin, S.J.6
Smerdon, S.J.7
Eccleston, J.F.8
-
77
-
-
0034647989
-
Functional specificity conferred by the unique plasticity of fully alpha-helical Ras and Rho GAPs
-
Souchet, M., Poupon, A., Callebaut, I., Leger, I., Mornon, J., Bril, A. & Calmels, T.P. (2000) Functional specificity conferred by the unique plasticity of fully alpha-helical Ras and Rho GAPs. FEBS Lett. 477, 99-105.
-
(2000)
FEBS Lett.
, vol.477
, pp. 99-105
-
-
Souchet, M.1
Poupon, A.2
Callebaut, I.3
Leger, I.4
Mornon, J.5
Bril, A.6
Calmels, T.P.7
-
78
-
-
0034623935
-
Structure of the BH domain from Graf and its implications for Rho GTPase recognition
-
Longenecker, K.L., Zhang, B., Derewenda, U., Sheffield, P.J., Dauter, Z., Parsons, J.T., Zheng, Y. & Derewenda, Z.S. (2000) Structure of the BH domain from Graf and its implications for Rho GTPase recognition. J. Biol. Chem. 275, 38605-38610.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 38605-38610
-
-
Longenecker, K.L.1
Zhang, B.2
Derewenda, U.3
Sheffield, P.J.4
Dauter, Z.5
Parsons, J.T.6
Zheng, Y.7
Derewenda, Z.S.8
-
79
-
-
0034634476
-
The Ras/p120 GTPase-activating protein (GAP) interaction is regulated by the p120 GAP pleckstrin homology domain
-
Drugan, J.K., Rogers-Graham, K., Gilmer, T., Campbell, S. & Clark, G.J. (2000) The Ras/p120 GTPase-activating protein (GAP) interaction is regulated by the p120 GAP pleckstrin homology domain. J. Biol. Chem. 275, 35021-35027.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35021-35027
-
-
Drugan, J.K.1
Rogers-Graham, K.2
Gilmer, T.3
Campbell, S.4
Clark, G.J.5
-
80
-
-
0030759770
-
Crystal structure of a small G protein in complex with the GTPase-activating protein RhoGAP
-
Rittinger, K., Walker, P.A., Eccleston, J.F., Nurmahomed, K., Laue, E., Owen, D., Ganbin, S.J. & Smerdon, S.J. (1997) Crystal structure of a small G protein in complex with the GTPase-activating protein RhoGAP. Nature 388, 693-697.
-
(1997)
Nature
, vol.388
, pp. 693-697
-
-
Rittinger, K.1
Walker, P.A.2
Eccleston, J.F.3
Nurmahomed, K.4
Laue, E.5
Owen, D.6
Ganbin, S.J.7
Smerdon, S.J.8
-
81
-
-
0035917523
-
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
-
Renault, L., Kuhlmann, J., Henkel, A. & Wittinghofer, A. (2001) Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Cell 105, 245-255.
-
(2001)
Cell
, vol.105
, pp. 245-255
-
-
Renault, L.1
Kuhlmann, J.2
Henkel, A.3
Wittinghofer, A.4
-
82
-
-
0032560850
-
The structural basis of the activation of Ras by Sos
-
Boriack-Sjodin, P.A., Margarit, S.M., Bar-Sagi, D. & Kuriyan, J. (1998) The structural basis of the activation of Ras by Sos. Nature 394, 337-343.
-
(1998)
Nature
, vol.394
, pp. 337-343
-
-
Boriack-Sjodin, P.A.1
Margarit, S.M.2
Bar-Sagi, D.3
Kuriyan, J.4
-
83
-
-
0032485074
-
Structure of the Sec7 domain of the Arf exchange factor ARNO
-
Cherfils, J., Menetrey, J., Mathieu, M., Le Bras, G., Robineau, S., Beraud-Dufour, S., Antonny, B. & Chardin, P. (1998) Structure of the Sec7 domain of the Arf exchange factor ARNO. Nature 392, 101-105.
-
(1998)
Nature
, vol.392
, pp. 101-105
-
-
Cherfils, J.1
Menetrey, J.2
Mathieu, M.3
Le Bras, G.4
Robineau, S.5
Beraud-Dufour, S.6
Antonny, B.7
Chardin, P.8
-
84
-
-
0029099915
-
Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface
-
Yu, H. & Schreiber, S.L. (1995) Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface. Nature 376, 788-791.
-
(1995)
Nature
, vol.376
, pp. 788-791
-
-
Yu, H.1
Schreiber, S.L.2
-
85
-
-
0032568868
-
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13
-
Hart, M.J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W.D., Gilman, A.G., Sternweis, P.C. & Bollag, G. (1998) Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science 280, 2112-2114.
-
(1998)
Science
, vol.280
, pp. 2112-2114
-
-
Hart, M.J.1
Jiang, X.2
Kozasa, T.3
Roscoe, W.4
Singer, W.D.5
Gilman, A.G.6
Sternweis, P.C.7
Bollag, G.8
-
86
-
-
0033772512
-
Activation of Rho GEF activity by G alpha 13
-
Hart, M.J., Roscoe, W. & Bollag, G. (2000) Activation of Rho GEF activity by G alpha 13. Methods Enzymol. 325, 61-71.
-
(2000)
Methods Enzymol.
, vol.325
, pp. 61-71
-
-
Hart, M.J.1
Roscoe, W.2
Bollag, G.3
-
87
-
-
0033605294
-
A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
-
Fukuhara, S., Murga, C., Zohar, M., Igishi, T. & Gutkind, J.S. (1999) A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J. Biol. Chem. 274, 5868-5879.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 5868-5879
-
-
Fukuhara, S.1
Murga, C.2
Zohar, M.3
Igishi, T.4
Gutkind, J.S.5
-
88
-
-
0027958423
-
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
-
Hart, M.J., Eva, A., Zangrilli, D., Aaronson, S.A., Evans, T., Cerione, R.A. & Zheng, Y. (1994) Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J. Biol. Chem. 269, 62-65.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 62-65
-
-
Hart, M.J.1
Eva, A.2
Zangrilli, D.3
Aaronson, S.A.4
Evans, T.5
Cerione, R.A.6
Zheng, Y.7
-
89
-
-
0030451173
-
The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor
-
Zheng, Y., Fischer, D.J., Santos, M.F., Tigyi, G., Pasteris, N.G., Gorski, J.L. & Xu, Y. (1996) The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor. J. Biol. Chem. 271, 33169-33172.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 33169-33172
-
-
Zheng, Y.1
Fischer, D.J.2
Santos, M.F.3
Tigyi, G.4
Pasteris, N.G.5
Gorski, J.L.6
Xu, Y.7
-
90
-
-
0032549710
-
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. Elegans
-
Steven, R., Kubiseski, T.J., Zheng, H., Kulkarni, S., Mancillas, J., Ruiz, Morales, A., Hogue, C.W., Pawson, T. & Culotti, J. (1998) UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92, 785-795.
-
(1998)
Cell
, vol.92
, pp. 785-795
-
-
Steven, R.1
Kubiseski, T.J.2
Zheng, H.3
Kulkarni, S.4
Mancillas, J.5
Ruiz6
Morales, A.7
Hogue, C.W.8
Pawson, T.9
Culotti, J.10
-
91
-
-
0028110120
-
A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways
-
Horii, Y., Beeler, J.F., Sakaguchi, K., Tachibana, M. & Miki, T. (1994) A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. EMBO J. 13, 4776-4786.
-
(1994)
EMBO J.
, vol.13
, pp. 4776-4786
-
-
Horii, Y.1
Beeler, J.F.2
Sakaguchi, K.3
Tachibana, M.4
Miki, T.5
-
92
-
-
0034702970
-
Ral-GEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral
-
de Bruyn, K.M., de Rooij, J., Wolthuis, R.M., Rehmann, H., Wesenbeek, J., Cool, R.H., Wittinghofer, A.H. & Bos, J.L. (2000) Ral-GEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral. J. Biol. Chem. 275, 29761-29766.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29761-29766
-
-
De Bruyn, K.M.1
De Rooij, J.2
Wolthuis, R.M.3
Rehmann, H.4
Wesenbeek, J.5
Cool, R.H.6
Wittinghofer, A.H.7
Bos, J.L.8
-
93
-
-
0027183541
-
The PH domain: A common piece in the structural patchwork of signalling proteins
-
Musacchio, A., Gibson, T., Rice, P., Thompson, J. & Saraste, M. (1993) The PH domain: A common piece in the structural patchwork of signalling proteins. Trends Biochem. Sci. 18, 343-348.
-
(1993)
Trends Biochem. Sci.
, vol.18
, pp. 343-348
-
-
Musacchio, A.1
Gibson, T.2
Rice, P.3
Thompson, J.4
Saraste, M.5
-
94
-
-
0031041282
-
Dbl family proteins
-
Whitehead, I.P., Campbell, S., Rossman, K.L. & Der, C.J. (1997) Dbl family proteins. Biochim. Biophys. Acta 1332, F1-F23.
-
(1997)
Biochim. Biophys. Acta
, vol.1332
-
-
Whitehead, I.P.1
Campbell, S.2
Rossman, K.L.3
Der, C.J.4
-
95
-
-
0028859279
-
Protein modules and signalling networks
-
Pawson, T. (1995) Protein modules and signalling networks. Nature 373, 573-580.
-
(1995)
Nature
, vol.373
, pp. 573-580
-
-
Pawson, T.1
-
96
-
-
0031788635
-
Structure and mutagenesis of the Dbl homology domain
-
Aghazadeh, B., Zhu, K., Kubiseski, T.J., Liu, G.A., Pawson, T., Zheng, Y. & Rosen, M.K. (1998) Structure and mutagenesis of the Dbl homology domain. Nat. Struct. Biol. 5, 1098-1107.
-
(1998)
Nat. Struct. Biol.
, vol.5
, pp. 1098-1107
-
-
Aghazadeh, B.1
Zhu, K.2
Kubiseski, T.J.3
Liu, G.A.4
Pawson, T.5
Zheng, Y.6
Rosen, M.K.7
-
97
-
-
0032538316
-
Crystal structure of the Dbl and pleckstrin homology domains from the human son of sevenless protein
-
Soisson, S.M., Nimnual, A.S., Uy, M., Bar-Sagi, D. & Kuriyan, J. (1998) Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell 95, 259-268.
-
(1998)
Cell
, vol.95
, pp. 259-268
-
-
Soisson, S.M.1
Nimnual, A.S.2
Uy, M.3
Bar-Sagi, D.4
Kuriyan, J.5
-
98
-
-
0030729024
-
The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains
-
Zheng, J., Chen, R.H., Corblan-Garcia, S., Cahill, S.M., Bar-Sagi, D. & Cowburn, D. (1997) The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. J. Biol. Chem. 272, 30340-30344.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30340-30344
-
-
Zheng, J.1
Chen, R.H.2
Corblan-Garcia, S.3
Cahill, S.M.4
Bar-Sagi, D.5
Cowburn, D.6
-
99
-
-
0034682668
-
2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins
-
2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins. J. Biol. Chem. 275, 25299-25307.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25299-25307
-
-
Zhang, B.1
Zhang, Y.2
Wang, Z.3
Zheng, Y.4
-
100
-
-
0033179296
-
GEFs: Structural basis for their activation of small GTP-binding proteins
-
Cherfils, J. & Chardin, P. (1999) GEFs: Structural basis for their activation of small GTP-binding proteins. Trends Biochem. Sci. 24, 306-311.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 306-311
-
-
Cherfils, J.1
Chardin, P.2
|