Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1

Biochemical and Biophysical Research Communications

Volumn 349, Issue 2, 2006, Pages 573-581

  Hsieh, Mei Ju ^b   Yao, Ya Li ^a,b   Lai, I Lu ^a,b   Yang, Wen Ming ^a,b  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

Author keywords

Competition; Heterochromatin; HP1; KAP1; Pax3; Subcellular localization

Indexed keywords

HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1 GAMMA; HISTONE; PROTEIN KAP1; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR PAX3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING COMPETITION; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELLULAR DISTRIBUTION; CHROMATIN; CONTROLLED STUDY; DEACETYLATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN METHYLATION; PROTEIN PROTEIN INTERACTION; RHABDOMYOSARCOMA; WAARDENBURG SYNDROME;

ANIMALS; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA-BINDING PROTEINS; HUMANS; MICE; MICE, INBRED ICR; MODELS, GENETIC; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33748413896     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.064     Document Type: Article

References (38)

1. Epstein J.A., Li J., Lang D., Chen F., Brown C.B., Jin F., Lu M.M., Thomas M., Liu E., Wessels A., and Lo C.W. Migration of cardiac neural crest cells in Splotch embryos. Development 127 (2000) 1869-1878
2. Mansouri A., Hallonet M., and Gruss P. Pax genes and their roles in cell differentiation and development. Curr. Opin. Cell Biol. 8 (1996) 851-857
3. Baldwin C.T., Hoth C.F., Macina R.A., and Milunsky A. Mutations in PAX3 that cause Waardenburg syndrome type I: ten new mutations and review of the literature. Am. J. Med. Genet. 58 (1995) 115-122
4. Tassabehji M., Read A.P., Newton V.E., Patton M., Gruss P., Harris R., and Strachan T. Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2. Nat. Genet. 3 (1993) 26-30
5. Steel K.P., and Smith R.J. Normal hearing in Splotch (Sp/+), the mouse homologue of Waardenburg syndrome type 1. Nat. Genet. 2 (1992) 75-79
6. Maulbecker C.C., and Gruss P. The oncogenic potential of Pax genes. EMBO J. 12 (1993) 2361-2367
7. Barr F.G. Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene 20 (2001) 5736-5746
8. Barr F.G., Galili N., Holick J., Biegel J.A., Rovera G., and Emanuel B.S. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. Nat. Genet. 3 (1993) 113-117
9. Galili N., Davis R.J., Fredericks W.J., Mukhopadhyay S., Rauscher F.J., Emanuel B.S., Rovera G., and Barr F.G. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat. Genet. 5 (1993) 230-235
10. Bennicelli J.L., Edwards R.H., and Barr F.G. Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma. Proc. Natl. Acad. Sci. USA 93 (1996) 5455-5459
11. Chalepakis G., Jones F.S., Edelman G.M., and Gruss P. Pax-3 contains domains for transcription activation and transcription inhibition. Proc. Natl. Acad. Sci. USA 91 (1994) 12745-12749
12. Fredericks W.J., Galili N., Mukhopadhyay S., Rovera G., Bennicelli J., Barr F.G., and Rauscher F.J. The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol. Cell. Biol. 15 (1995) 1522-1535
13. Wiggan O., Taniguchi-Sidle A., and Hamel P.A. Interaction of the pRB-family proteins with factors containing paired-like homeodomains. Oncogene 16 (1998) 227-236
14. Hollenbach A.D., Sublett J.E., McPherson C.J., and Grosveld G. The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx. EMBO J. 18 (1999) 3702-3711
15. Magnaghi P., Roberts C., Lorain S., Lipinski M., and Scambler P.J. HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3. Nat. Genet. 20 (1998) 74-77
16. Lang D., Lu M.M., Huang L., Engleka K.A., Zhang M., Chu E.Y., Lipner S., Skoultchi A., Millar S.E., and Epstein J.A. Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433 (2005) 884-887
17. Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
18. Rice J.C., and Allis C.D. Histone methylation versus histone acetylation: new insights into epigenetic regulation. Curr. Opin. Cell Biol. 13 (2001) 263-273
19. Dillon N., and Festenstein R. Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet. 18 (2002) 252-258
20. Yang W.M., Yao Y.L., and Seto E. The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1. EMBO J. 20 (2001) 4814-4825
21. Yao Y.-L., and Yang W.-M. The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. J. Biol. Chem. 278 (2003) 42560-42568
22. Graham F.L., and van der Eb A.J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52 (1973) 456-467
23. Orlando V., Strutt H., and Paro R. Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11 (1997) 205-214
24. Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., and Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16 (2004) 93-105
25. Feng Q., Cao R., Xia L., Erdjument-Bromage H., Tempst P., and Zhang Y. Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Mol. Cell. Biol. 22 (2002) 536-546
26. Barlow A.L., van Drunen C.M., Johnson C.A., Tweedie S., Bird A., and Turner B.M. dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Exp. Cell Res. 265 (2001) 90-103
27. Bannister A.J., Zegerman P., Partridge J.F., Miska E.A., Thomas J.O., Allshire R.C., and Kouzarides T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410 (2001) 120-124
28. Jacobs S.A., Taverna S.D., Zhang Y., Briggs S.D., Li J., Eissenberg J.C., Allis C.D., and Khorasanizadeh S. Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J. 20 (2001) 5232-5241
29. Lachner M., and Jenuwein T. The many faces of histone lysine methylation. Curr. Opin. Cell Biol. 14 (2002) 286-298
30. Kouzarides T. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev. 12 (2002) 198-209
31. Hwang K.-K., and Worman H.J. Gene regulation by human orthologs of Drosophila heterochromatin protein 1. Biochem. Biophys. Res. Commun. 293 (2002) 1217-1222
32. Kellum R. Is HP1 an RNA detector that functions both in repression and activation?. J. Cell Biol. 161 (2003) 671-672
33. Li Y., Kirschmann D.A., and Wallrath L.L. Does heterochromatin protein 1 always follow code?. Proc. Natl. Acad. Sci. USA 99 Suppl 4 (2002) 16462-16469
34. Cammas F., Oulad-Abdelghani M., Vonesch J.-L., Huss-Garcia Y., Chambon P., and Losson R. Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction. J. Cell Sci. 115 (2002) 3439-3448
35. Leichter M., and Thiel G. Transcriptional repression by the zinc finger protein REST is mediated by titratable nuclear factors. Eur. J. Neurosci. 11 (1999) 1937-1946
36. Underhill C., Qutob M.S., Yee S.P., and Torchia J. A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. J. Biol. Chem. 275 (2000) 40463-40470
37. Schultz D.C., Ayyanathan K., Negorev D., Maul G.G., and Rauscher F.J. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 16 (2002) 919-932
38. Li Y., Slansky J.E., Myers D.J., Drinkwater N.R., Kaelin W.G., and Farnham P.J. Cloning, chromosomal location, and characterization of mouse E2F1. Mol. Cell. Biol. 14 (1994) 1861-1869