Therapeutic advantage of combining calcium channel blockers and TRAIL in prostate cancer

Molecular Cancer Therapeutics

Volumn 5, Issue 8, 2006, Pages 1958-1966

  Kaddour Djebbar, Ismail ^a   Lakshmikanthan, Vijayabaskar ^a   Shirley, Robert B ^a   Ma, Yulin ^a   Lewis, Ronald W ^a   Kumar, M Vijay ^a,b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CALCIUM IONOPHORE; CYCLOSPORIN A; IONOMYCIN; SODIUM CALCIUM EXCHANGE PROTEIN; THAPSIGARGIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER COMBINATION CHEMOTHERAPY; CELL DAMAGE; CELL FUNCTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG POTENTIATION; HEART DISEASE; HUMAN; HUMAN CELL; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROSTATE CANCER;

ANDROGENS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CLONAZEPAM; DRUG SYNERGISM; HUMANS; MALE; MITOCHONDRIA; PROSTATIC NEOPLASMS; SODIUM-CALCIUM EXCHANGER; THIAZEPINES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED;

EID: 33748351614     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0011     Document Type: Article

References (45)

1. Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 2000;1:11-21.
2. Trump BF, Berezesky IK. Calcium-mediated cell injury and cell death. FASEB J 1995;9:219-28.
3. D'herbe K, Leybaert L. Intracellular free calcium related to apoptotic cell death in quail granulosa cell sheets kept in serum-free culture. Cell Death Differ 1997;4:59-65.
4. Werth JL, Thayer SA. Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons. J Neurosci 1994;14:348-56.
5. 2+ loads from rat adrenal chromaffin cells. Neuron 1996;16:219-28.
6. Kruman II, Mattson MP. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis. J Neurochem 1999;72:529-40.
7. Gunter TE, Buntinas L, Sparagna G, Eliseev R, Gunter K. Mitochondrial calcium transport: mechanisms and functions. Cell Calcium 2000;28: 285-96.
8. 2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. J Biol Chem 1993; 268:938-47.
9. White RJ, Reynolds IJ. Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J Neurosci 1996;16:5688-97.
10. Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441-6.
11. Zoratti M, Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta 1995;1241:139-76.
12. Schinzel AC, Takeuchi O, Huang Z, et al. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A 2005; 102:12005-10.
13. Goldstein JC, Waterhouse NJ, Juin P, Evan GI, Green DR. The coordinate release of cytochrome c during apoptosis is rapid, complete, and kinetically invariant. Nat Cell Biol 2000;2:156-62.
14. Madesh M, Antonsson B, Srinivasula SM, Alnemri ES, Hajnoczki G. Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J Biol Chem 2002;277:5651-9.
15. Zou H, Li Y, Liu X, Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 1999;274:11549-56.
16. Jiang X, Wang X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J Biol Chem 2000;275: 31199-203.
17. Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995;3:673-82.
18. Pitti RM, Marsters SA, Ruppert S, Dunahuo CJ, Moore A, Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 1996;271:12687-90.
19. Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997;276:111-3.
20. Pan G, Ni J, Wei YF, Yu GL, Gentz R, Dixit VM. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997; 277:815-8.
21. Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997; 277:818-21.
22. Walczak H, Degli-Esposti MA, Johnson RS, et al. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J 1997;16:5386-97.
23. Hengartner MO. The biochemistry of apoptosis. Nature 2000;407: 770-6.
24. Eid MA, Lewis RW, Kumar MV. Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL). Mol Cancer Ther 2002; 1: 831-40.
25. Lakshmikanthan V, Kaddour-Djebbar I, Lewis RW, Kumar MV. SAHA sensitized prostate cancer cells to TNFα related apoptosis inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis. Int J Cancer 2006; 119:221-8.
26. Slee EA, Keogh SA, Martin SJ. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell Death Differ 2000;7:556-65.
27. Insinga A, Monestiroli S, Ronzoni S, et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med 2005;11:71-6.
28. Ma Y, Lakshmikanthan V, Lewis RW, Kumar MV. Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low dose geldanamycin. Mol Cancer Ther 2006;5:170-8.
29. Nebbioso A, Clarke N, Voltz E, et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med 2005;11:77-84.
30. 2+ uniporter by pure and impure ruthenium red. Mol Cell Biochem 1994;139:33-40.
31. 2+-indicating fluorophores. Biophys J 2000;79:39-50.
32. 2+ antagonist drugs. J Biol Chem 1982; 257:6000-2.
33. Griffiths EJ, Wei SK, Haigney MCP, Ocampo CJ, Stern MID, Silverman HS. Inhibition of mitochondrial calcium efflux by clonazepam in intact single rat cardiomyocytes and effects on NADH production. Cell Calcium 1997;21:321-9.
34. Shirley RB, Kaddour-Djebbar I, Patel DM, Lakshmikanthan V, Lewis RW, Kumar MV. Combination of proteasomal inhibitors, lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells. Neoplasia 2005;7:1104-11.
35. 2+ and Bax in cells undergoing apoptosis. J Biol Chem 2001; 276:32257-63.
36. 2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol 2003;66:1335-40.
37. Liu C-M, Hermann TE. Characterization of ionomycin as a calcium ionophore. J Biol Chem 1978;253:5892-4.
38. 2+ oscillation in AR42J cells. J Biol Chem 1990;265: 20856-62.
39. Denmeade SR, Isaacs JT. The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer. Cancer Biol Ther 2005;4: 14-22.
40. Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S. 3,3′-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis 2006;27:717-28.
41. Mattson MP, Chan SL. Good and bad amyloid antibodies. Science 2003;301:1847-9.
42. Liang Y, Eid MA, Lewis RW, Kumar MV. Mitochondria from TRAIL-resistant prostate cancer cells are capable of responding to apoptotic stimuli. Cell Signal 2005;17:243-51.
43. Sridhar S, Ali AA, Liang Y, El Etreby MF, Lewis RW, Kumar MV. Differential expression of members of the tumor necrosis factor α-related apoptosis-inducing ligand pathway in prostate cancer cells. Cancer Res 2001;61:7179-83.
44. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 1999;341:233-49.
45. Vanoverberghe K, Mariot P, Vanden Abeele F, Delcourt P, Parys JB, Prevarskaya N. Mechanisms of ATP-induced calcium signaling and growth arrest in human prostate cancer cells. Cell Calcium 2003;34:75-85.