The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection

Biochemical Pharmacology

Volumn 72, Issue 7, 2006, Pages 869-880

  Mestre, Leyre ^a   Correa, Fernando ^a   Docagne, Fabian ^a   Clemente, Diego ^a   Guaza, Carmen ^a  

^a INSTITUTO CAJAL   (Spain)

Author keywords

Brain endothelial cells; Cannabinoids; COX 2; PGE2; Signaling pathways; TMEV

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABIDIOL DERIVATIVE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME SYNTHESIS; GENE OVEREXPRESSION; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS INFECTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ARACHIDONIC ACIDS; BRAIN; CELL NUCLEUS; CELL SURVIVAL; CHROMONES; CYCLOOXYGENASE 2; DINOPROSTONE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FLAVONOIDS; FLUORESCENT ANTIBODY TECHNIQUE; GLYCERIDES; IMIDAZOLES; MICE; MICROSCOPY, CONFOCAL; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NAPHTHALENES; PYRIDINES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RESORCINOLS; THEILOVIRUS;

EID: 33748056090     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.037     Document Type: Article

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