Ceramide Is Involved in R(+)-Methanandamide-Induced Cyclooxygenase-2 Expression in Human Neuroglioma Cells

Molecular Pharmacology

Volumn 64, Issue 5, 2003, Pages 1189-1198

  Ramer, Robert ^a   Weinzierl, Ulrike ^a   Schwind, Bianca ^a   Brune, Kay ^a   Hinz, Burkhard ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CANNABINOID; CERAMIDE; CYCLOOXYGENASE 2; CYCLOSERINE; DIHYDRO C2 CERAMIDE; FUMONISIN B1; GLUTATHIONE; ISP 1; METHANANDAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SERINE PALMITOYLTRANSFERASE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; SPIROEPOXIDE; THERMOZYMOCIDIN; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS CEREUS; CELL CULTURE; CELL LINE; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG MECHANISM; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLIOMA CELL; HUMAN; HUMAN CELL; NEUROGLIOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ARACHIDONIC ACIDS; CERAMIDES; CYCLOOXYGENASE 2; DINOPROSTONE; GENE EXPRESSION; GLIOMA; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECEPTORS, DRUG; RNA, MESSENGER; SPHINGOMYELIN PHOSPHODIESTERASE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0142179099     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.5.1189     Document Type: Article

References (40)

1. Arenz C and Giannis A (2000) Synthesis of the first selective irreversible inhibitor of neutral sphingomyelinase. Angew Chem Int Ed Engl 39:1440-1442.
2. Bagetta G, Corasaniti MT, Paoletti AM, Berliocchi L, Nistico R, Giammarioli AM, Malorni W, and Finazzi-Agro A (1998) HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2). Biochem Biophys Res Commun 244:819-824.
3. Blazquez C, Sanchez C, Daza A, Galve-Roperh I, and Guzman M (1999) The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. J Neurochem 72:1759-1768.
4. Bligh EG and Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917.
5. Burstein SH, Hull K, Hunter SA, and Shilstone J (1989) Immunization against prostaglandins reduces Δ1-tetrahydrocannabinol-induced catalepsy in mice. Mol Pharmacol 35:6-9.
6. Callsen D, Pfeilschifter J, and Brune B (1998) Rapid and delayed p42/p44 mitogen-activated protein kinase activation by nitric oxide: the role of cyclic GMP and tyrosine phosphatase inhibition. J Immunol 161:4852-4858.
7. 9-tetrahydrocannabinol. J Neurosci 18:5322-5332.
8. Corasaniti MT, Strongoli MC, Piccirilli S, Nistico R, Costa A, Bilotta A, Turano P, Finazzi-Agro A, and Bagetta G (2000) Apoptosis incuced by gp120 in the neocortex of rat involves enhanced expression of cyclooxygenase type 2 and is prevented by NMDA receptor antagonists and by the 21-aminosteroid U-74389G. Biochem Biophys Res Commun 274:664-669.
9. 9-THC dilation of cerebral arterioles is blocked by indomethacin. Am J Physiol 269:H1859-H1864.
10. Fukuzawa J, Nishihira J, Hasebe N, Haneda T, Osaki J, Saito T, Nomura T, Fujino T, Wakamiya N, and Kikuchi K (2002) Contribution of macrophage migration inhibitory factor to extracellular signal-regulated kinase activation by oxidative stress in cardiomyocytes. J Biol Chem 277:24889-24895.
11. Galve-Roperh I, Sanchez C, Cortes ML, del Pulgar TG, Izquierdo M, and Guzman M (2000) Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 6:313-319.
12. Gomez del Pulgar T, Velasco G, Sanchez C, Haro A, and Guzman M (2002) De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem J 363:183-188.
13. 9-tetrahydrocannabinol and indomethacin. Ophthalmic Res 33:217-220.
14. Guzman M, Galve-Roperh I, and Sanchez C (2001) Ceramide: a new second messenger of cannabinoid action. Trends Pharmacol Sci 22:19-22.
15. Guzman M and Sanchez C (1999) Effects of cannabinoids on energy metabolism. Life Sci 65:657-664.
16. Hannken T, Schroeder R, Zahner G, Stahl RA, and Wolf G (2000) Reactive oxygen species stimulate p44/42 mitogen-activated protein kinase and induce p27(Kip1): role in angiotensin II-mediated hypertrophy of proximal tubular cells. J Am Soc Nephrol 11:1387-1397.
17. Hannun YA (1994) The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 269:3125-3128.
18. Hinz B and Brune K (2002) Cyclooxygenase-2 - 10 years later. J Pharmacol Exp Ther 300:367-375.
19. Jacobsson SO, Wallin T, and Fowler CJ (2001) Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J Pharmacol Exp Ther 299:951-959.
20. Jayadev S, Linardic CM, and Hannun YA (1994) Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor α. J Biol Chem 269:5757-5763.
21. Jenkins GM, Cowart LA, Signorelli P, Pettus BJ, Chalfant CE, and Hannun YA (2002) Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. J Biol Chem 277:42572-42578.
22. Jin ZG, Melaragno MG, Liao DF, Yan C, Haendeler J, Suh YA, Lambeth JD, and Berk BC (2000) Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ Res 87:789-796.
23. Kolesnick RN and Krönke M (1998) Regulation of ceramide production and apoptosis. Annu Rev Physiol 60:643-665.
24. Liu B and Hannun YA (1997) Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem 272:16281-16287.
25. Meloche S, Seuwen K, Pages G, and Pouyssegur J (1992) Biphasic and synergistic activation of p44MAPK (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol Endocrinol 6:845-854.
26. Na HK and Surh YJ (2002) Induction of cyclooxygenase-2 in Ras-transformed human mammary epithelial cells undergoing apoptosis. Ann N Y Acad Sci 973:153-160.
27. 2 in pulmonary A549 cells does not involve activation of NF-κB. Biochem Biophys Res Commun 277:675-679.
28. Ohanian J, Cunliffe P, Ceppi E, Alder A, Heerkens E, and Ohanian V (2001) Activation of p38 mitogen-activated protein kinases by endothelin and noradrenaline in small arteries, regulation by calcium influx and tyrosine kinases and their role in contraction. Arterioscler Thromb Vasc Biol 21:1921-1927.
29. Perry DK (2002) Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses. Biochim Biophys Acta 1585:146-152.
30. Ramer R, Brune K, Pahl A, and Hinz B (2001) R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism. Biochem Biophys Res Commun 286:1144-1152.
31. Reunanen N, Westermarck J, Hakkinen L, Holmstrom TH, Elo I, Eriksson JE and Kahari VM (1998) Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways. J Biol Chem 273:5137-5145.
32. 9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes. Mol Pharmacol 54:834-843.
33. Sarker KP and Maruyama I (2003) Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. Cell Mol Life Sci 60:1200-1208.
34. Subbaramaiah K, Chung WJ, and Dannenberg AJ (1998) Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways. J Biol Chem 273:32943-32949.
35. Tonnetti L, Veri MC, Bonvini E, and D'Adamio L (1999) A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction. J Exp Med 189:1581-1589.
36. Tsujii M and DuBois RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2. Cell 83:493-501.
37. Ueda N, Camargo SMR, Hong X, Basnakina AG, Walker PD, and Shah SV (2001) Role of ceramide synthase in oxidant injury to renal tubular epithelial cells. J Am Soc Nephrol 12:2384-2391.
38. Wang E, Norred WP, Bacon CW, Riley RT, and Merrill AH Jr (1991) Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266:14486-14490.
39. Yamaguchi T, Shoyama Y, Watanabe S, and Yamamoto T (2001) Behavioral suppression induced by cannabinoids is due to activation of the arachidonic acid cascade in rats. Brain Res 889:149-154.
40. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, and Stork PJ (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature (Lond) 392:622-626.