Structurally distinct ligand-binding or ligand-independent Notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently

Journal of Immunology

Volumn 177, Issue 4, 2006, Pages 2153-2166

  Priceputu, Elena ^a   Bouallaga, Isabelle ^a   Zhang, YaoPing ^a   Li, Xiujie ^a   Chrobak, Pavel ^a   Hanna, Zaher S ^a,b   Poudrier, Johanne ^a   Kay, Denis G ^a   Jolicoeur, Paul ^a,b,c  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; CD28 ANTIBODY; CD28 ANTIGEN; CD3 ANTIBODY; CD4 ANTIGEN; DEXAMETHASONE; INTERLEUKIN 2 RECEPTOR ALPHA; LIGAND; MONOCLONAL ANTIBODY; MUTANT PROTEIN; NOTCH1 RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MATURATION; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; FETUS; FLUORESCENCE ACTIVATED CELL SORTING; GENE FUNCTION; LEUKEMIA; LEUKEMOGENESIS; LIGAND BINDING; LYMPHOCYTE DIFFERENTIATION; METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; THYMOCYTE; THYMOMA; TRANSGENIC MOUSE;

EID: 33746930860     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.4.2153     Document Type: Article

References (40)

1. Milner, L. A., and A. Bigas. 1999. Notch as a mediator of cell fate determination in hematopoiesis; evidence and speculation. Blood 93: 2431-2448.
2. Artavanis-Tsakonas, S., M. D. Rand, and R. J. Lake. 1999. Notch signaling: cell fate control and signal integration in development. Science 284: 770-776.
3. Robey, E., D. Chang, A. Itano, D. Cado, H. Alexander, D. Lans, G. Weinmaster, and P. Salmon. 1996. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87: 483-492.
4. Washburn, T., E. Schweighoffer, T. Gridley, D. Chang, B. J. Fowlkes, D. Cado, and E. Robey. 1997. Notch activity influences the αβ versus γδ T cell lineage decision. Cell 88: 833-843.
5. Deftos, M. L., E. Huang, E. W. Ojala, K. A. Forbush, and M. J. Bevan. 2000. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13: 73-84.
6. Fowlkes, B. J., and E. A. Robey. 2002. A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development. J. Immunol. 169: 1817-1821.
7. + thymocytes by modulating TCR signal strength. Immunity 14: 253-264.
8. Kawamata, S., C. Du, K. Li, and C. Lavau. 2002. Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. Oncogene 21: 3855-3863.
9. Bellavia, D., A. F. Campese, E. Alesse, A. Vacca, M. P. Felli, A. Balestri, A. Stoppacciaro, C. Tiveron, L. Tatangelo, M. Giovarelli, et al. 2000. Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 19: 3337-3348.
10. Ellisen, L. W., J. Bird, D. C. West, A. L. Soreng, T. C. Reynolds, S. D. Smith, and J. Sklar. 1991. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649-661.
11. Rohn, J. L., A. S. Lauring, M. L. Linenberger, and J. Overbaugh. 1996. Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma. J. Virol. 70: 8071-8080.
12. Girard, L., Z. Hanna, N. Beaulieu, C. D. Hoemann, C. Simard, C. A. Kozak, and P. Jolicoeur. 1996. Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes Dev. 10: 1930-1944.
13. Hoemann, C. D., N. Beaulieu, L. Girard, N. Rebai, and P. Jolicoeur. 2000. Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice. Mol. Cell. Biol. 20: 3831-3842.
14. D/myc transgenic mice. Oncogene 16: 517-522.
15. Weng, A. P., A. A. Ferrando, W. Lee, J. P. Morris, L. B. Silverman, C. Sanchez-Irizarry, S. C. Blacklow, A. T. Look, and J. C. Aster. 2004. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306: 269-271.
16. Pear, W. S., J. C. Aster, M. L. Scott, R. P. Hasserjian, B. Soffer, J. Sklar, and D. Baltimore. 1996. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated notch alleles. J. Exp. Med. 183: 2283-2291.
17. Aster, J. C., L. Xu, F. G. Karnell, V. Patriub, J. C. Pui, and W. S. Pear. 2000. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol. Cell. Biol. 20: 7505-7515.
18. Fowlkes, B. J., and D. M. Pardoll. 1989. Molecular and cellular events of T cell development. Adv. Immunol. 44: 207-264.
19. + T cells, and in macrophages of transgenic mice. Mol. Cell. Biol. 14: 1084-1094.
20. Kopan, R., and H. Weintraub. 1993. Mouse notch: expression in hair follicles correlates with cell fate determination. J. Cell Biol. 121: 631-641.
21. Goudreau, G., S. Carpenter, N. Beaulieu, and P. Jolicoeur. 1996. Vacuolar myelopathy in transgenic mice expressing human immunodeficiency virus type 1 proteins under the regulation of the myelin basic protein gene promoter. Nat. Med. 2: 655-661.
22. Bouchard, L., L. Lamarre, P. J. Tremblay, and P. Jolicoeur. 1989. Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell 57: 931-936.
23. Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor.
24. Aziz, N., M. R. Miglarese, R. C. Hendrickson, J. Shabanowitz, T. W. Sturgill, D. F. Hunt, and T. P. Bender. 1995. Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain. Proc. Natl. Acad. Sci. USA 92: 6429-6433.
25. - T cells. Mol. Cell. Biol. 12: 3522-3530.
26. Hanna, Z., D. G. Kay, M. Cool, S. Jothy, N. Rebai, and P. Jolicoeur. 1998. Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease. J. Virol. 72: 121-132.
27. Weng, X., E. Priceputu, P. Chrobak, J. Poudrier, D. G. Kay, Z. Hanna, T. W. Mak, and P. Jolicoeur. 2004. CD4 T cells from CD4C/HIV nef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro, but are dispensable for the development of a severe AIDS-like organ disease. J. Virol. 78: 5244-5257.
28. Hanna, Z., N. Rebai, J. Poudrier, and P. Jolicoeur. 2001. Distinct regulatory elements are required for faithful expression of human CD4 in T-cells, macrophages and dendritic cells of transgenic mice. Blood 98: 2275-2278.
29. Axelrod, J. D., K. Matsuno, S. Artavanis-Tsakonas, and N. Perrimon. 1996. Interaction between wingless and notch signaling pathways mediated by dishevelled. Science 271: 1826-1832.
30. Reynolds, P. J., J. Lesley, J. Trotter, R. Schulte, R. Hyman, and B. M. Sefton. 1990. Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development. Mol. Cell. Biol. 10: 4266-4270.
31. Sentman, C. L., J. R. Shutter, D. Hockenbery, O. Kanagawa, and S. J. Korsmeyer. 1991. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888.
32. Guo, M., L. Y. Jan, and Y. N. Jan. 1996. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 17: 27-41.
33. Deftos, M. L., Y. He, E. W. Ojala, and M. J. Bevan. 1998. Correlating Notch signaling with thymocyte maturation. Immunity 9: 777-786.
34. Jehn, B. M., W. Bielke, W. S. Pear, and B. A. Osborne. 1999. Protective effects of Notch-1 on TCR-induced apoptosis. J. Immunol. 162: 635-638.
35. Jundt, F., I. Anagnostopoulos, R. Forster, S. Mathas, H. Stein, and B. Dorken. 2002. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 99: 3398-3403.
36. high thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur. J. Immunol. 27: 2279-2289.
37. Ghendler, Y., E. Mizoguchi, A. K. Bhan, and L. K. Clayton. 1998. Double-positive thymocytes resistant to antigen-MHC-induced negative selection lack active caspase. Int. Immunol. 10: 767-774.
38. Melton, E., N. Sarner, M. Torkar, P. A. van der Merwe, J. Q. Russell, R. C. Budd, C. Mamalaki, M. Tolaini, D. Kioussis, and R. Zamoyska. 1996. Transgene-encoded human CD2 acts in a dominant negative fashion to modify thymocyte selection signals in mice. Eur. J. Immunol. 26: 2952-2963.
39. Palmer, E. 2003. Negative selection: clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3: 383-391.
40. Feldman, B. J., T. Hampton, and M. L. Cleary. 2000. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 96: 1906-1913.