Distinct regulatory elements are required for faithful expression of human CD4 in T cells, macrophages, and dendritic cells of transgenic mice

Blood

Volumn 98, Issue 7, 2001, Pages 2275-2278

  Hanna, Zaher ^a,b,c   Najet Rebai, Johanne Poudrier ^a,b,c   Jolicoeur, Paul ^a,b,c  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; DENDRITIC CELL; EXON; GENE CONTROL; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0035496910     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.7.2275     Document Type: Article

References (26)

1. Ellmeier W, Sawada S, Littman DR. The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Ann Rev Immunol. 1999;17:523-554.
2. Killeen N, Littman DR. The regulation and function of the CD4 coreceptor during T lymphocyte development. Curr Top Microbiol Immunol. 1996; 205:89-106.
3. Salomon B, Cohen JL, Masurier C, Klatzmann D. Three populations of mouse lymph node dendritic cells with different origins and dynamics. J Immunol. 1998;160:708-717.
4. Vremec D, Pooley J, Hochrein H, Wu L, Shortman K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol. 2000;164:2978-2986.
5. Wood GS, Warner NL, Warnke RA. Anti-Leu-3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J Immunol. 1983; 131:212-216.
6. Kazazi F, Mathijs JM, Foley P, Cunningham AL. Variations in CD4 expression by human monocytes and macrophages and their relationships to infection with the human immunodeficiency virus. J Gen Virol. 1989;70:2661-2672.
7. +T cells, and in macrophages of transgenic mice. Mol Cell Biol. 1994;14:1084-1094.
8. Berney C, Herren S, Power CA, Gordon S, Martinez-Pomares L, Kosco-Vilbois MH. A member of the dendritic cell family that enters B cell follicles and stimulates primary antibody responses identified by a mannose receptor fusion protein. J Exp Med. 1999;190:851-860.
9. Vremec D, Zorbas M, Scollay R, et al. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med. 1992;176:47-58.
10. Sawada S, Scarborough JD, Killeen N, Littman DR. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell. 1994;77:917-929.
11. Siu G, Wurster AL, Duncan D, Soliman TM, Hedrick SM. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 1994;13:3570-3579.
12. Gillespie FP, Doros L, Vitale J, Blackwell C, Gosselin J, Snyder BW. Tissue-specific expression of human CD4 in transgenic mice. Mol Cell Biol. 1993;13:2952-2958.
13. Blum MD, Wong GT, Higgins KM, Sunshine MJ, Lacy E. Reconstitution of subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. J Exp Med. 1993;177:1343-1358.
14. Donda A, Schulz M, Burki K, De Libero G, Uematsu Y. Identification and characterization of a human CD4 silencer. Eur J Immunol. 1996;26: 493-500.
15. Uematsu Y, Donda A, De Libero G. Thymocytes control the CD4 gene differently from mature T lymphocytes. Int Immunol. 1997;9:179-187.
16. Duncan DD, Adlam M, Siu G. Asymmetric redundancy in CD4 silencer function. Immunity. 1996;4: 301-311.
17. Adlam M, Duncan DD, Ng DK, Siu G. Positive selection induces CD4 promoter and enhancer function. Int Immunol. 1997;9:877-887.
18. Salmon P, Boyer O, Lores P, Jami J, Klatzmann D. Characterization of an intronless CD4 mini-gene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes. J Immunol. 1996;156:1873-1879.
19. + T cells. J Immunol. 1997;159:3383-3390.
20. Rushton JJ, Zorich GP, Stoic V, Neudorf SM. Characterization of a promoter within the first intron of the human CD4 gene. Eur J Biochem. 1997;245:768-773.
21. Shortman K. Burnet Oration: Dendritic cells: multiple subtypes, multiple origins, multiple functions. Immunol Cell Biol. 2000;78:161-165.
22. Siu G, Wurster AL, Lipsick JS, Hedrick SM. Expression of the CD4 gene requires a Myb transcription factor. Mol Cell Biol. 1992;12:1592-1604.
23. Duncan D, Stupakoff A, Hedrick SM, Marcu KB, Siu G. A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. Mol Cell Biol. 1995;15: 3179-3186.
24. Salmon P, Giovane A, Wasylyk B, Klatzmann D. Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins. Proc Natl Acad Sci U S A. 1993;90: 7739-7743.
25. Wurster AL, Siu G, Leiden JM, Hedrick SM. Elf-1 binds to a critical element in a second CD4 enhancer. Mol Cell Biol. 1994;14:6452-6463.
26. Sawada S, Littman DR. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol Cell Biol. 1991;11: 5506-5515.