Keratinocyte growth factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway

American Journal of Respiratory Cell and Molecular Biology

Volumn 35, Issue 2, 2006, Pages 268-274

  Chang, Yongsheng ^b   Edeen, Karen ^b   Lu, Xiaojun ^b   De Leon, Marino ^b   Mason, Robert J ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b NONE

Author keywords

Adenovirus; Fatty acid synthesis; Surfactant

Indexed keywords

ACYL COENZYME A DESATURASE; ADENOVIRUS VECTOR; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN DELTA; FATTY ACID; FATTY ACID SYNTHASE; KERATINOCYTE GROWTH FACTOR; LUNG SURFACTANT; PHOSPHOLIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL TYPE; CONTROLLED STUDY; ENZYME INDUCTION; FATTY ACID SYNTHESIS; GENE EXPRESSION; GENE INDUCTION; IN VITRO STUDY; LIPID METABOLISM; LIPOGENESIS; LUNG ALVEOLUS CELL; NONHUMAN; PHOSPHOLIPID SYNTHESIS; RAT; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; FATTY ACIDS; FIBROBLAST GROWTH FACTOR 7; HUMANS; LIPOGENESIS; MALE; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ADENOVIRIDAE;

EID: 33746856877     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2006-0037OC     Document Type: Article

References (29)

1. Mason RJ, Pan T, Edeen KE, Nielsen LD, Zhang F, Longphre M, Eckart MR, Neben S. Keratinocyte growth factor and the transcription factors C/EBP{alpha}, C/EBP{delta}, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells. J Clin Invest 2003;112:244-255.
2. Panos RJ, Rubin JS, Aaronson SA, Mason RJ. Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest 1993;92:969-977.
3. Ware LB, Matthay MA. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol 2002;282:L924-L940.
4. Portnoy J, Curran-Everett D, Mason RJ. Keratinocyte growth factor stimulates alveolar type II cell proliferation through the extracellular signal-regulated kinase and phosphatidylinositol 3-OH kinase pathways. Am J Respir Cell Mol Biol 2004;30:901-907.
5. Chang Y, Wang J, Lu X, Thewke DP, Mason RJ. KGF induces lipogenic genes through a P13K and JNK/SREBP-1 pathway in H292 cells. J Lipid Res 2005;46:2624-2635.
6. Fajas L, Fruchart JC, Auwerx J. Transcriptional control of adipogenesis. Curr Opin Cell Biol 1998;10:165-173.
7. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev 2000;14:1293-1307.
8. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997;89:331-340.
9. Brown MS, Goldstein JL. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 1999;96:11041-11048.
10. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002;109:1125-1131.
11. Lopez JM, Bennett MK, Sanchez HB, Rosenfeld JM, Osborne TE. Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. Proc Natl Acad Sci USA 1996;93:1049-1053.
12. Kim JB, Spiegelman BM. ADD1/SREBP1 promotesadipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 1996;10:1096-1107.
13. Latasa MJ, Moon YS, Kim KH, Sul HS. Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element. Proc Natl Acad Sci USA 2000;97:10619-10624.
14. Tabor DE, Kim JB, Spiegelman BM, Edwards PA. Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2. J Biol Chem 1999;274:20603-20610.
15. Zhang F, Pan T, Nielsen LD, Mason RJ. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Am J Respir Cell Mol Biol 2004;30:174-183.
16. Foufelle F, Ferre P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J 2002;366:377-391.
17. Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB, Spiegelman BM. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest 1998;101:1-9.
18. Foretz M, Guichard C, Ferre P, Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis- related genes. Proc Natl Acad Sci USA 1999;96:12737-12742.
19. Guillet-Deniau I, Mieulet V, Le Lay S, Achouri Y, Carre D, Girard J, Foufelle F, Ferre P. Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression. Diabetes 2002;51:1722-1728.
20. Le Lay S, Lefrere I, Trautwein C, Dugail I, Krief S. Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes: identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target. J Biol Chem 2002;277:35625-35634.
21. Foretz M, Pacot C, Dugail I, Lemarchand P, Guichard C, Le Liepvre X, Berthelier-Lubrano C, Spiegelman B, Kim JB, Ferre P, et al. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol Cell Biol 1999;19:3760-3768.
22. Guillet-Deniau I, Pichard AL, Kone A, Esnous C, Nieruchalski M, Girard J, Prip-Buus C. Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway. J Cell Sci 2004;117:1937-1944.
23. Jones BH, Standridge MK, Claycombe KJ, Smith PJ, Moustaid-Moussa N. Glucose induces expression of stearoyl-CoA desaturase in 3T3-L1 adipocytes. Biochem J 1998;335:405-408.
24. Mason RJ, Lewis MC, Edeen KE, McCormick-Shannon K, Nielsen LD, Shannon JM. Maintenance of surfactant protein A and D secretion by rat alveolar type II cells in vitro. Am J Physiol Lung Cell Mol Physiol 2002;282:L249-L258.
25. Gosmain Y, Lefai E, Ryser S, Roques M, Vidal H. Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells. Diabetes 2004;53:321-329.
26. Kern F, Ode-Hakim S, Nugel H, Vogt K, Volk HD, Reinke P. Peripheral T cell activation in long-term renal transplant patients: concordant upregulation of adhesion molecules and cytokine gene transcription. J Am Soc Nephrol 1996;7:2476-2482.
27. Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Isoform 1c of sterol regulatory element binding protein is sless active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 1997;99:846-854.
28. Becard D, Hainault I, Assout-Marniche D, Bertry-Coussot L, Ferre P, Foufelle F. Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice. Diabetes 2001;50:2425-2430.
29. Kotzka J, Muller-Wieland D, Koponen A, Njamen D, Kremer L, Roth G, Munck M, Knebel B, Krone W. ADD1/SREBP-1c mediates insulin-induced gene expression linked to the MAP kinase pathway. Biochem Biophys Res Commun 1998;249:375-379.