Keratinocyte growth factor and the transcription factors C/EBPα, C/EBPδ, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells

Journal of Clinical Investigation

Volumn 112, Issue 2, 2003, Pages 244-255

  Mason, Robert J ^a   Pan, Tianli ^a   Edeen, Karen E ^a   Nielsen, Larry D ^a   Zhang, Feijie ^a   Longphre, Malinda ^b   Eckart, Michael R ^b   Neben, Steven ^b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ACYL COENZYME A DESATURASE; CARRIER PROTEIN; CCAAT BINDING FACTOR; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN DELTA; FATTY ACID; FATTY ACID BINDING PROTEIN; FATTY ACID SYNTHASE; HORMONE RECEPTOR STIMULATING AGENT; KERATINOCYTE GROWTH FACTOR; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CEBPD PROTEIN, RAT; CELL RECEPTOR; COLLAGEN; DNA; DNA BINDING PROTEIN; FGF7 PROTEIN, RAT; FIBROBLAST GROWTH FACTOR; ISOPROTEIN; LAMININ; LIVER X RECEPTOR; MATRIGEL; OLIGONUCLEOTIDE; PHOSPHOLIPID; PROTEOGLYCAN; SREBF1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; FATTY ACID SYNTHESIS; GENE EXPRESSION; IN SITU HYBRIDIZATION; LIPOGENESIS; LUNG ALVEOLUS CELL TYPE 2; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RAT; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG COMBINATION; IMMUNOBLOTTING; LIPID METABOLISM; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CCAAT-ENHANCER-BINDING PROTEINS; COLLAGEN; DNA; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FATTY ACIDS; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; LAMININ; LIPID METABOLISM; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES; PHOSPHOLIPIDS; PROTEIN ISOFORMS; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTORS;

EID: 85047690323     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI16793     Document Type: Article

References (41)

1. Batenburg, JJ. 1992. Surfactant phospholipids: synthesis and storage. Am. J. Physiol. 262:L367-L383.
2. Rooney, S.A., Young, S.L., and Mendelson, C.R. 1994. Molecular and cellular processing of lung surfactant. FASEB J. 8:957-967.
3. van Golde, L.M.G., Batenburg, J.J., and Robertson, B. 1988. The pulmonary surfactant system: biochemical aspects and functional significance. Physiol. Rev. 68:374-455.
4. Mason, R.J., and Dobbs, L.G. 1980. Synthesis of phosphatidylcholine and phosphatidylglycerol by alveolar type II cells in primary culture. J. Biol. Chem. 255:5101-5107.
5. Mason, R.J., and Nellenbogen, J. 1984. Synthesis of saturated phosphatidylcholine and phosphatidylglycerol by freshly isolated rat alveolar type II cells. Biochim. Biophys. Acta. 794:392-402.
6. Mason, R.J., et al. 2002. Maintenance of surfactant protein A and D secretion by rat alveolar type II cells in vitro. Am. J. Physiol. Lung Cell. Mol. Physiol. 282:L249-L258.
7. Shannon, J.M., Pan, T., Nielsen, L.D., Edeen, K.E., and Mason, R.J. 2001. Lung fibroblasts improve differentiation of rat type II cells in primary culture. Am. J. Respir. Cell Mol. Biol. 24:235-244.
8. Chelly, N., et al. 1999. Keratinocyte growth factor enhances maturation of fetal rat lung type II cells. Am. J. Respir. Cell Mol. Biol. 20:423-432.
9. Monkawa, O., et al. 2000. Effect of adenovector-mediated gene transfer of keratinocyte growth factor on the proliferation of alveolar type II cells in vitro and in vivo. Am. J. Respir. Cell. Mol. Biol. 23:626-635.
10. Dobbs, L.G., and Mason, R.J. 1979. Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation. J. Clin. Invest. 63:378-387.
11. Labarca, C., and Paigen, K. 1980. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102:344-352.
12. Shimomura, I., Shimano, H., Horton, J.D., Goldstein, J.L., and Brown, M.S. 1997. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99:838-845.
13. Pan, T., et al. 2002. Serum SP-D is a marker of lung injury in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 282:L824-L832.
14. Deterding, R.R., and Shannon, J.M. 1995. Proliferation and differentiation of fetal rat pulmonary epithelium in the absence of mesenchyme. J. Clin. Invest. 95:2963-2972.
15. Fehrenbach, H., Fehrenbach, A., Pan, T., Kasper, M., and Mason, R.J. 2002. Keratinocyte growth factor-induced proliferation of rat airway epithelium is restricted to Clara cells in vivo. Eur. Respir. J. 20:1185-1197.
16. DeBose-Boyd, R.A., Ou, J., Goldstein, J.L., and Brown, M.S. 2001. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proc. Natl. Acad. Sci. U. S. A. 98:1477-1482.
17. Shimomura, I., et al. 1999. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl. Acad. Sci. U. S. A. 96:13656-13661.
18. Sugahara, K., Sadohara, T., Sugita, M., Iyama, K., and Takiguchi, M. 1999. Differential expression of CCAAT enhancer binding protein family in rat alveolar epithelial cell proliferation and in acute lung injury. Cell Tissue Res. 297:261-270.
19. Horton, J.D., Goldstein, J.L., and Brown, M.S. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109:1125-1131. doi: 10.1172/JCI200215593.
20. Gregoire, F.M., Smas, C.M., and Sul, H.S. 1998. Understanding adipocyte differentiation. Physiol. Rev. 78:783-809.
21. Morrison, R.F., and Farmer, S.R. 1999. Insights into the transcriptional control of adipocyte differentiation. J. Cell. Biochem. 75(Suppl. 32-33):59-67.
22. Soukas, A., Socci, N.D., Saatkamp, B.D., Novelli, S., and Friedman, J.M. 2001. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J. Biol. Chem. 276:34167-34174.
23. Mandrup, S., and Lane, M.D. 1997. Regulating adipogenesis. J. Biol. Chem. 272:5367-5370.
24. Li, F., et al. 1995. Correlation of expression of transcription factor C/EBPα and surfactant protein genes in lung cells. Am. J. Physiol. 269:L241-L247.
25. He, Y., and Crouch, E. 2002. Surfactant protein D gene regulation. Interactions among the conserved CCAAT/enhancer-binding protein elements. J. Biol. Chem. 277:19530-19537.
26. Flodby, P., Barlow, C., Kylefjord, H., Ahrlund-Richter, L., and Xanthopoulos, K.G. 1996. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J. Biol. Chem. 271:24753-24760.
27. Sugahara, K., et al. 2001., Mice lacking CCAAt/enhancer-binding protein-alpha show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs. Cell Tissue Res. 306:57-63.
28. Kersten, S. 2001. Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep. 2:282-286.
29. Edwards, P.A., Tabor, D., Kast, H.R., and Venkateswaran, A. 2000. Regulation of gene expression by SREBP and SCAP. Biochim. Biophys. Acta. 1529:103-113.
30. Shimano, H., et al. 1997. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J. Clin. Invest. 100:2115-2124.
31. Michalik, L., and Wahli, W. 1999. Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions. Curr. Opin. Biotechnol. 10:564-570.
32. Latruffe, N., and Vamecq, J. 1997. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie. 79:81-94.
33. Michael, L.F., Lazar, M.A., and Mendelson, C.R. 1997. Peroxisome proliferator-activated receptor gamma1 expression is induced during cyclic adenosine monophosphate-stimulated differentiation of alveolar type II pneumonocytes. Endocrinology. 138:3695-3703.
34. Ntambi, J.M. 1999. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J. Lipid Res. 40:1549-1558.
35. Kim, Y.C., and Ntambi, J.M. 1999. Regulation of stearoyl-CoA desaturase genes: role in cellular metabolism and preadipocyte differentiation. Biochem. Biophys. Res. Commun. 266:1-4.
36. Clements, J.A., Nellenbogen, J., and Traham, H.J. 1970. Pulmonary surfactant and evolution of the lungs. Science. 169:603-604.
37. Kaestner, K.H., Ntambi, J.M., Kelly, T.J., Jr., and Lane, M.D. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J. Biol. Chem. 264:14755-14761.
38. Baba, H., Fuss, B., Watson,J.B., Zane, L.T., and Macklin, WB. 1994. Identification of novel mRNAs expressed in oligodendrocytes. Neurochem. Res. 19:1091-1099.
39. Lykidis, A., and Jackowski, S. 2001. Regulation of mammalian cell membrane biosynthesis. Prog. Nucleic Acid Res. Mol. Biol. 65:361-393.
40. Kent, C. 1997. CTP:phosphocholine cytidylyltransferase. Biochim. Biophys. Acta. 1348:79-90.
41. Portnoy, J., and Mason, R.J. 2002. KGF utilizes both AKT/PKB and ERK signaling pathways in alveolar type II epithelial cells in vitro. Am. J. Respir. Crit. Care Med. 165:A429. (Abstr.)