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Volumn 20, Issue 2, 2006, Pages 164-175

Neuroimaging findings with MDMA/ecstasy: Technical aspects, conceptual issues and future prospects

Author keywords

1H MRSpectroscopy; Ecstasy; MDMA; Neuroimaging; Serotonin; SPECT

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; PSYCHEDELIC AGENT; SEROTONIN RECEPTOR AFFECTING AGENT; SEROTONIN TRANSPORTER;

EID: 33746825174     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881106061515     Document Type: Review
Times cited : (74)

References (82)
  • 4
    • 0037174806 scopus 로고    scopus 로고
    • MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: Effects on serotonin transporter densities
    • Boot B P, Mechan A O, McCann U D, Ricaurte G A (2002) MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities. Eur J Pharmacol 453: 239-244.
    • (2002) Eur J Pharmacol , vol.453 , pp. 239-244
    • Boot, B.P.1    Mechan, A.O.2    McCann, U.D.3    Ricaurte, G.A.4
  • 5
    • 84874778664 scopus 로고    scopus 로고
    • Retraction in: Ricaurte G A
    • Retraction in: Ricaurte G A. Euro J Pharmacol (2004) 489: 1.
    • (2004) Euro J Pharmacol , vol.489 , pp. 1
  • 8
    • 0032850840 scopus 로고    scopus 로고
    • Cerebral 1H-MRS alterations in recreational 3,4- methylenedioxymethamphetamine (MDMA, 'ecstasy') users
    • Chang L, Ernst T, Grob C S, Poland R E (1999) Cerebral 1H-MRS alterations in recreational 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') users. J Magn Reson Imaging 10: 521-526
    • (1999) J Magn Reson Imaging , vol.10 , pp. 521-526
    • Chang, L.1    Ernst, T.2    Grob, C.S.3    Poland, R.E.4
  • 10
    • 0023255308 scopus 로고
    • Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain
    • Commins D L, Vosmer G, Virus R M, Woolverton W L, Schuster C R, Seiden, L S (1987) Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 241: 338-345
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 338-345
    • Commins, D.L.1    Vosmer, G.2    Virus, R.M.3    Woolverton, W.L.4    Schuster, C.R.5    Seiden, L.S.6
  • 11
    • 0033921324 scopus 로고    scopus 로고
    • Is MDMA ('Ecstasy') neurotoxic in humans? An overview of evidence and of methodological problems in research
    • Curran H V (2000) Is MDMA ('Ecstasy') neurotoxic in humans? An overview of evidence and of methodological problems in research. Neuropsychobiology 42: 34-41
    • (2000) Neuropsychobiology , vol.42 , pp. 34-41
    • Curran, H.V.1
  • 13
    • 0026610622 scopus 로고
    • [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment
    • Dewar K M, Grondin L, Carli M, Lima L, Reader T A (1992) [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. J Neurochem 58: 250-257
    • (1992) J Neurochem , vol.58 , pp. 250-257
    • Dewar, K.M.1    Grondin, L.2    Carli, M.3    Lima, L.4    Reader, T.A.5
  • 20
    • 0033564773 scopus 로고    scopus 로고
    • Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4- methylenedioxymethamphetamine seven years previously: Factors influencing abnormal recovery
    • Hatzidimitriou G, McCann U D, Ricaurte G A (1999) Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4- methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery. J Neurosci 19: 5096-5107
    • (1999) J Neurosci , vol.19 , pp. 5096-5107
    • Hatzidimitriou, G.1    McCann, U.D.2    Ricaurte, G.A.3
  • 21
    • 0034435269 scopus 로고    scopus 로고
    • Serotonin transporters in ecstasy users
    • Heinz A, Jones D W (2000) Serotonin transporters in ecstasy users. Br J Psychiatry 176: 193-195
    • (2000) Br J Psychiatry , vol.176 , pp. 193-195
    • Heinz, A.1    Jones, D.W.2
  • 22
    • 4544334735 scopus 로고    scopus 로고
    • Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates
    • Heinz A, Jones D W, Zajicek K, Gorey J G, Juckel G, Higley J D, Weinberger D R (2004) Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates. J Neural Transm Suppl 68: 29-38
    • (2004) J Neural Transm Suppl , vol.68 , pp. 29-38
    • Heinz, A.1    Jones, D.W.2    Zajicek, K.3    Gorey, J.G.4    Juckel, G.5    Higley, J.D.6    Weinberger, D.R.7
  • 24
    • 0024383159 scopus 로고
    • 3,4-Methylenedioxymethamphetamine ('ecstasy') selectively destroys brain serotonin terminals in rhesus monkeys
    • Insel T R, Battaglia G, Johannessen J N, Marra S, De Souza E B (1989) 3,4-Methylenedioxymethamphetamine ('ecstasy') selectively destroys brain serotonin terminals in rhesus monkeys. J Pharmacol Exp Ther 49: 713-720
    • (1989) J Pharmacol Exp Ther , vol.49 , pp. 713-720
    • Insel, T.R.1    Battaglia, G.2    Johannessen, J.N.3    Marra, S.4    De Souza, E.B.5
  • 25
    • 0030748719 scopus 로고    scopus 로고
    • A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: The Baltimore Longitudinal Study of Aging
    • Kawas C, Resnick S, Morrison A, Brookmeyer R, Corrada M, Zonderman A, Bacal C, Lingle D D, Metter E (1997) A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology 48: 1517-1521
    • (1997) Neurology , vol.48 , pp. 1517-1521
    • Kawas, C.1    Resnick, S.2    Morrison, A.3    Brookmeyer, R.4    Corrada, M.5    Zonderman, A.6    Bacal, C.7    Lingle, D.D.8    Metter, E.9
  • 26
    • 13844317450 scopus 로고    scopus 로고
    • Regional distribution of serotonin transporter protein in postmortem human brain: Is the cerebellum a SERT-free brain region
    • Kish S J, Furukawa Y, Chang L J, Tong J, Ginovart N, Wilson A, Houle S, Meyer J H (2005) Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region? Nucl Med Biol 32: 123-128
    • (2005) Nucl Med Biol , vol.32 , pp. 123-128
    • Kish, S.J.1    Furukawa, Y.2    Chang, L.J.3    Tong, J.4    Ginovart, N.5    Wilson, A.6    Houle, S.7    Meyer, J.H.8
  • 27
    • 0033541208 scopus 로고    scopus 로고
    • Toxic effect of MDMA on brain serotonin neurons
    • Kuikka J T, Ahonen A K (1999) Toxic effect of MDMA on brain serotonin neurons. Lancet 353: 1269
    • (1999) Lancet , vol.353 , pp. 1269
    • Kuikka, J.T.1    Ahonen, A.K.2
  • 31
    • 0030087725 scopus 로고    scopus 로고
    • Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies
    • Lew R, Sabol K E, Chou C, Vosmer G L, Richards J, Seiden L S (1996) Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies. J Pharmacol Exp Ther 276: 855-865
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 855-865
    • Lew, R.1    Sabol, K.E.2    Chou, C.3    Vosmer, G.L.4    Richards, J.5    Seiden, L.S.6
  • 33
    • 0028827808 scopus 로고
    • Serotonin depletion decreases serotonin transporter mRNA levels in rat brain
    • Linnet K, Koed K, Wiborg O, Gregersen N (1995) Serotonin depletion decreases serotonin transporter mRNA levels in rat brain. Brain Res 697: 251-253
    • (1995) Brain Res , vol.697 , pp. 251-253
    • Linnet, K.1    Koed, K.2    Wiborg, O.3    Gregersen, N.4
  • 35
    • 0028176910 scopus 로고
    • Serotonin neurotoxicity after (+/-)3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'): A controlled study in humans
    • McCann U D, Ridenour A, Shaham Y, Ricaurte G A (1994) Serotonin neurotoxicity after (+/-)3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'): a controlled study in humans. Neuropsychopharmacology 10: 129-138
    • (1994) Neuropsychopharmacology , vol.10 , pp. 129-138
    • McCann, U.D.1    Ridenour, A.2    Shaham, Y.3    Ricaurte, G.A.4
  • 36
    • 0032585201 scopus 로고    scopus 로고
    • Positron emission tomographic evidence of toxic effect of MDMA ('Ecstasy') on brain serotonin neurones in human beings
    • McCann U D, Szabo Z, Scheffel U, Dannals R F, Ricaurte G A (1998) Positron emission tomographic evidence of toxic effect of MDMA ('Ecstasy') on brain serotonin neurones in human beings. Lancet 352: 1433-1437
    • (1998) Lancet , vol.352 , pp. 1433-1437
    • McCann, U.D.1    Szabo, Z.2    Scheffel, U.3    Dannals, R.F.4    Ricaurte, G.A.5
  • 38
    • 0032968382 scopus 로고    scopus 로고
    • Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine in humans
    • Mas M, Farre M, de la Torre R, Roset P N, Ortuno J, Segura J, Cami J (1999) Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine in humans. J Pharmacol Exp Ther 290: 136-145
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 136-145
    • Mas, M.1    Farre, M.2    De La Torre, R.3    Roset, P.N.4    Ortuno, J.5    Segura, J.6    Cami, J.7
  • 39
    • 30944431901 scopus 로고    scopus 로고
    • Pharmacokinetic profile of single and repeated oral doses of MDMA in squirrel monkeys: Relationship to lasting effects on brain serotonin neurons
    • (in press)
    • Mechan A, Yuan J, Hatzidimitriou G, Irvine R J, McCann U D, Ricaurte G A (2006) Pharmacokinetic profile of single and repeated oral doses of MDMA in squirrel monkeys: relationship to lasting effects on brain serotonin neurons. Neuropsychopharmacology (in press)
    • (2006) Neuropsychopharmacology
    • Mechan, A.1    Yuan, J.2    Hatzidimitriou, G.3    Irvine, R.J.4    McCann, U.D.5    Ricaurte, G.A.6
  • 40
    • 0036297999 scopus 로고    scopus 로고
    • Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain
    • Meyer J S, Ali S F (2002) Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain. Ann N Y Acad Sci 965: 373-380
    • (2002) Ann N y Acad Sci , vol.965 , pp. 373-380
    • Meyer, J.S.1    Ali, S.F.2
  • 43
    • 1842664351 scopus 로고    scopus 로고
    • Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ('Ecstasy') in rats
    • Morley K C, Li K M, Hunt G E, Mallet P E, McGregor I S (2004) Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ('Ecstasy') in rats. Neuropharmacology 46: 954-965
    • (2004) Neuropharmacology , vol.46 , pp. 954-965
    • Morley, K.C.1    Li, K.M.2    Hunt, G.E.3    Mallet, P.E.4    McGregor, I.S.5
  • 44
    • 2442681828 scopus 로고    scopus 로고
    • Nature editorial
    • DOI:10.1038/429113a
    • Nature 2004 Nature editorial 429: 113. DOI: 10.1038/429113a
    • (2004) Nature , vol.429 , pp. 113
  • 45
    • 23044469596 scopus 로고    scopus 로고
    • 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: A preliminary study
    • Newberg A B, Amsterdam J D, Wintering N, Ploessl K, Swanson R L, Shults J, Alavi A (2005) 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. J Nucl Med 46: 973-977
    • (2005) J Nucl Med , vol.46 , pp. 973-977
    • Newberg, A.B.1    Amsterdam, J.D.2    Wintering, N.3    Ploessl, K.4    Swanson, R.L.5    Shults, J.6    Alavi, A.7
  • 47
    • 0023735752 scopus 로고
    • Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity
    • O'Hearn E, Battaglia G, De Souza E B, Kuhar M J, Molliver M E (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J Neurosci 8: 2788-2803
    • (1988) J Neurosci , vol.8 , pp. 2788-2803
    • O'Hearn, E.1    Battaglia, G.2    De Souza, E.B.3    Kuhar, M.J.4    Molliver, M.E.5
  • 48
    • 0031879806 scopus 로고    scopus 로고
    • The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy')
    • O'Shea E, Granados R, Esteban B, Colado M I, Green A R (1998) The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy'). Neuropharmacology 37: 919-926
    • (1998) Neuropharmacology , vol.37 , pp. 919-926
    • O'Shea, E.1    Granados, R.2    Esteban, B.3    Colado, M.I.4    Green, A.R.5
  • 50
    • 0023616493 scopus 로고
    • Incidence of recreational use of 3,4-methylenedimethoxymethamphetamine (MDMA, 'ecstasy') on an undergraduate campus
    • Peroutka S J (1987) Incidence of recreational use of 3,4- methylenedimethoxymethamphetamine (MDMA, 'ecstasy') on an undergraduate campus. N Engl J Med 317: 1542-1543
    • (1987) N Engl J Med , vol.317 , pp. 1542-1543
    • Peroutka, S.J.1
  • 52
    • 0033618638 scopus 로고    scopus 로고
    • Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants
    • Ramamoorthy S, Blakely R D (1999) Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science 285: 763-766
    • (1999) Science , vol.285 , pp. 763-766
    • Ramamoorthy, S.1    Blakely, R.D.2
  • 53
    • 0036168326 scopus 로고    scopus 로고
    • Reduced N-acetylaspartate levels in the frontal cortex of 3,4-methylenedioxymethaphetamine ('Ecstasy') users-preliminary results
    • Reneman L, Majoie C B L M, Flick H, den Heeten G J (2002a) Reduced N-acetylaspartate levels in the frontal cortex of 3,4- methylenedioxymethaphetamine ('Ecstasy') users-preliminary results. AJNR Am J Neuroradiol 23: 231-237
    • (2002) AJNR Am J Neuroradiol , vol.23 , pp. 231-237
    • Reneman, L.1    Majoie, C.B.L.M.2    Flick, H.3    Den Heeten, G.J.4
  • 55
    • 0035657153 scopus 로고    scopus 로고
    • Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons
    • Reneman L, Booij J, de Bruin K, de Wolff F A, Gunning W B, den Heeten G J, van den Brink W (2001) Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons. Lancet 358: 1864-1869
    • (2001) Lancet , vol.358 , pp. 1864-1869
    • Reneman, L.1    Booij, J.2    De Bruin, K.3    De Wolff, F.A.4    Gunning, W.B.5    Den Heeten, G.J.6    Van Den Brink, W.7
  • 58
    • 0035651980 scopus 로고    scopus 로고
    • Assessing long-term effects of MDMA (Ecstasy)
    • Ricaurte G A, McCann U D (2001) Assessing long-term effects of MDMA (Ecstasy). Lancet 358: 1831-1832
    • (2001) Lancet , vol.358 , pp. 1831-1832
    • Ricaurte, G.A.1    McCann, U.D.2
  • 59
    • 0033623773 scopus 로고    scopus 로고
    • 3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: Studies in animals
    • Ricaurte G A, Yuan J, McCann U D (2000) (+/-)3,4- Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals. Neuropsychobiology 42: 5-10
    • (2000) Neuropsychobiology , vol.42 , pp. 5-10
    • Ricaurte, G.A.1    Yuan, J.2    McCann, U.D.3
  • 60
    • 0025650065 scopus 로고
    • Aminergic metabolites in cerebrospinal fluid of humans previously exposed to MDMA: Preliminary observations
    • Ricaurte G A, Finnegan K T, Irwin I, Langston J W (1990) Aminergic metabolites in cerebrospinal fluid of humans previously exposed to MDMA: preliminary observations. Ann N Y Acad Sci 600: 699-708
    • (1990) Ann N y Acad Sci , vol.600 , pp. 699-708
    • Ricaurte, G.A.1    Finnegan, K.T.2    Irwin, I.3    Langston, J.W.4
  • 61
    • 0023797477 scopus 로고
    • 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates
    • Ricaurte G A, DeLanney L E, Wiener S G, Irwin I, Langston J W (1988a) 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates. Brain Res 474: 359-363
    • (1988) Brain Res , vol.474 , pp. 359-363
    • Ricaurte, G.A.1    Delanney, L.E.2    Wiener, S.G.3    Irwin, I.4    Langston, J.W.5
  • 62
    • 0023819569 scopus 로고
    • 3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates
    • Ricaurte G A, Forno L S, Wilson M A, DeLanney L E, Irwin I, Molliver M E, Langston J W (1988b) (+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates. JAMA 260: 51-55
    • (1988) JAMA , vol.260 , pp. 51-55
    • Ricaurte, G.A.1    Forno, L.S.2    Wilson, M.A.3    Delanney, L.E.4    Irwin, I.5    Molliver, M.E.6    Langston, J.W.7
  • 63
    • 0037183866 scopus 로고    scopus 로고
    • Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ('ecstasy')
    • Ricaurte G A, Yuan J, Hatzidimitriou G, Cord B J, McCann U D (2002) Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ('ecstasy'). Science 297: 2260-2263
    • (2002) Science , vol.297 , pp. 2260-2263
    • Ricaurte, G.A.1    Yuan, J.2    Hatzidimitriou, G.3    Cord, B.J.4    McCann, U.D.5
  • 64
    • 85061887616 scopus 로고    scopus 로고
    • Retraction Science (2003) 301: 1479
    • (2003) Retraction Science , vol.301 , pp. 1479
  • 65
    • 14844297080 scopus 로고    scopus 로고
    • Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users
    • Roiser J P, Cook L J, Cooper J D, Rubinsztein D C, Sahakian B J (2005) Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users. Am J Psychiatry 162: 609-612
    • (2005) Am J Psychiatry , vol.162 , pp. 609-612
    • Roiser, J.P.1    Cook, L.J.2    Cooper, J.D.3    Rubinsztein, D.C.4    Sahakian, B.J.5
  • 66
    • 0025180948 scopus 로고
    • Paroxetine as an in vivo indicator of 3,4- methylenedioxymethamphetamine neurotoxicity: A presynaptic serotonergic positron emission tomograpy ligand
    • Scheffel U, Ricaurte G A (1990) Paroxetine as an in vivo indicator of 3,4- methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomograpy ligand? Brain Res 527: 89-95
    • (1990) Brain Res , vol.527 , pp. 89-95
    • Scheffel, U.1    Ricaurte, G.A.2
  • 69
    • 0023475168 scopus 로고
    • Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine
    • Schmidt C J, Taylor V L (1987) Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine. Biochem Pharmacol 36: 4095-4102
    • (1987) Biochem Pharmacol , vol.36 , pp. 4095-4102
    • Schmidt, C.J.1    Taylor, V.L.2
  • 70
    • 0032985047 scopus 로고    scopus 로고
    • Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users
    • Semple D M, Ebmeier K P, Glabus M F, O'Carroll R E, Johnstone E C (1999) Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users. Br J Psychiatry 175: 63-69
    • (1999) Br J Psychiatry , vol.175 , pp. 63-69
    • Semple, D.M.1    Ebmeier, K.P.2    Glabus, M.F.3    O'Carroll, R.E.4    Johnstone, E.C.5
  • 71
    • 0026000851 scopus 로고
    • Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
    • Simmons M L, Frondoza C G, Coyle J T (1991) Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 45: 37-45
    • (1991) Neuroscience , vol.45 , pp. 37-45
    • Simmons, M.L.1    Frondoza, C.G.2    Coyle, J.T.3
  • 72
    • 0023811368 scopus 로고
    • Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA)
    • Slikker W, Ali S F, Scallet A C, Frith C H, Newport G D, Bailey J R (1988) Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA). Toxicol Appl Pharmacol 94: 448-457
    • (1988) Toxicol Appl Pharmacol , vol.94 , pp. 448-457
    • Slikker, W.1    Ali, S.F.2    Scallet, A.C.3    Frith, C.H.4    Newport, G.D.5    Bailey, J.R.6
  • 73
    • 0030614781 scopus 로고    scopus 로고
    • Histological and 1H magnetic resonance spectroscopic imaging analysis of quinolinic acidinduced damage to the rat striatum
    • Strauss I, Williamson J M, Bertram E H (1997) Histological and 1H magnetic resonance spectroscopic imaging analysis of quinolinic acidinduced damage to the rat striatum. Magn Res Med 37: 24-33
    • (1997) Magn Res Med , vol.37 , pp. 24-33
    • Strauss, I.1    Williamson, J.M.2    Bertram, E.H.3
  • 75
    • 0022389956 scopus 로고
    • A sexually dimorphic nucleus in the human brain
    • Swaab D F, Fliers E (1985) A sexually dimorphic nucleus in the human brain. Science 228: 1112-1115
    • (1985) Science , vol.228 , pp. 1112-1115
    • Swaab, D.F.1    Fliers, E.2
  • 76
    • 84874779708 scopus 로고    scopus 로고
    • Ecstasy, what does it do to your brain?
    • June 5
    • Time Magazine (2000) Ecstasy, what does it do to your brain? June 5 155 (23)
    • (2000) Time Magazine , vol.23 , pp. 155
  • 77
    • 0027450301 scopus 로고
    • Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types
    • Urenjak J, Williams S R, Gadian D G, Noble M (1993) Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 13: 981-989
    • (1993) J Neurosci , vol.13 , pp. 981-989
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 79
    • 17644395630 scopus 로고    scopus 로고
    • 123I]β-CIT SPECT to assess serotonin transporters in vivo in humans: A double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopram
    • 123I]β-CIT SPECT to assess serotonin transporters in vivo in humans: a double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopram. Neuropsychopharmacology 30: 996-1005
    • (2005) Neuropsychopharmacology , vol.30 , pp. 996-1005
    • De Win, M.M.L.1    Habraken, J.B.A.2    Reneman, L.3    Van Den Brink, W.4    Den Heeten, G.J.5    Booij, J.6
  • 82
    • 0032517176 scopus 로고    scopus 로고
    • Serotonin transporters are located on the axons beyond the synaptic junctions: Anatomical and functional evidence
    • Zhou F C, Tao-Cheng J H, Segv L, Patel T, Wang Y (1998) Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence. Brain Res 805: 241-254
    • (1998) Brain Res , vol.805 , pp. 241-254
    • Zhou, F.C.1    Tao-Cheng, J.H.2    Segv, L.3    Patel, T.4    Wang, Y.5


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