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Volumn 29, Issue 2, 1998, Pages 183-192

In vivo detection of short- and long-term MDMA neurotoxicity - A positron emission tomography study in the living baboon brain

Author keywords

11C (+)McN5652; 11C ( )McN5652; 11C RTI 55 ( 11C CIT); MDMA (3,4 methylenedioxymethamphetamine); Neurotoxicity; Papio anubis; PET (positron emission tomography) imaging; Serotonin (5 HT)

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; CARBON 11; DOPAMINE TRANSPORTER; SEROTONIN TRANSPORTER;

EID: 0031945694     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199806)29:2<183::AID-SYN9>3.0.CO;2-3     Document Type: Article
Times cited : (143)

References (46)
  • 1
    • 0023272774 scopus 로고
    • 3,4 Methylenedioxymethamphetamine and 3,4 methylenedioxyamphetamine destroy serotonin terminals in rat brain: Quantification of neurodegeneration by measurement of 3H-paroxetine labeled serotonin uptake sites
    • Battaglia, G., Yeh, S.Y., O'Hearn, E., Molliver, M.E., Kuhar, M.J., and deSouza, E.B. (1987) 3,4 Methylenedioxymethamphetamine and 3,4 methylenedioxyamphetamine destroy serotonin terminals in rat brain: Quantification of neurodegeneration by measurement of 3H-paroxetine labeled serotonin uptake sites. J. Pharmacol. Exp. Ther., 242:911-916.
    • (1987) J. Pharmacol. Exp. Ther. , vol.242 , pp. 911-916
    • Battaglia, G.1    Yeh, S.Y.2    O'Hearn, E.3    Molliver, M.E.4    Kuhar, M.J.5    Desouza, E.B.6
  • 2
    • 0025817030 scopus 로고
    • Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylene dioxymethamphetamine): Assessment using quantitative autoradiography
    • Battaglia, G., Sharkey, J., Kuhar, M.J., and DeSouza, E.B. (1991) Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylene dioxymethamphetamine): Assessment using quantitative autoradiography. Synapse, 8:249-260.
    • (1991) Synapse , vol.8 , pp. 249-260
    • Battaglia, G.1    Sharkey, J.2    Kuhar, M.J.3    DeSouza, E.B.4
  • 3
    • 0027337040 scopus 로고
    • 125I]5-iodo-6-nitroquipazine: A potent and selective ligand for the 5-hydroxytryptamine uptake complex. II. In vivo studies in rats
    • 125I]5-iodo-6-nitroquipazine: A potent and selective ligand for the 5-hydroxytryptamine uptake complex. II. In vivo studies in rats. Brain Res., 619:236-246.
    • (1993) Brain Res. , vol.619 , pp. 236-246
    • Biegon, A.1    Mathis, C.A.2    Hanrahan, S.M.3    Jagust, W.J.4
  • 8
    • 0023255308 scopus 로고
    • Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in rat brain
    • Commins, D.L., Vosmer, G., Viris, R., Woolverton, W., Schuster, C., and Seiden, L.S. (1987) Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in rat brain. J. Pharmacol. Exp. Ther., 241:338-345.
    • (1987) J. Pharmacol. Exp. Ther. , vol.241 , pp. 338-345
    • Commins, D.L.1    Vosmer, G.2    Viris, R.3    Woolverton, W.4    Schuster, C.5    Seiden, L.S.6
  • 10
    • 0002479145 scopus 로고
    • Radioligand development for studying serotonin uptake sites with positron emission tomography
    • Dannals, R.F., Scheffel, U., Suehiro, M., and Ricaurte, G.A. (1994) Radioligand development for studying serotonin uptake sites with positron emission tomography. Med. Chem. Res., 5:228-244.
    • (1994) Med. Chem. Res. , vol.5 , pp. 228-244
    • Dannals, R.F.1    Scheffel, U.2    Suehiro, M.3    Ricaurte, G.A.4
  • 13
    • 0029125154 scopus 로고
    • Reorganization of ascending serotonin axon projections in animals previously exposed to the recreational drug 3,4-methylenedioxymethamphetamine
    • Fischer, C.A., Hatzidimitriou, G., Katz, J.L., and Ricaurte, G.A. (1995) Reorganization of ascending serotonin axon projections in animals previously exposed to the recreational drug 3,4-methylenedioxymethamphetamine. J. Neurosci., 15:5476-5485.
    • (1995) J. Neurosci. , vol.15 , pp. 5476-5485
    • Fischer, C.A.1    Hatzidimitriou, G.2    Katz, J.L.3    Ricaurte, G.A.4
  • 14
    • 0029067178 scopus 로고
    • Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy")
    • Green, A.R., Cross, A.J., and Goodwin, G.M. (1995) Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy"). Psychopharmacology, 119:247-260.
    • (1995) Psychopharmacology , vol.119 , pp. 247-260
    • Green, A.R.1    Cross, A.J.2    Goodwin, G.M.3
  • 17
    • 0024383159 scopus 로고
    • 3,4-Methylenedioxymethamphetamine ("Ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys
    • Insel, T.R., Battaglia, G., Johannson, J., Marra, S., and DeSouza, E.B. (1989) 3,4-Methylenedioxymethamphetamine ("Ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys. J. Pharmacol. Exp. Ther., 249:713-720.
    • (1989) J. Pharmacol. Exp. Ther. , vol.249 , pp. 713-720
    • Insel, T.R.1    Battaglia, G.2    Johannson, J.3    Marra, S.4    DeSouza, E.B.5
  • 21
    • 0028933124 scopus 로고
    • Comparison of iodine-123-labelled carbomethoxy-3-β-(4-iodophenyl) tropane and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain
    • Kuikka, J.T., Bergstrom, K.A., Ahonen, A., Hiltunen, J., Kaukka, J., Lansimies, E., Wang, S., and Neumeyer, J.L. (1995) Comparison of iodine-123-labelled carbomethoxy-3-β-(4-iodophenyl) tropane and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain. Eur. J. Nucl. Med., 22:356-360.
    • (1995) Eur. J. Nucl. Med. , vol.22 , pp. 356-360
    • Kuikka, J.T.1    Bergstrom, K.A.2    Ahonen, A.3    Hiltunen, J.4    Kaukka, J.5    Lansimies, E.6    Wang, S.7    Neumeyer, J.L.8
  • 25
    • 0024587639 scopus 로고
    • Quantitative autoradiographic mapping of serotonin 5-HT1 and 5-HT2 receptors and uptake sites in the neocortex of the rhesus monkey
    • Lidow, M., and Goldman-Rakic, P. (1989) Quantitative autoradiographic mapping of serotonin 5-HT1 and 5-HT2 receptors and uptake sites in the neocortex of the rhesus monkey. J. Comp. Neurol., 280:27-42.
    • (1989) J. Comp. Neurol. , vol.280 , pp. 27-42
    • Lidow, M.1    Goldman-Rakic, P.2
  • 27
    • 0026612598 scopus 로고
    • 125I]5-Iodo-6-nitro-2-piperazinylquinoline: A potent and selective ligand for the serotonin uptake complex
    • 125I]5-Iodo-6-nitro-2-piperazinylquinoline: A potent and selective ligand for the serotonin uptake complex. Eur. J. Pharm., 210:103-104.
    • (1992) Eur. J. Pharm. , vol.210 , pp. 103-104
    • Mathis, C.A.1    Biegon, A.2    Taylor, S.E.3    Enas, J.D.4    Hanrahan, S.M.5
  • 28
    • 0027337038 scopus 로고
    • 125I]5-Iodo-6-nitroquipazine: A potent and selective ligand for the 5-hydroxytrypt-amine uptake complex. I. In vitro studies
    • 125I]5-Iodo-6-nitroquipazine: A potent and selective ligand for the 5-hydroxytrypt-amine uptake complex. I. In vitro studies. Brain Res., 619:229-235
    • (1993) Brain Res. , vol.619 , pp. 229-235
    • Mathis, C.A.1    Taylor, S.E.2    Biegon, A.3    Enas, J.D.4
  • 30
    • 0023902232 scopus 로고
    • Toxic effects of 3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in the primate: Importance of route and frequency of drug administration
    • Ricaurte, G.A., Delanney, L.E., Irwin, I., and Langston, J.E. (1988a) Toxic effects of 3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in the primate: Importance of route and frequency of drug administration. Brain Res., 446:165-168.
    • (1988) Brain Res. , vol.446 , pp. 165-168
    • Ricaurte, G.A.1    Delanney, L.E.2    Irwin, I.3    Langston, J.E.4
  • 31
    • 0023797477 scopus 로고
    • 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of nonhuman primates
    • Ricaurte, G.A., Delanney, L.E., Wiener, S.G., Irwin, I., and Langston, J.W. (1988b) 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of nonhuman primates. Brain Res., 474:359-363.
    • (1988) Brain Res. , vol.474 , pp. 359-363
    • Ricaurte, G.A.1    Delanney, L.E.2    Wiener, S.G.3    Irwin, I.4    Langston, J.W.5
  • 32
    • 0023819569 scopus 로고
    • (±)3,4 Methylenedioxymethamphetamine (MDMA) selectively damages central serotonergic neurons in nonhuman primates
    • Ricaurte, G.A., Forno, L.S., Wilson, M.A., DeLanney, L.E., Irwin, I., Molliver, M.E., and Langston, J.W. (1988c) (±)3,4 Methylenedioxymethamphetamine (MDMA) selectively damages central serotonergic neurons in nonhuman primates. JAMA, 260:51-55.
    • (1988) JAMA , vol.260 , pp. 51-55
    • Ricaurte, G.A.1    Forno, L.S.2    Wilson, M.A.3    DeLanney, L.E.4    Irwin, I.5    Molliver, M.E.6    Langston, J.W.7
  • 33
    • 0026612759 scopus 로고
    • Lasting effects of (±)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: Neurochemical observation
    • Ricaurte, G.A., Martello, A.L., Katz, J.L., and Martello, M.B. (1992) Lasting effects of (±)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: Neurochemical observation. J. Pharmacol. Exp. Ther., 261:616-622.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 616-622
    • Ricaurte, G.A.1    Martello, A.L.2    Katz, J.L.3    Martello, M.B.4
  • 38
    • 0023163857 scopus 로고
    • Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine
    • Schmidt, C.J. (1986) Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J. Pharmacol. Exp. Ther., 240: 1-7.
    • (1986) J. Pharmacol. Exp. Ther. , vol.240 , pp. 1-7
    • Schmidt, C.J.1
  • 41
    • 0023484528 scopus 로고
    • Immediate and long term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat
    • Stone, D.M., Merchant, K.M., Hanson, G.R., and Gibb, J.W. (1987) Immediate and long term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat. Neuropharmacology, 26:1677-1783.
    • (1987) Neuropharmacology , vol.26 , pp. 1677-1783
    • Stone, D.M.1    Merchant, K.M.2    Hanson, G.R.3    Gibb, J.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.