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Volumn 37, Issue 7, 1998, Pages 919-926

The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy')

Author keywords

3,4 Methylenedioxymethamphetamine; 5 Hydroxytryptamine; 3H paroxetine binding; Ecstasy; Hyperthermia; Neurodegeneration

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 5 HYDROXYINDOLEACETIC ACID; PAROXETINE;

EID: 0031879806     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00029-X     Document Type: Article
Times cited : (217)

References (48)
  • 1
    • 0027157108 scopus 로고
    • Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the non-human primate
    • Ali, S.F., Newport, G.D., Scallet, A.C., et al., 1993. Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the non-human primate. Neurotoxicol. Teratol. 15, 91-96.
    • (1993) Neurotoxicol. Teratol. , vol.15 , pp. 91-96
    • Ali, S.F.1    Newport, G.D.2    Scallet, A.C.3
  • 3
    • 0024159060 scopus 로고
    • MDMA-induced neurotoxicity parameters of degeneration and recovery of brain serotonin systems
    • Battaglia, G., Yeh, S.Y., De Souza, E.B., 1988. MDMA-induced neurotoxicity parameters of degeneration and recovery of brain serotonin systems. Pharmacol. Biochem. Behav. 29, 269-274.
    • (1988) Pharmacol. Biochem. Behav. , vol.29 , pp. 269-274
    • Battaglia, G.1    Yeh, S.Y.2    De Souza, E.B.3
  • 4
    • 0028856659 scopus 로고
    • Age dependent sensitivity of rats to the long term effects of the serotonergic neurotoxicant (±)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response
    • Broening, H.W., Bowyer, J.F., Slikker, W. Jr., 1995. Age dependent sensitivity of rats to the long term effects of the serotonergic neurotoxicant (±)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. J. Pharmacol. Exp. Ther. 275, 325-333.
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 325-333
    • Broening, H.W.1    Bowyer, J.F.2    Slikker W., Jr.3
  • 5
    • 0027978346 scopus 로고
    • CuZn-superoxide dismutase (CuZn-SOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA)
    • Cadet, J.L., Ladenheim, B., Baum, I., Carlson, E., Epstein, C., 1994. CuZn-superoxide dismutase (CuZn-SOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA). Brain Res. 655, 259-262.
    • (1994) Brain Res. , vol.655 , pp. 259-262
    • Cadet, J.L.1    Ladenheim, B.2    Baum, I.3    Carlson, E.4    Epstein, C.5
  • 6
    • 0029793919 scopus 로고    scopus 로고
    • Alpha-phenyl-N-tert-butyl nitrone attenuates methamphetamine-induced depletion of striatal dopamine without altering hyperthermia
    • Cappon, G.D., Broening, H.W., Pu, C., Morford, L., Vorhees, C.V., 1996. Alpha-phenyl-N-tert-butyl nitrone attenuates methamphetamine-induced depletion of striatal dopamine without altering hyperthermia. Synapse 24, 173-181.
    • (1996) Synapse , vol.24 , pp. 173-181
    • Cappon, G.D.1    Broening, H.W.2    Pu, C.3    Morford, L.4    Vorhees, C.V.5
  • 7
    • 84872641620 scopus 로고
    • Aggregation as a factor influencing the toxicity of sympathomimetic amines in mice
    • Chance, M.R.A., 1946. Aggregation as a factor influencing the toxicity of sympathomimetic amines in mice. J. Pharmacol. Exp. Ther. 87, 214-219.
    • (1946) J. Pharmacol. Exp. Ther. , vol.87 , pp. 214-219
    • Chance, M.R.A.1
  • 8
    • 0000940667 scopus 로고
    • Factors influencing the toxicity of sympathomimetic amines to solitary mice
    • Chance, M.R.A., 1947. Factors influencing the toxicity of sympathomimetic amines to solitary mice. J. Pharmacol. Exp. Ther. 89, 289-296.
    • (1947) J. Pharmacol. Exp. Ther. , vol.89 , pp. 289-296
    • Chance, M.R.A.1
  • 9
    • 0029916656 scopus 로고    scopus 로고
    • Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion
    • Chu, T., Kumagai, Y., Di Stefano, E.W., Cho, A.K., 1996. Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion. Biochem. Pharmacol. 51, 789-796.
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 789-796
    • Chu, T.1    Kumagai, Y.2    Di Stefano, E.W.3    Cho, A.K.4
  • 10
    • 0028331550 scopus 로고
    • A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds
    • Colado, M.I., Green, A.R., 1994. A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds. Br. J. Pharmacol. 111, 131-136.
    • (1994) Br. J. Pharmacol. , vol.111 , pp. 131-136
    • Colado, M.I.1    Green, A.R.2
  • 11
    • 0029006196 scopus 로고
    • The spin trap reagent α-phenyl-N-tert-butyl nitrone prevents neurodegeneration following administration of 'ecstasy'
    • Colado, M.I., Green, A.R., 1995. The spin trap reagent α-phenyl-N-tert-butyl nitrone prevents neurodegeneration following administration of 'ecstasy'. Eur. J. Pharmacol. 280, 343-346.
    • (1995) Eur. J. Pharmacol. , vol.280 , pp. 343-346
    • Colado, M.I.1    Green, A.R.2
  • 12
    • 0027462464 scopus 로고
    • 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine
    • Colado, M.I., Murray, T.K., Green, A.R., 1993. 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. Br. J. Pharmacol. 108, 583-589.
    • (1993) Br. J. Pharmacol. , vol.108 , pp. 583-589
    • Colado, M.I.1    Murray, T.K.2    Green, A.R.3
  • 13
    • 0029112473 scopus 로고
    • The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4-methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metaboliser phenotype
    • Colado, M.I., Williams, J.L., Green, A.R., 1995. The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4-methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metaboliser phenotype. Br. J. Pharmacol. 115, 1281-1289.
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1281-1289
    • Colado, M.I.1    Williams, J.L.2    Green, A.R.3
  • 14
    • 0030986255 scopus 로고    scopus 로고
    • In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine
    • Colado, M.I., O'Shea, E., Granados, R., Murray, T.K., Green, A.R., 1997a. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine. Br. J. Pharmacol. 121, 889-900.
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 889-900
    • Colado, M.I.1    O'Shea, E.2    Granados, R.3    Murray, T.K.4    Green, A.R.5
  • 15
    • 0345228392 scopus 로고    scopus 로고
    • The role of temperature in the neuroprotective effect of clomethiazole against MDMA-induced degeneration in rat brain
    • in press
    • Colado, M.I., Granados, R., O'Shea, E., Esteban, B., Green, A.R., 1997b. The role of temperature in the neuroprotective effect of clomethiazole against MDMA-induced degeneration in rat brain. Br. J. Pharmacol. (in press).
    • (1997) Br. J. Pharmacol.
    • Colado, M.I.1    Granados, R.2    O'Shea, E.3    Esteban, B.4    Green, A.R.5
  • 16
    • 0030980379 scopus 로고    scopus 로고
    • A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy
    • Colado, M.I., O'Shea, E., Granados, R., Misra, A., Murray, T.K., Green, A.R., 1997c. A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy. Br. J. Pharmacol. 121, 827-833.
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 827-833
    • Colado, M.I.1    O'Shea, E.2    Granados, R.3    Misra, A.4    Murray, T.K.5    Green, A.R.6
  • 17
    • 0008246356 scopus 로고    scopus 로고
    • Relationship between the dose of MDMA and frequency of administration on the subsequent neurodegeneration of rat brain 5-HT
    • Colado, M.I., O'Shea, E., Granados, R., Esteban, E., Green, A.R., 1997d. Relationship between the dose of MDMA and frequency of administration on the subsequent neurodegeneration of rat brain 5-HT. Br. J. Pharmacol. 122, 303.
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 303
    • Colado, M.I.1    O'Shea, E.2    Granados, R.3    Esteban, E.4    Green, A.R.5
  • 18
    • 0028335838 scopus 로고
    • Effects of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymetham-phetamine (MDMA or 'ecstasy') in rats
    • Dafters, R.I., 1994. Effects of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymetham-phetamine (MDMA or 'ecstasy') in rats. Psychopharmacology 114, 505-508.
    • (1994) Psychopharmacology , vol.114 , pp. 505-508
    • Dafters, R.I.1
  • 19
    • 0028835738 scopus 로고
    • Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments with 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX
    • Farfel, C.M., Seiden, L.S., 1995. Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments with 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX. J. Pharmacol. Exp. Ther. 272, 868-875.
    • (1995) J. Pharmacol. Exp. Ther. , vol.272 , pp. 868-875
    • Farfel, C.M.1    Seiden, L.S.2
  • 20
    • 0028947076 scopus 로고
    • Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: Impact of methamphetamine
    • Giovanni, A., Liang, L.P., Hastings, T.G., Zigmond, M.J., 1995. Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: impact of methamphetamine. J. Neurochem. 64, 1819-1825.
    • (1995) J. Neurochem. , vol.64 , pp. 1819-1825
    • Giovanni, A.1    Liang, L.P.2    Hastings, T.G.3    Zigmond, M.J.4
  • 21
    • 0029112937 scopus 로고
    • Detection of free radical formation during transient global ischemia and recirculation: Effects of intraischemic brain temperature modulation
    • Globus, M.Y.-T., Busto, R., Lin, B., Schnippering, H., Ginsberg, M.D., 1995. Detection of free radical formation during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J. Neurochem. 65, 1250-1256.
    • (1995) J. Neurochem. , vol.65 , pp. 1250-1256
    • Globus, M.Y.-T.1    Busto, R.2    Lin, B.3    Schnippering, H.4    Ginsberg, M.D.5
  • 22
    • 0026081849 scopus 로고
    • Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses in the rat
    • Gordon, C.J., Watkinson, W.P., O'Callaghan, J.P., Miller, D.B., 1991. Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses in the rat. Pharmacol. Biochem. Behav. 38, 339-344.
    • (1991) Pharmacol. Biochem. Behav. , vol.38 , pp. 339-344
    • Gordon, C.J.1    Watkinson, W.P.2    O'Callaghan, J.P.3    Miller, D.B.4
  • 23
    • 0029948929 scopus 로고    scopus 로고
    • Ecstasy and neurodegeneration
    • Green, A.R., Goodwin, G.M., 1996. Ecstasy and neurodegeneration. Br. Med. J. 312, 1493-1494.
    • (1996) Br. Med. J. , vol.312 , pp. 1493-1494
    • Green, A.R.1    Goodwin, G.M.2
  • 24
    • 0029067178 scopus 로고
    • Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy')
    • Green, A.R., Cross, A.J., Goodwin, G.M., 1995. Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy'). Psychopharmacology 119, 247-260.
    • (1995) Psychopharmacology , vol.119 , pp. 247-260
    • Green, A.R.1    Cross, A.J.2    Goodwin, G.M.3
  • 26
    • 0029846521 scopus 로고    scopus 로고
    • Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS
    • Helmlin, H.J., Bracher, K., Bourquin, D., Vonlanthern, D., Brenneisen, R., 1996. Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS. J. Anal. Toxicol. 20, 432-440.
    • (1996) J. Anal. Toxicol. , vol.20 , pp. 432-440
    • Helmlin, H.J.1    Bracher, K.2    Bourquin, D.3    Vonlanthern, D.4    Brenneisen, R.5
  • 27
    • 0026680529 scopus 로고
    • Toxicity and deaths from 3,4-methylenedioxmethamphetamine
    • Henry, J.A., Jefferys, K.T., Dawling, S., 1992. Toxicity and deaths from 3,4-methylenedioxmethamphetamine. Lancet 340, 384-387.
    • (1992) Lancet , vol.340 , pp. 384-387
    • Henry, J.A.1    Jefferys, K.T.2    Dawling, S.3
  • 28
    • 0028557961 scopus 로고
    • Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy')
    • Hewitt, K.E., Green, A.R., 1994. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy'). Neuropharmacology 33, 1589-1595.
    • (1994) Neuropharmacology , vol.33 , pp. 1589-1595
    • Hewitt, K.E.1    Green, A.R.2
  • 29
    • 0025121255 scopus 로고
    • Metabolism of methylenedioxymethamphetamine: Formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct
    • Hiramatsu, M., Kumagai, Y., Unger, S.E., Cho, A.K., 1990. Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct. J. Pharmacol. Exp. Ther. 254, 521-527.
    • (1990) J. Pharmacol. Exp. Ther. , vol.254 , pp. 521-527
    • Hiramatsu, M.1    Kumagai, Y.2    Unger, S.E.3    Cho, A.K.4
  • 30
    • 0003110629 scopus 로고    scopus 로고
    • Brain temperature alters hydroxyl radical production during cerebral ischaemia/reperfusion in rats
    • Kil, H.Y., Zhang, J., Piantadosi, L.A., 1996. Brain temperature alters hydroxyl radical production during cerebral ischaemia/reperfusion in rats. J. Cereb. Blood Flow Metab. 16, 100-106.
    • (1996) J. Cereb. Blood Flow Metab. , vol.16 , pp. 100-106
    • Kil, H.Y.1    Zhang, J.2    Piantadosi, L.A.3
  • 31
    • 0028069445 scopus 로고
    • Participation of cytochrome P-450-2B and -2D isozymes in the demethyleneation of methylenedioxymethamphetamine enantiomers in rat
    • Kumagai, Y., Lin, L.Y., Hiratsuka, A., et al., 1994. Participation of cytochrome P-450-2B and -2D isozymes in the demethyleneation of methylenedioxymethamphetamine enantiomers in rat. Mol. Pharmacol. 45, 359-365.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 359-365
    • Kumagai, Y.1    Lin, L.Y.2    Hiratsuka, A.3
  • 32
    • 0025747988 scopus 로고
    • Ion trap mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine
    • Lim, H.K., Foltz, R.L., 1991. Ion trap mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine. Chem. Res. Toxicol. 4, 626-632.
    • (1991) Chem. Res. Toxicol. , vol.4 , pp. 626-632
    • Lim, H.K.1    Foltz, R.L.2
  • 33
    • 0026731379 scopus 로고
    • Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes
    • Lin, L.Y., Kumagai, Y., Cho, A.K., 1992. Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes. Chem. Res. Toxicol. 5, 402-406.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 402-406
    • Lin, L.Y.1    Kumagai, Y.2    Cho, A.K.3
  • 35
    • 0029846728 scopus 로고    scopus 로고
    • Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy')
    • McCann, U.D., Slate, S.O., Ricaurte, G.A., 1996. Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy'). Drug Saf. 15, 107-115.
    • (1996) Drug Saf. , vol.15 , pp. 107-115
    • McCann, U.D.1    Slate, S.O.2    Ricaurte, G.A.3
  • 36
    • 0025014763 scopus 로고
    • Neurochemistry and neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy')
    • McKenna, D.J., Peroutka, S.J., 1990. Neurochemistry and neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy'). J. Neurochem. 54, 14-22.
    • (1990) J. Neurochem. , vol.54 , pp. 14-22
    • McKenna, D.J.1    Peroutka, S.J.2
  • 37
    • 0023898060 scopus 로고
    • Elevation of serum prolactin and corticosterone concentrations after administration of 3,4-methylenedioxymethamphetamine
    • Nash, J.F., Meltzer, H.Y., Gudelsky, G.A., 1988. Elevation of serum prolactin and corticosterone concentrations after administration of 3,4-methylenedioxymethamphetamine. J. Pharmacol. Exp. Ther. 245, 873-879.
    • (1988) J. Pharmacol. Exp. Ther. , vol.245 , pp. 873-879
    • Nash, J.F.1    Meltzer, H.Y.2    Gudelsky, G.A.3
  • 38
    • 0023902232 scopus 로고
    • Toxic effects of MDMA on central serotonergic neurons in the primate: Importance of route and frequency of drug administration
    • Ricaurte, G.A., Delaney, L.E., Irwin, I., Langston, J.W., 1988. Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration. Brain Res. 446, 165-168.
    • (1988) Brain Res. , vol.446 , pp. 165-168
    • Ricaurte, G.A.1    Delaney, L.E.2    Irwin, I.3    Langston, J.W.4
  • 39
    • 0023109989 scopus 로고
    • In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain
    • Schmidt, C.J., Levin, J.A., Lovenberg, W., 1987. In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. Biochem. Pharmacol. 36, 747-755.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 747-755
    • Schmidt, C.J.1    Levin, J.A.2    Lovenberg, W.3
  • 40
    • 0025092714 scopus 로고
    • MDMA-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors
    • Schmidt, L.J., Black, C.K., Abbate, G.M., Taylor, V.L., 1990. MDMA-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors. Brain Res. 529, 85-90.
    • (1990) Brain Res. , vol.529 , pp. 85-90
    • Schmidt, L.J.1    Black, C.K.2    Abbate, G.M.3    Taylor, V.L.4
  • 41
    • 0029682999 scopus 로고    scopus 로고
    • Methamphetamine and methylenedioxymethamphetamine neurotoxicity: Possible mechanisms of cell destruction
    • Seiden, L.S., Sabol, K.E., 1996. Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction. NIDA Res. Monogr. 163, 251-276.
    • (1996) NIDA Res. Monogr. , vol.163 , pp. 251-276
    • Seiden, L.S.1    Sabol, K.E.2
  • 42
    • 0025880607 scopus 로고
    • Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ('Ecstasy')
    • Sharkey, J., McBean, D.E., Kelly, P.A.T., 1991. Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ('Ecstasy'). Psychopharmacology 105, 113-118.
    • (1991) Psychopharmacology , vol.105 , pp. 113-118
    • Sharkey, J.1    McBean, D.E.2    Kelly, P.A.T.3
  • 43
    • 0029078456 scopus 로고
    • The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits
    • Sprague, J.E., Nichols, D.E., 1995. The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. J. Pharmacol. Exp. Ther. 273, 667-673.
    • (1995) J. Pharmacol. Exp. Ther. , vol.273 , pp. 667-673
    • Sprague, J.E.1    Nichols, D.E.2
  • 44
    • 0028292728 scopus 로고
    • 3,4-Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): Pharmacology and toxicology in animals and humans
    • Steele, T.D., McCann, U.D., Ricaurte, G.A., 1994. 3,4-Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): pharmacology and toxicology in animals and humans. Addiction 89, 539-551.
    • (1994) Addiction , vol.89 , pp. 539-551
    • Steele, T.D.1    McCann, U.D.2    Ricaurte, G.A.3
  • 45
    • 0022911033 scopus 로고
    • The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxy-amphetamine (MDA) on monoaminergic systems in the rat brain
    • Stone, D.M., Stahl, D.C., Hanson, G.R., Gibb, J.W., 1986. The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxy-amphetamine (MDA) on monoaminergic systems in the rat brain. Eur. J. Pharmacol. 128, 41-48.
    • (1986) Eur. J. Pharmacol. , vol.128 , pp. 41-48
    • Stone, D.M.1    Stahl, D.C.2    Hanson, G.R.3    Gibb, J.W.4
  • 46
    • 0028178550 scopus 로고
    • The demethylenation of methylenedioxymethamphetamine ('Ecstasy') by debrisoquine hydroxylase (CYP 206)
    • Tucker, G.T., Lennard, M.S., Ellis, S.W., et al., 1994. The demethylenation of methylenedioxymethamphetamine ('Ecstasy') by debrisoquine hydroxylase (CYP 206). Biochem. Pharmacol. 47, 1151-1156.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 1151-1156
    • Tucker, G.T.1    Lennard, M.S.2    Ellis, S.W.3
  • 47
    • 0030218082 scopus 로고    scopus 로고
    • The effects of methylenedioxymethamphetamine (MDMA, 'ecstasy') on monoaminergic neurotransmission in the central nervous system
    • White, S.R., Obradovic, T., Imel, K.M., Wheaton, M.J., 1996. The effects of methylenedioxymethamphetamine (MDMA, 'ecstasy') on monoaminergic neurotransmission in the central nervous system. Prog. Neurobiol. 49, 455-479.
    • (1996) Prog. Neurobiol. , vol.49 , pp. 455-479
    • White, S.R.1    Obradovic, T.2    Imel, K.M.3    Wheaton, M.J.4
  • 48
    • 0345715067 scopus 로고    scopus 로고
    • Attenuation of 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity by phenyl-t-butyl nitrone (PBN) in rats
    • Yeh, S. Y. (1996). Attenuation of 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity by phenyl-t-butyl nitrone (PBN) in rats. Am. Soc. Neurosci. Abst. 749.2.
    • (1996) Am. Soc. Neurosci. Abst. 749.2.
    • Yeh, S.Y.1


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