Imaging serotonin and dopamine transporters with 123I-β-CIT SPECT: Binding kinetics and effects of normal aging

Journal of Nuclear Medicine

Volumn 41, Issue 1, 2000, Pages 36-44

  Pirker, Walter ^a   Asenbaum, Susanne ^b   Hauk, Martin ^b   Kandlhofer, Susanne ^b   Tauscher, Johannes ^b   Willeit, Matthäus ^b   Neumeister, Alexander ^b   Praschak Rieder, Nicole ^b   Angelberger, Peter ^b   Brücke, Thomas ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b NONE

Author keywords

123I CIT; Age dependency; Kinetics; Serotonin transporter; SPECT

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; DOPAMINE TRANSPORTER; IODINE 123; SEROTONIN TRANSPORTER;

AGING; ARTICLE; BINDING AFFINITY; BINDING KINETICS; DOPAMINERGIC SYSTEM; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; MALE; MESENCEPHALON; NORMAL HUMAN; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS;

ADULT; AGING; BRAIN; CARRIER PROTEINS; CASE-CONTROL STUDIES; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; HUMANS; IODINE RADIOISOTOPES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0033972410     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Perry EK, Marshall EF, Blessed G, Tomlinson BE, Perry RH. Decreased imipramine binding in the brains of patients with depressive illness. Br J Psychiatry. 1983;142:188-192.
2. Leake A, Fairbairn AF, Mc Keith IG, Ferrier IN. Studies on the serotonin uptake binding site in major depressive disorder and control post-mortem brain: neurochemical and clinical correlates. Psychiatry Res. 1991;39:155-165.
3. 3H]-imipramine binding sites in control and parkinsonian brain. Eur J Pharmacol. 1985;117: 71-80.
4. Chinaglia G, Landwehrmeyer B, Probst A, Palacios JM. Serotonergic terminal transporters are differentially affected in Parkinson's disease and progressive supranuclear palsy: an autoradiographic study with [3H]citalopram. Neuroscience. 1993;54:691-699.
5. 3H]imipramine binding of protean nature in the human brain: part 2. Effect of normal aging and dementia disorders. Brain Res. 1987;425:137-145.
6. Barker EL, Blakely RD. Norepinephrine and serotonin transporters: molecular targets of antidepressant drugs. In: Bloom FE, Kupfer DJ. eds. Psychopharmacology: The Fourth Generation in Progress. New York, NY: Raven: 1995:321-333.
7. 125I]RTI-55: a potent ligand for dopamine transporters. Eur J Pharmacol. 1991;194:133-134.
8. 123I]-2β-carbomethoxy-3-β-(iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in the brain. J Med Chem. 1991;34:3144-3146.
9. 123/125I]RTI-55, an in vivo label for the serotonin transporter. Synapse. 1992;11:134-139.
10. 123I]CIT. Eur J Pharmacol. 1991;299:369-370.
11. Shaya EK, Scheffel U, Dannals RF, et al. In vivo imaging of dopamine uptake sites in primate brain using single photon emission tomography (SPECT) with iodine-123 labeled RTI-55. Synapse. 1992;10:169-172.
12. 123I]β-CIT: pharmacological characterization of brain uptake in non-human primates. Synapse. 1993;13:295-309.
13. Kuikka JT, Bergström KA, Vanninen E, Laulumaa V, Hartikainen P, Länsimies E. Initial experience with single photon emission tomography using iodine-123-labelled 2β-carbomethoxy-3-β-(iodophenyl)tropane in human brain. Eur J Nucl Med. 1993;20:783-786.
14. 123I]β-CIT: binding kinetics in the human brain. J Neural Transm Gen Sect. 1993;94:137-146.
15. Innis RB, Seibyl JP, Scanley BE, et al. Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporter in Parkinson disease. Proc Natl Acad Sci USA. 1993;90:11965-11969.
16. 125I]RTI-55: in vitro binding and autoradiographic characterization. J Neurochem. 1994;62:549-556.
17. 123I]β-CIT binding to dopamine transporters in healthy human subjects. J Cereb Blood Flow Metab. 1994;14:982-994.
18. van Dyck CH, Seibyl JP, Matison RT, et al. Age-related decline in striatal dopamine transporter binding wilh iodine-123-β-CIT SPECT. J Nucl Med. 1995;36:1175-1181.
19. Pirker W, Asenbaum S, Kasper S, et al. β-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo. J Neural Transm Gen Sect. 1995;100:247-256.
20. 123I]β-CIT and SPECT: correlation with clinical findings and comparison with multiple system atrophy and progressive supranuclear palsy. J Neural Transm. 1997;50(suppl):9-24.
21. 3H]paroxetine binding to serotonin uptake sites in human brain tissue. Brain Res. 1989;486:261-268.
22. 3H]GBR-12935 binding to dopamine uptake sites in the human brain. J Neurochem. 1989;53:1400-1404.
23. 18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab. 1993;13:24-42.
24. Farde L, Hall H, Ehrin E, Sedvall G. Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science. 1986;231:258-261.
25. Seibyl JP, Wallace E, Smith EO, et al. Whole-body biodistribution, radiation absorbed dose and brain SPECT imaging with iodine-123-β-CIT in healthy human subjects. J Nucl Med. 1994;35:764-770.
26. 11C]nomifensine and positron emission tomography: the effects of age and Parkinson's disease. Acta Neurol Scand. 1988;77:192-201.
27. Volkow ND, Fowler JS, Wang GJ, et al. Decreased dopamine transporters with age in healthy human subjects. Ann Neurol. 1994;36:237-239.
28. Volkow ND, Ding YS, Fowler JS, et al. Dopamine transporters decrease with age. J Nucl Med. 1996;37:554-559.
29. Zelnik N, Angel I, Paul SM, Kleinman JE. Decreased density of human striatal dopamine uptake sites with age. Eur J Pharmacol. 1986;126:175-176.
30. 3H ]GBR-12935 in human putamen. Neurobiol Aging. 1989;10:661-664.
31. De Keyser JD, Ebinger G, Vauquelin G. Age-related changes in the human nigrostriatal dopaminergic system. Ann Neurol. 1990;27:157-161.
32. Bannon MJ, Poosch MS, Xia Y, et al. Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age. Proc Natl Acad Sci USA. 1992;89:7095-7099.
33. Fearnly JM, Lees AJ. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain. 1991;114:23:2283-2301.
34. 3H]paroxetine binding. Gerontology. 1992;38:127-132.
35. Neumeyer JL, Tamagnan G, Wang S, et al. N-substituted analogs of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. J Med Chem. 1996;39:543-548.
36. 11C]β-CIT binding to monoamine transporters in the monkey and human brain. Synapse. 1994;16:93-103.
37. 3H]nisoxetine: a radioligand for quantification of norepinephrine uptake sites by autoradiography or by homogenate binding. J Pharmacol Exp Ther. 1992;260:427-436.
38. 3H]nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus in humans. Brain Res. 1992;583: 312-315.
39. 125I]PE2I. Neuroimage. 1999;9:108-116.
40. Murphy DGM, DeCarli C, Schapiro MB, Rapoport SI, Horwitz B. Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Arch Neurol. 1992;49:839-845.