Metformin prevents glucose-induced protein kinase C-β2 activation in human umbilical vein endothelial cells through an antioxidant mechanism

Diabetes

Volumn 54, Issue 4, 2005, Pages 1123-1131

  Gallo, Alessandra ^a   Ceolotto, Giulio ^a   Pinton, Paolo ^b   Iori, Elisabetta ^a   Murphy, Ellen ^a   Rutter, Guy A ^c   Rizzuto, Rosario ^b   Semplicini, Andrea ^a   Avogaro, Angelo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(9 ACRIDINECARBONYL)AMINO] 2,2,6,6 TETRAMETHYLPIPERIDINOXYL; ADENOVIRUS VECTOR; ANTIDIABETIC AGENT; CHIMERIC PROTEIN; FLUORESCENT DYE; FREE RADICAL; GLUCOSE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ISOENZYME; METFORMIN; OXYGEN RADICAL; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA2; TEMPOL; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; BIOSYNTHESIS; CARDIOVASCULAR DISEASE; CELL LEVEL; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSOL; DIABETIC ANGIOPATHY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INTRACELLULAR TRANSPORT; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; UMBILICAL VEIN;

CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; METFORMIN; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; UMBILICAL VEINS;

EID: 15944412463     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.4.1123     Document Type: Article

References (32)

1. De Vriese AS, Verbeuren TJ, Van de Voorde, Lamiere NH, Vanhoutte PM: Endothelial dysfunction in diabetes. Br J Pharmacol 130:963-974, 2000
2. Yuan SY, Ustinova EE, Wu MH, Tinsley JH, Xu W, Korompai FL, Taulman AC: Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages. Circ Res 87:412-417, 2000
3. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U, Munzel T: Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88:E14-E22, 2002
4. King GL: The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes. Ann Med 5:427-432, 1996
5. Nishikawa T, Edelstein D, Browrdee M: The missing link: a single unifying mechanism for diabetic complications. Kidney Int 58:S26-S33, 2000
6. Way KJ, Katai N, King GL: Protein kinase C and the development of diabetic vascular complications. Diabet Med 18:945-956, 2001
7. Gopalakrishna R, Jaken S: Protein kinase C signalling and oxidative stress. Free Radic Biol Med 28:1349-1361, 2000
8. Pricci F, Leto G, Amadio L, Iacobini C, Cordone S, Catalano S, Zicari A, Sorcini M, Di Mario U, Pugliese G: Oxidative stress in diabetic-induced endothelial dysfunction involvement of nitric oxide and protein kinase C. Free Radic Biol Med 35:683-694, 2003
9. Martinez J, Moreno JJ: Role of Ca2+-independent phospholipase A2 on arachidonic acid release induced by reactive oxygen species. Arch Biochem Biophys 392:257-262, 2001
10. Haffner SM: The importance of hyperglycemia in the nonfasting state to the development of cardiovascular disease. Endocr Rev 19:583-592, 1998
11. Laakso M: Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 48:937-942, 1999
12. Ceolotto G, Gallo A, Miola M, Sartori M, Trevisan R, Del Prato S, Semplicini A, Avogaro A: Protein kinase activity is acutely regulated by plasma glucose concentration in human monocytes in vivo. Diabetes 48:1316-1322, 1999
13. UKPDS Group: Effects of intensive blood glucose control with metformin on complication in overweight patients with type 2 diabetes. Lancet 352:854-865, 1998
14. Nosadini R, Avogaro A, Trevisan R, Valerio A, Tessari P, Duner E, Tiengo A, Velussi M, Del Prato S, De Kreutzenberg S, et al.: Effect of metformin on insulin-stimulated glucose turnover and insulin binding to receptors in type II diabetes. Diabetes Care 10:62-67, 1987
15. Bonnefont-Rousseot D, Ray B, Walrand S, Gardes-Albert M, Jore D, Legrand A, Peynet J, Vasson MP: An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism 586-589, 2003
16. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE: Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174, 2001
17. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B: A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A 95:2509-2514, 1998
18. Rizzuto R, Carrington W, Tuft RA: Digital imaging microscopy of living cells. Trends Cell Biol 8:288-292, 1998
19. Tabet F, Savoia C, Schiffrin EL, Touyz RM: Differential calcium regulation by hydrogen peroxide in vascular smooth muscle cells from spontaneously hypertensive rats. J Cardiovasc Pharmacol 44:200-208, 2004
20. Ohara Y, Peterson TE, Harrison DG: Hypercolesterolemia increases endothelial superoxide anion production. J Clin Invest 91:2546-2551, 1993
21. Rapoport R, Sklan D, Wolfenson D, Shaham-Albalancy A, Hanukoglu I: Antioxidant capacity is correlated with steroidogenic status of the corpus luteum during the bovine estrous cycle. Biochim Biophys Acta 1380:133-140, 1998
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275, 1951
23. Ido Y, Carting D, Ruderman N: Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes 51:159-167, 2002
24. Meier M, King GL: Protein kinase C and its pharmacological inhibition in vascular disease. Vasc Med 5:173-185, 2000
25. Mather KJ, Verma S, Anderson TJ: Improved endothelial function with metformin in type 2 diabetes mellitus. J Am Coll Cardiol 37:1344-1350, 2001
26. Katakam PVG, Ujhelyi MR, Hoenig M, Miller AW: Metformin improves vascular function in insulin-resistant rats. Hypertension 35:108-112, 2000
27. Kitada M, Koya D, Sugimoto T, Isono M, Araki S, Kashiwagi A, Haneda M: Translocation of glomerular p47phox and p67phox by protein kinase C-β activation is required for oxidative stress in diabetic nephropathy. Diabetes 52:2603-2614, 2003
28. Kunisaki M, Fumio U, Nawata H, King GL: Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycaemia in rat vascular tissues. Diabetes 45:8117-8119, 1996
29. Lee IK, Koya D, Ishi H, Kanoh H, King GL: Alpha-tocopherol prevents the hyperglycaemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. Diabetes Res Clin Pract 45:183-190, 1999
30. Winder WW, Hardie DG: AMP-activated protein kinase, a metabolic master switch: possible role in type 2 diabetes. Am Physiol Soc 277:E1-E10, 1999
31. Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH: Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: role of mitochondrial reactive nitrogen species. J Biol Chem 279:43940-43951, 2004
32. Michell BJ, Chen ZP, Tiganis T, Stapleton D, Katsis F, Power DA, Sim AT, Kemp BE: Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 276:17625-17628, 2001