The myocardial and vascular pathology of diabetic cardiomyopathy

Coronary Artery Disease

Volumn 7, Issue 2, 1996, Pages 99-108

  Hardin, Nicholas J ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

cardiomyopathy; diabetes mellitus; microvascular pathology; myocardium pathology

Indexed keywords

ARTERY INTIMA PROLIFERATION; CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; CORONARY ARTERY ATHEROSCLEROSIS; DIABETES MELLITUS; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE FIBROSIS; HUMAN; HYPERTENSION; MICROANEURYSM; MICROANGIOPATHY; MYOCARDIAL DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0030037306     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-199602000-00002     Document Type: Review

References (62)

1. Asmal AC, Leary WP, Thandroyen F: Diabetic heart disease. S Afr Med J 1980, 57:788-790.
2. Johnson RA, Palacios I: Dilated cardiomyopathies of the adult Parts 1 and 2). N Engl J Med 1982, 307:1051-1058, 1119-1126.
3. Fein FS, Sonnenblick EH: Diabetic cardiomyopathy. Prog Cardiovasc • Dis 1985, 27:255-270. The authors present an excellent overall review of the subject to 1984 with representative illustrations of myocardial and vascular pathology, including 80 reterences.
4. Zoneraich S: Small-vessel disease, coronary artery vasodilator reserve, and diabetic cardiomyopathy. Chest 1988, 94:5-7
5. Das AK: Diabetic heart disease - current problems and their management [review]. J Assoc Phys India 1989, 37: 163-165.
6. Rodrigues B, McNeill JH: The diabetic heart: metabolic causes for the development of a cardiomyopathy. Cardiovasc Res 1992, 26:913-922.
7. van Hoeven KH, Factor SM: Diabetic heart disease: the clinical and • pathological spectrum: Part I [review]. Clin Cardiol 1989, 12:600-604. This is an overview of diabetic heart disease with a critical analysis of epidemiologic, clinical, and pathologic data.
8. van Hoeven KH, Factor SM: Diabetic heart disease. Part II: The • clinical and pathological spectrum. Clin Cardiol 1989, 12:667-671. This review of diabetic heart disease includes a critical analysis of epidemiologic, clinical, and pathologic data.
9. Zarich SW, Nesto RW: Diabetic cardiomyopathy. Am Heart J 1989. 118:1000-1012.
10. Giles TD, Sander GE: Myocardial disease in hypertensive-diabetic patients. Am J Med 1 989, 87 (suppl):23S-28S.
11. Fein FS: Diabetic cardiomyopathy. Diabetes Care 1990, • 13:1169-1179. The author reviewed 57 pathologic, hemodynamic, and experimental studies related to diabetic cardiomyopathy, with particular reference to hypertension and the black population.
12. Fisher BM, Frier BM: Evidence for a specific heart disease of diabetes in humans. Diabet Med 1990, 7:478-489.
13. Uusitupa MI, Mustonen JN, Airaksinen KE: Diabetic heart muscle disease. Ann Med 1990, 22:377-386.
14. Martinez R: Diabetic cardiomyopathy: possible pathogenetic role of coronary microcirculation. Minerva Cardioangiol 1992, 40:1-5
15. Nathan DM: Long-term complications of diabetes mellitus. N Engl J Med 1993, 328:1676-1685.
16. Fein FS, Sonnenblick EH: Diabetic cardiomyopathy. Cardiovasc Drugs •• Ther 1994, 8:65-73. This up-to-date review pays significant attention to more recent experimental studies, and includes 128 references.
17. Regan TJ, Ahmed S, Haider B, Moschos C, Weisse A: Diabetic cardiomyopathy: experimental and clinical observations. New Jersey Med 1994, 91:776-778.
18. Kannel WB, Hjortland M, Castelli WP: Role of diabetes in congestive • heart failure: the Framingham Study. Am J Cardiol 1974, 34:29-34. A large epidemiologic study of 292 diabetics and 4900 non-diabetics, demonstrated increased risk of congestive heart failure in diabetics.
19. Hamby RI, Zoneraich S, Sherman L: Diabetic cardiomyopathy. JAMA •• 1974, 229:1749-1759. Data were obtained from 16 diabetic patients with idiopathic dilated cardiomyopathy, with autopsies on three diabetic patients. Small vessel changes in myocardium are emphasized and numerous good illustrations are included.
20. Stone PH, Muller JE, Hartwell T, York BJ, Rutherford JD, Parker CB, et al.: The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis. The MILIS Study Group. J Am Coll Cardiol 1989, 14:49-57.
21. Roberts WC, Siegel RJ, McManus BM: Idiopathic dilated cardiomyopathy: analysis of 152 necropsy patients. Am J Cardiol 1987, 60:1340-1355.
22. Coughlin SS, Pearle DL, Baughman KL, Wasserman A, Tefft MC: Diabetes mellitus and risk of idiopathic dilated cardiomyopathy. The Washington, DC Dilated Cardiomyopathy Study. Ann Epidemiol 1994, 4:67-74.
23. Coughlin SS, Neaton JD, Sengupta A, Kuller LH: Predictors of mortality from idiopathic dilated cardiomyopathy in 356,222 men screened for the Multiple Risk Factor Intervention Trial. Am J Epidemiol 139:166-172.
24. Rubler S, Dlugash J, Yuceoglu Y-Z, Kumral T, Branwood AW, Grishman •• A: New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol 1972, 30:595-602. The existence of a cardiomyopathy in diabetes was first proposed in this report of an autopsy study of four patients with diabetes and congestive heart failure.
25. Regan TJ, Lyons MM, Ahmed SS, Levinson GE, Oldewurtel HA, Ahmad • MR, et al.: Evidence for cardiomyopathy in familial diabetes mellitus. J Clin Invest 1977, 60:884-899. This report descnbing postmortem studies of 11 diabetics includes good illustrations of myocardial pathology.
26. Ledet T: Diabetic cardiomyopathy: quantitative histological studies of the heart from young juvenile diabetics. Acta Pathol Microbiol Scand [A] 1976, 84:421-428.
27. Factor SM, Minase T, Sonnenblick EH: Clinical and morphological •• features of human hypertensive-diabetic cardiomyopathy. Am Heart J 1980, 99:446-458. The authors present an autopsy study with detailed morphologic data of nine patients with diabetic cardiomyopathy who also had hypertension. Gross and microscopic photographs of myocardial pathology are included.
28. Nunoda S, Genda A, Sugihara N, Nakayama A, Mizuno S, Takeda R: • Quantitative approach to the histopathology of the biopsied right ventricular myocardium in patients with diabetes mellitus. Heart Vessels 1985, 1:43-47. An endomyocardial biopsy study of nine diabetics without hypertension or coronary atherosclerosis.
29. Das AK, Das JP, Chandrasekar S: Specific heart muscle disease in • diabetes mellitus-a functional structural correlation, Intl J Cardiol 1987, 17:299-302. Another endomyocardial biopsy study was made of 16 diabetics, six with congestive heart failure.
30. Syrovy I, Hodny Z: Non-enzymatic glycosylation of myosin: effects of diabetes and aging. Gen Physiol Biophys 1992, 11:301-307.
31. Fischer VW, Barner HB, Larose LS: Pathomorphologic aspects • of muscular tissue in diabetes mellitus. Hum Pathol 1984, 15:1127-1136. The authors give detailed myocardial pathology for 145 patients.
32. Fischer VW, Barner HB, Leskiw ML: Capillary basal laminar thickness in diabetic human myocardium. Diabetes 1979, 28:713-719.
33. Giacomelli F, Weiner J: Primary myocardial disease In the diabetic mouse: an ultrastructural study. Lab Invest 1979, 40:460-473.
34. Regan TJ, Ettinger PO, Kahn MI, Jesrani MU, Lyons MM, Oldewurtel HA, et al.: Altered myocardial function and metabolism in chronic diabetes mellitus without ischemia in dogs. Circ Res 1974, 35:222-237.
35. Regan TJ, Wu CF, Yeh CK, Oldewurtel HA, Haider B: Myocardial composition and function in diabetes: the effects of chronic insulin use. Circ Res 1981, 49:1268-1277.
36. Haider B, Yeh CK, Thomas G, Oldewurtel HA, Lyons MM, Regan TJ: Influence of diabetes on the myocardium and coronary arteries of rhesus monkey fed an atherogenic diet Circ Res 1981, 49:1278-1288.
37. Pagatsa G, Bihari-Varga M, Szinay G: Effect of diabetes therapy on the myocardium in experimental diabetes. Acta Diabetol Lat 1979, 16:129-138.
38. Jackson CV, McGrath GM, Tahiliani AG, Vadlamudi R, McNeill JH: A functional and ultrastructural analysis of experimental diabetic rat myocardium. Manifestation of a cardiomyopathy. Diabetes 1985, 34:876-883.
39. Tahiliani AG, McNeill JH: Diabetes-induced abnormalities in the myocardium. Life Sci 1986, 38:959-974.
40. Thompson EW: Structural manifestations of diabetic cardiomyopathy in the rat and its reversal by insulin treatment Am J Anat 1988, 182:270-282.
41. Spiro MJ, Kumar BR, Crowley TJ: Myocardial glycoproteins in diabetes: type VI collagen is a major PAS-reactive extracellular matrix protein. J Mol Cell Cardiol 1992, 24:397-410.
42. Blumenthal HT, Alex M, Goidenberg S: A study of lesions of the •• intramural coronary artery branches in diabetes mellitus. Arch Pathol 1960, 70:27-42. A detailed morphologic study showed increased intimai proliferation in intramural coronary artery branches in 116 diabetics at autopsy.
43. Ledet T: Histological and histochemical changes in the coronary arteries of old diabetic patients. Diabetologia 1968, 4:268-272.
44. Factor SM, Okun EM, Minase T: Capillary microaneurysms in the •• human diabetic heart. N Engl J Med 1980, 302:384-388. An autopsy study of six diabetic patients demonstrated capillary microaneurysms by microvascular silicone injection. The authors included good illustrations.
45. Fischer VW, Barner HB, LaRose LS: Quadriceps and myocardial capillary basal laminae: their comparison in diabetic patients. Arch Pathol Lab Med 1982, 106:336-341.
46. Fisher BM, Gillen G, Lindop GBM, Dargie HJ, Frier BM: Cardiac function and coronary arteriography in asymptomatic type I (insulin-dependent) diabetic patients: evidence for a specific diabetic heart disease. Diabetologia 1986, 29:706-712.
47. Regan TJ, Ahmed SS, Haider B, Lyons MM: The myocardium and its vasculature in diabetes mellitus: part II. Mod Concepts Cardiovasc Dis 1978, 47:75-78.
48. Factor SM: Intramural pathology in the diabetic heart: interstitial and microvascular alterations. Mt. Sinai J Med 1982, 49:208-214.
49. Gherasim L, Tasca C, Havriliuc C, Vasilescu C: A morphological quantitative study of small vessels in diabetic cardiomyopathy. Morphol Embryol 1985, 31:191-195.
50. Tasca C, Stevaneaunu L, Vasilescu C: The myocardial microangiopathy in human and experimental diabetes mellitus. A microscopic, ultrastructural, morphometric and computer-assisted symbolic-logic analysis. Endocrinologie 1986, 24:59-69.
51. Porta M, La Selva M, Molinatti P, Molinatti GM: Endothelial cell function in diabetic microangiopathy. Diabetologia 1987, 30:601-609.
52. Yarom R, Zirkin H, Stammler G, Rose AG: Human coronary microvessels in diabetes and ischaemia. Morphometric study of autopsy material. J Pathol 1992, 166:265-270.
53. Nitenberg A, Valensi P, Sachs R, Dali M, Aptecar E, Attali J-R: Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. Diabetes 1993, 42:1017-1025.
54. Cohen RA: Dysfunction of vascular endothelium in diabetes mellitus. Circulation 1993, 87(Suppl V):V67-V76.
55. Crall FV Jr, Roberts WC: The extramural and intramural coronary arteries in juvenile diabetes mellitus. Analysis of nine necropsy patients aged 19-38 years with onset of diabetes before age 15 years. Am J Med 1978, 64:221-230.
56. Sunni S, Bishop SP, Kent SP, Geer JC: Diabetic cardiomyopathy. •• A morphological study of intramyocardial arteries. Arch Pathol Lab Med 1986, 110:375-381. This morphologic study of intramyocardial arteries in diabetics using perfusion fixation was carefully done and good illustrations are included.
57. Durante W, Sunahara FA, Sen AK: Effect of diabetes on metabolic coronary dilation in the rat Cardiovasc Res 1989, 23:40-45.
58. Factor SM, Minase T, Cho S, Fein F, Capasso JM, Sonnenblick EH: •• Coronary microvascular abnormalities in the hypertensive-diabetic rat A primary cause of cardiomyopathy? Am J Pathol 1984, 116:9-20. Silicone injection studies showed microaneurysms of coronary mtcrovasculature in the diabetic rat. The authors present good illustrations.
59. Williamson JR, Kilo C: Vascular complications in diabetes mellitus. N Engl J Med 1980, 302:399-400.
60. Factor SM, Bhan R, Minase T, Wolinsky H, Sonnenblick EH: • Hypertensive-diabetic cardiomyopathy in the rat An experimental model of human disease. Am J Pathol 1981, 102:219-228. This paper has good illustrations of the myocardial and small vessel pathology of diabetes, hypertension or the combination of both, in a rat model.
61. van Hoeven KH, Factor SM: A comparison of the pathological • spectrum of hypertensive, diabetic, and hypertensive-diabetic heart disease. Circulation 1990, 82:848-855. The authors performed an autopsy study of 67 human hearts from patients with diabetes, hypertension, or both. The results emphasize the importance of hypertension in diabetic heart disease.
62. van Hoeven KH, Factor SM: The diabetic heart: clinical, experimental and pathological features. Acta Cardiol 1991, 46:329-339.