Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1

Molecular and Cellular Biology

Volumn 19, Issue 9, 1999, Pages 6458-6468

  McCaffrey, Jennifer ^a   Yamasaki, Lili ^b,c   Dyson, Nicholas J ^b   Harlow, Ed ^b   Griep, Anne E ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENT; LENS; LENS EPITHELIUM; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; WART VIRUS;

EID: 0032772127     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.9.6458     Document Type: Article

References (59)

1. Adams, P., and W. J. Kaelin. 1996. The cellular effects of E2F overexpression, p. 79-94. In P. Farnham (ed.), Transcriptional control of cell growth: the E2F gene family, vol. 208. Springer-Verlag, New York, N.Y.
2. Banks, L., C. Esmonds, and K. H. Vousden. 1990. Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells. Oncogene 5:1383-1389.
3. Broekhuyse, R. M., E. D. Kuhlman, and A. L. Stols. 1979. Lens membranes. VII. MIP is an immunologically specific component of lens fiber membranes and is identical with the 26K band protein. Exp. Eye Res. 29:303-313.
4. Chellappan, S., V. B. Kraus, B. Kroger, K. Munger, P. M. Howley, W. C. Phelps, and J. R. Nevins. 1992. Adenovirus EIA, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. USA 89:4549-4553.
5. Chepelinsky, A. E. 1994. The MIP transmembrane channel family. p. 413-432. In C. Peracchia (ed.), Handbook of membrane channels: molecular and cellular physiology. Academic Press, New York, N.Y.
6. Cobrinik, D. 1996. Regulatory interactions among E2Fs and cell cycle control proteins, p. 31-62. In P. Farnham (ed.), Transcriptional control of cell growth: the E2F gene family, vol. 208. Springer-Verlag, New York, N.Y.
7. Cress, W., and J. Nevins. 1996. Use of the E2F transcription factor by DNA tumor virus regulatory proteins. Curr. Top. Microbiol. Immunol. 208:63-78.
8. DeGregori, J., G. Leone, A. Miron, L. Jakoi, and J. R. Nevins. 1997. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94:7245-7250.
9. Du, W., M. Vidal, J.-E. Xie, and N. Dyson. 1996. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10:1206-1218.
10. Du, W., J. Xie, and N. Dyson. 1996. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15: 3684-3692.
11. Duronio, R., P. O'Farrell, J.-E. Xie, A. Brook, and N. Dyson. 1995. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 9:1445-1455.
12. Dynlacht, B., A. Brook, M. Dembski, L. Yenush, and N. Dyson. 1994. DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc. Natl. Acad. Sci. USA 91:6359-6363.
13. Dyson, N., P. Guida, K. Munger, and E. Harlow. 1992. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J. Virol. 66:6893-6902.
14. Dyson, N., P. Howley, K. Munger, and H. E. Harlow. 1989. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937.
15. Field, S., F. Tsai, F. Kuo, A. Zubiaga, W. G. Kaelin, Jr., D. Livingston, S. Orkin, and M. Greenberg. 1996. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85:549-561.
16. Fromm, L., W. Shawlot, K. Gunning, J. S. Butel, and P. A. Overbeek. 1994. The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice. Mol. Cell. Biol. 14:6743-6754.
17. Funk, J. O., S. Waga, J. B. Harry, E. Espling, B. Stillman, and D. A. Galloway. 1997. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev. 11:2090-2100.
18. Garner, W. H., M. H. Garner, and A. Spector. 1981. Gamma-crystallin, a major cytoplasmic polypeptide disulfide linked to membrane proteins in human cataract. Biochem. Biophys. Res. Commun. 98:439-447.
19. Graw, J. 1996. Cataract mutations as a tool for developmental genetics. Ophthalmic Res. 28(Suppl. 1):8-18.
20. Griep, A., and H. Westphal. 1990. Differentiation versus proliferation of transgenic mouse lens cells expressing polyoma large T antigen: evidence for regulation by endogenous growth factor. New Biol. 2:727-738.
21. Gu, W., J. W. Schneider, G. Condorelli, S. Kaushal, V. Mahdavi, and B. Nadal Ginard. 1993. Interaction of myogenic factors and the retinoblastoma protein mediates muscle commitment and differentiation. Cell 72:309-324.
22. Herber, R., L. A., H. Pitot, and P. F. Lambert. 1996. Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J. Virol. 70:1873-1881.
23. Herwig, S., and M. Strauss. 1997. The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur. J. Biochem. 246: 581-601.
24. Hsieh, J.-K., S. Fredersdorf, T. Kouzarides, K. Martin, and X. Lu. 1997. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11:1840-1852.
25. Johnson, D. G., J. K. Schwartz, W. D. Cress, and J. R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365:349-352.
26. Jones, D. L., R. M. Alani, and K. Munger. 1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev. 11:2101-2111.
27. Jones, D. L., D. A. Thompson, and K. Munger. 1997. Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis. Virology 239:97-107.
28. Kowalik, T. F., J. DeGregori, J. K. Schwarz, and J. R. Nevins. 1995. E2F1 overexpression in quiescent fibroblasts leads to an induction of cellular DNA synthesis and apoptosis. J. Virol. 69:2491-2500.
29. Lin, S.-C., S. Skapek, and E. Y.-H. P. Lee. 1996. Genes in the RB pathway and their knockout in mice. Semin. Cancer Biol. 7:279-289.
30. MacLeod, K. F., Y. Hu, and T. Jacks. 1996. Loss of RB activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15:6178-6188.
31. Martin, K., D. Trouche, C. Hagemeier, T. S. Sorensen, N. B. L. Thangue, and T. Kouzarides. 1995. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375:691-697.
32. McAvoy, J. 1978. Cell division, cell elongation and distribution of α, β, and γ-crystallins in the rat lens. J. Embryol. Exp. Morphol. 44:149-165.
33. McAvoy, J. 1978. Cell division, cell elongation and the co-ordination of crystallin gene expression during lens morphogenesis in the rat. J. Embryol. Exp. Morphol. 45:271-281.
34. McAvoy, J. W. 1980. Induction of the eye lens. Differentiation 17:137-149.
35. Morgenbesser, S. D., A. N. Schreiber, M. Bidder, K. A. Mahon, P. A. Overbeek, J. Horner, and R. A. DePinho. 1995. Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. EMBO J. 14:743-756.
36. Morgenbesser, S. D., B. O. Williams, T. Jacks, and R. A. DePinho. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371:72-74.
37. Munger, K., W. C. Phelps, V. Bubb, P. M. Howley, and R. Schlegel. 1989. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63:4417-4421.
38. Munger, K., B. A. Werness, N. Dyson, W. C. Phelps, E. Harlow, and P. M. Howley. 1989. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8:4099-4105.
39. Nevins, J. R. 1992. E2F; a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
40. Ohtani, K., and J. Nevins. 1994. Functional properties of a Drosophila homolog of the E2F1 gene. Mol. Cell. Biol. 14:1603-1612.
41. Pan, H. 1995. Ph.D. thesis. University of Wisconsin, Madison.
42. Pan, H., and A. E. Griep. 1994. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev. 8:1285-1299.
43. Pan, H., and A. E. Griep. 1995. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development. Genes Dev. 9:2157-2169.
44. Pan, H., C. Yni, N. J. Dyson, E. Harlow, L. Yamasaki, and T. Van Dyke. 1998. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol. Cell 2:283-292.
45. Phillips, A. C., S. Bates, K. M. Ryan, K. Helin, and K. H. Vousden. 1997. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11:1853-1863.
46. Platigorsky, J. 1981. Lens differentiation invertebrates. A review of cellular and molecular features. Differentiation 19:134-153.
47. Qin, X. Q., D. M. Livingston, W. G. J. Kaelin, and P. D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91:10918-10922.
48. Rampalli, A. M., C. Y. Gao, V. M. Chauthaiwale, and P. S. Zelenka. 1998. pRb and p107 regulate E2F activity during lens fiber cell differentiation. Oncogene 16:399-408.
49. Royzman, I., A. J. Whittaker, and T. L. Orr-Weaver. 1997. Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev. 11:1999-2011.
50. Russell, P., S. G. Smith, D. A. Carper, and J. H. Kinoshita. 1979. Age and cataract-related changes in the heavy molecular weight proteins and gamma crystallin composition of the mouse lens. Exp. Eye Res. 29:245-255.
51. Shan, B., and W. H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14:8166-8173.
52. Shiels, A., and S. Bassnett 1996. Mutations in the founder of the MIP family underlie cataract development in the mouse. Nat. Genet. 12:212-215.
53. Stolen, C. M., M. W. Jackson, and A. E. Griep. 1997. Overexpression of FGF-2 modulates fiber cell differentiation and survival in the mouse lens. Development 124:4009-4017.
54. Symonds, H., L. Krall, L. Remington, M. Saenz-Robles, S. Lowe, T. Jacks, and T. van Dyke. 1994. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78:703-711.
55. Tsai, K. Y., Y. Hu, K. F. Macleod, D. Crowley, L. Yamasaki, and T. Jacks. 1998. Mutation of E2F-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2:293-304.
56. Wu, X., and A. J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91:3602-3606.
57. Xiao, Z.-X., J. Chen, A. J. Levine, N. Modjtahedi, J. Xing, W. R. Sellers, and D. M. Livingston. 1995. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375:694-698.
58. Yamasaki, L., T. Jacks, R. Bronson, E. Goillot, E. Harlow, and N. Dyson. 1996. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85: 537-548.
59. Zerfass-Thome, K., W. Zwerschke, B. Mannhardt, R. Tindle, J. W. Botz, and P. Jansen-Durr. 1996. Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein. Oncogene 13:2323-2330.