5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-α-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells

Journal of Biological Chemistry

Volumn 281, Issue 30, 2006, Pages 21004-21012

  Göoz, Monika ^a   Göoz, Pal ^b   Luttrell, Louis M ^b   Raymond, John R ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELLS; DNA; ENZYMES; GROWTH KINETICS; IMMUNOLOGY; ONCOLOGY; PROTEINS;

ERK PHOSPHORYLATION; HEPARIN-BOUND EPIDERMAL GROWTH FACTOR (HB-EGF); RECEPTOR; TUMOR NECROSIS FACTOR-Α-CONVERTING ENZYME (TACE);

TUMORS;

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; AMPHIREGULIN; CHLOROTRIANISENE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; ILOMASTAT; METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; SEROTONIN 2A RECEPTOR; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; ADAM PROTEIN; HEPARIN; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA CONTENT; DRUG INHIBITION; DRUG MECHANISM; GENE MAPPING; GENE SILENCING; IMMUNOPRECIPITATION; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL CULTURE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RAT; TRANSACTIVATION;

ADAM PROTEINS; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEPARIN; MESANGIAL CELLS; PHOSPHORYLATION; RATS; RECEPTOR, SEROTONIN, 5-HT2A; TRANS-ACTIVATION (GENETICS);

EID: 33746328093     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512096200     Document Type: Article

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