mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family

Genes and Development

Volumn 16, Issue 3, 2002, Pages 388-398

  Chen, Hua Wei ^a   Chen, Xiu ^a   Oh, Su Wan ^a   Marinissen, Maria J ^b   Silvio Gutkind, J ^b   Hou, Steven X ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Cytokine receptor; Drosophila; JAK STAT; Signal transduction

Indexed keywords

CYTOKINE RECEPTOR; JANUS KINASE; PROTEIN HOPSCOTCH; PROTEIN MARELLE; PROTEIN MASTER OF MARELLE; STAT PROTEIN; STAT92E PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA TRANSFECTION; DROSOPHILA MELANOGASTER; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE IDENTIFICATION; GENETIC ANALYSIS; MALE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BODY PATTERNING; CELLS, CULTURED; CLONING, MOLECULAR; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EXONS; FEMALE; GLYCOPROTEINS; IN SITU HYBRIDIZATION; INSECT PROTEINS; INTRONS; JANUS KINASE 1; JANUS KINASES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN-TYROSINE KINASES; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TRACHEA; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; DROSOPHILA MELANOGASTER; HEXAPODA; HUMULUS; JANUS; MAMMALIA; MELANOGASTER;

EID: 0036468052     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.955202     Document Type: Article

References (48)

1. Stripe-specific regulation of pair-rule genes by hopscotch, a putative JAK family tyrosine kinase in Drosophila
2. The syntax of immune-neuroendocrine communication
3. Targeted gene expression as a mean of altering cell fates and generating dominant phenotypes
4. Functional cDNA libraries from Drosophila embryos
5. Association of STATs with relatives and friends
6. Characterization of a unique lethal tumorous mutation in Drosophila
7. Fruit fly "leukemia."
8. JAKs and STATs in invertebrate model organisms
9. Introduction: STATs as essential intracellular mediators of cytokine responses
10. Transcription factor activity of STAT proteins: Structural requirements and regulation by phosphorylation and interacting proteins
11. Reiterative use of the EGF receptor triggers differentiation of aa cell types in the Drosophila eye
12. The oncostatin M signalling pathway: Reversing the neoplastic phenotype?
13. Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects
14. Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
15. Signaling mechanisms through gp130: A model of the cytokine system
16. The JAK-STAT pathway in Drosophila
17. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs
18. Study of the posterior spiracles of Drosophila as a model to understand the genetic and cellular mechanisms controlling morphogenesis
19. The Jak-STAT pathway
20. The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster
21. Physiological significance of STAT proteins: Investigations through gene disruption in vivo
22. The genome of Drosophila melanogaster part 4: Genes L-Z, balancers, transposable elements
23. Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway
24. Genetic control of branching morphogenesis
25. The role of STATs in proliferation, differentiation, and apoptosis
26. Sevenless: Seven found?
27. Homology of a domain of the growth hormone/ prolactin receptor family with type III modules of fibronectin
28. 1(1)hopscotch, a larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila
29. A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogaster
30. Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on X chromosome
31. Generating lineage-specific markers to study Drosophila development
32. Transcriptional responses to polypepetide ligands: The JAK-STAT pathway
33. An extracellular activator of the Drosophila JAK/ STAT pathway is a sex-determination signal element
34. Differentiation inhibiting activity (DIA/LIF) and mouse development
35. A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila
36. Branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
37. Gp130 and the interleukin-6 family of cytokines
38. Vectors for Drosophila P-element-mediated transformation and tissue culture transfection
39. RNA interference demonstrates a role for nautilus in the myogenic conversion of Schneider cells by daughterless
40. Filgrastim (r-metHuG-CSF): The first 10 years
41. Maximal activation of transcription by Statl and Stat3 requires both tyrosine and serine phosphorylation
42. STAT signalling in cell proliferation and in development
43. The structure of an antigenic determinant in a protein
44. Identification of a Stat gene that functions in Drosophila development
45. The Janus kinase family of protein tyrosine kinases and their role in signaling
46. Sex determination: Coopted signals determine gender
47. The roles of the Drosophila JAK/STAT pathway
48. Positional cloning of the mouse obese gene and its human homologue