Toward a biaxial model of "bipolar" affective disorders: Spectrum phenotypes as the products of neuroelectrical and neurochemical alterations

Journal of Affective Disorders

Volumn 94, Issue 1-3, 2006, Pages 15-33

  Askland, Kathleen ^a   Parsons, Margaret ^b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b MaineGeneral Health   (United States)

Author keywords

Anticonvulsants; Bipolar spectrum; Ion channels; Mood disorders; Na(+) K(+) exchanging ATPase; Phenomenology

Indexed keywords

ANTIDEPRESSANT AGENT; CARBAMAZEPINE; CHLORIDE CHANNEL; LAMOTRIGINE; LITHIUM; MOOD STABILIZER; NEUROTRANSMITTER; POTASSIUM CHANNEL; RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SODIUM CHANNEL; TRICYCLIC ANTIDEPRESSANT AGENT; VALPROIC ACID;

AFFECT; BIPOLAR DEPRESSION; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; BIPOLAR III DISORDER; BIPOLAR IV DISORDER; BIPOLAR MANIA; BIPOLAR V DISORDER; CLINICAL FEATURE; CLINICAL TRIAL; COMORBIDITY; CYCLOTHYMIA; ELECTRONEUROLOGY; FAMILY HISTORY; GENETICS; HUMAN; HYPOMANIA; MAJOR DEPRESSION; MEDICAL LITERATURE; MEDICAL RESEARCH; MOOD; NEUROCHEMISTRY; NEUROIMAGING; NEUROMODULATION; NEUROPATHOLOGY; ONSET AGE; PATHOPHYSIOLOGY; PHENOMENOLOGY; PHENOTYPE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; RAPID CYCLING BIPOLAR DISORDER; REGULATORY MECHANISM; REVIEW; SEASONAL VARIATION; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANTICONVULSANTS; BIPOLAR DISORDER; BRAIN; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; HUMANS; ION CHANNELS; MODELS, NEUROLOGICAL; NA(+)-K(+)-EXCHANGING ATPASE; NEUROTRANSMITTER AGENTS; PHENOTYPE; PRESYNAPTIC TERMINALS; RECEPTORS, NEUROTRANSMITTER; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 33746242434     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2006.02.024     Document Type: Review

References (138)

1. Aderem A. Systems biology: its practice and challenges. Cell 121 (2005) 511-513
2. Akiskal H.S. The prevalent clinical spectrum of bipolar disorders: beyond DSM-IV. Journal of Clinical Psychopharmacology 16 supp 1 (1996) 4S-14S
3. Akiskal H.S., and McKinney W.T. Depressive disorders: toward a unified hypothesis. Science 182 (1973) 20-29
4. Akiskal H.S. The bipolar spectrum-the shaping of a new paradigm in psychiatry. Current Psychiatry Reports 4 (2002) 1-3
5. Akiskal H.S., 2002b. Familial-genetic principles for validating the bipolar spectrum: their application in clinical practice. http://www.medscape.com/viewarticle/436384.
6. Akiskal H.S. Validating 'hard' and 'soft' phenotypes within the bipolar spectrum: continuity or discontinuity?. Journal of Affective Disorders 73 (2003) 1-5
7. Akiskal H.S., and Benazzi F. Psychopathologic correlates of suicidal ideation in major depressive outpatients: is it all due to unrecognized (bipolar) depressive mixed states?. Psychopathology 38 (2005) 273-280
8. Akiskal H.S., and Mallya G. Criteria for the "soft" bipolar spectrum: treatment implications. Psychopharmacology Bulletin 23 (1987) 68-73
9. Akiskal H.S., and Pinto O. The evolving bipolar spectrum. Prototypes I, II, III, and IV. Psychiatric Clinics Of North America 22 3 (1999) 517-534
10. Akiskal H.S., Maser J.D., Zeller P.J., Endicott J., Coryell W., Keller M., Warshaw M., Clayton P., and Goodwin F. Switching from 'unipolar' to bipolar II. An 11-year prospective study of clinical and temperamental predictors in 559 patients. Archives of General Psychiatry 52 (1995) 114-123
11. Akiskal H.S., Bourgeoi M.L., Angst J., Post R., Moller H., and Hirschfeld R. Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. Journal of Affective Disorders 59 Suppl 1 (2000) S5-S30
12. Akiskal H.S., Azorin J.M., and Hantouche E.G. Proposed multidimensional structure of mania: beyond the euphoric-dysphoric dichotomy. Journal of Affective Disorders 73 (2003) 7-18
13. Akiskal H.S., Hantouche E.-G., Allilaire J.-F., Sechter D., Bourgeois M.L., Azorin J.-M., Chatenet-Duchene L., and Lancrenon S. Validating antidepressant-associated hypomania (bipolar III) a systematic comparison with spontaneous hypomania (bipolar II). Journal of Affective Disorders 73 (2003) 65-74
14. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth edition (1994), American Psychiatric Association, Washington, DC
15. Angst J., and Marneros A. Bipolarity from ancient to modern times: conception, birth and rebirth. Journal of Affective Disorders 67 (2001) 3-19
16. Angst F., Stassen H.H., Clayton P.J., and Angst J. Mortality of patients with mood disorders: follow-up over 34-38 years. Journal of Affective Disorders 68 (2002) 167-181
17. Anguelova M., Benkelfat C., and Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Molecular Psychiatry 8 (2003) 574-591
18. Askland K.D. Toward a biaxial model of "bipolar" affective disorders: further exploration of genetic, molecular and cellular substrates. Journal of Affective Disorders 94 (2006) 35-66 10.1016/j.jad.2006.01.033
19. Avshalom C., Sugden K., Moffit T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
20. Avramopoulos D., Willour V.L., Zandi P.P., Huo Y., MacKinnon D.F., Potash J.B., et al. Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis. Molecular Psychiatry 9 (2004) 191-196
21. Badenhop R.F., Moses M.J., Scimone A., Mitchell P.B., Ewen-White K.R., Rosso A., et al. A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19. Molecular Psychiatry 7 (2002) 851-859
22. Bahrami B., Seyedsadjadi R., Babadi B., and Noroozian M. Brain complexity increases in mania. Neuroreport 16 (2005) 187-191
23. Bailer U., Leish F., Meszaros K., Lenzinger E., Willinger U., and Strobl R. Genome scan for susceptibility loci for schizophrenia and bipolar disorder. Biological Psychiatry 52 (2002) 40-52
24. Barbee J.G., and Jamhour N.J. Lamotrigine as an augmentation agent in treatment-resistant depression. Journal of Clinical Psychiatry 63 (2002) 737-741
25. Barbosa L., Berk M., and Vorster M. A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. Journal of Clinical Psychiatry 64 (2003) 403-407
26. Benazzi F. Is 4 days the minimum duration of hypomania in bipolar II disorder?. European Archives of Psychiatry and Clinical Neuroscience 251 (2001) 32-34
27. Benazzi F. Highly recurrent unipolar may be related to bipolar II. Comprehensive Psychiatry 43 (2002) 263-268
28. Benazzi F. Unipolar depression with bipolar family history: links with the bipolar spectrum. Psychiatry and Clinical Neurosciences 57 (2003) 497-503
29. Benazzi F. Toward better probing for hypomania of bipolar-II disorder by using Angst's checklist. International Journal of Methods in Psychiatric Research. 13 (2004) 1-9
30. Berns G.S., and Nemeroff C.B. The neurobiology of bipolar disorder. American Journal of Medical Genetics Part C (Semin Medical Genet) 123C (2003) 76-84
31. Berrettini W.H. Molecular linkage studies of bipolar disorders. Bipolar Disorders 3 (2001) 276-283
32. + channels as targets of CNS drug development. Current Drug Targets. CNS and Neurological Disorders 3 (2004) 161-167
33. Bogdanski D.F., and Brodie B.B. Role of sodium and potassium ions in storage of norepinephrine by sympathetic nerve endings. Life Science 5 (1966) 1563-1569
34. Bradford-Hill A. The environment and disease: association or causation?. Proceedings of the Royal Society of Medicine 58 (1966) 295
35. Bunney Jr. W.E., Goodwin F.K., and Murphy D.L. The "switch process" in manic-depressive illness. 3. Theoretical implications. Archives of General Psychiatry 27 (1972) 312-317
36. Califano A., Stolovitzky G., and Tu Y. Analysis of gene expression microarrays for phenotype classification. Proceedings (International Conference on Intelligent Systems for Molecular Biology) 8 (2000) 75-85
37. Camp N.J., Lowry M.R., Richards R.L., Plenk A.M., Carter C., Hensel C.H., et al. Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 135B (2005) 85-93
38. Cassano G.B., Dell'Osso L., Frank E., Miniati M., Fagiolini A., Shear K., et al. The bipolar spectrum: a clinical reality in search of diagnostic criteria and an assessment methodology. Journal of Affective Disorders 54 (1999) 319-328
39. Castren E. Is Mood Chemistry?. Nature Reviews. Neuroscience 6 (2005) 241-246
40. Catterall W.A. Molecular properties of brain sodium channels: an important target for anticonvulsant drugs. In: Delgado-Escueta A.V., Wilson W.A., Olsen R.W., and Porter R.J. (Eds). Jaspers Basic Mechanisms of the Epilepsies (Third Edition) Advances in Neurology (1999), Lippincott Williams and Wilkins, Philadelphia 441-456
41. Chandy K.G., Fantino E., Wittekindt O., Kalman K., Tong L.L., Ho T.H., et al. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?. Molecular Psychiatry 3 (1998) 32-37
42. Cho H.J., Meira-Lima I., Cordeiro Q., Michelon L., Sham P., Vallada H., and Collier D.A. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Molecular Psychiatry 10 (2005) 771-781
43. Choi S.J., Taylor M.A., and Abrams R. Depression, ECT and erythrocyte adenosine triphosphatase activity. Biological Psychiatry 12 (1977) 75-81
44. Coppen A., and Shaw D.M. Mineral metabolism in melancholia. British Medical Journal 5370 (1963) 1439-1444
45. Coryell W., Endicott J., Maser J., Keller M., Leon A., and Akiskal H. Long-term stability of polarity distinctions in the affective disorders. American Journal of Psychiatry 152 (1995) 385-390
46. Dager S.R., Friedman S.D., Parow A., Demopulos C., Stoll A.L., Lyoo I.K., et al. Brain metabolic alterations in medication-free patients with bipolar disorder. Archives of General Psychiatry 61 (2004) 450-458
47. Davidson R.J., Lewis D.A., Alloy L.B., Amaral D.G., Bush G., Cohen J.D., et al. Neural and behavioral substrates of mood and mood regulation. Biological Psychiatry 52 (2002) 479-502
48. De bruyn A., Mendelbaum K., Sandkuijl L.A., Delvenne V., Hirsch D., Staner L., et al. Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11. American Journal of Psychiatry 151 (1994) 102-106
49. + pump alpha-2 subunit associated with familial hemiplegic migraine type 2. Nature Genetics 33 (2003) 192-196
50. Dean B. The neurobiology of bipolar disorder: findings using human postmortem central nervous system tissue. Australian and New Zealand Journal of Psychiatry 38 (2004) 135-140
51. Deckersbach T., Perlis R.H., Frankle W.G., Gray S.M., Grandin L., Dougherty D.D., et al. Presence of irritability during depressive episodes in bipolar disorder. CNS Spectrums 9 (2004) 227-231
52. Denicoff K.D., Smith-Jackson E.E., Disney E.R., Ali S.O., Leverich G.S., and Post R.M. Comparative prophylactic efficacy of lithium, carbamazepine, and the combination in bipolar disorder. Journal of Clinical Psychiatry 58 (1997) 470-478
53. Dilsaver S.C., Chen R., Shoaib A.M., and Swann A.C. Phenomenology of mania: evidence for distinct depressed, dysphoric, and euphoric presentations. American Journal of Psychiatry 156 (1999) 426-430
54. Dunner D.L., Fleiss J.L., and Fieve R.R. The course of development of mania in patients with recurrent depression. American Journal of Psychiatry 133 (1976) 905-908
55. El-Mallakh R.S., and Huff M.O. Mood stabilizers and ion regulation. Harvard Review of Psychiatry 9 (2001) 23-32
56. El-Mallakh R.S., and Jaziri W.A. Calcium channel blockers in affective illness: role of sodium-calcium exchange. Journal of Clinical Psychopharmacology 10 (1990) 203-206
57. El-Mallakh R.S., and Wyatt R.J. The Na, K-ATPase hypothesis for bipolar illness. Biological Psychiatry 37 (1995) 235-244
58. Ewald H., Kruse T.A., and Mors O. Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance. American Journal of Medical Genetics 120B (2003) 63-71
59. Faraone S.V., Su J., and Tsuang M.T. A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probands. Journal of Affective Disorders 82S (2004) S71-S78
60. Fasmer O.B. The prevalence of migraine in patients with bipolar and unipolar affective disorders. Cephalalgia 21 (2001) 894-899
61. Fergus E.L., Miller R.B., Luckenbaugh D.A., Leverich G.S., Findling R.L., Speer A.M., et al. Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar children. Journal of Affective Disorders 77 (2003) 71-78
62. GeneCards, 2005. An integrated database of information dealing with human genes and their products. Crown Human Genomics Center and the Bioinformatics Unit of the Weizmann Institute of Science. Rehovot, Israel (retrieved July 26th, 2005 from, http://bioinfo1.weizmann.ac.il/genecards).
63. Ghaemi S.N., Lenox M.S., and Baldessarini R.J. Effectiveness and safety of long-term antidepressant treatment of bipolar disorder. Journal of Clinical Psychiatry 62 (2001) 565-569
64. Ghaemi S.N., Ko J.Y., and Goodwin F.K. "Cade's disease" and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder. Canadian Journal of Psychiatry 47 (2002) 125-134
65. Glatt S.J., Faraone S.V., and Tsuang M.T. CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics 121 (2003) 14-20
66. Goodwin F.K., and Jamison K.R. Manic-Depressive Illness (1990), Oxford University Press, New York
67. Gutman G.A., Chandy K.G., Adelman J.P., Aiyar J., Bayliss D.A., Clapham D.E., Covarriubias M., Desir G.V., Furuichi K., Ganetzky B., Garcia M.L., Grissmer S., Jan L.Y., Karschin A., Kim D., Kuperschmidt S., Kurachi Y., Lazdunski M., Lesage F., Lester H.A., McKinnon D., Nichols C.G., O'Kelly I., Robbins J., Robertson G.A., Rudy B., Sanguinetti M., Seino S., Stuehmer W., Tamkun M.M., Vandenberg C.A., Wei A., Wulff H., Wymore R.S., and International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews 55 (2003) 583-586
68. Guy C.A., Bowen T., Williams N., Jones I.R., McCandless F., McGuffin P., et al. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88 (1999) 57-60
69. Hasler G., Drevets W.C., Manji H.K., and Charney D.S. Discovering endophenotypes for major depression. Neuropsychopharmacology 29 (2004) 1765-1781
70. Hattori E., Liu C., Zhu H., and Gershon E.S. Genetic tests of biologic systems in affective disorders. Molecular Psychiatry 10 (2005) 719-740
71. Hawi Z., Mynett-Johnson L., Murphy V., Straub R.E., Kendler K.S., Walsh D., et al. No evidence to support the association of the potassium channel gene hSKCa3 CAG repeat with schizophrenia or bipolar disorder in the Irish population. Molecular Psychiatry 4 (1999) 488-491
72. Hokin-Neaverson M., and Jefferson J.W. Deficient erythrocyte Na, K-ATPase in different affective states in bipolar affective disorder and normalization by lithium therapy. Neuropsychobiology 22 (1989) 18-25
73. Hokin Neaverson M., and Jefferson J.W. Erythrocyte sodium pump activity in bipolar affective disorder and other psychiatric disorders. Neuropsychobiology 22 (1989) 1-7
74. Jones S.H. Circadian rhythms, multilevel models of emotion and bipolar disorder-an initial step towards integration. Clinical Psychology Review 21 (2001) 1193-1209
75. Judd L.L., and Akiskal H.S. The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases. Journal of Affective Disorders 73 (2003) 123-131
76. Judd L.L., Akiskal H.S., Schettler P.J., Coryell W., Endicott J., Maser J.D., et al. A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Archives of General Psychiatry 60 (2003) 261-269
77. Kearney J.A., Plummer N.W., Smith M.R., Kapur J., Cummins T.R., Waxman S.G., et al. A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities. Neuroscience 102 (2001) 307-317
78. Lerer B., and Macciardi F. Pharmacogenetics of antidepressant and mood-stabilizing drugs: a review of candidate-gene studies and future research directions. International Journal of Neuropsychopharmacology 5 (2002) 255-275
79. Li R., El-Mallakh R.S., Herman M.M., and Kleinman J.E. Trinucleotide repeat expansion in the beta1 subunit of the sodium pump in manic-depression illness: a negative study. Journal of Affective Disorders 60 (2000) 131-136
80. A receptors. British Journal of Anaesthesia 90 (2003) 199-211
81. Looney S.W., and el-Mallakh R.S. Meta-analysis of erythrocyte Na, K-ATPase activity in bipolar illness. Depression and Anxiety 5 (1997) 53-65
82. Maas J.W., Fawcett J.A., and Dekirmenjian H. Catecholamine metabolism, depressive illness, and drug response. Archives of General Psychiatry 26 (1972) 252-262
83. MacIntyre D.J., Blackwood D.H.R., Porteous D.J., Pickard B.S., and Muir W.J. Chromosomal abnormalities and mental illness. Molecular Psychiatry 8 (2003) 275-287
84. MacQueen G.M., Marriott M., Begin H., Robb J., Joffe R.T., and Young L.T. Subsyndromal symptoms assessed in longitudinal, prospective follow-up of a cohort of patients with bipolar disorder. Bipolar Disorders 5 (2003) 349-355
85. Mahmood T., and Silverstone T. Serotonin and bipolar disorder. Journal of Affective Disorders 66 (2001) 1-11
86. Maier W., Zobel A., and Rietschel M. Genetics of schizophrenia and affective disorders. Pharmacopsychiatry 36 (2003) 195-202
87. Maj M., Pirozzi R., Magliano L., and Bartoli L. The prognostic significance of 'switching' in patients with bipolar disorder: a 10-year prospective follow-up study. American Journal of Psychiatry 159 (2002) 1711-1717
88. Manji H.K., and Lenox R.H. Signalling: cellular insights into the pathophysiology of bipolar disorder. Biological Psychiatry 48 (2000) 518-540
89. Matthews C.A., and Reus V.I. Genetic linkage in bipolar disorder. CNS Spectrums 8 (2003) 891-904
90. McElroy S.L., Altshuler L.L., Suppes T., Keck Jr. P.E., Frye M.A., Denicoff K.D., Nolen W.A., Kupka R.W., Leverich G.S., Rochussen J.R., Rush A.J., and Post R.M. Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. American Journal of Psychiatry 158 (2001) 420-426
91. McGuffin P., Rijsdijk F., Andrew M., Sham P., Katz R., and Cardno A. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Archives of General Psychiatry 60 (2003) 497-502
92. Mechaly I., Scamps F., Chabbert C., Sans A., and Valmier J. Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells. Neuroscience 130 (2005) 389-396
93. Meira-Lima I.V., Zhao J., Sham P., Pereira A.C., Krieger J.E., and Vallada H. Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3. Molecular Psychiatry 6 (2001) 565-569
94. Meltzer H.L. Is there a specific membrane deffect in bipolar disorders?. Biological Psychiatry 30 (1991) 1071-1074
95. Mir K.U., and Southern E.M. Sequence variation in genes and genomic DNA: methods for large-scale analysis. Annual Review of Genomics and Human Genetics 1 (2000) 329-360
96. Morselli P.L., Elgie R., and Cesana B.M. GAMIAN-Europe/BEAM survey II: cross-national analysis of unemployment, family history, treatment satisfaction and impact of the bipolar disorder on life style. Bipolar Disorders 6 (2004) 487
97. Murray C.J., and Lopez A.D. The Global Burden of Disease Summary (1996), Harvard School of Public Health, Cambridge
98. + adenosine triphosphatase α subunit gene (ATP1A3). Biological Psychiatry 44 (1998) 47-51
99. Naylor G.J., and Smith A.H.W. Defective genetic control of sodium-pump density in manic depressive psychosis. Psychological Medicine 11 (1981) 257-263
100. Newton J.R. Action potential conduction speed and dyscorrelation, affective disorders and the influence of n-3 essential fatty acids. Medical Hypotheses 63 (2004) 681-683
101. Normann C., Hummel B., Scharer L.O., Horn M., Grunze H., and Walden J. Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study. Journal of Clinical Psychiatry (2002) 337-344
102. Oswald P., Souery D., and Mendlewicz J. Molecular genetics of affective disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 28 (2004) 865-877
103. Papolos D.F., Veit S., Faedda G.L., Saito T., and Lachman H.M. Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele. Molecular Psychiatry 3 (1998) 346-349
104. Passmore M.I., Garnham J., Duffy A., MacDougall M., Munro A., Slaney C., et al. Phenotypic spectra of bipolar disorder in responders to lithium versus lamotrigine. Bipolar Disorders 5 (2003) 110-114
105. +-ATPase subunit ATP1A3 and ATP1B3 genotypes and bipolar affective disorder in the old-order Amish. American Journal of Medical Genetics 105 (2001) 291-294
106. Post R.M., and Weiss S.R.B. Convergences in course of illness and treatments of the epilepsies and recurrent affective disorders. Clinical EEG and Neuroscience 35 (2004) 14-24
107. Post R.M., Weiss S.R., Leverich G.S., Smith M., and Zhang L.X. Sensitization and kindling-like phenomena in bipolar disorder: implications for psychopharmacology. Clinical Neuroscience Research 1 (2001) 69-81
108. Post R.M., Denicoff K.D., Leverich G.S., Altshuler L.L., Frye M.A., Suppes T.M., et al. Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH Life Chart Method. Journal of Clinical Psychiatry 64 (2003) 680-690
109. Prange Jr. A.J., Wilson I.C., Knox A.E., McClane T.K., Breese G.R., Martin B.R., et al. Thyroid-imipramine clinical and chemical interaction: evidence for a receptor deficit in depression. Journal of Psychiatry Research 9 (1972) 187-205
110. Putzhammer A., Schoeler A., Rohrmeier T., Sand P., Hajak G., and Eichhammer P. Evidence of a role for the 5-HTTLPR genotype in the modulation of motor response to antidepressant treatment. Psychopharmacology (Berl) 178 (2005) 303-308
111. Remy S., Gabriel S., Urban B.W., Dietrich D., Lehmann T.N., Elger C.E., et al. A novel mechanism underlying drug resistance in chronic epilepsy. Annals of Neurology 53 (2003) 469-479
112. Rihmer Z., and Kiss K. Bipolar disorders and suicidal behaviour. Bipolar Disorders 4 Suppl 1 (2002) 21-25
113. Rocha F.L., and Hara C. Lamotrigine augmentation in unipolar depression. International Clinical Psychopharmacology (2003) 97-99
114. Rogawski M.A., and Loscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nature Medicine 10 (2004) 685-692
115. Rose A.M., Mellett B.J., Valdes R., Kleinman J.E., Herman M.M., Li R., and El-Mallakh R.S. Alpha2 isoform of the Na, K-adenosine triphosphatase is reduced in temporal cortex of bipolar individuals. Biological Psychiatry 44 (1998) 892-897
116. Rothschild M. Challenges in the treatment of depression with psychotic features. Biological Psychiatry 53 (2003) 680-690
117. Ryback R. Bioelectrical modulators and the cell membrane in psychiatric medicine. Psychopharmacology Bulletin 35 (2001) 1-44
118. Sachs G.S. Affective Disorders Evaluation (ADE. version 3.1) (2001), Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston. http://www.manicdepressive.org/tools_clinical.html Retrieved: January 3, 2005 from, http://www.manicdepressive.org/tools_clinical.html
119. Saleem Q., Sreevidya V.S., Sudhir J., Savithri J.V., Gowda Y., B-Rao C., et al. Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia. American Journal of Medical Genetics 96 (2000) 744-748
120. Sanacora G., Rothman D.L., Mason G., and Krystal J.H. Clinical studies implementing glutamate neurotransmission in mood disorders. Annals of the New York Academy of Sciences (online) 1003 (2003) 292-308
121. Schou M. Lithium as a prophylactic agent in unipolar affective illness: comparison with cyclic antidepressants. Archives of General Psychiatry 36 (1979) 849-851
122. Segurado R., Detera-Wadleigh S.D., Levinson D.F., Lewis C.M., Gill M., Nurnberger J.I., et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. American Journal of Human Genetics 73 (2003) 49-62
123. Soares J.C. Contributions from brain imaging to the elucidation of pathophysiology of bipolar disorder. International Journal of Neuropsychopharmacology 6 (2003) 171-180
124. Solomon D.A., Leon A.C., Endicott J., Coryell W.H., Mueller T.I., Posternak M.A., et al. Unipolar mania over the course of a 20-year follow-up study. American Journal of Psychiatry 160 (2003) 2049-2051
125. Spampanato J., Escayg A., Meisler M.H., and Goldin A.L. Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2. Journal of Neuroscience 21 (2001) 7481-7490
126. Stimpson N., Agrawal N., and Lewis G. Randomized controlled trials investigating pharmacological and psychological interventions for treatment-refractory depression. British Journal of Psychiatry 181 (2002) 284-294
127. Stoll A.L., and Severus W.E. Mood stabilizers: shared mechanisms of action at postsynaptic signal-transduction and kindling processes. Harvard Review of Psychiatry 4 (1996) 77-89
128. Tam W.C., and Liu Z. Comparison of neurocognition between drug-free patients with schizophrenia and bipolar disorder. Journal of Nervous and Mental Disease 192 (2004) 464-470
129. Thiruvengadam A. Effect of lithium and sodium valproate ions on resting membrane potentials in neurons: a hypothesis. Journal of Affective Disorders 65 (2001) 95-99
130. Thornton-Wells T.A., Moore J.H., and Haines J.L. Genetics, statistics and human disease: analytical retooling for complexity. Trends in Genetics 20 (2004) 640-647
131. Turecki G., Grof P., Cavazzoni P., Duffy A., Grof E., Martin R., et al. Lithium responsive bipolar disorder, unilineality, and chromosome 18: a linkage study. American Journal of Medical Genetics 88 (1999) 411-415
132. Ujike H., Yamamoto A., Tanaka Y., Takehisa Y., Takaki M., Taked T., et al. Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder. Psychiatry Research 101 (2001) 203-207
133. Vawter M.P., Freed W.J., and Kleinman J.E. Neuropathology of bipolar disorder. Biological Psychiatry 48 (2000) 486-504
134. White H.S. Mechanism of action of newer anticonvulsants. Journal of Clinical Psychiatry 64 suppl 8 (2003) 5-8
135. Whybrow P.C., and Mendels J. Toward a biology of depression: some suggestions from neurophysiology. American Journal of Psychiatry 125 (1969) 1491-1500
136. Xie X., and Hagan R.M. Cellular and molecular actions of lamotrigine: possible mechanisms of efficacy in bipolar disorder. Neuropsychobiology 38 (1998) 119-130
137. Yazici O., Kora K., Ucok A., Saylan M., Ozdemir O., Kiziltan E., and Ozpulat T. Unipolar mania: a distinct disorder?. Journal of Affective Disorders 71 (2002) 97-103
138. Zandi P.P., Willour V.L., Huo Y., Chellis J., Potash J.B., MacKinnon D.F., et al. Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X. American Journal of Medical Genetics 119B (2003) 69-76