Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis

Journal of the American Chemical Society

Volumn 128, Issue 28, 2006, Pages 9086-9102

  Fuhrmann, Cynthia N ^a   Daugherty, Matthew D ^a   Agard, David A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME INHIBITION; HYDROGEN BONDS; REACTION KINETICS;

BACKREACTIONS; SERINE PROTEASE CATALYSIS; SUBANGSTROM CRYSTALLOGRAPHY; TRANSITION STATES;

PROTEINS;

ASPARTIC ACID; BORONIC ACID DERIVATIVE; CHYMOTRYPSIN; HISTIDINE; HYDROGEN; SERINE; SERINE PROTEINASE;

ACYLATION; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HYDROGEN BOND; HYDROLYSIS; PH; PROTEIN DEGRADATION; PROTON TRANSPORT; X RAY CRYSTALLOGRAPHY;

ASPARAGINE; CATALYSIS; CRYSTALLOGRAPHY; HISTIDINE; HYDROGEN; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN CONFORMATION; SERINE; SERINE ENDOPEPTIDASES;

EID: 33746083605     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja057721o     Document Type: Article

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