Enzyme specificity under dynamic control II: Principal component analysis of α-lytic protease using global and local solvent boundary conditions

Protein Science

Volumn 10, Issue 7, 2001, Pages 1403-1414

  Ota, N ^a   Agard, D A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

lytic protease; Molecular dynamics; Principal component analysis; Solvent boundary condition; Substrate specificity

Indexed keywords

ALANINE; METHIONINE; MUTANT PROTEIN; PROTEINASE; SOLVENT;

ARTICLE; CALCULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; HYDROPHOBICITY; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SOLVENTS; SUBSTRATE SPECIFICITY; VIBRATION;

EID: 0034966704     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.800101     Document Type: Article

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