Modeling deuterium exchange behavior of ERK2 using pepsin mapping to probe secondary structure

Journal of the American Society for Mass Spectrometry

Volumn 10, Issue 8, 1999, Pages 685-702

  Resing, K A ^a   Hoofnagle, A N ^a   Ahn, N G ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEUTERIUM; MITOGEN ACTIVATED PROTEIN KINASE 1; PEPSIN A;

DEUTERIUM;

ARTICLE; CALCULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; ION EXCHANGE; MASS SPECTROMETRY; PROBABILITY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; STANDARD;

ALGORITHMS; AMIDES; AMINO ACID SEQUENCE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DEUTERIUM; HYDROGEN BONDING; MASS SPECTROMETRY; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PEPSIN A; PEPTIDE MAPPING; PROTEIN STRUCTURE, SECONDARY; RATS; X-RAY DIFFRACTION;

EID: 0033474495     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-0305(99)00037-9     Document Type: Article

References (35)

1. Hydrogen exchange and protein folding
2. Mechanisms and uses of hydrogen exchange
3. Structural dynamics of proteins and nucleic acids
4. Protein conformational dynamics measured by hydrogen isotope exchange techniques
5. Protein folding studied using hydrogen-exchange labeling and two-dimensional NMR
6. Probing the non-covalent structure of proteins by amide hydrogen exchange and mass spectrometry
7. Local structure and dynamics in proteins characterized by hydrogen exchange and mass spectrometry
8. Determination of amide hydrogen exchange by mass spectrometry; a new tool for protein structure elucidation
9. Amide hydrogen exchange determined by mass spectrometry; application to rabbit muscle aldolase
10. Mass spectrometric measurement of protein amide hydrogen exchange rates of apo- and holo-myoglobin
11. Measurement of amide hydrogen exchange by MALDI-TOF mass spectrometry
12. Determinants of protein hydrogen exchange studied in equine cytochrome c
13. Mass spectrometric determination of isotopic exchange rates of amide hydrogens located on the surfaces of proteins
14. Primary structure effects on peptide group hydrogen exchange
15. Primary structure effects on peptide group hydrogen exchange
16. Hydrogen exchange in chymotrypsin inhibitor 2 probed by mutagenesis
17. Human recombinant [C22A] FK506-binding protein amide hydrogen exchange rates from mass spectrometry match and extend those from NMR
18. 1H NMR studies of cytochrome c; Hydrogen exchange in the N-terminal helix
19. The mobile defect hypothesis of protein function
20. Packing defects, cavities, volume fluctuations, and access to the interior of proteins
21. Protein folding intermediates; native-state hydrogen exchange
22. Local perturbations by ligand binding of hydrogen deuterium exchange kinetics in a four-helix bundle protein, acyl coenzyme A binding protein (ACBP)
23. Microsecond protein folding kinetics from native-state hydrogen exchange
24. Direct evidence for a two-state protein unfolding transition from hydrogen-deuterium exchange, mass spectrometry, and NMR
25. A statistical mechanical model for hydrogen exchange in globular proteins
26. Three protein kinases structures define a common motif
27. Signal transduction through MAP kinase cascades
28. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution
29. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro
30. Deuterium exchange mass spectrometry as a probe of protein kinase activation. Analysis of wild-type and constitutively active mutants of MAP kinase kinase-1
31. Enhancement of the effective resolution of mass spectra of high-mass biomolecules by maximum entropy-based deconvolution to eliminate the isotopic natural abundance distribution
32. Fast atom bombardment mass spectrometry following hydrogen-deuterium exchange
33. High resolution three dimensional structure of horse heart cytochrome c
34. Solvent-acessible surfaces of proteins and nucleic acids
35. Hydrogen exchange kinetics of surface peptide amides in bovine pancreatic trypsin inhibitor