Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae

Molecular Biology of the Cell

Volumn 10, Issue 7, 1999, Pages 2425-2440

  Wu, Cunle ^a   Leberer, Ekkehard ^a   Thomas, David Y ^a   Whiteway, Malcolm ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; GLYCEROL; MITOGEN ACTIVATED PROTEIN KINASE; PHEROMONE; PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; ENZYME SUBSTRATE; HORMONE RESPONSE; MATING; NONHUMAN; OSMOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

MAMMALIA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0032837521     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.10.7.2425     Document Type: Article

References (39)

1. Banuett, F. (1998). Signaling in the yeasts: an informational cascade with links to the filamentous fungi. Microbiol. Mol. Biol. Rev. 62, 249-274.
2. Barr, M.M., Tu, H., Van Aelst, L., and Wigler, M. (1996). Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Mol. Cell. Biol. 26, 5597-5603.
3. Boguslawski, G., and Polazzi, J.O. (1987). Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases. Proc. Natl. Acad. Sci. USA 84, 5848-5852.
4. Brewster, J.L., de Valoir, T., Dwyer, N.D., Winter, E., and Gustin, M.C, (1993). An osmosensing signal transduction pathway in yeast. Science 259, 1760-1763.
5. Cairns, B.R., Ramer, S.W., and Kornberg, R.D. (1992). Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. Genes Dev. 6, 1305-1318.
6. Choi, K.-Y., Satterberg, B., Lyons, D.M., and Elion, E.A. (1994). Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78, 499-512.
7. Fanger, G.R., Gerwins, P., Widmann, C., Jarpe, M.B., and Johnson, G.L. (1997). MEKKs, GCKs, MLKs, PAKs, TAKs, and rpls: upstream regulators of the c-Jun amino-terminal kinases? Curr. Opin. Genet. Dev. 7, 67-74.
8. Feng, Y., Song, L.Y., Kincaid, E., Mahanty, S.K., and Elion, E.A. (1998). Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11. Curr. Biol. 8, 267-278.
9. Herskowitz, I. (1995). MAP kinase pathways in yeast: for mating and more. Cell 80, 187-197.
10. Leberer, E., Dignard, D., Hougan, L., Thomas, D.Y., and Whiteway, M. (1992). Dominant-negative mutants of a yeast G-protein β subunit identify two functional regions involved in pheromone signaling. EMBO J. 11, 4805-4813.
11. Leberer, E., Wu, C., Leeuw, T., Fourest-Lieuvin, A., Segall, J.E., and Thomas, D.Y. (1997). Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J. 16, 83-97.
12. Maeda, T., Takekawa, M., and Saito, H. (1995). Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269, 554-558.
13. Maeda, T., Wurgler-Murphy, S.M., and Saito, H. (1994). A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369, 242-245.
14. Manser, E., Leung, T., Salihuddin, H., Zhao, Z., and Lim, L. (1994). A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40-46.
15. Marcus, S., Polverino, A., Barr, M., and Wigler, M. (1994). Complexes between STE5 and components of the pheromone mitogenactivated protein kinase module. Proc. Natl. Acad. Sci. USA 91, 7762-7766.
16. Morrison, D.K., and Cutler, R.E. (1997). The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9, 174-179.
17. Newton, A.C. (1997). Regulation of protein kinase C. Curr. Opin. Cell Biol. 9, 161-167.
18. O'Rourke, S.M., and Herskowitz, I. (1998). The Hog1 MAPK prevents cross talk between the HOG and pheromone response pathways in Saccharomyces cerevisiae. Genes Dev. 22, 2874-2886.
19. Ponting, C.P. (1995). SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins. Protein Sci. 4, 1928-1930.
20. Posas, F., and Saito, H. (1997). Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276, 1702-1705.
21. Posas, F., and Saito, H. (1998). Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator. EMBO J. 17, 1385-1394.
22. Posas, F., Witten, E.A., and Saito, H. (1998). Requirement of STE50 for the osmostress induced activation of the STE11 MAPKKK in the HOG pathway. Mol. Cell. Biol. 18, 5788-5796.
23. Posas, F., Wurgler-Murphy, S.M., Maeda, T., Witten, H.A., Thai, T.C., and Saito, H. (1996). Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell 86, 865-875.
24. Printen, J.A., and Sprague, G., Jr. (1994). Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138, 609-619.
25. Rad, M.R., Xu, G., and Hollenberg, C.P. (1992). STE50, a novel gene required for activation of conjugation at an early step in mating in Saccharomyces cerevisiae. Mol. Gen. Genet. 236, 145-154.
26. Rhodes, N., Connell, L., and Errede, B. (1990). STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast. Genes Dev. 4, 1862-1874.
27. Robinson, M.J., and Cobb, M.H. (1997). Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9, 180-186.
28. Rose, M.D., Winston, F., and Hieter, P. (1990). Methods in Yeast Genetics. A Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
29. Saiki, R.J., Gelfand, D.H., Stoffel, S., Scharf, S.J., Higuchi, R., Horn, G.T., Mullis, K.B., and Erlich, H.A. (1988). Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487-491.
30. Schultz, J., Ponting, C.P., Hofmann, K., and Bork, P. (1997). SAM as a protein interaction domain involved in developmental regulation. Protein Sci. 6, 249-253.
31. Stevenson, B.J., Rhodes, N., Errede, B., and Sprague, G., Jr. (1992). Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein. Genes Dev. 6, 1293-1304.
32. Therrien, M., Michaud, N.R., Rubin, G.M., and Morrison, D.K. (1996). KSR modulates signal propagation within the MAPK cascade. Genes Dev. 10, 2684-2695.
33. Tu, H., Barr, M., Dong, D.L., and Wigler, M. (1997). Multiple regulatory domains on the Byr2 protein kinase. Mol. Cell. Biol. 17, 5876-5887.
34. Tzivion, G., Luo, Z., and Avruch, J. (1998). A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature 394, 88-92.
35. Wang, Y., Xu, H.-P., Riggs, M., Rodgers, L., and Wigler, M. (1991). byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Mol. Cell. Biol. 11, 3554-3563.
36. Whiteway, M.S., Wu, C., Leeuw, T., Clark, K., Fourest, A., Thomas, D.Y., and Leberer, E. (1995). Association of the yeast pheromone response G protein βγ subunits with the MAP kinase scaffold Ste5p. Science 269, 1572-1575.
37. Wu, C., Lytvyn, V., Thomas, D.Y., and Leberer, E. (1997). The phosphorylation site for Ste20p-like protein kinases is essential for the function of myosin-I in yeast. J. Biol. Chem. 272, 30623-30626.
38. Wu, C., Whiteway, M., Thomas, D.Y., and Leberer, E. (1995). Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae. J. Biol. Chem. 270, 15984-15992.
39. Xu, G., Jansen, G., Thomas, D.Y., Hollenberg, C.P., and Ramezani Rad, M. (1996). Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 20, 773-783.