Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20

Molecular and Cellular Biology

Volumn 22, Issue 9, 2002, Pages 2939-2951

  Lamson, Rachel E ^a   Winters, Matthew J ^a   Pryciak, Peter M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; PHEROMONE; PROTEIN CDC42; PROTEIN P21; PROTEIN STE20; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; GENE DISRUPTION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; YEAST;

AMINO ACID SEQUENCE; CDC42 GTP-BINDING PROTEIN; MOLECULAR SEQUENCE DATA; PHEROMONES; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

FUNGI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036240658     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.9.2939-2951.2002     Document Type: Article

References (69)

1. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae
2. Genetic relationships between the G protein βγ complex, Ste5p, Ste20p and Cdc42p: Investigation of effector roles in the yeast pheromone response pathway
3. High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A
4. Pak to the future
5. Analyzing protein-protein interactions using two-hybrid system
6. Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis
7. Rho GTPases and their effector proteins
8. Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast
9. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway
10. Conformational switch and role of phosphorylation in PAK activation
11. The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating
12. Glucose depletion causes haploid invasive growth in yeast
13. Ste20-1ike protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast
14. The Ste20 group kinases as regulators of MAP kinase cascades
15. Regulation of G protein-initiated signal transduction in yeast: Paradigms and principles
16. Actin cytoskeleton organization regulated by the PAK family of protein kinases
17. Pheromone response, mating and cell biology
18. Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11
19. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS
20. MAP kinase pathways in the yeast Saccharomyces cerevisiae
21. Flipping the switch: The structural basis for signaling through the CRIB motif
22. PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae
23. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
24. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
25. Active site-directed protein regulation
26. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein βγ subunits to downstream signalling components
27. Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase
28. Pheromone response in yeast: Association of Bem1p with proteins of the MAP kinase cascade and actin
29. Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases
30. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
31. Elements of the yeast pheromone response pathway required for filamentous growth of diploids
32. The G protein-coupled receptor Gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae
33. Combinatorial control required for the specificity of yeast MAPK signaling
34. Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants
35. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation
36. Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade
37. Structure of Cdc42 bound to the GTPase binding domain of PAK
38. Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae
39. Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae
40. A Cdc24p-Far1p-Gβγ protein complex required for yeast orientation during mating
41. A GTP-exchange factor required for cell orientation
42. The role of Cdc42 in signal transduction and mating of the budding yeast Saccharomyces cerevisiae
43. The Hogi MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae
44. Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
45. Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast
46. AKR1 encodes a candidate effector of the Gβγ complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction
47. Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gβγ complex underlies activation of the yeast pheromone response pathway
48. Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Shol-dependent activation of the Hog1 MAPK pathway
49. A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae
50. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles
51. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: Mating and invasive growth
52. The Spa2-related protein, Sph1p, is important for polarized growth in yeast
53. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene
54. Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein
55. Polarized growth controls cell shape and bipolar bud site selection in Saccharomyces cerevisiae
56. Spa2p interacts with cell polarity proteins and signaling components involved in yeast cell morphogenesis
57. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
58. Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway
59. Genetic evidence for Pak1 autoinhibition and its release by Cdc42
60. Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo
61. MAP kinase dynamics in response to pheromones in budding yeast
62. Association of the yeast pheromone response G protein βγ subunits with the MAP kinase scaffold Ste5p
63. Activation of myosinby members of the Ste20p protein kinase family
64. Cell cycle- and Cln2p-Cdc28p-dependent phosphorylation of the yeast Ste20p protein kinase
65. Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae
66. Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity
67. Pheromone signaling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24
68. A conserved negative regulatory region in αPAK: Inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1
69. Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity