메뉴 건너뛰기




Volumn 7, Issue 4, 2004, Pages 350-357

Candida morphogenesis and host-pathogen interactions

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CYCLIC AMP; CYCLIC AMP PHOSPHODIESTERASE; PROTEIN CDC42;

EID: 4143081347     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2004.06.005     Document Type: Review
Times cited : (164)

References (82)
  • 1
    • 0036895608 scopus 로고    scopus 로고
    • Candida albicans: A molecular revolution built on lessons from budding yeast
    • J. Berman, and P.E. Sudbery Candida albicans: a molecular revolution built on lessons from budding yeast Nat Rev Genet 3 2002 918 930
    • (2002) Nat Rev Genet , vol.3 , pp. 918-930
    • Berman1    Sudbery, P.E.J.2
  • 2
    • 0037490129 scopus 로고    scopus 로고
    • Relationship between switching and mating in Candida albicans
    • D.R. Soll, S.R. Lockhart, and R. Zhao Relationship between switching and mating in Candida albicans Eukaryot Cell 2 2003 390 397
    • (2003) Eukaryot Cell , vol.2 , pp. 390-397
    • Soll, D.R.1    Lockhart2    Zhao, R.S.R.3
  • 3
    • 0344199896 scopus 로고    scopus 로고
    • Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator
    • A. Sonneborn, D.P. Bockmuhl, and J.F. Ernst Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator Infect Immun 67 1999 5514 5517
    • (1999) Infect Immun , vol.67 , pp. 5514-5517
    • Sonneborn, A.1    Bockmuhl2    Ernst, J.F.D.P.3
  • 4
    • 0343199707 scopus 로고    scopus 로고
    • Phenotypic switching in Candida albicans is controlled by a SIR2 gene
    • J. Perez-Martin, J.A. Uria, and A.D. Johnson Phenotypic switching in Candida albicans is controlled by a SIR2 gene EMBO J 18 1999 2580 2592
    • (1999) EMBO J , vol.18 , pp. 2580-2592
    • Perez-Martin, J.1    Uria2    Johnson, A.D.J.A.3
  • 5
    • 1242330005 scopus 로고    scopus 로고
    • Susceptibility of Candida albicans biofilms grown in a constant depth film fermentor to chlorhexidine, fluconazole and miconazole: A longitudinal study
    • H. Lamfon, S.R. Porter, M. McCullough, and J. Pratten Susceptibility of Candida albicans biofilms grown in a constant depth film fermentor to chlorhexidine, fluconazole and miconazole: a longitudinal study J Antimicrob Chemother 53 2004 383 385
    • (2004) J Antimicrob Chemother , vol.53 , pp. 383-385
    • Lamfon, H.1    Porter, S.R.2    McCullough3    Pratten, J.M.4
  • 6
    • 0032722557 scopus 로고    scopus 로고
    • Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infection
    • C. Kvaal, S.A. Lachke, T. Srikantha, K. Daniels, J. McCoy, and D.R. Soll Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infection Infect Immun 67 1999 6652 6662
    • (1999) Infect Immun , vol.67 , pp. 6652-6662
    • Kvaal, C.1    Lachke, S.A.2    Srikantha, T.3    Daniels, K.4    McCoy5    Soll, D.R.J.6
  • 9
    • 0030824249 scopus 로고    scopus 로고
    • Control of filament formation in Candida albicans by the transcriptional repressor TUP1
    • B.R. Braun, and A.D. Johnson Control of filament formation in Candida albicans by the transcriptional repressor TUP1 Science 277 1997 105 109
    • (1997) Science , vol.277 , pp. 105-109
    • Braun1    Johnson, A.D.B.R.2
  • 10
    • 0034865464 scopus 로고    scopus 로고
    • Candida albicans proteinases: Resolving the mystery of a gene family
    • B. Hube, and J. Naglik Candida albicans proteinases: resolving the mystery of a gene family Microbiology 147 2001 1997 2005
    • (2001) Microbiology , vol.147 , pp. 1997-2005
    • Hube1    Naglik, J.B.2
  • 11
    • 0036670881 scopus 로고    scopus 로고
    • Adhesion in Candida spp
    • P. Sundstrom Adhesion in Candida spp Cell Microbiol 4 2002 461 469
    • (2002) Cell Microbiol , vol.4 , pp. 461-469
    • Sundstrom, P.1
  • 12
    • 0036854503 scopus 로고    scopus 로고
    • Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence
    • C.S. Hwang, G.E. Rhie, J.H. Oh, W.K. Huh, H.S. Yim, and S.O. Kang Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence Microbiology 148 2002 3705 3713
    • (2002) Microbiology , vol.148 , pp. 3705-3713
    • Hwang, C.S.1    Rhie, G.E.2    Oh, J.H.3    Huh, W.K.4    Yim5    Kang, S.O.H.S.6
  • 13
    • 0742288065 scopus 로고    scopus 로고
    • Superoxide dismutases in Candida albicans: Transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene
    • M. Martchenko, A.M. Alarco, D. Harcus, and M. Whiteway Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene Mol Biol Cell 15 2004 456 467
    • (2004) Mol Biol Cell , vol.15 , pp. 456-467
    • Martchenko, M.1    Alarco, A.M.2    Harcus3    Whiteway, M.D.4
  • 14
    • 0036129840 scopus 로고    scopus 로고
    • Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation
    • P. Van Dijck, L. De Rop, K. Szlufcik, E. Van Ael, and J.M. Thevelein Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation Infect Immun 70 2002 1772 1782
    • (2002) Infect Immun , vol.70 , pp. 1772-1782
    • Van Dijck, P.1    De Rop, L.2    Szlufcik, K.3    Ael, V.4    Thevelein, J.M.E.5
  • 15
    • 0242606099 scopus 로고    scopus 로고
    • Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1
    • T. Limjindaporn, R.A. Khalaf, and W.A. Fonzi Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1 Mol Microbiol 50 2003 993 1004
    • (2003) Mol Microbiol , vol.50 , pp. 993-1004
    • Limjindaporn, T.1    Khalaf2    Fonzi, W.A.R.A.3
  • 17
    • 0141780881 scopus 로고    scopus 로고
    • Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus
    • S. Cheng, M.H. Nguyen, Z. Zhang, H. Jia, M. Handfield, and C.J. Clancy Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus Infect Immun 71 2003 6101 6103
    • (2003) Infect Immun , vol.71 , pp. 6101-6103
    • Cheng, S.1    Nguyen, M.H.2    Zhang, Z.3    Jia, H.4    Handfield5    Clancy, C.J.M.6
  • 18
    • 0037322293 scopus 로고    scopus 로고
    • URA3 as a selectable marker for disruption and virulence assessment of Candida albicans genes
    • J.F. Staab, and P. Sundstrom URA3 as a selectable marker for disruption and virulence assessment of Candida albicans genes Trends Microbiol 11 2003 69 73
    • (2003) Trends Microbiol , vol.11 , pp. 69-73
    • Staab1    Sundstrom, P.J.F.2
  • 19
    • 0036801212 scopus 로고    scopus 로고
    • Co-regulation of pathogenesis with dimorphism and phenotypic switching in Candida albicans, a commensal and a pathogen
    • H. Liu Co-regulation of pathogenesis with dimorphism and phenotypic switching in Candida albicans, a commensal and a pathogen Int J Med Microbiol 292 2002 299 311
    • (2002) Int J Med Microbiol , vol.292 , pp. 299-311
    • Liu, H.1
  • 20
    • 0043197392 scopus 로고    scopus 로고
    • Adaptation of Candida albicans to the host environment: The role of morphogenesis in virulence and survival in mammalian hosts
    • L. Romani, F. Bistoni, and P. Puccetti Adaptation of Candida albicans to the host environment: the role of morphogenesis in virulence and survival in mammalian hosts Curr Opin Microbiol 6 2003 338 343
    • (2003) Curr Opin Microbiol , vol.6 , pp. 338-343
    • Romani, L.1    Bistoni2    Puccetti, P.F.3
  • 21
    • 0036220079 scopus 로고    scopus 로고
    • Bud-site selection and cell polarity in budding yeast
    • A. Casamayor, and M. Snyder Bud-site selection and cell polarity in budding yeast Curr Opin Microbiol 5 2002 179 186
    • (2002) Curr Opin Microbiol , vol.5 , pp. 179-186
    • Casamayor1    Snyder, M.A.2
  • 22
    • 0037507285 scopus 로고    scopus 로고
    • Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans
    • M.A. Uhl, M. Biery, N. Craig, and A.D. Johnson Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans EMBO J 22 2003 2668 2678 This paper describes a large-scale loss-of-function genetic screen for yeast-to-filament defective C. albicans mutants based on haplo-insufficiency and transposon mutagenesis. In this screen, the authors have identified 146 mutants including mutations in genes known for their involvement in this switch. This screen can be applied also for the identification of genes involved in phenotypic switching, chlamydospore and biofilm formation.
    • (2003) EMBO J , vol.22 , pp. 2668-2678
    • Uhl, M.A.1    Biery, M.2    Craig3    Johnson, A.D.N.4
  • 24
    • 0141818929 scopus 로고    scopus 로고
    • Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
    • T. Roemer, B. Jiang, J. Davison, T. Ketela, K. Veillette, A. Breton, F. Tandia, A. Linteau, S. Sillaots, and C. Marta Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery Mol Microbiol 50 2003 167 181 This study describes the use of gene replacement and conditional expression (GRACE) to identify genes encoding essential functions of C. albicans as potential targets for the development of antifungal drugs. This technology can also be useful for the identification of genes involved in morphogenesis.
    • (2003) Mol Microbiol , vol.50 , pp. 167-181
    • Roemer, T.1    Jiang, B.2    Davison, J.3    Ketela, T.4    Veillette, K.5    Breton, A.6    Tandia, F.7    Linteau, A.8    Sillaots9    Marta, C.S.10
  • 25
    • 0036151624 scopus 로고    scopus 로고
    • Hyphal elongation is regulated independently of cell cycle in Candida albicans
    • I. Hazan, M. Sepulveda-Becerra, and H. Liu Hyphal elongation is regulated independently of cell cycle in Candida albicans Mol Biol Cell 13 2002 134 145 In this study, the authors demonstrate that hyphal elongation is regulated independently of the cell cycle. Importantly, they show that cell cycle progression is similar between the apical hyphal and yeast cells, and that the Swe1 protein kinase of the morphogenesis checkpoint is probably not involved in mediating continuous apical growth. Finally, they show that germ tube evagination can occur at any point of the cell cycle. These results imply that a different mechanism for regulation of the morphogenesis machinery occurs in hyphal versus yeast cells.
    • (2002) Mol Biol Cell , vol.13 , pp. 134-145
    • Hazan, I.1    Sepulveda-Becerra2    Liu, H.M.3
  • 26
    • 0032588942 scopus 로고    scopus 로고
    • A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans
    • J.D. Loeb, M. Sepulveda-Becerra, I. Hazan, and H. Liu A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans Mol Cell Biol 19 1999 4019 4027
    • (1999) Mol Cell Biol , vol.19 , pp. 4019-4027
    • Loeb, J.D.1    Sepulveda-Becerra, M.2    Hazan3    Liu, H.I.4
  • 27
    • 0036778310 scopus 로고    scopus 로고
    • A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans
    • E.S. Bensen, S.G. Filler, and J. Berman A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans Eukaryot Cell 1 2002 787 798 The authors show a role of the Fkh2 transcription factor in regulating the yeast-to-hyphae transition possibly by repressing transcription of the G2-cyclin CYB4. This implies that the G2 cyclins may be involved in regulating morphogenesis.
    • (2002) Eukaryot Cell , vol.1 , pp. 787-798
    • Bensen, E.S.1    Filler2    Berman, J.S.G.3
  • 28
    • 1242307458 scopus 로고    scopus 로고
    • In Candida albicans, the Nim1 kinases Gin4 and Hsl1 negatively regulate pseudohypha formation and Gin4 also controls septin organization
    • R. Wightman, S. Bates, P. Amornrrattanapan, and P. Sudbery In Candida albicans, the Nim1 kinases Gin4 and Hsl1 negatively regulate pseudohypha formation and Gin4 also controls septin organization J Cell Biol 164 2004 581 591 The authors describe the role of Gin4 in hyphal formation and septin function. They are the first to describe the presence of a septin basal band at the base of the germ tube that is distinct from the septin rings. They show that Gin4 is not required for basal band but for septin ring assembly. Moreover, they suggest that both Nim-1 kinases, Gin4 and Hsl1, negatively regulate pseudohyphal growth. Finally, regulation of Gin4 levels or activity may be involved in the developmental switch from pseudohyphae to hyphae.
    • (2004) J Cell Biol , vol.164 , pp. 581-591
    • Wightman, R.1    Bates, S.2    Amornrrattanapan3    Sudbery, P.P.4
  • 29
    • 0038586381 scopus 로고    scopus 로고
    • Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growth
    • C. Bachewich, D.Y. Thomas, and M. Whiteway Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growth Mol Biol Cell 14 2003 2163 2180 This study describes novel hyphal-like forms, which occur in response to a replication block with hydroxyurea or to a spindle defect as in the cdc5 null mutant suggesting that blocks in cell cycle progression can trigger filamentation. Interestingly, these hyphal-like forms are dependent on the Cdc35 adenylate cyclase but not on the Efg1 and Cph1 transcription factors.
    • (2003) Mol Biol Cell , vol.14 , pp. 2163-2180
    • Bachewich, C.1    Thomas2    Whiteway, M.D.Y.3
  • 30
    • 0036042504 scopus 로고    scopus 로고
    • Spindle assembly checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice
    • C. Bai, N. Ramanan, Y.M. Wang, and Y. Wang Spindle assembly checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice Mol Microbiol 45 2002 31 44
    • (2002) Mol Microbiol , vol.45 , pp. 31-44
    • Bai, C.1    Ramanan, N.2    Wang3    Wang, Y.Y.M.4
  • 31
    • 0022456151 scopus 로고
    • Differences in actin localization during bud and hypha formation in the yeast Candida albicans
    • J.M. Anderson, and D.R. Soll Differences in actin localization during bud and hypha formation in the yeast Candida albicans J Gen Microbiol 132 1986 2035 2047
    • (1986) J Gen Microbiol , vol.132 , pp. 2035-2047
    • Anderson1    Soll, D.R.J.M.2
  • 32
    • 0011083189 scopus 로고    scopus 로고
    • Hyphal tip-associated localization of Cdc42 is F-actin dependent in Candida albicans
    • I. Hazan, and H. Liu Hyphal tip-associated localization of Cdc42 is F-actin dependent in Candida albicans Eukaryot Cell 1 2002 856 864
    • (2002) Eukaryot Cell , vol.1 , pp. 856-864
    • Hazan1    Liu, H.I.2
  • 33
    • 0033007293 scopus 로고    scopus 로고
    • Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
    • D.I. Johnson Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity Microbiol Mol Biol Rev 63 1999 54 105
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 54-105
    • Johnson, D.I.1
  • 34
    • 0036035420 scopus 로고    scopus 로고
    • Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes
    • S. Michel, S. Ushinsky, B. Klebl, E. Leberer, D. Thomas, M. Whiteway, and J. Morschhauser Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes Mol Microbiol 46 2002 269 280 This work describes the use of regulated deletion to analyze the function of essential genes. This technology provides an alternative to regulated promoter shut-off strategies that may not create a completely null phenotype.
    • (2002) Mol Microbiol , vol.46 , pp. 269-280
    • Michel, S.1    Ushinsky, S.2    Klebl, B.3    Leberer, E.4    Thomas, D.5    Whiteway6    Morschhauser, J.M.7
  • 36
    • 0038199777 scopus 로고    scopus 로고
    • Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicans
    • M. Bassilana, J. Blyth, and R.A. Arkowitz Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicans Eukaryot Cell 2 2003 9 18
    • (2003) Eukaryot Cell , vol.2 , pp. 9-18
    • Bassilana, M.1    Blyth2    Arkowitz, R.A.J.3
  • 39
    • 0028199751 scopus 로고
    • The role of the cytoskeleton in the polarized growth of the germ tube in Candida albicans
    • T. Akashi, T. Kanbe, and K. Tanaka The role of the cytoskeleton in the polarized growth of the germ tube in Candida albicans Microbiology 140 1994 271 280
    • (1994) Microbiology , vol.140 , pp. 271-280
    • Akashi, T.1    Kanbe2    Tanaka, K.T.3
  • 41
    • 0141789783 scopus 로고    scopus 로고
    • CaSPA2 is important for polarity establishment and maintenance in Candida albicans
    • X.D. Zheng, Y.M. Wang, and Y. Wang CaSPA2 is important for polarity establishment and maintenance in Candida albicans Mol Microbiol 49 2003 1391 1405
    • (2003) Mol Microbiol , vol.49 , pp. 1391-1405
    • Zheng, X.D.1    Wang2    Wang, Y.Y.M.3
  • 42
    • 0037458151 scopus 로고    scopus 로고
    • MYO2 is not essential for viability, but is required for polarized growth and dimorphic switches in Candida albicans
    • M. Woo, K. Lee, and K. Song MYO2 is not essential for viability, but is required for polarized growth and dimorphic switches in Candida albicans FEMS Microbiol Lett 218 2003 195 202
    • (2003) FEMS Microbiol Lett , vol.218 , pp. 195-202
    • Woo, M.1    Lee2    Song, K.K.3
  • 43
    • 4143151145 scopus 로고    scopus 로고
    • Polarized hyphal growth in Candida albicans requires the Wiskott-Aldrich Syndrome protein homolog Wal1p
    • A. Walther, and J. Wendland Polarized hyphal growth in Candida albicans requires the Wiskott-Aldrich Syndrome protein homolog Wal1p Eukaryot Cell 3 2004 471 482
    • (2004) Eukaryot Cell , vol.3 , pp. 471-482
    • Walther1    Wendland, J.A.2
  • 44
    • 0036679377 scopus 로고    scopus 로고
    • Septin function in Candida albicans morphogenesis
    • A.J. Warenda, and J.B. Konopka Septin function in Candida albicans morphogenesis Mol Biol Cell 13 2002 2732 2746
    • (2002) Mol Biol Cell , vol.13 , pp. 2732-2746
    • Warenda1    Konopka, J.B.A.J.2
  • 45
    • 0037634190 scopus 로고    scopus 로고
    • Candida albicans septin mutants are defective for invasive growth and virulence
    • A.J. Warenda, S. Kauffman, T.P. Sherrill, J.M. Becker, and J.B. Konopka Candida albicans septin mutants are defective for invasive growth and virulence Infect Immun 71 2003 4045 4051
    • (2003) Infect Immun , vol.71 , pp. 4045-4051
    • Warenda, A.J.1    Kauffman, S.2    Sherrill, T.P.3    Becker4    Konopka, J.B.J.M.5
  • 46
    • 1442334322 scopus 로고    scopus 로고
    • Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4
    • M. Versele, and J. Thorner Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4 J Cell Biol 164 2004 701 715
    • (2004) J Cell Biol , vol.164 , pp. 701-715
    • Versele1    Thorner, J.M.2
  • 47
    • 0038482192 scopus 로고    scopus 로고
    • Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans
    • C.J. Barelle, E.A. Bohula, S.J. Kron, D. Wessels, D.R. Soll, A. Schafer, A.J. Brown, and N.A. Gow Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans Eukaryot Cell 2 2003 398 410 This study shows the dynamics of vacuolar morphology and inheritance during the cell cycle of a growing hyphal filament using time-lapse microscopy, flow cytometry and a novel three-dimensional-imaging system. Importantly, this study indicates that vacuolar biogenesis plays a role in cell cycle regulation and morphogenesis.
    • (2003) Eukaryot Cell , vol.2 , pp. 398-410
    • Barelle, C.J.1    Bohula, E.A.2    Kron, S.J.3    Wessels, D.4    Soll, D.R.5    Schafer, A.6    Brown7    Gow, N.A.A.J.8
  • 48
    • 0036892955 scopus 로고    scopus 로고
    • Ash1 protein, an asymmetrically localized transcriptional regulator, controls filamentous growth and virulence of Candida albicans
    • D.O. Inglis, and A.D. Johnson Ash1 protein, an asymmetrically localized transcriptional regulator, controls filamentous growth and virulence of Candida albicans Mol Cell Biol 22 2002 8669 8680
    • (2002) Mol Cell Biol , vol.22 , pp. 8669-8680
    • Inglis1    Johnson, A.D.D.O.2
  • 49
    • 0038820095 scopus 로고    scopus 로고
    • Candida albicans VPS11 is required for vacuole biogenesis and germ tube formation
    • G.E. Palmer, A. Cashmore, and J. Sturtevant Candida albicans VPS11 is required for vacuole biogenesis and germ tube formation Eukaryot Cell 2 2003 411 421
    • (2003) Eukaryot Cell , vol.2 , pp. 411-421
    • Palmer, G.E.1    Cashmore2    Sturtevant, J.A.3
  • 51
    • 0037069364 scopus 로고    scopus 로고
    • Metabolic specialization associated with phenotypic switching in Candida albicans
    • C.Y. Lan, G. Newport, L.A. Murillo, T. Jones, S. Scherer, R.W. Davis, and N. Agabian Metabolic specialization associated with phenotypic switching in Candida albicans Proc Natl Acad Sci USA 99 2002 14907 14912 This study shows global expression profiles for white and opaque cell types using a custom Affimetrix Genechip of the entire C. albicans genome. Comprehensive sets of white and opaque specific genes are described. Surprisingly, differences in metabolic gene expression were found which might correlate with differences in metabolism associated with these cell types.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14907-14912
    • Lan, C.Y.1    Newport, G.2    Murillo, L.A.3    Jones, T.4    Scherer, S.5    Davis6    Agabian, N.R.W.7
  • 52
    • 0141450719 scopus 로고    scopus 로고
    • Signaling through protein kinases and transcriptional regulators in Candida albicans
    • N.K. Dhillon, S. Sharma, and G.K. Khuller Signaling through protein kinases and transcriptional regulators in Candida albicans Crit Rev Microbiol 29 2003 259 275
    • (2003) Crit Rev Microbiol , vol.29 , pp. 259-275
    • Dhillon, N.K.1    Sharma2    Khuller, G.K.S.3
  • 53
    • 0142030056 scopus 로고    scopus 로고
    • Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP, limits hypha production and promotes virulence of Candida albicans
    • Y.S. Bahn, J. Staab, and P. Sundstrom Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP, limits hypha production and promotes virulence of Candida albicans Mol Microbiol 50 2003 391 409 In this paper, the authors show that the high-affinity phosphodiesterase PDE2 plays a role in regulating the levels of cAMP. Specifically, they show that deletion of pde2 leads to higher basal cAMP levels and suppresses the filamentation defect of the cyclase-associated protein, cap1 mutant. By contrast, overexpression of PDE2 completely inhibits hyphal formation. These results suggest that cAMP levels might play a role in modulating morphogenesis. See also [54].
    • (2003) Mol Microbiol , vol.50 , pp. 391-409
    • Bahn, Y.S.1    Staab2    Sundstrom, P.J.3
  • 54
    • 0142074768 scopus 로고    scopus 로고
    • The cAMP phosphodiesterase encoded by CaPDE2 is required for hyphal development in Candida albicans
    • W.H. Jung, and L.I. Stateva The cAMP phosphodiesterase encoded by CaPDE2 is required for hyphal development in Candida albicans Microbiology 149 2003 2961 2976
    • (2003) Microbiology , vol.149 , pp. 2961-2976
    • Jung1    Stateva, L.I.W.H.2
  • 55
    • 1242345184 scopus 로고    scopus 로고
    • Candida albicans lacking the gene encoding the regulatory subunit of protein kinase a displays a defect in hyphal formation and an altered localization of the catalytic subunit
    • A. Cassola, M. Parrot, S. Silberstein, B.B. Magee, S. Passeron, L. Giasson, and M.L. Cantore Candida albicans lacking the gene encoding the regulatory subunit of protein kinase A displays a defect in hyphal formation and an altered localization of the catalytic subunit Eukaryot Cell 3 2004 190 199
    • (2004) Eukaryot Cell , vol.3 , pp. 190-199
    • Cassola, A.1    Parrot, M.2    Silberstein, S.3    Magee, B.B.4    Passeron, S.5    Giasson6    Cantore, M.L.L.7
  • 56
    • 0037995222 scopus 로고    scopus 로고
    • Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicans
    • C. Sanchez-Martinez, and J. Perez-Martin Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicans Eukaryot Cell 1 2002 865 874
    • (2002) Eukaryot Cell , vol.1 , pp. 865-874
    • Sanchez-Martinez1    Perez-Martin, J.C.2
  • 57
    • 0038016755 scopus 로고    scopus 로고
    • Calcineurin a of Candida albicans: Involvement in antifungal tolerance, cell morphogenesis and virulence
    • D. Sanglard, F. Ischer, O. Marchetti, J. Entenza, and J. Bille Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence Mol Microbiol 48 2003 959 976
    • (2003) Mol Microbiol , vol.48 , pp. 959-976
    • Sanglard, D.1    Ischer, F.2    Marchetti, O.3    Entenza4    Bille, J.J.5
  • 58
    • 0038127624 scopus 로고    scopus 로고
    • Biochemical characterization of Ca2+/calmodulin dependent protein kinase from Candida albicans
    • N.K. Dhillon, S. Sharma, and G.K. Khuller Biochemical characterization of Ca2+/calmodulin dependent protein kinase from Candida albicans Mol Cell Biochem 252 2003 183 191
    • (2003) Mol Cell Biochem , vol.252 , pp. 183-191
    • Dhillon, N.K.1    Sharma2    Khuller, G.K.S.3
  • 59
    • 1242277768 scopus 로고    scopus 로고
    • Candida albicans Csy1p is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesis
    • E. Brega, R. Zufferey, and C.B. Mamoun Candida albicans Csy1p is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesis Eukaryot Cell 3 2004 135 143
    • (2004) Eukaryot Cell , vol.3 , pp. 135-143
    • Brega, E.1    Zufferey2    Mamoun, C.B.R.3
  • 60
    • 0037323797 scopus 로고    scopus 로고
    • A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene in Candida albicans crucial for morphogenesis
    • M. Rottmann, S. Dieter, H. Brunner, and S. Rupp A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene in Candida albicans crucial for morphogenesis Mol Microbiol 47 2003 943 959
    • (2003) Mol Microbiol , vol.47 , pp. 943-959
    • Rottmann, M.1    Dieter, S.2    Brunner3    Rupp, S.H.4
  • 61
    • 0038735200 scopus 로고    scopus 로고
    • The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans
    • R. Alonso-Monge, F. Navarro-Garcia, E. Roman, A.I. Negredo, B. Eisman, C. Nombela, and J. Pla The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans Eukaryot Cell 2 2003 351 361
    • (2003) Eukaryot Cell , vol.2 , pp. 351-361
    • Alonso-Monge, R.1    Navarro-Garcia, F.2    Roman, E.3    Negredo, A.I.4    Eisman, B.5    Nombela6    Pla, J.C.7
  • 62
    • 0036961514 scopus 로고    scopus 로고
    • Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis
    • D.A. Davis, V.M. Bruno, L. Loza, S.G. Filler, and A.P. Mitchell Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis Genetics 162 2002 1573 1581 The authors describe a library of 217 insertion mutants obtained by gene replacement with transposon-mutagenized alleles using the UAU1 cassette, followed by homozygosis of the disrupted alleles. The library was successfully used to identify genes involved in pH-mediated filamentation, including Mds3 a novel player in this process. Genes mutated in the library represent a wide spectrum of cellular functions and this library can therefore be used to identify genes involved in other developmental processes.
    • (2002) Genetics , vol.162 , pp. 1573-1581
    • Davis, D.A.1    Bruno, V.M.2    Loza, L.3    Filler4    Mitchell, A.P.S.G.5
  • 63
    • 0030945488 scopus 로고    scopus 로고
    • Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi
    • V.R. Stoldt, A. Sonneborn, C.E. Leuker, and J.F. Ernst Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi EMBO J 16 1997 1982 1991
    • (1997) EMBO J , vol.16 , pp. 1982-1991
    • Stoldt, V.R.1    Sonneborn, A.2    Leuker3    Ernst, J.F.C.E.4
  • 64
    • 0032810568 scopus 로고    scopus 로고
    • Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator
    • A. Sonneborn, B. Tebarth, and J.F. Ernst Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator Infect Immun 67 1999 4655 4660
    • (1999) Infect Immun , vol.67 , pp. 4655-4660
    • Sonneborn, A.1    Tebarth2    Ernst, J.F.B.3
  • 65
    • 0037183376 scopus 로고    scopus 로고
    • The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans
    • G. Ramage, K. VandeWalle, J.L. Lopez-Ribot, and B.L. Wickes The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans FEMS Microbiol Lett 214 2002 95 100
    • (2002) FEMS Microbiol Lett , vol.214 , pp. 95-100
    • Ramage, G.1    Vandewalle, K.2    Lopez-Ribot3    Wickes, B.L.J.L.4
  • 66
    • 0037107425 scopus 로고    scopus 로고
    • Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans
    • G. Tripathi, C. Wiltshire, S. Macaskill, H. Tournu, S. Budge, and A.J. Brown Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans EMBO J 21 2002 5448 5456 In this paper, the authors show that the Gcn4 transcription factor provides a link between transcription activation of amino acid biosynthetic genes and regulation of morphogenesis in response to amino acid starvation. Regulation of morphogenesis is thought to occur through interaction of Gcn4 with the Ras-cAMP at the level or downstream of Ras1. It will be interesting to understand how changes in metabolism are coordinated with morphogenesis in other morphological transitions or in response to other signals such as phagocytosis by macrophages or colonization of target organs.
    • (2002) EMBO J , vol.21 , pp. 5448-5456
    • Tripathi, G.1    Wiltshire, C.2    MacAskill, S.3    Tournu, H.4    Budge5    Brown, A.J.S.6
  • 67
    • 0038496702 scopus 로고    scopus 로고
    • The regulation of EFG1 in white-opaque switching in Candida albicans involves overlapping promoters
    • S.A. Lachke, T. Srikantha, and D.R. Soll The regulation of EFG1 in white-opaque switching in Candida albicans involves overlapping promoters Mol Microbiol 48 2003 523 536
    • (2003) Mol Microbiol , vol.48 , pp. 523-536
    • Lachke, S.A.1    Srikantha2    Soll, D.R.T.3
  • 68
    • 0038206537 scopus 로고    scopus 로고
    • Adaptation of the Efg1p morphogenetic pathway in Candida albicans by negative autoregulation and PKA-dependent repression of the EFG1 gene
    • B. Tebarth, T. Doedt, S. Krishnamurthy, M. Weide, F. Monterola, A. Dominguez, and J.F. Ernst Adaptation of the Efg1p morphogenetic pathway in Candida albicans by negative autoregulation and PKA-dependent repression of the EFG1 gene J Mol Biol 329 2003 949 962
    • (2003) J Mol Biol , vol.329 , pp. 949-962
    • Tebarth, B.1    Doedt, T.2    Krishnamurthy, S.3    Weide, M.4    Monterola, F.5    Dominguez6    Ernst, J.F.A.7
  • 69
    • 0035053398 scopus 로고    scopus 로고
    • A potential phosphorylation site for an A-type kinase in the Efg1 regulator protein contributes to hyphal morphogenesis of Candida albicans
    • D.P. Bockmuhl, and J.F. Ernst A potential phosphorylation site for an A-type kinase in the Efg1 regulator protein contributes to hyphal morphogenesis of Candida albicans Genetics 157 2001 1523 1530
    • (2001) Genetics , vol.157 , pp. 1523-1530
    • Bockmuhl1    Ernst, J.F.D.P.2
  • 70
    • 0036240684 scopus 로고    scopus 로고
    • Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression
    • A.D. Giusani, M. Vinces, and C.A. Kumamoto Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression Genetics 160 2002 1749 1753
    • (2002) Genetics , vol.160 , pp. 1749-1753
    • Giusani, A.D.1    Vinces2    Kumamoto, C.A.M.3
  • 71
    • 0035159043 scopus 로고    scopus 로고
    • Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans
    • E. Leberer, D. Harcus, D. Dignard, L. Johnson, S. Ushinsky, D.Y. Thomas, and K. Schroppel Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans Mol Microbiol 42 2001 673 687
    • (2001) Mol Microbiol , vol.42 , pp. 673-687
    • Leberer, E.1    Harcus, D.2    Dignard, D.3    Johnson, L.4    Ushinsky, S.5    Thomas6    Schroppel, K.D.Y.7
  • 72
    • 0035033538 scopus 로고    scopus 로고
    • CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans
    • Y.S. Bahn, and P. Sundstrom CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans J Bacteriol 183 2001 3211 3223
    • (2001) J Bacteriol , vol.183 , pp. 3211-3223
    • Bahn1    Sundstrom, P.Y.S.2
  • 73
    • 0142216110 scopus 로고    scopus 로고
    • Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection
    • S.P. Saville, A.L. Lazzell, C. Monteagudo, and J.L. Lopez-Ribot Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection Eukaryot Cell 2 2003 1053 1060 These researchers describe a tet-NRG1 engineered strain in which the yeast-to-hyphae transition can be modulated in a mouse model of hematogeneously disseminated candidiasis. They found that the yeast strain alone was able to exit the blood system and disseminate to target organs but the hyphal form was essential for killing the host indicating that of the two forms the hyphae is the most virulent. This strain could also be used to study host-pathogen interactions in other models of candidiasis.
    • (2003) Eukaryot Cell , vol.2 , pp. 1053-1060
    • Saville, S.P.1    Lazzell, A.L.2    Monteagudo3    Lopez-Ribot, J.L.C.4
  • 74
    • 0037329251 scopus 로고    scopus 로고
    • Comparative virulence of Candida albicans yeast and filamentous forms in orally and intravenously inoculated mice
    • C.M. Bendel, D.J. Hess, R.M. Garni, M. Henry-Stanley, and C.L. Wells Comparative virulence of Candida albicans yeast and filamentous forms in orally and intravenously inoculated mice Crit Care Med 31 2003 501 507
    • (2003) Crit Care Med , vol.31 , pp. 501-507
    • Bendel, C.M.1    Hess, D.J.2    Garni, R.M.3    Henry-Stanley4    Wells, C.L.M.5
  • 75
    • 0034658107 scopus 로고    scopus 로고
    • Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo
    • C.F. d'Ostiani, G. Del Sero, A. Bacci, C. Montagnoli, A. Spreca, A. Mencacci, P. Ricciardi-Castagnoli, and L. Romani Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo J Exp Med 191 2000 1661 1674
    • (2000) J Exp Med , vol.191 , pp. 1661-1674
    • D'Ostiani, C.F.1    Del Sero, G.2    Bacci, A.3    Montagnoli, C.4    Spreca, A.5    Mencacci, A.6    Ricciardi-Castagnoli7    Romani, L.P.8
  • 76
    • 0347989290 scopus 로고    scopus 로고
    • The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans
    • L. Romani, C. Montagnoli, S. Bozza, K. Perruccio, A. Spreca, P. Allavena, S. Verbeek, R.A. Calderone, F. Bistoni, and P. Puccetti The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans Int Immunol 16 2004 149 161 In this paper, the authors dissect the complex interactions occurring between the yeast and hyphal forms with human and murine dendritic cells (DC). The DC and Th cell responses triggered by these interactions depend on the receptors involved in the uptake of C. albicans and prior opsonization. These results have implications for the development of fungal vaccines.
    • (2004) Int Immunol , vol.16 , pp. 149-161
    • Romani, L.1    Montagnoli, C.2    Bozza, S.3    Perruccio, K.4    Spreca, A.5    Allavena, P.6    Verbeek, S.7    Calderone, R.A.8    Bistoni9    Puccetti, P.F.10
  • 77
    • 0033664620 scopus 로고    scopus 로고
    • Differential chemokine response of human monocytes to yeast and hyphal forms of Candida albicans and its relation to the beta-1,6 glucan of the fungal cell wall
    • A. Torosantucci, P. Chiani, and A. Cassone Differential chemokine response of human monocytes to yeast and hyphal forms of Candida albicans and its relation to the beta-1,6 glucan of the fungal cell wall J Leukoc Biol 68 2000 923 932
    • (2000) J Leukoc Biol , vol.68 , pp. 923-932
    • Torosantucci, A.1    Chiani2    Cassone, A.P.3
  • 78
    • 10744220321 scopus 로고    scopus 로고
    • Candida albicans yeast and germ tube forms interfere differently with human monocyte differentiation into dendritic cells: A novel dimorphism-dependent mechanism to escape the host's immune response
    • A. Torosantucci, G. Romagnoli, P. Chiani, A. Stringaro, P. Crateri, S. Mariotti, R. Teloni, G. Arancia, A. Cassone, and R. Nisini Candida albicans yeast and germ tube forms interfere differently with human monocyte differentiation into dendritic cells: a novel dimorphism-dependent mechanism to escape the host's immune response Infect Immun 72 2004 833 843
    • (2004) Infect Immun , vol.72 , pp. 833-843
    • Torosantucci, A.1    Romagnoli, G.2    Chiani, P.3    Stringaro, A.4    Crateri, P.5    Mariotti, S.6    Teloni, R.7    Arancia, G.8    Cassone9    Nisini, R.A.10
  • 79
    • 0037150709 scopus 로고    scopus 로고
    • Pseudomonas-Candida interactions: An ecological role for virulence factors
    • D.A. Hogan, and R. Kolter Pseudomonas-Candida interactions: an ecological role for virulence factors Science 296 2002 2229 2232 This study highlights the importance of studying host-pathogen interactions in the context of the natural environment of C. albicans where the presence of other microorganisms such as Pseudomonas aeruginosa can affect the outcome of disease.
    • (2002) Science , vol.296 , pp. 2229-2232
    • Hogan1    Kolter, R.D.A.2
  • 80
    • 0032570872 scopus 로고    scopus 로고
    • Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1
    • C.A. Gale, C.M. Bendel, M. McClellan, M. Hauser, J.M. Becker, J. Berman, and M.K. Hostetter Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1 Science 279 1998 1355 1358
    • (1998) Science , vol.279 , pp. 1355-1358
    • Gale, C.A.1    Bendel, C.M.2    McClellan, M.3    Hauser, M.4    Becker, J.M.5    Berman6    Hostetter, M.K.J.7
  • 81
    • 0030867751 scopus 로고    scopus 로고
    • A Candida albicans RAS-related gene (CaRSR1) is involved in budding, cell morphogenesis and hypha development
    • L. Yaar, M. Mevarech, and Y. Koltin A Candida albicans RAS-related gene (CaRSR1) is involved in budding, cell morphogenesis and hypha development Microbiology 143 1997 3033 3044
    • (1997) Microbiology , vol.143 , pp. 3033-3044
    • Yaar, L.1    Mevarech2    Koltin, Y.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.