Development of tumor targeting anti-MUC-1 multimer: Effects of di-scFv unpaired cysteine location on PEGylation and tumor binding

Protein Engineering, Design and Selection

Volumn 19, Issue 8, 2006, Pages 359-367

  Xiong, Cheng Yi ^a   Natarajan, Arutselvan ^a   Shi, Xu Bao ^a   Denardo, Gerald L ^a   Denardo, Sally J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

di scFv; MUC 1; PEGylation; Pretargeting

Indexed keywords

AMINO ACIDS; ANTIBODIES; GENETIC ENGINEERING; IMMUNOLOGY; MEDICAL IMAGING; ONCOLOGY; POLYETHYLENE GLYCOLS; PROTEINS;

DI-SCFV; MUC-1; PEGYLATION; PRETARGETING;

TUMORS;

CYSTEINE; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; MACROGOL; MALEIMIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY B2729; MONOCLONAL ANTIBODY LYM 1; MUCIN 1; POLYMER; RECOMBINANT ANTIBODY; SYNTHETIC PEPTIDE; THIOL; UNCLASSIFIED DRUG;

ANTIBODY COMBINING SITE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER THERAPY; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DNA MODIFICATION; DRUG CONJUGATION; DRUG EFFECT; DRUG EFFICACY; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; ESCHERICHIA COLI; GENE CONSTRUCT; GENE LOCATION; GENE TARGETING; GENETIC ENGINEERING; GENETIC LINKAGE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PROTEIN INTERACTION; TUMOR BIOPSY;

CA-15-3 ANTIGEN; CELL LINE, TUMOR; CHROMATOGRAPHY, AFFINITY; CYSTEINE; EPITHELIAL CELLS; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MALEIMIDES; POLYETHYLENE GLYCOLS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; TRANSFECTION;

ESCHERICHIA COLI;

EID: 33745877260     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzl020     Document Type: Article

References (59)

1. Adams,G.P., Schier,R., Marshall,K., Wolf,E.J., McCall,A.M., Marks,J.D. and Weiner,L.M. (1998) Cancer Res., 58, 485-490.
2. Adams,G.P., Schier,R., McCall,A.M., Simmons,H.H., Horak,E.M., Alpaugh,R.K., Marks,J.D. and Weiner,L.M. (2001) Cancer Res., 61, 4750-4755.
3. Albrecht,H., Burke,P.A., Natarajan,A., Xiong,C.Y., Kalicinsky,M., DeNardo,G.L. and DeNardo,S.J. (2004) Bioconjug. Chem., 15, 16-26.
4. Arndt,M.A., Krauss,J. and Rybak,S.M. (2004) FEBS Lett., 578, 257-261.
5. Begent,R.H. et al. (1996) Nat. Med., 2, 979-984.
6. Bramwell,M.E., Wiseman,G. and Shotton,D.M. (1986) J. Cell Sci., 86, 249-261.
7. Braun,S., Hepp,F., Sommer,H.L. and Pantel,K. (1999) Int. J. Cancer, 84, 1-5.
8. Buchegger,F., Pelegrin,A., Delaloye,B., Bischof-Delaloye,A. and Mach,J.P. (1990) J. Nucl. Med., 31, 1035-1044.
9. Burchell,J., Gendler,S., Taylor-Papadimitriou,J., Girling,A., Lewis,A., Millis,R. and Lamport,D. (1987) Cancer Res., 47, 5476-5482.
10. Colcher,D., Pavlinkova,G., Beresford,G., Booth,B.J., Choudhury,A. and Batra,S.K. (1998) Q. J. Nucl. Med., 42, 225-241.
11. Deiters,A., Cropp,T.A., Summerer,D., Mukherji,M. and Schultz,P.G. (2004) Bioorg. Med. Chem. Lett., 14, 5743-5745.
12. DeNardo,S.J. (1999) Adv. Oncol., 15, 23-29.
13. DeNardo,S.J., Kramer,E.L., O'Donnell,R.T., Richman,C.M., Salako,Q.A., Shen,S., Noz,M., Glenn,S.D., Ceriani,R.L. and DeNardo,G.L. (1997) J. Nucl. Med., 38, 1180-1185.
14. Denton,G., Sekowski,M., Spencer,D.I.R., Hughes,O.D.M., Murray,A., Denley,H., Tendler,S.J.B. and Price,M.R. (1997) Br. J. Cancer, 76, 614-621.
15. Denton,G., Brady,K., Lo,B.K., Murray,A., Graves,C.R., Hughes,O.D., Tendler,S.J., Laughton,C.A. and Price,M.R. (1999) Cancer Immunol. Immunother., 48, 29-38.
16. Desai,S.A., Wang,X., Noronha,E.J., Kageshita,T. and Ferrone,S. (1998) Cancer Res., 58, 2417-2415.
17. Epstein,A.L., Marder,R.J., Winter,J.N., Stathopoulos,E., Chen,F.M., Parker,J.W. and Taylor,C.R. (1987) Cancer Res., 47, 830-840.
18. Gendler,S.J., Lancaster,C.A., Taylor-Papadimitriou,J., Duhig,T., Peat,N., Burchell,J., Pemberton,L., Lalani,E.-N. and Wilson,D. (1990) J. Biol. Chem., 265, 15286-15293.
19. Goel,A., Colcher,D., Baranowska-Kortylewicz,J., Augustine,S., Booth,B.J.M., Pavlinkova,G. and Batra,S.K. (2000) Cancer Res., 60, 6964-6971.
20. Grinstead,J.S., Schuman,J.T. and Campbell,A.P. (2003) Biochemistry, 42, 14293-14305.
21. Henderikx,P., Kandilogiannaki,M., Petrarca,C., von Mensdorff-Pouilly,S., Hilgers,J.H., Krambovitis,E., Arends,J.W. and Hoogenboom,H.R. (1999) Cancer Res., 58, 4324-4332.
22. Huang,B.C., Foote,L.J., Lankford,T.K., Davern,S.M., McKeown,C.K. and Kennel,S.J. (2005) Biochem. Biophys. Res. Commun., 327, 999-1005.
23. Huston,J.S., Levinson,D., Mudgett-Hunter,M., Tai,M.S., Novotny,J., Margolies,M.N., Ridge,R.J., Bruccoleri,R.E., Haber,E. and Crea,R. (1988) Proc. Natl Acad. Sci. USA, 85, 5879-5883.
24. Jo,Y., Youn,Y., Lee,S., Kim,B., Kang,S., Yoo,M., Chol,E. and Lee,K. (2006) Int. J. Pharm., 309, 87-93.
25. Kipriyanov,S.M., Cochlovius,B., Schafer,H.J., Moldenhauer,G., Bahre,A., Le Gall,F., Knaackmuss,S. and Little,M. (2002) J. Immunol., 169, 137-144.
26. Kirschenbaum,A., Itzkowitz,S.H., Wang,J.P., Eliashvili,M. and Levine,A.C. (1999) Mol. Urol., 3, 163-168.
27. Kontermann,R.E. (2005) Acta Pharmacol. Sin., 26, 1-9.
28. Kramer,E.L., Liebes,L., Wasserheit,C., Noz,M.E., Blank,E.W., Zabalegui,A., Melamed,J., Furmanski,P., Peterson,J.A. and Ceriani,R.L. (1998) Clin. Cancer Res., 4, 1679-1688.
29. Larson,S.M. et al. (1997) Cancer Suppl., 80, 2458-2468.
30. Le Gall,F., Reusch,U., Little,M. and Kipriyanov,S.M. (2004) Protein Eng. Des. Sel., 17, 357-366.
31. Li,L., Olafsen,T., Anderson,A.L., Wu,A., Raubitschek,A.A. and Shively,J.E. (2002) Bioconjug. Chem., 13, 985-995.
32. Lloyd,K.O., Burchell,J., Kudryashov,V., Yin,B.W.T. and Taylor-Papadimitriou,J. (1996) J. Biol. Chem., 271, 33325-33334.
33. Lu,D., Jimenez,X., Zhang,H., Wu,Y., Bohlen,P. and Witte,L. (2001) Cancer Res., 61, 7002-7008.
34. Masaki,I., Hee-Young, James,S. and Norris,S.T. (2004) Immunology, 111, 291-297.
35. Michaela,A.E., Arndt,J.K. and Susanna,M.R. (2004) FEBS Lett., 538, 257-261.
36. Molineux,G. (2002) Cancer Treat. Rev., 28, 13-16.
37. Molineux,G. (2003) Pharmacotherapy, 23, 3S-8S.
38. Natarajan,A., Xiong,C.Y., Albrecht,H., DeNardo,G.L. and DeNardo,S.J. (2005) Bioconjug. Chem., 16, 113-121.
39. Nielsen,U.B., Adams,G.P., Weiner,L.M. and Marks,J.D. (2000) Cancer Res., 60, 6434-6440.
40. Ottonello,L., Morone,P., Dapino,P. and Dallegri,F. (1996) Blood, 87, 5171-5178.
41. Padlan,E.A. (1994) Mol. Immunol., 31, 169-217.
42. Peter,J.C., Eftekhari,P., Billiald,P., Wallukat,G. and Hoebeke,J. (2003) J. Biol. Chem., 278, 36740-36747.
43. Reilly,R.M., Sandhu,J., Alvarez-Diez,T.M, Gallinger,S., Kirsh,J. and Stern,H. (1995) Clin. Pharmacokinet., 28, 126-142.
44. Richman,C.M. and DeNardo,S.J. (2001) Crit. Rev. Oncol. Hematol., 38, 25-35.
45. Robinson,M.K., Doss,M., Shaller,C., Narayanan,D., Marks,J.D., Adler,L.P., Gonzalez Trotter,D.E. and Adams,G.P. (2005) Cancer Res., 65, 1471-1478.
46. Santimaria,M. et al. (2003) Clin. Cancer Res., 9, 571-579.
47. Schut,I.C., Waterfall,P.M., Ross,M., Miller, W.R., Habib,F.K. and Bayne,C.W. (2003) Br. J. Urol. Int., 91, 278-283.
48. Tahtis,K., Lee,F.T., Smyth,F.E., Power,B.E., Renner,C., Brechbiel,M.W., Old,L.J., Hudson,P.J. and Scott,A.M. (2001) Clin. Cancer Res., 7, 1061-1072.
49. Takemura,S.I., Asano,R., Tsumoto,K., Kodama,H., Yoshida,H., Suzuki,H., Imai,K., Matsuno,S., Kudo,T. and Kumagai,I. (2000) Protein Eng., 13, 583-588.
50. Tang,Y., Jiang,N., Parakh,C. and Hilvert,D. (1996) J. Biol. Chem., 271, 15682-15686.
51. Todorovska,A., Roovers,R.C., Dolezal,O., Kortt,A.A., Hoogenboora,H.R. and Hudson,P.J. (2001) J. Immunol. Methods, 248, 47-66.
52. Tsutsumi,Y., Onda,M., Nagata,S., Lee,B., Kreitman,R.J. and Pastan,I. (2000) Proc. Natl Acad. Sci. USA, 97, 8548-8553.
53. Turner,D.J., Ritter,M.A. and George,A.J.T. (1997) J. Immunol. Methods, 205, 43-54.
54. Willuda,J., Honegger,A., Waibel,R., Schubiger,P.A., Stahel,R., Zangemeister,U. and Pluckthun,A. (1999) Cancer Res., 59, 5758-5767.
55. Willuda,J., Kubetzko,S., Waibel,R., Schubiger,P.A., Zangemeister-Wittke, U. and Pluckthun,A. (2001) J. Biol. Chem., 17, 14385-14392.
56. Winthrop,M.D., DeNardo,S.J. and DeNardo,G.L. (1999) Clin. Cancer Res., 10, 3088-3094.
57. Winthrop,M.D., DeNardo,S.J., Albrecht,H., Mirick,G.R., Kroger,L.A., Lamborn,K.R., Venclovas,C., Colvin,M.E., Burke,P.A. and DeNardo,G.L. (2003) Clin. Cancer Res., 9, 3845s-3853s.
58. Wu,A.M., Chen,W., Raubitschek,L., Williams,L., Neumaier,M., Fischer,R., Hu,S.Z., Odom-Maryon,T., Wong,J. and Shively,J.E. (1996) Immunotechnology, 2, 21-36.
59. Yang,K. et al. (2003) Protein Eng., 16, 761-770.