Tumor Targeting of Mono-, Di-, and Tetravalent Anti-p185HER-2 Miniantibodies Multimerized by Self-associating Peptides

Journal of Biological Chemistry

Volumn 276, Issue 17, 2001, Pages 14385-14392

  Willuda, Jörg ^a,b,d   Kubetzko, Susanne ^a,b   Waibel, Robert ^c   Schubiger, P August ^c   Zangemeister Wittke, Uwe ^b   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

^d BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BLOOD; DIAGNOSIS; DIMERS; ESCHERICHIA COLI; MOLECULAR WEIGHT; TUMORS;

MULTIMERIZATION;

ANTIBODIES;

ANTIBODY; MINIANTIBODY; PROTEIN P185; TECHNETIUM 99M; UNCLASSIFIED DRUG; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PEPTIDE; RECOMBINANT PROTEIN; TECHNETIUM;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER IMMUNOTHERAPY; CANCER THERAPY; COMPLEX FORMATION; DRUG TARGETING; ESCHERICHIA COLI; GENE EXPRESSION; ISOTOPE LABELING; MAMMAL CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RADIOIMMUNOTHERAPY; SURFACE PLASMON RESONANCE; THERMOSTABILITY; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; CELL CULTURE; CHEMISTRY; CYTOPLASM; DIMERIZATION; DOSE RESPONSE; FEMALE; GEL CHROMATOGRAPHY; HUMAN; IMMUNOLOGY; KINETICS; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TEMPERATURE; TIME; TISSUE DISTRIBUTION;

ANIMALIA; ESCHERICHIA COLI; MAMMALIA; MUS MUSCULUS;

ANIMALS; ANTIBODIES; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; FEMALE; HUMANS; KINETICS; MICE; MICE, INBRED BALB C; MODELS, GENETIC; PEPTIDES; PERIPLASM; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RADIOIMMUNOASSAY; RECEPTOR, ERBB-2; RECOMBINANT PROTEINS; TECHNETIUM; TEMPERATURE; TIME FACTORS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 0035957934     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011669200     Document Type: Article

References (36)

1. Holliger, P., and Hoogenboom, H. (1998) Nat. Biotechnol. 16, 1015-1016
2. Begent, R. H., Verhaar, M. J., Chester, K. A., Casey, J. L., Green, A. J., Napier, M. P., Hope-Stone, L. D., Cushen, N., Keep, P. A., Johnson, C. J., Hawkins, R. E., Hilson, A. J., and Robson, L. (1996) Nat. Med. 2, 979-984
3. Adams, G. P., Schier, R., Marshall, K., Wolf, E. J., McCall, A. M., Marks, J. D., and Weiner, L. M. (1998) Cancer Res. 58, 485-490
4. Rowlinson-Busza, G. (1996) Tumor Targeting 2, 37-48
5. Hudson, P. J. (1999) Curr. Opin. Immunol. 11, 548-557
6. Plückthun, A., and Pack, P. (1997) Immunotechnology 3, 83-105
7. Hu, S., Shively, L., Raubitschek, A., Sherman, M., Williams, L. E., Wong, J. Y., Shively, J. E., and Wu, A. M. (1996) Cancer Res. 56, 3055-3061
8. Werlen, R. C., Lankinen, M., Offord, R. E., Schubiger, P. A., Smith, A., and Rose, K. (1996) Cancer Res. 56, 809-815
9. King, D. J., Turner, A., Farnsworth, A. P., Adair, J. R., Owens, R. J., Pedley, R. B., Baldock, D., Proudfoot, K. A., Lawson, A. D., and Beeley, N. R. (1994) Cancer Res. 54, 6176-6185
10. Casey, J. L., King, D. J., Chaplin, L. C., Haines, A. M., Pedley, R. B., Mountain, A., Yarranton, G. T., and Begent, R. H. (1996) Br. J. Cancer 74, 1397-1405
11. Huston, J. S., Adams, G. P., McCartney, J. E., Tai, M. S., Hudziak, R. M., Oppermann, H., Stafford, W. F., III, Liu, S., Fand, I., and Apell, G. (1994) Cell Biophys. 25, 267-78
12. Adams, G. P., McCartney, J. E., Tai, M. S., Oppermann, H., Huston, J. S., Stafford, W. F. D., Bookman, M. A., Fand, I., Houston, L. L., and Weiner, L. M. (1993) Cancer Res. 53, 4026-4034
13. Holliger, P., and Winter, G. (1997) Cancer Immunol. Immunother. 45, 128-130
14. Adams, G. P., Schier, R., McCall, A. M., Crawford, R. S., Wolf, E. J., Weiner, L. M., and Marks, J. D. (1998) Br. J. Cancer 77, 1405-1412
15. Viti, F., Tarli, L., Giovannoni, L., Zardi, L., and Neri, D. (1999) Cancer Res. 59, 347-352
16. Plückthun, A., Krebber, A., Krebber, C., Horn, U., Knüpfer, U., Wenderoth, R., Nieba, L., Proba, K., and Riesenberg, D. (1996) in Antibody Engineering, A Practical Approach (McCafferty, J., Hoogenboom, H. R., and Chiswell, D. J., eds) pp. 203-252, IRL Press, Oxford.
17. Pack, P., Kujau, M., Schroeckh, V., Knüpfer, U., Wenderoth, R., Riesenberg, D., and Plückthun, A. (1993) Bio/Technology 11, 1271-1277
18. Horn, U., Strittmatter, W., Krebber, A., Knüpfer, U., Kujau, M., Wenderoth, R., Müller, K., Matzku, S., Plückthun, A., and Riesenberg, D. (1996) Appl. Microbiol. Biotechnol. 46, 524-532
19. Knappik, A., and Plückthun, A. (1995) Protein Eng. 8, 81-89
20. Carter, P., Presta, L., Gorman, C. M., Ridgway, J. B., Henner, D., Wong, W. L., Rowland, A. M., Kotts, C., Carver, M. E., and Shepard, H. M. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 4285-4289
21. Wörn, A., and Plückthun, A. (1998) FEBS Lett. 427, 357-361
22. Willuda, J., Honegger, A., Waibel, R., Schubiger, P. A., Stahel, R., Zangemeister-Wittke, U., and Plückthun, A. (1999) Cancer Res. 59, 5758-5767
23. Waibel, R., Alberto, R., Willuda, J., Finnern, R., Schibli, R., Stichelberger, A., Egli, A., Abram, U., Mach, J. P., Plückthun, A., and Schubiger, P. A. (1999) Nat. Biotechnol. 17, 897-901
24. Müller, K. M., Arndt, K. M., and Plückthun, A. (1998) FEBS Lett. 432, 45-49
25. Ge, L., Knappik, A., Pack, P., Freund, C., and Plückthun, A. (1995) in Antibody Engineering (Borrebaeck, C. A. K., ed) 2nd Ed., pp. 229-261, Oxford University Press, Oxford
26. Rheinnecker, M., Hardt, C., Ilag, L. L., Kufer, P., Gruber, R., Hoess, A., Lupas, A., Rottenberger, C., Plückthun, A., and Pack, P. (1996) J. Immunol. 157, 2989-2997
27. Bass, S., Gu, Q., and Christen, A. (1996) J. Bacteriol. 178, 1154-1161
28. Lindmo, T., Boven, E., Cuttitta, F., Fedorko, J., and Bunn, P. A., Jr. (1984) J. Immunol. Methods 72, 77-89
29. Vaughan, T. J., Williams, A. J., Pritchard, K., Osbourn, J. K., Pope, A. R., Earnshaw, J. C., McCafferty, J., Hodits, R. A., Wilton, J., and Johnson, K. S. (1996) Nat. Biotechnol. 14, 309-314
30. O'Shea, E. K., Rutkowski, R., and Kim, P. S. (1989) Science 243, 538-542
31. Pack, P., and Plückthun, A. (1992) Biochemistry 31, 1579-1584
32. Behr, T. M., Goldenberg, D. M., and Becker, W. (1998) Eur. J. Nucl. Med. 25, 201-212
33. Carter, P., Kelley, R. F., Rodrigues, M. L., Snedecor, B., Covarrubias, M., Velligan, M. D., Wong, W. L., Rowland, A. M., Kotts, C. E., and Carver, M. E. (1992) Bio/Technology 10, 163-167
34. Tsai, S. W., Sun, Y. Y., Williams, L. E., Raubitschek, A. A., Wu, A. M., and Shively, J. E. (2000) Bioconjugate Chem. 11, 327-334
35. Arndt, K. M., Pelletier, J. N., Müller, K. M., Alber, T., Michnick, S. W., and Plückthun, A. (2000) J. Mol. Biol. 295, 627-639
36. Bloemendal, H. J., Logtenberg, T., and Voest, E. E. (1999) Eur. J. Clin. Invest. 29, 802-809