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Volumn 2, Issue 9, 1996, Pages 979-984

Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY MFE 23; BACTERIUM ANTIBODY; CARCINOEMBRYONIC ANTIBODY; CARCINOEMBRYONIC ANTIGEN; FV ANTIBODY; UNCLASSIFIED DRUG;

EID: 9544250404     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0996-979     Document Type: Article
Times cited : (240)

References (33)
  • 1
    • 0029114768 scopus 로고
    • Clinical issues in antibody design
    • Chester, K.A. & Hawkins, R.E. Clinical issues in antibody design. Trends Biotechnol. 13, 294-300 (1995)
    • (1995) Trends Biotechnol. , vol.13 , pp. 294-300
    • Chester, K.A.1    Hawkins, R.E.2
  • 2
    • 0026684815 scopus 로고
    • Rapid tumour penetration of a single-chain Fv and comparison with other immunoglobulin forms
    • Yokota, T , Milenic, D.E., Whitlow, M. & Schlom, J. Rapid tumour penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res 52, 3402-3408 (1992).
    • (1992) Cancer Res , vol.52 , pp. 3402-3408
    • Yokota, T.1    Milenic, D.E.2    Whitlow, M.3    Schlom, J.4
  • 3
    • 0004198722 scopus 로고
    • Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli
    • Huston, J.S. et al. Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 85, 5879-5883 (1988).
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5879-5883
    • Huston, J.S.1
  • 4
    • 0025362523 scopus 로고
    • In vivo tumor targeting of a recombinant single-chain antigen-binding protein
    • Colcher, D. et al. In vivo tumor targeting of a recombinant single-chain antigen-binding protein. J. Natl. Cancer Inst. 82, 1191-1197 (1990).
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 1191-1197
    • Colcher, D.1
  • 5
    • 0026327378 scopus 로고
    • Construction, binding properties, metabolism, and tumor targeting of a single chain Fv derived from the pancarcinoma monoclonal antibody CC49
    • Milenic, D.E. et al Construction, binding properties, metabolism, and tumor targeting of a single chain Fv derived from the pancarcinoma monoclonal antibody CC49. Cancer Res. 51, 6363-6371 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 6363-6371
    • Milenic, D.E.1
  • 6
    • 0027454278 scopus 로고
    • Construction, characterisation and kinetics of a single chain antibody recognising the tumour associated antigen placental alkaline phosphatase
    • Savage, P. et al. Construction, characterisation and kinetics of a single chain antibody recognising the tumour associated antigen placental alkaline phosphatase. Br. J. Cancer 68, 738-742 (1993).
    • (1993) Br. J. Cancer , vol.68 , pp. 738-742
    • Savage, P.1
  • 7
    • 0024833055 scopus 로고
    • Generation of a large combinatorial library of the immunological repertoire in phage lambda
    • Huse, W.E. et al. Generation of a large combinatorial library of the immunological repertoire in phage lambda. Science 246, 1275-1281 (1989)
    • (1989) Science , vol.246 , pp. 1275-1281
    • Huse, W.E.1
  • 8
    • 0025226085 scopus 로고
    • Phage antibodies: Filamentous phage displaying antibody variable domains
    • McCafferty, J., Griffiths, A.D., Winter, G. & Chiswell, D J. Phage antibodies: Filamentous phage displaying antibody variable domains. Nature 348, 552-554 (1990).
    • (1990) Nature , vol.348 , pp. 552-554
    • McCafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 9
    • 0025835310 scopus 로고
    • Making antibody fragments using phage display libraries
    • Clackson, T., Hoogenboom, H.R., Griffiths, A.D. & Winter, G. Making antibody fragments using phage display libraries. Nature 352, 624-628 (1991).
    • (1991) Nature , vol.352 , pp. 624-628
    • Clackson, T.1    Hoogenboom, H.R.2    Griffiths, A.D.3    Winter, G.4
  • 10
    • 0026699293 scopus 로고
    • Selection of phage antibodies by binding affinity: Mimicking affinity maturation
    • Hawkins, R.E., Russell, S.J. & Winter, G. Selection of phage antibodies by binding affinity: Mimicking affinity maturation. J. Mol. Biol. 226, 889-896 (1992).
    • (1992) J. Mol. Biol. , vol.226 , pp. 889-896
    • Hawkins, R.E.1    Russell, S.J.2    Winter, G.3
  • 11
    • 0028078866 scopus 로고
    • Phage libraries for generation of clinically useful antibodies
    • Chester, K.A. et al. Phage libraries for generation of clinically useful antibodies. Lancet 343, 455-456 (1994).
    • (1994) Lancet , vol.343 , pp. 455-456
    • Chester, K.A.1
  • 12
    • 0028291823 scopus 로고
    • Isolation of high affinity human antibodies directly from large synthetic repertoires
    • Griffiths, A D. et al Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13, 3245-3260 (1994).
    • (1994) EMBO J. , vol.13 , pp. 3245-3260
    • Griffiths, A.D.1
  • 13
    • 0028989908 scopus 로고
    • A single chain Fv derived from a filamentous phage library has distinct tumour targeting advantages over one derived from a hybridoma
    • Verhaar, M.J et al. A single chain Fv derived from a filamentous phage library has distinct tumour targeting advantages over one derived from a hybridoma. Int. J. Cancer 61, 497-501 (1995).
    • (1995) Int. J. Cancer , vol.61 , pp. 497-501
    • Verhaar, M.J.1
  • 14
    • 0028836167 scopus 로고
    • Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography
    • Casey, J.L. et al. Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography. J Immunol. Methods 179, 105-116 (1995).
    • (1995) J Immunol. Methods , vol.179 , pp. 105-116
    • Casey, J.L.1
  • 15
    • 0022773783 scopus 로고
    • Cancer Research Campaign operation manual for control of production, preclinical toxicology and phase I trials of anti tumour antibodies and drug antibody conjugates
    • Operation Manual
    • Operation Manual. Cancer Research Campaign operation manual for control of production, preclinical toxicology and phase I trials of anti tumour antibodies and drug antibody conjugates. Br. J. Cancer 54, 557-568 (1986).
    • (1986) Br. J. Cancer , vol.54 , pp. 557-568
  • 16
    • 0026419319 scopus 로고
    • Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
    • Houghten, R.A et al. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 354, 84-86 (1991).
    • (1991) Nature , vol.354 , pp. 84-86
    • Houghten, R.A.1
  • 17
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk, C. & Gold, L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase Science 249, 505-510 (1990).
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 18
    • 0028278170 scopus 로고
    • The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library
    • Bunin, B A , Plunkett, M.J. & Ellman, J A. The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library. Proc. Natl. Acad. Sci. USA 91, 4708-4712 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4708-4712
    • Bunin, B.A.1    Plunkett, M.J.2    Ellman, J.A.3
  • 20
    • 0027958916 scopus 로고
    • 2 antibodies
    • 2 antibodies. Br. J. Cancer 70, 521-525 (1994).
    • (1994) Br. J. Cancer , vol.70 , pp. 521-525
    • Lane, D.M.1
  • 21
    • 0024416962 scopus 로고
    • Antibody distribution and dosimetry in patients receiving radiolabelled antibody therapy for colorectal cancer
    • Begent, R.H.J. et al. Antibody distribution and dosimetry in patients receiving radiolabelled antibody therapy for colorectal cancer. Br. J. Cancer 60, 406-412 (1989).
    • (1989) Br. J. Cancer , vol.60 , pp. 406-412
    • Begent, R.H.J.1
  • 22
    • 0025148495 scopus 로고
    • Disposition characteristics of macromolecules in tumour-bearing mice
    • Takakura, Y., Fujita, T , Hashido, M. & Sezoni, H. Disposition characteristics of macromolecules in tumour-bearing mice. Pharm. Res. 7, 339-346 (1990).
    • (1990) Pharm. Res. , vol.7 , pp. 339-346
    • Takakura, Y.1    Fujita, T.2    Hashido, M.3    Sezoni, H.4
  • 23
    • 18544410822 scopus 로고    scopus 로고
    • 2::anti-CEA scFv fusion protein
    • 2::anti-CEA scFv fusion protein. Immunotechnology 2, 47-57 (1996).
    • (1996) Immunotechnology , vol.2 , pp. 47-57
    • Michael, N.P.1
  • 24
    • 0002726158 scopus 로고
    • Antibody directed enzyme prodrug therapy: Pilot scale clinical trial
    • Bagshawe, K.D., Sharma, S.K., Springer, C.S. & Antoniw, P Antibody directed enzyme prodrug therapy: Pilot scale clinical trial. Tumour Target 1, 17-29 (1995).
    • (1995) Tumour Target , vol.1 , pp. 17-29
    • Bagshawe, K.D.1    Sharma, S.K.2    Springer, C.S.3    Antoniw, P.4
  • 25
    • 0029564921 scopus 로고
    • CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV antibody into the picomolar range
    • Yang, W-P et al. CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV antibody into the picomolar range. J. Mol. Biol. 254, 392-403 (1995).
    • (1995) J. Mol. Biol. , vol.254 , pp. 392-403
    • Yang, W.-P.1
  • 26
    • 0029111580 scopus 로고
    • Synthetic human antibodies
    • Barbas, C.F. III. Synthetic human antibodies Nature Med 1, 837-839 (1995).
    • (1995) Nature Med , vol.1 , pp. 837-839
    • Barbas III, C.F.1
  • 28
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • Moertel, C.G. Chemotherapy for colorectal cancer. N. Engl. J. Med. 330, 1136-1142 (1994)
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1136-1142
    • Moertel, C.G.1
  • 29
    • 4244039573 scopus 로고
    • Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: A randomized trial
    • Glimelius, B. for the Nordic Gastrointestinal Tumour Adjuvant Therapy Group. Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: A randomized trial Eur J. Cancer S82 (Suppl. 2), 462 (1991).
    • (1991) Eur J. Cancer , vol.S82 , Issue.2 SUPPL. , pp. 462
    • Glimelius, B.1
  • 30
    • 0030140040 scopus 로고    scopus 로고
    • 99TTc radiolabelling using a phage-derived single chain Fv with C- terminal cysteine for colorectal tumour imaging
    • 99TTc radiolabelling using a phage-derived single chain Fv with C- terminal cysteine for colorectal tumour imaging J. Nucl. Med. 37, 868-872 (1996).
    • (1996) J. Nucl. Med. , vol.37 , pp. 868-872
    • Verhaar, M.J.1
  • 31
    • 0027500724 scopus 로고
    • Cancer Research Campaign operation manual for control recommendations for products derived from recombinant DNA technology prepared for investigational administration to patients with cancer in phase I trials
    • Begent, R.H.J et al. Cancer Research Campaign operation manual for control recommendations for products derived from recombinant DNA technology prepared for investigational administration to patients with cancer in phase I trials Eur. J. Cancer 29A, 1907-1910 (1993).
    • (1993) Eur. J. Cancer , vol.29 A , pp. 1907-1910
    • Begent, R.H.J.1
  • 32
    • 34547383713 scopus 로고
    • Preparation of iodine-131 labelled human growth hormone of high specific activity
    • Hunter, W.M. & Greenwood, F.C Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature 194, 495-496 (1962).
    • (1962) Nature , vol.194 , pp. 495-496
    • Hunter, W.M.1    Greenwood, F.C.2
  • 33
    • 0025731301 scopus 로고
    • A phase-I study of repeated therapy with radiolabelled antibody to carcinoembryonic antigen using intermittent or continuous administration of cyclosporin A to suppress the immune response
    • Ledermann, J.A et al. A phase-I study of repeated therapy with radiolabelled antibody to carcinoembryonic antigen using intermittent or continuous administration of cyclosporin A to suppress the immune response. Int. J. Cancer 47, 659-664 (1991).
    • (1991) Int. J. Cancer , vol.47 , pp. 659-664
    • Ledermann, J.A.1


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