Quantifying gluconeogenesis during fasting

American Journal of Physiology - Endocrinology and Metabolism

Volumn 273, Issue 6 36-6, 1997, Pages

  Chandramouli, Visvanathan ^b   Ekberg, Karin ^b   Schumann, William C ^b   Kalhan, Satish C ^b   Wahren, John ^b   Landau, Bernard R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Deuterium oxide; Glucose; Glycogen; Hexamethylenetetramine

Indexed keywords

DEUTERIUM OXIDE; FORMALDEHYDE; GLUCOSE; GLYCOGEN; HYDROGEN; METHENAMINE;

ADULT; ARTICLE; BLOOD SAMPLING; BODY WATER; DIET RESTRICTION; DRUG ABSORPTION; DRUG HALF LIFE; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOGENOLYSIS; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; MALE; MASS SPECTROMETRY; METABOLIC RATE; NORMAL HUMAN; PRIORITY JOURNAL; STEADY STATE; TURNOVER TIME; URINE LEVEL;

EID: 0031426379     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.273.6.e1209     Document Type: Article

References (21)

1. Dekker, E., J. A. Romijn, K. Ekberg, J. Wahren, H. V. Thien, M. T. Ackermans, L. T. D. Thuy, V. Chandramouli, P. A. Kager, B. R. Landau, and H. P. Sauerwein. Glucose production and gluconeogenesis in adults with uncomplicated falciparum malaria. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E1059-E1064, 1997.
2. Dittmer, D. Blood and other body fluids. In: Biological Handbooks. Washington, DC: Fed. Am. Soc. Exp. Biol., 1961, p. 186.
3. Fried, R., N. Beckmann, U. Keller, R. Ninnis, G. Stalder, and J. Seelig. Early glycogenolysis and late glycogenesis in human liver after intravenous administration of galactose. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G14-G19, 1996.
4. Gay, L. J., P. Schneiter, Y. Schutz, V. Di Vetta, E. Jequier, and L. Tappy. A non-invasive assessment of hepatic glycogen kinetics and post-absorptive gluconeogenesis in man. Diabetologia 37: 517-523, 1994.
5. Hellerstein, M., R. Neese, P. Linfoot, M. Christiansen, and A. Letscher. Detailed characterization in fasting humans of intrahepatic fluxes through gluconeogenesis (GNG) and glycogen (Abstract). Diabetes 45: 36A, 1996.
6. 3H-glucose infusion. Diabetologia 33: 603-610, 1990.
7. Kalhan, S. C., R. Trivedi, S. Singh, V. Chandramouli, W. C. Schumann, and B. R. Landau. A micromethod for measurement of deuterium bound to carbon 6 of glucose to quantify gluconeogenesis in-vivo. J. Mass Spectrom. 30: 1588-1592, 1995.
8. Landau, B. R., C. A. Fernandez, S. F. Previs, K. Ekberg, V. Chandramouli, J. Wahren, S. C. Kalhan, and H. Brunengraber. A limitation in the use of mass isotopomer distributions to measure gluconeogenesis in fasting humans. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E18-E26, 1995.
9. Landau, B. R., J. Wahren, V. Chandramouli, W. C. Schumann, K. Ekberg, and S. C. Kalhan. Contributions of gluconeogenesis to glucose production in the fasted state. J. Clin. Invest. 98: 378-385, 1996.
10. 2O for estimating rates of gluconeogenesis. Application to the fasted state. J. Clin. Invest. 95: 172-178, 1995.
11. Magnusson, I., D. L. Rothman, B. Jucker, G. W. Cline, R. G. Shulman, and G. I. Shulman. Liver glycogen turnover in fed and fasted humans. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E796-E803, 1994.
12. Newsholme, E., and A. Leech. Biochemistry for the Medical Sciences. New York: Wiley, 1985, p. 586.
13. Petersen, K., D. Laurent, G. Cline, G. Perseghin, and G. Shulman. Hepatic glycogen cycling in humans during euglycemic-hyperinsulinemia (Abstract). Diabetes 45: 254A, 1996.
14. Petersen, K. F., T. Price, G. W. Cline, D. L. Rothman, and G. I. Shulman. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E186-E191, 1996.
15. Previs, S. F., C. A. Fernandez, D. Yang, M. V. Soloviev, F. David, and H. Brunengraber. Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis. Substrate cycling between glycerol and triose phosphates in liver. J. Biol. Chem. 270: 19806-19815, 1995.
16. 13C NMR. Science 254: 573-576, 1991.
17. Schwenk, W. F., and J. C. Kahl. Acetaminophen glucuronidation accurately reflects gluconeogenesis in fasted dogs. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E529-E534, 1996.
18. 13C]glucose study. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E709-E717, 1996.
19. Tayek, J. A., and J. Katz. Glucose production, recycling, Cori cycling and gluconeogenesis in humans: relationship to serum cortisol. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E476-E484, 1997.
20. Taylor, C., B. Mikkelson, J. Anderson, and D. Forman. Human serum cholesterol synthesis measured with the deuterium label. Arch. Pathol. 81: 213-232, 1966.
21. Williamson, D., and J. Brosnan. Concentrations of metabolites in animal tissue. In: Methods of Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic/Verlag Chemie, 1974, p. 2266-2302.