-
1
-
-
0037267936
-
The further evolution of biotech
-
Nagle T., et al. The further evolution of biotech. Nat. Rev. Drug Discov. 2 (2003) 75-79
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 75-79
-
-
Nagle, T.1
-
2
-
-
11144334098
-
Recombinant protein therapeutics success rates, market trends and values to 2010
-
Pavlou A.K., and Reichert J.M. Recombinant protein therapeutics success rates, market trends and values to 2010. Nat. Biotechnol. 22 (2004) 1513-1519
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1513-1519
-
-
Pavlou, A.K.1
Reichert, J.M.2
-
3
-
-
0037264969
-
Therapeutic antibodies for human diseases at the dawn of the twenty-first century
-
Brekke O.H., and Sandlie I. Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nat. Rev. Drug Discov. 2 (2003) 52-62
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 52-62
-
-
Brekke, O.H.1
Sandlie, I.2
-
4
-
-
84889966052
-
Current status of biopharmaceuticals: approved products and trends in approvals
-
Knablein J. (Ed), Wiley-VCH Verlag
-
Walsh G. Current status of biopharmaceuticals: approved products and trends in approvals. In: Knablein J. (Ed). Modern biopharmeceuticals: design, development and optimization (2005), Wiley-VCH Verlag 1-34
-
(2005)
Modern biopharmeceuticals: design, development and optimization
, pp. 1-34
-
-
Walsh, G.1
-
7
-
-
23444448006
-
Next-generation monoclonals less profitable than trailblazers?
-
Mitchell P. Next-generation monoclonals less profitable than trailblazers?. Nat. Biotechnol. 23 (2005) 906
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 906
-
-
Mitchell, P.1
-
8
-
-
0033928586
-
Impact of genomics on drug discovery and clinical medicine
-
Emilien G., et al. Impact of genomics on drug discovery and clinical medicine. QJM 93 (2000) 391-423
-
(2000)
QJM
, vol.93
, pp. 391-423
-
-
Emilien, G.1
-
9
-
-
12844271561
-
High-throughput target discovery using cell-based genetics
-
Jackson P.D., and Harrington J.J. High-throughput target discovery using cell-based genetics. Drug Discov. Today 10 (2005) 53-60
-
(2005)
Drug Discov. Today
, vol.10
, pp. 53-60
-
-
Jackson, P.D.1
Harrington, J.J.2
-
10
-
-
26844550896
-
Accelerated discovery of novel protein function in cultured human cells
-
Hodges E., et al. Accelerated discovery of novel protein function in cultured human cells. Mol. Cell. Proteomics 4 (2005) 1319-1327
-
(2005)
Mol. Cell. Proteomics
, vol.4
, pp. 1319-1327
-
-
Hodges, E.1
-
11
-
-
23744508957
-
Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis
-
Harada J.N., et al. Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis. Genome Res. 15 (2005) 1136-1144
-
(2005)
Genome Res.
, vol.15
, pp. 1136-1144
-
-
Harada, J.N.1
-
12
-
-
0142059834
-
Genome-scale functional profiling of the mammalian AP-1 signaling pathway
-
Chanda S.K., et al. Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12153-12158
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 12153-12158
-
-
Chanda, S.K.1
-
13
-
-
10744220468
-
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment
-
Clark H.F., et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 13 (2003) 2265-2270
-
(2003)
Genome Res.
, vol.13
, pp. 2265-2270
-
-
Clark, H.F.1
-
14
-
-
0037338366
-
TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model
-
Fiscella M., et al. TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model. Nat. Biotechnol. 21 (2003) 302-307
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 302-307
-
-
Fiscella, M.1
-
18
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang J.-H., et al. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4 (1999) 67-73
-
(1999)
J. Biomol. Screen.
, vol.4
, pp. 67-73
-
-
Zhang, J.-H.1
-
19
-
-
2442501720
-
Determining appropriate substrate conversion for enzymatic assays in high-throughput screening
-
Wu G., et al. Determining appropriate substrate conversion for enzymatic assays in high-throughput screening. J. Biomol. Screen. 8 (2003) 694-700
-
(2003)
J. Biomol. Screen.
, vol.8
, pp. 694-700
-
-
Wu, G.1
-
20
-
-
13344261467
-
High-throughput screening: searching for higher productivity
-
Fox S., et al. High-throughput screening: searching for higher productivity. J. Biomol. Screen. 9 (2004) 354-358
-
(2004)
J. Biomol. Screen.
, vol.9
, pp. 354-358
-
-
Fox, S.1
-
21
-
-
0037338037
-
An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis
-
Chen C., et al. An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat. Biotechnol. 21 (2003) 294-301
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 294-301
-
-
Chen, C.1
-
22
-
-
23844449940
-
Computer-based de novo design of drug-like molecules
-
Schneider G., and Fechner U. Computer-based de novo design of drug-like molecules. Nat. Rev. Drug Discov. 4 (2005) 649-663
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 649-663
-
-
Schneider, G.1
Fechner, U.2
-
23
-
-
7444260846
-
The ENCODE (ENCyclopedia Of DNA Elements) project
-
ENCODE Project Consortium. The ENCODE (ENCyclopedia Of DNA Elements) project. Science 306 (2004) 636-640
-
(2004)
Science
, vol.306
, pp. 636-640
-
-
ENCODE Project Consortium1
-
24
-
-
4344623260
-
Integrative annotation of 21,037 human genes validated by full-length cDNA clones
-
Imanishi T., et al. Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol. 2 (2004) e162
-
(2004)
PLoS Biol.
, vol.2
-
-
Imanishi, T.1
-
25
-
-
28844443172
-
Genome annotation past, present, and future: How to define an ORF at each locus
-
Brent M.R. Genome annotation past, present, and future: How to define an ORF at each locus. Genome Res. 15 (2005) 1777-1786
-
(2005)
Genome Res.
, vol.15
, pp. 1777-1786
-
-
Brent, M.R.1
-
26
-
-
24644519490
-
The transcriptional landscape of the Mamm. Genome
-
The FANTOM Consortium. The transcriptional landscape of the Mamm. Genome. Science 309 (2005) 1559-1563
-
(2005)
Science
, vol.309
, pp. 1559-1563
-
-
The FANTOM Consortium1
-
27
-
-
0035104193
-
Computer-based methods for the mouse full-length cDNA encyclopedia: real-time sequence clustering for construction of a nonredundant cDNA library
-
Konno H., et al. Computer-based methods for the mouse full-length cDNA encyclopedia: real-time sequence clustering for construction of a nonredundant cDNA library. Genome Res. 11 (2001) 281-289
-
(2001)
Genome Res.
, vol.11
, pp. 281-289
-
-
Konno, H.1
-
28
-
-
0035162594
-
RefSeq and LocusLink: NCBI gene-centered resources
-
Pruitt K.D., and Maglott D.R. RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Res. 29 (2001) 137-140
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 137-140
-
-
Pruitt, K.D.1
Maglott, D.R.2
-
29
-
-
7444262496
-
The status, quality, and expansion of the NIH full-length cDNA project: the mammalian gene collection (MGC)
-
The MGC Project Team. The status, quality, and expansion of the NIH full-length cDNA project: the mammalian gene collection (MGC). Genome Res. 14 (2004) 2121-2127
-
(2004)
Genome Res.
, vol.14
, pp. 2121-2127
-
-
The MGC Project Team1
-
30
-
-
0031905770
-
Thermostabilization and thermoactivation of thermolabile enzymes by trehalose and its application for the synthesis of full length cDNA
-
Carninci P., et al. Thermostabilization and thermoactivation of thermolabile enzymes by trehalose and its application for the synthesis of full length cDNA. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 520-524
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 520-524
-
-
Carninci, P.1
-
31
-
-
0033791308
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes
-
Carninci P., et al. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 10 (2000) 1617-1630
-
(2000)
Genome Res.
, vol.10
, pp. 1617-1630
-
-
Carninci, P.1
-
32
-
-
0037673675
-
Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia
-
Carninci P., et al. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res. 13 (2003) 1273-1289
-
(2003)
Genome Res.
, vol.13
, pp. 1273-1289
-
-
Carninci, P.1
-
33
-
-
0031588566
-
High efficiency selection of full-length cDNA by improved biotinylated cap trapper
-
Carninci P., et al. High efficiency selection of full-length cDNA by improved biotinylated cap trapper. DNA Res. 4 (1997) 61-66
-
(1997)
DNA Res.
, vol.4
, pp. 61-66
-
-
Carninci, P.1
-
34
-
-
0031240609
-
A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
-
Nielsen H., et al. A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Int. J. Neural Syst. 8 (1997) 581-599
-
(1997)
Int. J. Neural Syst.
, vol.8
, pp. 581-599
-
-
Nielsen, H.1
-
35
-
-
13444269483
-
SPD - a web-based secreted protein database
-
Chen Y., et al. SPD - a web-based secreted protein database. Nucleic Acids Res. 33 (2005) D169-D173
-
(2005)
Nucleic Acids Res.
, vol.33
-
-
Chen, Y.1
-
36
-
-
2542520784
-
Identifying secretomes in people, pufferfish and pigs
-
Klee E.W., et al. Identifying secretomes in people, pufferfish and pigs. Nucleic Acids Res. 32 (2004) 1414-1421
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 1414-1421
-
-
Klee, E.W.1
-
37
-
-
4644320152
-
Signal peptide prediction based on analysis of experimentally verified cleavage sites
-
Zhang Z., and Henzel W.J. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 13 (2004) 2819-2824
-
(2004)
Protein Sci.
, vol.13
, pp. 2819-2824
-
-
Zhang, Z.1
Henzel, W.J.2
-
38
-
-
0000207681
-
TMBASE - a database of membrane spanning protein segments
-
Hofmann K., and Stoffel W. TMBASE - a database of membrane spanning protein segments. Biol. Chem. Hoppe-Seyler 374 (1993) 166
-
(1993)
Biol. Chem. Hoppe-Seyler
, vol.374
, pp. 166
-
-
Hofmann, K.1
Stoffel, W.2
-
39
-
-
9144257886
-
The Pfam protein families database
-
Bateman A., et al. The Pfam protein families database. Nucleic Acids Res. 32 (2004) D138-D141
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Bateman, A.1
-
40
-
-
0034677817
-
Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence
-
Revest J.-M., et al. Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence. J. Biol. Chem. 275 (2000) 8083-8090
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8083-8090
-
-
Revest, J.-M.1
-
41
-
-
0037192838
-
US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide
-
Gewurz B.E., et al. US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide. J. Biol. Chem. 277 (2002) 11306-11313
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11306-11313
-
-
Gewurz, B.E.1
-
42
-
-
0042817917
-
Secretion of FGF-16 requires an uncleaved bipartite signal sequence
-
Miyakawa K., and Imamura T. Secretion of FGF-16 requires an uncleaved bipartite signal sequence. J. Biol. Chem. 278 (2003) 35718-35724
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35718-35724
-
-
Miyakawa, K.1
Imamura, T.2
-
43
-
-
3042692704
-
Feature-based prediction of non-classical and leaderless protein secretion
-
Bendtsen J.D., et al. Feature-based prediction of non-classical and leaderless protein secretion. Protein Eng. Des. Sel. 17 (2004) 349-356
-
(2004)
Protein Eng. Des. Sel.
, vol.17
, pp. 349-356
-
-
Bendtsen, J.D.1
-
44
-
-
19944433652
-
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin
-
Fukuhara A., et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307 (2005) 426-430
-
(2005)
Science
, vol.307
, pp. 426-430
-
-
Fukuhara, A.1
-
45
-
-
24344500165
-
Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues
-
Goldstein A.L., et al. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol. Med. 11 (2005) 421-429
-
(2005)
Trends Mol. Med.
, vol.11
, pp. 421-429
-
-
Goldstein, A.L.1
-
46
-
-
20144387833
-
Robotic cloning and protein production platform of the northeast structural genomics consortium
-
Acton T.B., et al. Robotic cloning and protein production platform of the northeast structural genomics consortium. Methods Enzymol. 394 (2005) 210-243
-
(2005)
Methods Enzymol.
, vol.394
, pp. 210-243
-
-
Acton, T.B.1
-
47
-
-
26844509944
-
Automated expression and solubility screening of His-tagged proteins in 96-well format
-
Vincentelli R., et al. Automated expression and solubility screening of His-tagged proteins in 96-well format. Anal. Biochem. 346 (2005) 77-84
-
(2005)
Anal. Biochem.
, vol.346
, pp. 77-84
-
-
Vincentelli, R.1
-
48
-
-
8344271026
-
Production of recombinant protein therapeutics in cultivated mammalian cells
-
Wurm F.M. Production of recombinant protein therapeutics in cultivated mammalian cells. Nat. Biotechnol. 22 (2004) 1393-1398
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1393-1398
-
-
Wurm, F.M.1
-
49
-
-
0037394124
-
Designing screens: how to make your hits a hit
-
Walters W.P., and Namchuk M. Designing screens: how to make your hits a hit. Nat. Rev. Drug Discov. 2 (2003) 259-266
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 259-266
-
-
Walters, W.P.1
Namchuk, M.2
-
50
-
-
0142091390
-
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
-
Iourgenko V., et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12147-12152
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 12147-12152
-
-
Iourgenko, V.1
-
51
-
-
16544380146
-
The use of 3-D cultures for high-throughput screening: the multicellular spheroid model
-
Kunz-Schughart L.A., et al. The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J. Biomol. Screen. 9 (2004) 273-285
-
(2004)
J. Biomol. Screen.
, vol.9
, pp. 273-285
-
-
Kunz-Schughart, L.A.1
-
52
-
-
0001341562
-
High-content screening: a new approach to easing key bottlenecks in the drug discovery process
-
Giuliano K.A., et al. High-content screening: a new approach to easing key bottlenecks in the drug discovery process. J. Biomol. Screen. 2 (1997) 249-259
-
(1997)
J. Biomol. Screen.
, vol.2
, pp. 249-259
-
-
Giuliano, K.A.1
-
53
-
-
14044275761
-
Label-free detection
-
Comley J. Label-free detection. Drug Discovery World 6 (2005) 63-74
-
(2005)
Drug Discovery World
, vol.6
, pp. 63-74
-
-
Comley, J.1
-
54
-
-
8844262805
-
Cellular dielectric spectroscopy: a powerful new approach to label-free cellular analysis
-
Ciambrone G.J., et al. Cellular dielectric spectroscopy: a powerful new approach to label-free cellular analysis. J. Biomol. Screen. 9 (2004) 467-480
-
(2004)
J. Biomol. Screen.
, vol.9
, pp. 467-480
-
-
Ciambrone, G.J.1
-
55
-
-
8844247382
-
Label-free assays on the bind system
-
Cunningham B.T., et al. Label-free assays on the bind system. J. Biomol. Screen. 9 (2004) 481-490
-
(2004)
J. Biomol. Screen.
, vol.9
, pp. 481-490
-
-
Cunningham, B.T.1
-
56
-
-
0032832775
-
Drug Screening-beyond the bottleneck
-
Dove A. Drug Screening-beyond the bottleneck. Nat. Biotechnol. 17 (1999) 859-863
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 859-863
-
-
Dove, A.1
-
57
-
-
3943067061
-
Drug Discovery: As high-throughput draws fire, researchers leverages science to put automation into perspective
-
Mullin R. Drug Discovery: As high-throughput draws fire, researchers leverages science to put automation into perspective. C&EN 26 (2004) 23-32
-
(2004)
C&EN
, vol.26
, pp. 23-32
-
-
Mullin, R.1
-
58
-
-
33745849037
-
The industrial evolution of screening infrastructure
-
Molloy C. The industrial evolution of screening infrastructure. Drug Discovery World 4 (2003) 23-32
-
(2003)
Drug Discovery World
, vol.4
, pp. 23-32
-
-
Molloy, C.1
-
59
-
-
0040956397
-
Intuitive data analysis: the next generation
-
Ladd B. Intuitive data analysis: the next generation. Modern Drug Discovery 3 (2000) 46-51
-
(2000)
Modern Drug Discovery
, vol.3
, pp. 46-51
-
-
Ladd, B.1
-
60
-
-
24144456190
-
Adopting a practical statistical approach for evaluating assay agreement in drug discovery
-
Sun D., et al. Adopting a practical statistical approach for evaluating assay agreement in drug discovery. J. Biomol. Screen. 10 (2005) 508-516
-
(2005)
J. Biomol. Screen.
, vol.10
, pp. 508-516
-
-
Sun, D.1
|