Human immunodeficiency virus-mononuclear phagocyte interactions: Emerging avenues of biomarker discovery, modes of viral persistence and disease pathogenesis

Current HIV Research

Volumn 4, Issue 3, 2006, Pages 279-291

  Ciborowski, Pawel ^a,b   Gendelman, Howard E ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Biomarker; HIV 1; Macrophage; Neuroinflammation; Proteomics

Indexed keywords

BIOLOGICAL MARKER; ION CHANNEL; SCAVENGER;

BONE MARROW CELL; CELL FUNCTION; CELL SECRETION; CELL VOLUME; DEMENTIA; DISEASE ASSOCIATION; DISEASE MARKER; FUNCTIONAL GENOMICS; GIANT CELL; HISTIOCYTE; HOST CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOREGULATION; KUPFFER CELL; LIFE CYCLE; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; METABOLIC ENCEPHALOPATHY; MICROGLIA; MONONUCLEAR PHAGOCYTE; NONHUMAN; PATHOGENESIS; PERSISTENT VIRUS INFECTION; PROTEIN EXPRESSION; PROTEOMICS; RESERVOIR; REVIEW; TISSUE INJURY; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS REPLICATION;

AIDS DEMENTIA COMPLEX; ANIMALS; BIOLOGICAL MARKERS; GENOMICS; HIV; HUMANS; MACROPHAGES; PROTEOMICS; VIRUS REPLICATION;

EID: 33745855899     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016206777709474     Document Type: Review

References (136)

1. Alaiya A, Al-Mohanna M and Linder S. (2005). Clinical cancer proteomics: promises and pitfalls. Journal of Proteome Research 4:1213-1222.
2. Albright AV and Gonzalez-Scarano F. (2004). Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression. Journal of Neuroimmunology 157:27-38.
3. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM and Berger EA. (1996). CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955-1958.
4. Anderson E, Zink W, Xiong H and Gendelman HE. (2002). HIV-1-associated dementia: a metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes. Journal of Acquired Immune Deficiency Syndromes 31 Suppl 2:S43-54.
5. Bakkali L, Guillou R, Gonzague M and Cruciere C. (1994). A rapid and sensitive chemiluminescence dot-immunobinding assay for screening hybridoma supernatants. Journal of Immunology Methods 170:177-184.
6. Billecke C, Malik I, Movsisyan A, Sulghani S, Sharif A, Mikkelsen T, Farrell NP and Bogler O. (2005). Analysis of glioma cell platinum response by metacomparison of 2-D chromatographic proteome profiles. Molecular & Cellular Proteomics 5:35-42.
7. Boomker JM, de Leij LF, The TH and Harmsen MC. (2005). Viral chemokine-modulatory proteins: tools and targets. Cytokine & Growth Factor Reviews 16:91-103.
8. Caldwell RL and Caprioli RM. (2005). Tissue profiling by mass spectrometry: a review of methodology and applications. Molecular & Cellular Proteomics 4:394-401.
9. Campbell SM, Crowe SM and Mak J. (2001). Lipid rafts and HIV-1: from viral entry to assembly of progeny virions. J Clin Virol 22:217-227.
10. Cantin R, Fortin JF, Lamontagne G and Tremblay M. (1997). The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity. Journal of Virology 71:1922-1930.
11. Carlson KA, Cotter RL, Williams C, Branecki C, Zheng J and Gendelman HE. (2002). The Role of Mononuclear Phagocytes in the Pathogenesis of Alzheimer's Disease. In The Macrophage. B. Burke and C. Lewis, eds. Oxford University Presss, Oxford. 138-210.
12. Chromy BA, Gonzales AD, Perkins J, Choi MW, Corzett MH, Chang BC, Corzett CH and McCutchen-Maloney SL. (2004). Proteomic analysis of human serum by two-dimensional differential gel electrophoresis after depletion of high-abundant proteins. Journal of Proteome Research 3:1120-1127.
13. Chun TW, Justement JS, Lempicki RA, Yang J, Dennis G Jr., Hallahan CW, Sanford C, Pandya P, Liu S, McLaughlin M, Ehler LA, Moir S and Fauci AS. (2003). Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proceedings of the National Academy of Sciences USA 100:1908-1913.
14. Ciborowski P, Enose Y, Mack A, Fladseth M and Gendelman HE. (2004). Diminished matrix metalloproteinase 9 secretion in human immunodeficiency virus-infected mononuclear phagocytes: modulation of innate immunity and implications for neurological disease. Journal of Neuroimmunology 157:11-16.
15. Clerici M, Sarin A, Berzofsky JA, Landay AL, Kessler HA, Hashemi F, Hendrix CW, Blatt SP, Rusnak J, Dolan MJ, Coffman RL, Henkart PA and Shearer GM. (1996). Antigen-stimulated apoptotic T-cell death in HIV infection is selective for CD4+ T cells, modulated by cytokines and effected by lymphotoxin. AIDS 10:603-611.
16. Coberley CR, Kohler JJ, Brown JN, Oshier JT, Baker HV, Popp MP, Sleasman JW and Goodenow MM. (2004). Impact on genetic networks in human macrophages by a CCR5 strain of human immunodeficiency virus type 1. Journal of Virology 78:11477-11486.
17. Cohn ZA. (1986). Biochemistry of macrophages. The first line of defence: chairman's introduction. Ciba Foundation Symposium 118:1-6.
18. Collman RG, Perno CF, Crowe SM, Stevenson M and Montaner LJ. (2003). HIV and cells of macrophage/dendritic lineage and other non-T cell reservoirs: new answers yield new questions. Journal of Leukocyte Biology 74:631-634.
19. Conant K, McArthur JC, Griffin DE, Sjulson L, Wahl LM and Irani DN. (1999). Cerebrospinal fluid levels of MMP-2, 7 and 9 are elevated in association with human immunodeficiency virus dementia. Annals of Neurology 46:391-398.
20. Conrads TP, Hood BL, Petricoin EF, 3rd, Liotta LA and Veenstra TD. (2005). Cancer proteomics: many technologies, one goal. Expert Review of Proteomics 2:693-703.
21. Crowe SM, Vardaxis NJ, Kent SJ, Maerz AL, Hewish MJ, McGrath MS and Mills J. (1994). HIV infection of monocyte-derived macrophages in vitro reduces phagocytosis of Candida albicans. Journal of Leukocyte Biology 56:318-327.
22. Doms RW and Peiper SC. (1997). Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry. Virology 235:179-190.
23. Eckel-Passow JE, Hoering A, Therneau TM and Ghobrial I. (2005). Experimental design and analysis of antibody microarrays: applying methods from cDNA arrays. Cancer Research 65:2985-2989.
24. Eger KA and Unutmaz D. (2005). The Innate Immune System and HIV Pathogenesis. Current HIV/AIDS Rep 2:10-15.
25. Enose Y, Destache CJ, Mack AL, Anderson JR, Ullrich F, Ciborowski PS and Gendelman HE. (2005). Proteomic fingerprints distinguish microglia, bone marrow and spleen macrophage populations. Glia 51:161-172.
26. Ferri N, Paoletti R and Corsini A. (2005). Lipid-modified proteins as biomarkers for cardiovascular disease: a review. Biomarkers 10:219-237.
27. Fountoulakis M, Juranville JF, Jiang L, Avila D, Roder D, Jakob P, Berndt P, Evers S and Langen H. (2004). Depletion of the high-abundance plasma proteins. Amino Acids 27:249-259.
28. Freed EO. (2004). HIV-1 and the host cell: an intimate association. Trends in Microbiology 12:170-177.
29. Garter S and Popovic M. (1990). Macrophage tropism of HIV-1. AIDS Research and Human Retroviruses 6:1017-1021.
30. Gartner S, Markovits P, Markovitz DM, Betts RF and Popovic M. (1986). Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS. JAMA 256:2365-2371.
31. Gartner S, Markovits P, Markovitz DM, Kaplan MH, Gallo RC and Popovic M. (1986). The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233:215-219.
32. Geijtenbeek TB and van Kooyk Y. (2003). DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission. Current Topics in Microbiology and Immunology 276:31-54.
33. Geiss GK, Bumgarner RE, An MC, Agy MB, van't Wout AB, Hammersmark E, Carter VS, Upchurch D, Mullins JI and Katze MG. (2000). Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology 266:8-16.
34. Gelbard HA, Nottet HS, Swindells S, Jett M, Dzenko KA, Genis P, White R, Wang L, Choi YB, Zhang D, Lipton SA, Tourtellotte W, Epstein L and Gendelman HE. (1994). Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. Journal of Virology 68:4628-4635.
35. Gendelman HE, Narayan O, Molineaux S, Clements JE and Ghotbi Z. (1985). Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow. Proceedings in the National Academy of Sciences USA 82:7086-7090.
36. Gendelman HE, Orenstein JM, Baca LM, Weiser B, Burger H, Kalter DC and Meltzer MS. (1989). The macrophage in the persistence and pathogenesis of HIV infection. AIDS 3:475-495.
37. Gendelman HE, Narayan O, Kennedy-Stoskopf S, Kennedy PG, Ghotbi Z, Clements JE, Stanley J and Pezeshkpour G. (1986). Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. Journal of Virology 58:67-74.
38. Gendelman HE, Baca LM, Husayni H, Turpin JA, Skillman D, Kalter DC, Orenstein JM, Hoover DL and Meltzer MS. (1990). Macrophage-HIV interaction: viral isolation and target cell tropism. AIDS 4:221-228.
39. Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ, Epstein LG and Gendelman HE. (1992). Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. Journal of Experimental Medicine 176:1703-1718.
40. Ghaffari G, Tuttle DL, Briggs D, Burkhardt BR, Bhatt D, Andiman WA, Sleasman JW and Goodenow MM. (2005). Complex determinants in human immunodeficiency virus type 1 envelope gp120 mediate CXCR4-dependent infection of macrophages. Journal of Virology 79:13250-13261.
41. Ghorpade A, Persidskaia R, Suryadevara R, Che M, Liu XJ, Persidsky Y and Gendelman HE. (2001). Mononuclear phagocyte differentiation, activation and viral infection regulate matrix metalloproteinase expression: implications for human immunodeficiency virus type 1-associated dementia. Journal of Virology 75:6572-6583.
42. Giguere JF, Diou J, Madrenas J and Tremblay MJ. (2005). Virus Attachment and Replication Are Promoted after Acquisition of Host CD28 and CD152 by HIV-1. Journal of Infectious Diseases 192:1265-1268.
43. Giguere JF, Paquette JS, Bounou S, Cantin R and Tremblay MJ. (2002). New insights into the functionality of a virion-anchored host cell membrane protein: CD28 versus HIV type 1. Journal of Immunology 169:2762-2771.
44. Glass JD, Fedor H, Wesselingh SL and McArthur JC. (1995). Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Annals of Neurology 38:755-762.
45. Gray F, Belec L, Chretien F, Dubreuil-Lemaire ML, Ricolfi F, Wingertsmann L, Poron F and Gherardi R. (1998). Acute, relapsing brain oedema with diffuse blood-brain barrier alteration and axonal damage in the acquired immunodeficiency syndrome. Neuropathology and Applied Neurobiology 24:209-216.
46. Gorry PR, Churchill M, Crowe SM, Cunningham AL and Gabuzda D. (2005). Pathogenesis of macrophage tropic HIV-1. Current HIV Research 3:53-60.
47. Gredmark S, Britt WB, Xie X, Lindbom L and Soderberg-Naucler C. (2004). Human cytomegalovirus induces inhibition of macrophage differentiation by binding to human aminopeptidase N/CD13. Journal Immunology 173:4897-4907.
48. Green AJ, Giovannoni G, Hall-Craggs MA, Thompson EJ and Miller RF. (2000). Cerebrospinal fluid tau concentrations in HIV infected patients with suspected neurological disease. Sexually Transmitted Infections 76:443-446.
49. Gronborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A and Pandey A. (2006). Biomarker discovery from pancreatic cancer secretome using a differential proteomics approach. Molecular & Cellular Proteomics 5(1):157-171.
50. Gruber MP and Geraci MW. (2005). Practical cancer genetics, genomics and proteomics. J Insurance Medicine 37:190-200.
51. Guillemin GJ and Brew BJ. (2004). Microglia, macrophages, perivascular macrophages and pericytes: a review of function and identification. Journal of Leukocyte Biology 75:388-397.
52. Helke KL, Queen SE, Tarwater PM, Turchan-Cholewo J, Nath A, Zink MC, Irani DN and Mankowski JL. (2005). 14-3-3 protein in CSF: an early predictor of SIV CNS disease. Journal of Neuropathology & Experimental Neurology 64:202-208.
53. Hernandez P, Muller M and Appel RD. (2006). Automated protein identification by tandem mass spectrometry: Issues and strategies. Mass Spectrometry Review 25(2):235-254.
54. Ho L, Sharma N, Blackman L, Festa E, Reddy G and Pasinetti GM. (2005). From proteomics to biomarker discovery in Alzheimer's disease. Brain Research Reviews 48:360-369.
55. Iwadate Y, Sakaida T, Saegusa T, Hiwasa T, Takiguchi M, Fujimoto S and Yamaura A. (2005). Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas. International Journal of Oncology 26:993-998.
56. Janssen RS, Cornblath DR, Epstein LG, McArthur J and Price RW. (1989). Human immunodeficiency virus (HIV) infection and the nervous system: report from the American Academy of Neurology AIDS Task Force. Neurology 39:119-122.
57. Jeffrey CJ. (2003). Moonlighting proteins: old proteins learning new tricks. Trends in Genetics. 19:415-417.
58. Jeffries N. (2005). Algorithms for alignment of mass spectrometry proteomic data. Bioinformatics 21:3066-73.
59. Johnson MD, Yu LR, Conrads TP, Kinoshita Y, Uo T, McBee JK, Veenstra TD and Morrison RS. (2005). The proteomics of neurodegeneration. American Journal of PharmacoGenomics 5:259-270.
60. Joly M and Pinto JM. (2005). CXCR4 and CCR5 regulation and expression patterns on T- and monocyte-macrophage cell lineages: implications for susceptibility to infection by HIV-1. Mathematical Biosciences 195:92-126.
61. Kadiu I, Glanzer JG, Kipnis J, Gendelman HE and Thomas MP. (2005). Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. Neurotoxicolgy Research 8:25-50.
62. Kalter DC, Gendelman HE and Meltzer MS. (1991). Monocytes, dendritic cells and Langerhans cells in human immunodeficiency virus infection. Dermatologic Clinics 9:415-428.
63. Kastenbauer S, Angele B, Sporer B, Pfister HW and Koedel U. (2005). Patterns of protein expression in infectious meningitis: A cerebrospinal fluid protein array analysis. Journal of Neuroimmunology 164(1-2):134-139.
64. Kim A, Pettoello-Mantovani M and Goldstein H. (1998). Decreased susceptibility of peripheral blood mononuclear cells from individuals heterozygous for a mutant CCR5 allele to HIV infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 19:145-149.
65. Kim MG, Shin YB, Jung JM, Ro HS and Chung BH. (2005). Enhanced sensitivity of surface plasmon resonance (SPR) immunoassays using a peroxidase-catalyzed precipitation reaction and its application to a protein microarray. Journal of Immunology Methods 297:125-132.
66. Kroger M, Hellmann J, Toldo L, Gluckmann M, von Eiff B, Fella K and Kramer PJ. (2004). [Toxicoproteomics: first experiences in a BMBF-study]. Altex 21 Suppl 3:28-40.
67. Lee PL, Yiannoutsos CT, Ernst T, Chang L, Marra CM, Jarvik JG, Richards TL, Kwok EW, Kolson DL, Simpson D, Tang CY, Schifitto G, Ketonen LM, Meyerhoff DJ, Lenkinski RE, Gonzalez RG and Navia BA. (2003). A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. Journal of Magnetic Resonance Imaging 17:625-633.
68. Lehmann-Che J and Saib A. (2004). Early stages of HIV replication: how to hijack cellular functions for a successful infection. AIDS Review 6:199-207.
69. Leonard J, Khillan JS, Gendelman HE, Adachi A, Lorenzo S, Westphal H, Martin MA and Meltzer MS. (1989). The human immunodeficiency virus long terminal repeat is preferentially expressed in Langerhans cells in transgenic mice. AIDS Research and Human Retroviruses 5:421-430.
70. Lin YL, Mettling C, Portales P, Reynes J, Clot J and Corbeau P. (2002). Cell surface CCR5 density determines the postentry efficiency of R5 HIV-1 infection. Proceedings in the National Academy of Sciences USA 99:15590-15595.
71. Mack KD, Jin X, Yu S, Wei R, Kapp L, Green C, Herndier B, Abbey NW, Elbaggari A, Liu Y and McGrath MS. (2003). HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression. Journal of Acquired Immune Deficiency Syndromes 33:308-320.
72. Mann DL, Gartner S, Le Sane F, Buchow H and Popovic M. (1990). HIV-1 transmission and function of virus-infected monocytes/macrophages. Journal of Immunology 144:2152-2158.
73. McArthur JC, Brew BJ and Nath A. (2005). Neurological complications of HIV infection. Lancet Neurology 4:543-555.
74. McArthur JC, Haughey N, Gartner S, Conant K, Pardo C, Nath A and Sacktor N. (2003). Human immunodeficiency virus-associated dementia: an evolving disease. Journal of Neurovirology 9:205-221.
75. McConnell JR, Swindells S, Ong CS, Gmeiner WH, Chu WK, Brown DK and Gendelman HE. (1994). Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment. AIDS Research and Human Retroviruses 10:977-982.
76. Mellors JW, Munoz A, Giorgi JV, Margolick JB, Tassoni CJ, Gupta P, Kingsley LA, Todd JA, Saah AJ, Detels R, Phair JP and Rinaldo CR, Jr. (1997). Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Annals of Internal Medicine 126:946-954.
77. Meltzer MS and Gendelman HE. (1992). Mononuclear phagocytes as targets, tissue reservoirs and immunoregulatory cells in human immunodeficiency virus disease. Current Topics in Microbiology and Immunology 181:239-263.
78. Meltzer MS, Skillman DR, Hoover DL, Hanson BD, Turpin JA, Kalter DC and Gendelman HE. (1990). Macrophages and the human immunodeficiency virus. Immunology Today 11:217-223.
79. Meltzer MS, Skillman DR, Hoover DL, Hansen BD, Turpin JA, Kalter DC and Gendelman HE. (1991). Macrophages and the human immunodeficiency virus. In HIV and the Immune System. Elsevier, Cambridge. 4-21.
80. Meyerhoff DJ, Bloomer C, Cardenas V, Norman D, Weiner MW and Fein G. (1999). Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients. Neurology 52:995-1003.
81. Mossman KL and Ashkar AA. (2005). Herpesviruses and the innate immune response. Viral Immunology 18:267-281.
82. Naarding MA, Ludwig IS, Groot F, Berkhout B, Geijtenbeek TB, Pollakis G and Paxton WA. (2005). Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4 T lymphocytes. Journal of Clinical Investigation 115:3256-3264.
83. Navia BA, Jordan BD and Price RW. (1986). The AIDS dementia complex: I. Clinical features. Annals of Neurology 19:517-524.
84. Navia BA, Cho ES, Petito CK and Price RW. (1986). The AIDS dementia complex: II. Neuropathology. Annals of Neurology 19:525-535.
85. Nguyen MD, Julien JP and Rivest S. (2002). Innate immunity: the missing link in neuroprotection and neurodegeneration? Nature Reviews Neuroscience 3:216-227.
86. Nibbering PH, Leijh PC and van Furth R. (1987). Quantitative immunocytochemical characterization of mononuclear phagocytes. II. Monocytes and tissue macrophages. Immunology 62:171-176.
87. Omenn GS, States DJ, Adamski M, Blackwell TW, Menon R, Hermjakob H, Apweiler R, Haab BB, Simpson RJ, Eddes JS, Kapp EA, Moritz RL, Chan DW, Rai AJ, Admon A, Aebersold R, Eng J, Hancock WS, Hefta SA, Meyer H, Paik YK, Yoo JS, Ping P, Pounds J, Adkins J, Qian X, Wang R, Wasinger V, Wu CY, Zhao X, Zeng R, Archakov A, Tsugita A, Beer I, Pandey A, Pisano M, Andrews P, Tammen H, Speicher DW and Hanash SM. (2005). Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics 5:3226-3245.
88. Ometto L, Zanchetta M, Cabrelle A, Esposito G, Mainardi M, Chieco-Bianchi L and De Rossi A. (1999). Restriction of HIV type 1 infection in macrophages heterozygous for a deletion in the CC-chemokine receptor 5 gene. AIDS Research and Human Retroviruses 15:1441-1452.
89. Ott DE. (2002). Potential roles of cellular proteins in HIV-1. Reviews in Medical Virology 12:359-374.
90. Perry AK, Chen G, Zheng D, Tang H and Cheng G. (2005). The host type I interferon response to viral and bacterial infections. Cell Res 15:407-422.
91. Petricoin EF and Liotta LA. (2003). Clinical applications of proteomics. Journal of Nutrition 133:2476S-2484S.
92. Pfefferbaum A, Adalsteinsson E and Sullivan EV. (2005). Cortical NAA deficits in HIV infection without dementia: influence of alcoholism comorbidity. Neuropsychopharmacology 30:1392-1399.
93. Philpott SM. (2003). HIV-1 coreceptor usage, transmission and disease progression. Current HIV Research 1:217-227.
94. Pietiainen VM, Marjomaki V, Heino J and Hyypia T. (2005). Viral entry, lipid rafts and caveosomes. Annals of Medicine 37:394-403.
95. Ping P, Vondriska TM, Creighton CJ, Gandhi TK, Yang Z, Menon R, Kwon MS, Cho SY, Drwal G, Kellmann M, Peri S, Suresh S, Gronborg M, Molina H, Chaerkady R, Rekha B, Shet AS, Gerszten RE, Wu H, Raftery M, Wasinger V, Schulz-Knappe P, Hanash SM, Paik YK, Hancock WS, States DJ, Omenn GS and Pandey A. (2005). A functional annotation of subproteomes in human plasma. Proteomics 5:3506-3519.
96. Poetz O, Schwenk JM, Kramer S, Stoll D, Templin MF and Joos TO. (2005). Protein microarrays: catching the proteome. Mechanisms of Ageing Development 126:161-170.
97. Polsinelli T, Meltzer MS and Fortier AH. (1994). Nitric oxide-independent killing of Francisella tularensis by IFN-gamma-stimulated murine alveolar macrophages. Journal of Immunology 153:1238-1245.
98. Provitera P, El-Maghrabi R and Scarlata S. (2006). The effect of HIV-1 Gag myristoylation on membrane binding. Biophysical Chemistry 119, 23-32.
99. Ramstrom M, Hagman C, Mitchell JK, Derrick PJ, Hakansson P and Bergquist J. (2005). Depletion of high-abundant proteins in body fluids prior to liquid chromatography fourier transform ion cyclotron resonance mass spectrometry. Journal of Proteome Research 4:410-416.
100. Rana S, Besson G, Cook DG, Rucker J, Smyth RJ, Yi Y, Turner JD, Guo HH, Du JG, Peiper SC, Lavi E, Samson M, Libert F, Liesnard C, Vassart G, Doms RW, Parmentier M and Collman RG. (1997). Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation. Journal of Virology 71:3219-3227.
101. Reyzer ML, Caldwell RL, Dugger TC, Forbes JT, Ritter CA, Guix M, Arteaga CL and Caprioli RM. (2004). Early changes in protein expression detected by mass spectrometry predict tumor response to molecular therapeutics. Cancer Research 64:9093-9100.
102. Rhim AD, Stoykova LI, Trindade AJ, Glick MC and Scanlin TF. (2004). Altered terminal glycosylation and the pathophysiology of CF lung disease. Journal of Cystic Fibrosis 3 Suppl 2:95-96.
103. Roberts ES, Zandonatti MA, Watry DD, Madden LJ, Henriksen SJ, Taffe MA and Fox HS. (2003). Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS. American Journal of Pathology 162:2041-2057.
104. Rohlff C and Southan C. (2002). Proteomic approaches to central nervous system disorders. Current Opinion in Molecular Therapuetics 4:251-258.
105. Sacktor N, Skolasky RL, Ernst T, Mao X, Selnes O, Pomper MG, Chang L, Zhong K, Shungu DC, Marder K, Shibata D, Schifitto G, Bobo L and Barker PB. (2005). A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia. Journal of Magnetic Resonance Imaging 21:325-333.
106. Saha RN and Pahan K. (2003). Tumor necrosis factor-alpha at the crossroads of neuronal life and death during HIV-associated dementia. Journal of Neurochemistry 86:1057-1071.
107. Salkowitz JR, Bruse SE, Meyerson H, Valdez H, Mosier DE, Harding CV, Zimmerman PA and Lederman MM. (2003). CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro. Clinical Immunology 108:234-240.
108. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Collman RG, Doms RW, Vassart G and Parmentier M. (1996). Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722-725.
109. Sandhu GS, Eckloff BW and Kline BC. (1991). Chemiluminescent substrates increase sensitivity of antigen detection in western blots. Biotechniques 11:14-16.
110. Shi S, Blumenthal A, Hickey CM, Gandotra S, Levy D and Ehrt S. (2005). Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. Journal of Immunology 175:3318-3328.
111. Sluiter W, Hulsing-Hesselink E, Elzenga-Claasen I, van Hemsbergen-Oomens LW, van der Voort van der Kleij-van Andel A and van Furth R. (1987). Macrophages as origin of factor increasing monocytopoiesis. Journal of Experimental Medicine 166:909-922.
112. Soares M, Hanisch FG, Finn OJ and Ciborowski P. (2001). Recombinant human tumor antigen MUC1 expressed in insect cells: structure and immunogenicity. Protein Expression and Purification 22:92-100.
113. Soldi M, Sarto C, Valsecchi C, Magni F, Proserpio V, Ticozzi D and Mocarelli P. (2005). Proteome profile of human urine with two-dimensional liquid phase fractionation. Proteomics 5(10): 2641-2647.
114. Souchelnytskyi S. (2005). Bridging proteomics and systems biology: what are the roads to be traveled? Proteomics 5:4123-4137.
115. Sporer B, Missler U, Magerkurth O, Koedel U, Wiesmann M and Pfister H. (2004). Evaluation of CSF glial frbrillary acidic protein (GFAP) as a putative marker for HIV-associated dementia. Infection 32:20-23.
116. Steel LF, Haab BB and Hanash SM. (2005). Methods of comparative proteomic profiling for disease diagnostics. Journal of Chromatography B 815:275-284.
117. Stein DS, Lyles RH, Graham NM, Tassoni CJ, Margolick JB, Phair JP, Rinaldo C, Detels R, Saah A and Bilello J. (1997). Predicting clinical progression or death in subjects with early-stage human immunodeficiency virus (HIV) infection: a comparative analysis of quantification of HIV RNA, soluble tumor necrosis factor type II receptors, neopterin and beta2-microglobulin. Multicenter AIDS Cohort Study. Journal of Infectious Diseases 176:1161-1167.
118. Stevenson M and Gendelman HE. (1994). Cellular and viral determinants that regulate HIV-1 infection in macrophages. Journal of Leukocyte Biology 56:278-288.
119. Sui Y, Potula R, Pinson D, Adany I, Li Z, Day J, Buch E, Segebrecht J, Villinger F, Liu Z, Huang M, Narayan O and Buch S. (2003). Microarray analysis of cytokine and chemokine genes in the brains of macaques with SHIV-encephalitis. J Med Primatol 32:229-239.
120. Sun X, Chiu JF and He QY. (2005). Application of immobilized metal affinity chromatography in proteomics. Expert Reviews in Proteomics 2:649-657.
121. Swindells S, McConnell JP, McComb RD and Gendelman HE. (1995). Utility of cerebral proton magnetic resonance spectroscopy in differential diagnosis of HIV-related dementia. Journal of Neurovirology 1:268-274.
122. Tardieu M. (2005). Mechanisms of macrophage-mediated neurotoxicity. In The Neurology of AIDS, 2 ed. H. E. Gendelman, I. Grant, I. P. Everall, S. A. Lipton and S. Swindells, eds. Oxford University Press, Oxford. 177-180.
123. Templin MF, Stoll D, Schwenk JM, Potz O, Kramer S and Joos TO. (2003). Protein microarrays: promising tools for proteomic research. Proteomics 3:2155-2166.
124. Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR and Mucke L. (1994). Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367:188-193.
125. Tornatore C, Nath A, Amemiya K and Major EO. (1991). Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta. Journal of Virology 65:6094-6100.
126. Tremblay MJ, Fortin JF and Cantin R. (1998). The acquisition of host-encoded proteins by nascent HIV-1. Immunol Today 19:346-351.
127. van Furth R. (1989). Origin and turnover of monocytes and macrophages. Curr Top Pathol 79:125-150.
128. Wang KJ, Wang RT and Zhang JZ. (2004). Identification of tumor markers using two-dimensional electrophoresis in gastric carcinoma. World Journal of Gastroenterology 10:2179-2183.
129. Yao JD, Arkin CF, Doweiko JP and Hammer SM. (1990). Disseminated cryptococcosis diagnosed on peripheral blood smear in a patient with acquired immunodeficiency syndrome. The American Journal of Medicine 89:100-102.
130. Zhang L, Hurek T and Reinhold-Hurek B. (2005). Position of the fluorescent label is a crucial factor determining signal intensity in microarray hybridizations. Nucleic Acids Research 33:e166.
131. Zheng J, Pen H, Rose J and Herek S. (2005). Neurogenesis and its links to brain development, developmental therapeutics and the pathogenesis of neurodegenerative disorders including HIV-1-associated dementia. In The Neurology of AIDS, 2 ed. H. E. Gendelman, I. Grant, I. P. Everall, S. A. Lipton and S. Swindells, eds. Oxford University Press, Oxford. 239-253.
132. Zhou Y, Wang Y, Kovacs M, Jin J and Zhang J. (2005). Microglial activation induced by neurodegeneration: a proteomic analysis. Molecular & Cellular Proteomics 4:1471-1479.
133. Zimmerman C, Klein KC, Kiser PK, Singh AR, Firestein BL, Riba SC and Lingappa JR. (2002). Identification of a host protein essential for assembly of immature HIV-1 capsids. Nature 415:88-92.
134. Zink MC, Uhrlaub J, DeWitt J, Voelker T, Bullock B, Mankowski J, Tarwater P, Clements J and Barber S. (2005). Neuroprotective and anti-human immunodeficiency virus activity of minocycline. JAMA 293:2003-2011.
135. Zink W, Ryan L and Gendelman HE. (2002). Macrophage - virus interactions. In The Macrophage. C. Lewis, ed. Oxford University Press, London. 305-356.
136. Zink WE, Anderson E, Boyle J, Hock L, Rodriguez-Sierra J, Xiong H, Gendelman HE and Persidsky Y. (2002). Impaired spatial cognition and synaptic potentiation in a murine model of human immunodeficiency virus type 1 encephalitis. Journal of Neuroscience 22:2096-2105.