Antigen-stimulated apoptotic T-cell death in HIV infection is selective for CD4+ T cells, modulated by cytokines and effected by lymphotoxin

AIDS

Volumn 10, Issue 6, 1996, Pages 603-611

  Clerici, Mario ^a   Sarin, Apurva ^b   Berzofsky, Jay A ^b   Landay, Alan L ^c   Kessler, Harold A ^c   Hashemi, Farah ^c   Hendrix, Craig W ^d   Blatt, Stephen P ^d   Rusnak, Janice ^d   Dolan, Matthew J ^d   Coffman, Robert L ^e   Henkart, Pierre A ^b   Shearer, Gene M ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

^c RUSH MEDICAL COLLEGE   (United States)

^d WILFORD HALL MEDICAL CENTER   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Apoptosis; CD4+ T cells; Cytokines; HIV infection

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; LYMPHOTOXIN; VIRUS ENVELOPE PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSTIMULATION; INFLUENZA VIRUS A; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 9344261434     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199606000-00005     Document Type: Article

References (44)

1. Shearer GM, Clerici M: Early T-helper cell defects in HIV infection. AIDS 1991, 5:243-253.
2. Levy JA: Pathogenesis of human immumodeficiency virus infection. Microbiol Revs 1993, 57:183-289.
3. Wain-Hobson S: Immunologic mayhem [letter]. Nature 1995, 373:102.
4. Finkel TH, Banda NK: Indirect mechanisms of HIV pathogeneisi: how does HIV kill T cells? Curr Opm Immunol 1994, 6:605-615.
5. Finkel TH, Tudor-Williams G, Banda NK, et al.: Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Med 1995, 1:129-134.
6. Gougeon M-L, Garcia S, Heeney J, et al.: Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retroviruses 1993, 9:553-560.
7. Groux H, Monte D, Bourrez JM, Capron A, Ameisen J-C: Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992, 175:331-340.
8. Ameisen J-C, Capron A: Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis. Immunol Today 1991, 12:102-104.
9. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet IPM, Mediema F: Programmed cell death of T cells in HIV-1 infections. Science 1992, 257:217-219.
10. Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ: Inhibition of CD4+ T cell function by the HIV envelope protein gp120. J Immunol 1998, 141:3715-3717.
11. Oyaizu N, Chirmule N, Karyanarmann VS, Hall WW, Good RA, Pahwa S: Human immunodeficiency type 1 envelope protein gp120 produced immune defects in CD4+ T lymphocytes by inhibiting interleukin-2 mRNA. Proc Natl Acad Sci USA 1990, 87:2379-2383.
12. Oyaizu N, Pahwa S: Role of apoptosis in HIV disease pathogenesis. J Clin Immunol 1995, 15:217-231.
13. Moro-Cacho CA, Pantaleo G, Fauci AS: Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J Immunol 1995, 154:5555-5566.
14. Sarin A, Clerici M, Blatt SP, Hendrix CW, Shearer GM, Henkart PA: Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J Immunol 1994, 153:862-872.
15. Clerici M, Sarin A, Coffman RL, et al.: Type 1/type 2 cytokine modulation of T cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci USA 1994, 91:11811-11815.
16. Clerici M, Stocks NI, Zajac RA, et al.: IL-2 production permits detection of antigenic peptide recognition by T helper lymphocytes from asymptomatic, HIV seropositive individuals. Nature 1989, 339:383-385.
17. Clerici M, Stocks NI, Zajac RA, et al.: Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging. J Clin Invest 1989, 84:1892-1899.
18. Via CS, Tsokos GC, Stocks NI, Clerici M, Shearer GM: Human in vitro allogeneic responses: demonstration of three pathways of T helper cell activation. Immunol 1991, 144:2524-2528.
19. Shearer GM, Bernstein DC, Tung KSK, et al.: A model for the selective loss of major histocompatibility complex self-restricted T cell immune responses during the development of acquired immune deficiency syndrome (AIDS). J Immunol 1986, 137:2514-2521.
20. Clerici M, Lucey DR, Zajac RA, et al.: Detection of cytotoxic T lymphocytes specific for synthetic peptides of gp160 in HIV-seropositive individuals. J Immunol 1991, 146:2214-2219.
21. Cease KB, Berzofsky JA: Toward a vaccine for AIDS: the emergence of immunology-based vaccine development. Annu Rev Immunol 1994, 12:923-989.
22. Vassalli P: The pathophysiology of tumor necrosis factors. Annu Rev Immunol 1992, 10:411-452.
23. Sarin A, Conan-Cibotti M, Henkart PA: Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts. J Immunol 1993, 155:3716-3718.
24. Chehimi J, Trinchieri G, Frank I, et al.: IL-12 deficiency in HIV-infected patients. J Exp Med 1994, 179:1361-1366.
25. Clerici M, Lucey DR, Pinto LA, et al.: Restoration of HIV-specific cell mediated immune responses by interleukin-12 in vitro. Science 1993, 262:1721-1724.
26. Chougnet C, Clerici M, Shearer GM. Role of IL-12 in HIV disease/AIDS. Res Immunol 1995, 146:615-622.
27. Lane HC, Depper JM, Greene WC, et al.: Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome: evidence for a selective defect in soluble antigens recognition. N Eng J Med 1985, 313:79-84.
28. Giorgi JV, Fahey JL, Smith DC, et al.: Early effects of HIV on CD4 lymphocytes in vivo. J Immunol 1987, 138:3725-3730.
29. Miedema F, Petit AJ, Terpstra FG, et al.: Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs. J Clin Invest 1988, 82:1908-1916.
30. Kestens L, Vanham G, Vereecken C, et al.: Selective increase of activation antigens HLA-DR and CD38 on CD4+CD45RO+ T lymphocytes during HIV-1 infection. Clin Exp Immunol 1994, 95:436-441.
31. Banda NK, Bernier J, Kurahara DK, et al.: Crosslinking CD4 by HIV gp120 primes T cells for activation-induced apoptosis. J Exp Med 1992, 176:1099-1106.
32. Oh S-K, Cruishank WW, Raina J, et al.: Identification of HIV-1 envelope glyoprotein in the serum of AIDS and ARC patients. J Acquir Immune Defic Syndr 1992, 5:251-256.
33. Amadori A, Silvestro GD, Zamarchi R, et al.: CD4 epitope masking by gp120/antigp120 antibody complexes. A potential mechanism for CD4+ cell function down-regulation in AIDS patients. J Immunol 1992, 148:2709-2716.
34. Oyazu N, McCloskey TW, Coronesi M, Chirmule N, Kalyanaraman VS, Pawha S: Accelerated apoptosis in PBMC from HIV-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood 1993, 82:3392-3400.
35. Newell MK, Hughn LJ, Maroun CN, Julius MH: Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature 1990, 347:286-289.
36. Meyaard L, Otto SA, Keet IPM, Roos MTL, Miedema F: Programmed cell death of T cells in HIV infection. J Clin Invest 1994, 93:982-988.
37. Raddrizzani M, Accornero P, Amidei A, et al.: IL-12 inhibits apoptosis induced in a human TH1 clone by gp120/CD4 crosslinking and CD3/TcR activation or by IL-2 deprivation. Cell Immunol 1995, 161:14-21.
38. Westendorp MO, Frank R, Ochsenbauer C, et al.: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 1995, 375:497-500.
39. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 1995, 181:2019-2036.
40. Badley AD, McElhinny JA, Liebson PJ, et al.: Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 1996, 70:119-206.
41. Wei X, Ghosh SK, Taylor ME, et al.: Viral dynamics in HIV-1 infection. Nature 1995, 373:117-122.
42. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markovitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123-127.
43. Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB: Induction of apoptosis in uninfected lymphocytes by HIV-1 tat protein. Science 1995, 268:429-431.
44. Kovacs JA, Baseler M, Dewar RS, et al.: Increases in CD4T lymphocytes with intermittent courses of interleukin-2 in patients with human immuno-deficiency virus infection. N Engl J Med 1995, 332:567-575.