메뉴 건너뛰기




Volumn 39, Issue 1, 2006, Pages 113-124

Hereditary hemochromatosis: An opportunity for gene therapy

Author keywords

Cirrhosis; DMT1; Gene therapy; Hemochromatosis; HFE; Intestine; Iron

Indexed keywords

ADENOVIRUS VECTOR; ANTISENSE OLIGONUCLEOTIDE; CHITOSAN; FERROPORTIN 1; HEPCIDIN; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PLASMID DNA; RIBOZYME; SMALL INTERFERING RNA;

EID: 33745839602     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602006000100014     Document Type: Conference Paper
Times cited : (11)

References (83)
  • 1
    • 0025877002 scopus 로고
    • Clinical presentation of hemochromatosis: A changing scene
    • ADAMS PC, KERTESZ AE, VALBERG LS (1991) Clinical presentation of hemochromatosis: A changing scene. Am J Med 90: 445-449
    • (1991) Am J Med , vol.90 , pp. 445-449
    • Adams, P.C.1    Kertesz, A.E.2    Valberg, L.S.3
  • 5
    • 0033599057 scopus 로고    scopus 로고
    • Disorders of iron metabolism
    • ANDREWS NC (1999) Disorders of iron metabolism. N Engi J Med. 341: 1986-1995
    • (1999) N Engi J Med. , vol.341 , pp. 1986-1995
    • Andrews, N.C.1
  • 6
    • 0035344458 scopus 로고    scopus 로고
    • HFE inhibits apical iron uptake by intestinal epithelial (Caco-2) cells
    • ARREDONDO M, MUÑOZ P, MURA CV, NÚÑEZ MT (2001) HFE inhibits apical iron uptake by intestinal epithelial (Caco-2) cells. FASEB J 15: 1276-1278
    • (2001) FASEB J , vol.15 , pp. 1276-1278
    • Arredondo, M.1    Muñoz, P.2    Mura, C.V.3    Núñez, M.T.4
  • 10
    • 0032427653 scopus 로고    scopus 로고
    • Kupffer cell staining by an HFE-specific monoclonal antibody: Implications for hereditary haemochromatosis
    • BASTIN JM, JONES M, OCALLAGHAN CA, SCHIMANSKI L, MASON DY, TOWNSEND AR (1998) Kupffer cell staining by an HFE-specific monoclonal antibody: Implications for hereditary haemochromatosis. Br J Haematol 103: 931-941
    • (1998) Br J Haematol , vol.103 , pp. 931-941
    • Bastin, J.M.1    Jones, M.2    Ocallaghan, C.A.3    Schimanski, L.4    Mason, D.Y.5    Townsend, A.R.6
  • 14
    • 4644273498 scopus 로고    scopus 로고
    • Progress in the use of adeno-associated viral vectors for gene therapy
    • BUNING H, BRAUN-FALCO M, HALLEK M (2004) Progress in the use of adeno-associated viral vectors for gene therapy. Cells Tissues Organs 177: 139-150
    • (2004) Cells Tissues Organs , vol.177 , pp. 139-150
    • Buning, H.1    Braun-Falco, M.2    Hallek, M.3
  • 16
    • 0034219436 scopus 로고    scopus 로고
    • Adeno-associated viral vectors as gene delivery vehicles
    • CARTER PJ, SAMULSKI RJ (2000) Adeno-associated viral vectors as gene delivery vehicles. Int J Mol Med 6: 17-27
    • (2000) Int J Mol Med , vol.6 , pp. 17-27
    • Carter, P.J.1    Samulski, R.J.2
  • 17
    • 0346685833 scopus 로고    scopus 로고
    • Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles
    • CHEN J, YANG WL, LI G, QIAN J, XUE JL, FU SK, LU DR (2004) Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles. World J Gastroenterol 10(1): 112-116
    • (2004) World J Gastroenterol , vol.10 , Issue.1 , pp. 112-116
    • Chen, J.1    Yang, W.L.2    Li, G.3    Qian, J.4    Xue, J.L.5    Fu, S.K.6    Lu, D.R.7
  • 18
    • 0031593872 scopus 로고    scopus 로고
    • In vitro and in vivo assessment of adenovirus 41 as a vector for gene delivery to the intestine
    • CROYLE MA, STONE M, AMIDON GL, ROESSLER BJ (1998) In vitro and in vivo assessment of adenovirus 41 as a vector for gene delivery to the intestine. Gene Ther 5: 645-654
    • (1998) Gene Ther , vol.5 , pp. 645-654
    • Croyle, M.A.1    Stone, M.2    Amidon, G.L.3    Roessler, B.J.4
  • 19
    • 2942537827 scopus 로고    scopus 로고
    • Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells
    • DAVIES PS, ENNS CA (2004) Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells. J Biol Chem 279: 25085-25092
    • (2004) J Biol Chem , vol.279 , pp. 25085-25092
    • Davies, P.S.1    Enns, C.A.2
  • 21
    • 0031721136 scopus 로고    scopus 로고
    • Peroral gene therapy of lactose intolerance using an adeno-associated virus vector
    • DURING MJ, XU R, YOUNG D, KAPLITT MG, SHERWIN RS, LEONE P (1998) Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. Nat Med 4: 1131-1135
    • (1998) Nat Med , vol.4 , pp. 1131-1135
    • During, M.J.1    Xu, R.2    Young, D.3    Kaplitt, M.G.4    Sherwin, R.S.5    Leone, P.6
  • 22
    • 0034815085 scopus 로고    scopus 로고
    • Evidence for cadmium uptake through Nramp2: Metal speciation studies with Caco-2 cells
    • ELISMA F, JUMARIE C (2001) Evidence for cadmium uptake through Nramp2: Metal speciation studies with Caco-2 cells. Biochem Biophys Res Commun 285: 662-668
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 662-668
    • Elisma, F.1    Jumarie, C.2
  • 23
    • 33745849776 scopus 로고    scopus 로고
    • Hemochromatosis: Antisense gene against the DMT-1 transporter inhibits iron uptake in human intestinal cells and shows RNAi and antisense effects
    • EZQUE F, NÚxZ M T, ISRAEL Y (2004) Hemochromatosis: Antisense gene against the DMT-1 transporter inhibits iron uptake in human intestinal cells and shows RNAi and antisense effects. Biol Res 37 (Supplement A): R89
    • (2004) Biol Res , vol.37 , Issue.SUPPL. A
    • Ezque, F.1    Núxz, M.T.2    Israel, Y.3
  • 24
    • 19344373782 scopus 로고    scopus 로고
    • Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: Potential application in hemochromatosis
    • EZQUER F, NÚÑEZ M T, ISRAEL Y (2005) Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: Potential application in hemochromatosis. Biochem Pharmacol 69: 1559-1566
    • (2005) Biochem Pharmacol , vol.69 , pp. 1559-1566
    • Ezquer, F.1    Núñez, M.T.2    Israel, Y.3
  • 29
  • 32
    • 0041940266 scopus 로고    scopus 로고
    • Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane
    • FORBES JR, GROS P (2003) Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane. Blood 102: 1884-1892
    • (2003) Blood , vol.102 , pp. 1884-1892
    • Forbes, J.R.1    Gros, P.2
  • 34
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • GANZ T (2003) Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102: 783-788
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 35
    • 0036177909 scopus 로고    scopus 로고
    • Population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation
    • GOCHEE PA, POWELL LW, CULLEN DJ, DU SART D, ROSSI E, OLYNYK JK (2002) population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation. Gastroenterology 122: 646-651
    • (2002) Gastroenterology , vol.122 , pp. 646-651
    • Gochee, P.A.1    Powell, L.W.2    Cullen, D.J.3    Du Sart, D.4    Rossi, E.5    Olynyk, J.K.6
  • 36
    • 5444276384 scopus 로고    scopus 로고
    • Gene transfer vector biodistribution: Pivotal safety studies in clinical gene therapy development
    • GONIN P, GAILLARD C (2004) Gene transfer vector biodistribution: Pivotal safety studies in clinical gene therapy development. Gene Ther. 11(Suppl 1): S98-S108
    • (2004) Gene Ther. , vol.11 , Issue.SUPPL. 1
    • Gonin, P.1    Gaillard, C.2
  • 37
    • 0037406254 scopus 로고    scopus 로고
    • Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells
    • GRIFFITHS WJ, COX TM (2003) Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells. J Histochem Cytochem 51: 613-624
    • (2003) J Histochem Cytochem , vol.51 , pp. 613-624
    • Griffiths, W.J.1    Cox, T.M.2
  • 38
    • 0032555601 scopus 로고    scopus 로고
    • Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation
    • GROSS CN, IRRINKI A, FEDER JN, ENNS CA (1998) Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation. J Biol Chem 273: 22068-22074
    • (1998) J Biol Chem , vol.273 , pp. 22068-22074
    • Gross, C.N.1    Irrinki, A.2    Feder, J.N.3    Enns, C.A.4
  • 40
    • 0037126002 scopus 로고    scopus 로고
    • Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function
    • HUBERT N, HENTZE MW (2002) Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function. Proc Nat Acad Sci USA 99: 12345-12350
    • (2002) Proc Nat Acad Sci USA , vol.99 , pp. 12345-12350
    • Hubert, N.1    Hentze, M.W.2
  • 44
    • 0033168767 scopus 로고    scopus 로고
    • The C282Y mutation causing hereditary hemochromatosis does not produce a null allele
    • LEVY JE, MONTROSS LK, COHEN DE, FLEMING MD, ANDREWS NC (1999) The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood 94: 9-11
    • (1999) Blood , vol.94 , pp. 9-11
    • Levy, J.E.1    Montross, L.K.2    Cohen, D.E.3    Fleming, M.D.4    Andrews, N.C.5
  • 45
    • 0034062537 scopus 로고    scopus 로고
    • Genes that modify the hemochromatosis phenotype in mice
    • LEVY JE, MONTROSS LK, ANDREWS NC (2000) Genes that modify the hemochromatosis phenotype in mice. J Clin Invest 105: 1209-1216
    • (2000) J Clin Invest , vol.105 , pp. 1209-1216
    • Levy, J.E.1    Montross, L.K.2    Andrews, N.C.3
  • 46
    • 0024446959 scopus 로고
    • Food iron absorption in idiopathic hemochromatosis
    • LYNCH SR, SKIKNE BS, COOK JD (1989) Food iron absorption in idiopathic hemochromatosis. Blood 74: 2187-2193
    • (1989) Blood , vol.74 , pp. 2187-2193
    • Lynch, S.R.1    Skikne, B.S.2    Cook, J.D.3
  • 47
    • 6344283047 scopus 로고    scopus 로고
    • Clinical trials in neurological disorders using AAV vectors: Promises and challenges
    • MANDEL RJ, BURGER C (2004) Clinical trials in neurological disorders using AAV vectors: Promises and challenges. Curr Opin Mol Ther 6: 482-490
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 482-490
    • Mandel, R.J.1    Burger, C.2
  • 51
    • 0028786481 scopus 로고
    • The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications
    • MEUNIER V, BOURRIE M, BERGER Y, FABRE G (1995) The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications. Cell Biol Toxicol 11: 187-194
    • (1995) Cell Biol Toxicol , vol.11 , pp. 187-194
    • Meunier, V.1    Bourrie, M.2    Berger, Y.3    Fabre, G.4
  • 52
    • 0033761804 scopus 로고    scopus 로고
    • Adeno-associated virus vectors for gene therapy: More pros than cons?
    • MONAHAN PE, SAMULSKI RJ (2000) Adeno-associated virus vectors for gene therapy: more pros than cons? Mol Med Today 6: 433-440
    • (2000) Mol Med Today , vol.6 , pp. 433-440
    • Monahan, P.E.1    Samulski, R.J.2
  • 54
    • 0034511786 scopus 로고    scopus 로고
    • Human 293 cell metabolism in low glutamine-supplied culture: Interpretation of metabolic changes through metabolic flux analysis
    • NADEAU I, SABATIÉ J, KOEHL M, PERRIER M, KAMEN A (2000a) Human 293 cell metabolism in low glutamine-supplied culture: Interpretation of metabolic changes through metabolic flux analysis. Metabolic Engineering 2: 277-292
    • (2000) Metabolic Engineering , vol.2 , pp. 277-292
    • Nadeau, I.1    Sabatié, J.2    Koehl, M.3    Perrier, M.4    Kamen, A.5
  • 55
    • 0034281747 scopus 로고    scopus 로고
    • 293SF Metabolic flux analysis during cell growth and infection with an adenoviral vector
    • NADEAU I, JACOB D, PERRIER M, KAMEN A (2000b) 293SF Metabolic flux analysis during cell growth and infection with an adenoviral vector. Biotechnology Progress 16: 872-884
    • (2000) Biotechnology Progress , vol.16 , pp. 872-884
    • Nadeau, I.1    Jacob, D.2    Perrier, M.3    Kamen, A.4
  • 56
    • 0037021789 scopus 로고    scopus 로고
    • Low-protein medium affects the 293SF central metabolism during growth and infection with adenovirus
    • NADEAU I, GILBERT PA, JACOB D, PERRIER M, KAMEN A (2001) Low-protein medium affects the 293SF central metabolism during growth and infection with adenovirus. Biotechnology and Bioengineering 77: 93-104
    • (2001) Biotechnology and Bioengineering , vol.77 , pp. 93-104
    • Nadeau, I.1    Gilbert, P.A.2    Jacob, D.3    Perrier, M.4    Kamen, A.5
  • 58
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • NICOLÁS G, BENNOUN M, DEVAUX I, BEAUMONT C, GRANDCHAMP B, KAHN A, VAULONT S (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 98: 8780-8785
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolás, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6    Vaulont, S.7
  • 61
    • 0022368621 scopus 로고
    • Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis
    • NIEDERAU C, FISCHER R, SONNENBERG A, STREMMEL W, TRAMPISCH HJ, STROHMEYER G (1985) Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med 313: 1256-1262
    • (1985) N Engl J Med , vol.313 , pp. 1256-1262
    • Niederau, C.1    Fischer, R.2    Sonnenberg, A.3    Stremmel, W.4    Trampisch, H.J.5    Strohmeyer, G.6
  • 63
    • 0033934482 scopus 로고    scopus 로고
    • Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient diet
    • OATES PS, JEFFREY GP, BASCLAIN KA, THOMAS C, MORGAN EH (2000) Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient diet. J Gastroenterol Hepatol 15: 665-674
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 665-674
    • Oates, P.S.1    Jeffrey, G.P.2    Basclain, K.A.3    Thomas, C.4    Morgan, E.H.5
  • 64
    • 0034837108 scopus 로고    scopus 로고
    • Involvement of DMT1 in uptake of Cd in MDCK cells: Role of protein kinase C
    • OLIVI L, SISK J, BRESSLER J (2001) Involvement of DMT1 in uptake of Cd in MDCK cells: Role of protein kinase C. Am J Physiol Cell Physiol 281: C793-800
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Olivi, L.1    Sisk, J.2    Bressler, J.3
  • 66
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • PARK CH, VALORE EV, WARING AJ, GANZ T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276: 7806-7810
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 67
    • 0031002910 scopus 로고    scopus 로고
    • Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
    • PARKKILA S, WAHEED A, BRITTON RS, FEDER JN, TSUCHIHASHI Z, SCHATZMAN RC, BACON BR, SLY WS (1997) Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci USA 94: 2534-2539
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2534-2539
    • Parkkila, S.1    Waheed, A.2    Britton, R.S.3    Feder, J.N.4    Tsuchihashi, Z.5    Schatzman, R.C.6    Bacon, B.R.7    Sly, W.S.8
  • 69
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • PIGEON C, ILYIN G, COURSELAUD B, LEROYER P, TURLIN B, BRISSOT P, LOREAL O (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 71
    • 0030624029 scopus 로고    scopus 로고
    • Regulation of iron metabolism in eukaryotes
    • ROUAULT T, KLAUSNER R (1997) Regulation of iron metabolism in eukaryotes. Curr Top Cell Regul 35: 1-19
    • (1997) Curr Top Cell Regul , vol.35 , pp. 1-19
    • Rouault, T.1    Klausner, R.2
  • 72
    • 0033605595 scopus 로고    scopus 로고
    • The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
    • ROY CN, PENNY DM, FEDER JN, ENNS CA (1999) The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. J Biol Chem 274: 9022-9028
    • (1999) J Biol Chem , vol.274 , pp. 9022-9028
    • Roy, C.N.1    Penny, D.M.2    Feder, J.N.3    Enns, C.A.4
  • 73
    • 0032530922 scopus 로고    scopus 로고
    • The G185R mutation isrupts function of iron transporter Nramp2
    • SU MA, TRENOR CC, FLEMING JC, FLEMING MD, AND ANDREWS MC (1998) The G185R mutation isrupts function of iron transporter Nramp2. Blood 92: 2157-2163
    • (1998) Blood , vol.92 , pp. 2157-2163
    • Su, M.A.1    Trenor, C.C.2    Fleming, J.C.3    Fleming, M.D.4    Andrews, M.C.5
  • 74
    • 0035918904 scopus 로고    scopus 로고
    • DMT1 gene expression and cadmium absorption in human absorptive enterocytes
    • TALLKVIST J, BOWLUS CL, LONNERDAL B (2001) DMT1 gene expression and cadmium absorption in human absorptive enterocytes. Toxicol Lett 122: 171-177
    • (2001) Toxicol Lett , vol.122 , pp. 171-177
    • Tallkvist, J.1    Bowlus, C.L.2    Lonnerdal, B.3
  • 76
    • 0030732164 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells
    • WAHEED A, PARKKILA S, ZHOU XY, TOMATSU S, TSUCHIHASHI Z, FEDER JN, SCHATZMAN RC, BRITTON RS, BACON BR, SLY WS (1997) Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. Proc Natl Acad Sci USA 94: 12384-12389
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12384-12389
    • Waheed, A.1    Parkkila, S.2    Zhou, X.Y.3    Tomatsu, S.4    Tsuchihashi, Z.5    Feder, J.N.6    Schatzman, R.C.7    Britton, R.S.8    Bacon, B.R.9    Sly, W.S.10
  • 77
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • WEINSTEIN DA, ROY CN, FLEMING MD, LODA MF, WOLFSDORF JI, ANDREWS NC (2002) Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease. Blood 100: 3776-3781
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 79
    • 0028587794 scopus 로고
    • An integrin-mobilferrin Iron transport pathway in intestine and hematopoietic cells
    • WOLF G, WESSLING-RESNICK M (1994) An integrin-mobilferrin Iron transport pathway in intestine and hematopoietic cells. Nutr Rev 52: 387-389
    • (1994) Nutr Rev , vol.52 , pp. 387-389
    • Wolf, G.1    Wessling-Resnick, M.2
  • 80
    • 1342322891 scopus 로고    scopus 로고
    • Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat
    • YEH KY, YEH M, GLASS J (2004) Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Am J Physiol Gastrointest Liver Physiol 286: G385-394
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286
    • Yeh, K.Y.1    Yeh, M.2    Glass, J.3
  • 81
    • 0042324650 scopus 로고    scopus 로고
    • Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis
    • ZOLLER H, THEURL I, KOCH RO, MCKIE AT, VOGEL W, WEISS G (2003) Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. Gastroenterology 125: 746-754
    • (2003) Gastroenterology , vol.125 , pp. 746-754
    • Zoller, H.1    Theurl, I.2    Koch, R.O.3    McKie, A.T.4    Vogel, W.5    Weiss, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.