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Volumn 51, Issue 5, 2003, Pages 613-623

Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells

Author keywords

Crypts; HFE; Homeostasis; Iron; Localization; TfR1; TfR2

Indexed keywords

CD63 ANTIGEN; CELL PROTEIN; GENE PRODUCT; IRON; LIGAND; PEPTIDE ANTIBODY; TRANSFERRIN; TRANSFERRIN RECEPTOR;

EID: 0037406254     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540305100507     Document Type: Article
Times cited : (52)

References (42)
  • 1
    • 0034572933 scopus 로고    scopus 로고
    • Iron homeostasis: Insights from genetics and animal models
    • Andrews NC (2000) Iron homeostasis: insights from genetics and animal models. Nature Rev Genet 1:208-217
    • (2000) Nature Rev Genet , vol.1 , pp. 208-217
    • Andrews, N.C.1
  • 3
    • 0035865527 scopus 로고    scopus 로고
    • Expression of the DMT1 (NRAMP2/ DCT1) iron transporter in mice with genetic iron overload disorders
    • Canonne-Hergaux F, Levy JE, Fleming MD, Montross LK, Andrews NC, Gros P (2001) Expression of the DMT1 (NRAMP2/ DCT1) iron transporter in mice with genetic iron overload disorders. Blood 97:1138-1140
    • (2001) Blood , vol.97 , pp. 1138-1140
    • Canonne-Hergaux, F.1    Levy, J.E.2    Fleming, M.D.3    Montross, L.K.4    Andrews, N.C.5    Gros, P.6
  • 4
    • 0016325705 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine
    • Cheng H, Leblond CF (1974) Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. Am J Anat 141:537-562
    • (1974) Am J Anat , vol.141 , pp. 537-562
    • Cheng, H.1    Leblond, C.F.2
  • 6
    • 0025325233 scopus 로고
    • Haemochromatosis
    • Cox TM (1990) Haemochromatosis. Blood Rev 4:75-87
    • (1990) Blood Rev , vol.4 , pp. 75-87
    • Cox, T.M.1
  • 9
    • 13144282684 scopus 로고    scopus 로고
    • The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
    • Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, Tsuchihashi Z, et al. (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95:1472-1477
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1472-1477
    • Feder, J.N.1    Penny, D.M.2    Irrinki, A.3    Lee, V.K.4    Lebron, J.A.5    Watson, N.6    Tsuchihashi, Z.7
  • 10
    • 17644434333 scopus 로고    scopus 로고
    • The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression
    • Feder JN, Tsuchihashi Z, Irrinki A, Lee VK, Mapa FA, Morikang E, Prass CE, et al. (1997) The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J. Biol Chem 272:14025-14028
    • (1997) J. Biol Chem , vol.272 , pp. 14025-14028
    • Feder, J.N.1    Tsuchihashi, Z.2    Irrinki, A.3    Lee, V.K.4    Mapa, F.A.5    Morikang, E.6    Prass, C.E.7
  • 12
    • 0034007995 scopus 로고    scopus 로고
    • Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
    • Fleming RE, Migas MC, Holden CC, Waheed A, Britton RS, Tomatsu S, Bacon BR, et al. (2000) Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci USA 97:2214-2219
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2214-2219
    • Fleming, R.E.1    Migas, M.C.2    Holden, C.C.3    Waheed, A.4    Britton, R.S.5    Tomatsu, S.6    Bacon, B.R.7
  • 13
    • 0024521960 scopus 로고
    • Immunohistochemical evidence for a lack of ferritin in duodenal absorptive epithelial cells in idiopathic hemochromatosis
    • Francanzani AL, Fargion S, Romano R, Piperno A, Arosio P, Ruggeri G, Ronchi G, et al. (1989) Immunohistochemical evidence for a lack of ferritin in duodenal absorptive epithelial cells in idiopathic hemochromatosis. Gastroenterology 96:1071-1078
    • (1989) Gastroenterology , vol.96 , pp. 1071-1078
    • Francanzani, A.L.1    Fargion, S.2    Romano, R.3    Piperno, A.4    Arosio, P.5    Ruggeri, G.6    Ronchi, G.7
  • 14
    • 0036242163 scopus 로고    scopus 로고
    • Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene
    • Girelli D, Bozzini C, Roetto A, Alberti F, Daraio F, Colombari R, Olivieri O, et al. (2002) Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene. Gastroenterology 122:1295-1302
    • (2002) Gastroenterology , vol.122 , pp. 1295-1302
    • Girelli, D.1    Bozzini, C.2    Roetto, A.3    Alberti, F.4    Daraio, F.5    Colombari, R.6    Olivieri, O.7
  • 15
    • 0033759823 scopus 로고    scopus 로고
    • Haemochromatosis: Novel gene discovery and the molecular pathophysiology of iron metabolism
    • Griffiths WJH, Cox TM (2000) Haemochromatosis: novel gene discovery and the molecular pathophysiology of iron metabolism. Hum Mol Genet 9:2377-2382
    • (2000) Hum Mol Genet , vol.9 , pp. 2377-2382
    • Griffiths, W.J.H.1    Cox, T.M.2
  • 16
    • 0033834707 scopus 로고    scopus 로고
    • Localization of iron transport and regulatory proteins in human cells
    • Griffiths WJH, Kelly AL, Smith SJ, Cox TM (2000) Localization of iron transport and regulatory proteins in human cells. Q J Med 93:575-587
    • (2000) Q J Med , vol.93 , pp. 575-587
    • Griffiths, W.J.H.1    Kelly, A.L.2    Smith, S.J.3    Cox, T.M.4
  • 17
    • 0035048737 scopus 로고    scopus 로고
    • Intestinal iron uptake determined by divalent metal transporter (DMT1) is enhanced in HFE-deficient mice with hemochromatosis
    • Griffiths WJH, Sly WS, Cox TM (2001) Intestinal iron uptake determined by divalent metal transporter (DMT1) is enhanced in HFE-deficient mice with hemochromatosis. Gastroenterology 120:1420-1429
    • (2001) Gastroenterology , vol.120 , pp. 1420-1429
    • Griffiths, W.J.H.1    Sly, W.S.2    Cox, T.M.3
  • 18
    • 0032555601 scopus 로고    scopus 로고
    • Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation
    • Gross CN, Irrinki A, Feder JN, Enns CA (1998) Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation. J Biol Chem 273:22068-22074
    • (1998) J Biol Chem , vol.273 , pp. 22068-22074
    • Gross, C.N.1    Irrinki, A.2    Feder, J.N.3    Enns, C.A.4
  • 19
    • 0024516594 scopus 로고
    • Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction
    • Hentze MW, Rouault TA, Harford JB, Klausner RD (1989) Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science 244:357-359
    • (1989) Science , vol.244 , pp. 357-359
    • Hentze, M.W.1    Rouault, T.A.2    Harford, J.B.3    Klausner, R.D.4
  • 21
    • 0034595856 scopus 로고    scopus 로고
    • Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo
    • Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, Koeffler HP (2000) Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem 275:16618-16625
    • (2000) J Biol Chem , vol.275 , pp. 16618-16625
    • Kawabata, H.1    Germain, R.S.2    Vuong, P.T.3    Nakamaki, T.4    Said, J.W.5    Koeffler, H.P.6
  • 22
    • 0033597780 scopus 로고    scopus 로고
    • Molecular cloning of transferrin receptor 2.A new member of the transferrin receptor-like family
    • Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, Koeffler HP (1999) Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem 274:20826-20832
    • (1999) Biol Chem , vol.274 , pp. 20826-20832
    • Kawabata, H.1    Yang, R.2    Hirama, T.3    Vuong, P.T.4    Kawano, S.5    Gombart, A.F.6    Koeffler, H.P.7
  • 24
    • 0032478524 scopus 로고    scopus 로고
    • Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
    • Lebron JA, Bennet MJ, Vaughan DE, Chirino AJ, Snow PM, Mintier GA, Feder JN, et al. (1998) Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93:111-123
    • (1998) Cell , vol.93 , pp. 111-123
    • Lebron, J.A.1    Bennet, M.J.2    Vaughan, D.E.3    Chirino, A.J.4    Snow, P.M.5    Mintier, G.A.6    Feder, J.N.7
  • 25
    • 0025233620 scopus 로고
    • Differential expression of transferrin receptor in duodenal mucosa in iron overload. Evidence for a site-specific defect in genetic hemochromatosis
    • Lombard M, Bomford AB, Polson RJ, Bellingham AJ, Williams R (1990) Differential expression of transferrin receptor in duodenal mucosa in iron overload. Evidence for a site-specific defect in genetic hemochromatosis. Gastroenterology 98:976-984
    • (1990) Gastroenterology , vol.98 , pp. 976-984
    • Lombard, M.1    Bomford, A.B.2    Polson, R.J.3    Bellingham, A.J.4    Williams, R.5
  • 26
    • 0036683019 scopus 로고    scopus 로고
    • Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: Identification of a novel TfR2 mutation
    • Mattman A, Huntsman D, Lockitch G, Langlois S, Buskard N, Ralston D, Butterfield Y, et al. (2002) Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation. Blood 100:1075-1077
    • (2002) Blood , vol.100 , pp. 1075-1077
    • Mattman, A.1    Huntsman, D.2    Lockitch, G.3    Langlois, S.4    Buskard, N.5    Ralston, D.6    Butterfield, Y.7
  • 27
    • 0025819331 scopus 로고
    • CD63 antigen.A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells
    • Metzlaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC (1991) CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. J Biol Chem 266:3239-3245
    • (1991) J Biol Chem , vol.266 , pp. 3239-3245
    • Metzlaar, M.J.1    Wijngaard, P.L.2    Peters, P.J.3    Sixma, J.J.4    Nieuwenhuis, H.K.5    Clevers, H.C.6
  • 28
    • 0031002910 scopus 로고    scopus 로고
    • Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
    • Parkkila S, Waheed A, Britton RS, Feder JN, Tsuchihashi Z, Schatzman RC, Bacon BR, et al. (1997) Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci USA 94:2534-2539
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2534-2539
    • Parkkila, S.1    Waheed, A.2    Britton, R.S.3    Feder, J.N.4    Tsuchihashi, Z.5    Schatzman, R.C.6    Bacon, B.R.7
  • 30
    • 0000683220 scopus 로고
    • Iron absorption: The effect of an iron deficient diet
    • Pollack S, Kaufman RM, Crosby WH (1964) Iron absorption: the effect of an iron deficient diet. Science 144:1015-1016
    • (1964) Science , vol.144 , pp. 1015-1016
    • Pollack, S.1    Kaufman, R.M.2    Crosby, W.H.3
  • 31
    • 0033231035 scopus 로고    scopus 로고
    • Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice
    • Raja KB, Pountney DJ, Simpson RJ, Peters TJ (1999) Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice. Blood 94:3185-3192
    • (1999) Blood , vol.94 , pp. 3185-3192
    • Raja, K.B.1    Pountney, D.J.2    Simpson, R.J.3    Peters, T.J.4
  • 33
    • 0035353167 scopus 로고    scopus 로고
    • New mutations inactivating transferrin receptor 2 in hemochromatosis type 3
    • Roetto A, Totaro A, Piperno A, Piga A, Longo F, Garozzo G, Cali A, et al. (2001) New mutations inactivating transferrin receptor 2 in hemochromatosis type 3. Blood 97:2555-2560
    • (2001) Blood , vol.97 , pp. 2555-2560
    • Roetto, A.1    Totaro, A.2    Piperno, A.3    Piga, A.4    Longo, F.5    Garozzo, G.6    Cali, A.7
  • 34
    • 0033605595 scopus 로고    scopus 로고
    • The hereditary hemochromatosis protein HFE, specifically regulates transferrinmediated iron uptake in HeLa cells
    • Roy CN, Penny DM, Feder JN, Enns CA (1999) The hereditary hemochromatosis protein, HFE, specifically regulates transferrinmediated iron uptake in HeLa cells. J Biol Chem 274:9022-9028
    • (1999) Biol Chem , vol.274 , pp. 9022-9028
    • Roy, C.N.1    Penny, D.M.2    Feder, J.N.3    Enns, C.A.4
  • 36
    • 0013973902 scopus 로고
    • Iron absorption in relation to transferrin saturation and other factors
    • Taylor MR, Gatenby PB (1966) Iron absorption in relation to transferrin saturation and other factors. Br J Haematol 12:747-753
    • (1966) Br J Haematol , vol.12 , pp. 747-753
    • Taylor, M.R.1    Gatenby, P.B.2
  • 37
    • 0037117603 scopus 로고    scopus 로고
    • Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse
    • Trinder D, Olynyk JK, Sly WS, Morgan EH (2002) Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proc Natl Acad Sci USA 99:5622-5626
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5622-5626
    • Trinder, D.1    Olynyk, J.K.2    Sly, W.S.3    Morgan, E.H.4
  • 40
    • 0030732164 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells
    • Waheed A, Parkkila S, Zhou XY, Tomatsu S, Tsuchihashi Z, Feder JN, Schatzman RC, et al. (1997) Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. Proc Natl Acad Sci USA 94:12384-12389
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12384-12389
    • Waheed, A.1    Parkkila, S.2    Zhou, X.Y.3    Tomatsu, S.4    Tsuchihashi, Z.5    Feder, J.N.6    Schatzman, R.C.7
  • 41
    • 0034623930 scopus 로고    scopus 로고
    • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
    • West AP Jr, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (2000) Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem 275: 38135-38138
    • (2000) J Biol Chem , vol.275 , pp. 38135-38138
    • West A.P., Jr.1    Bennett, M.J.2    Sellers, V.M.3    Andrews, N.C.4    Enns, C.A.5    Bjorkman, P.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.