Synthesis and evaluation of α-helix mimetics based on a trans-fused polycyclic ether: sequence-selective binding to aspartate pairs in α-helical peptides

Tetrahedron Letters

Volumn 47, Issue 32, 2006, Pages 5801-5805

  Oguri, Hiroki ^a   Tanabe, Shintaro ^a   Oomura, Akifumi ^a   Umetsu, Mitsuo ^a   Hirama, Masahiro ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Helix mimetic; Molecular recognition; Polycyclic ether; Scaffold

Indexed keywords

ASPARTIC ACID; ETHER DERIVATIVE; GUANIDINE; HYDROXYL GROUP; PEPTIDE; POLYCYCLIC ETHER; RECEPTOR; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CIRCULAR DICHROISM; MOLECULAR RECOGNITION; PROTEIN BINDING; TITRIMETRY;

EID: 33745737798     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.05.170     Document Type: Article

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46. 5b