Convergent Synthesis of the ABCDEF-Ring System of Yessotoxin and Adriatoxin

Organic Letters

Volumn 4, Issue 22, 2002, Pages 3943-3946

  Suzuki, Keisuke ^a,c   Nakata, Tadashi ^a,b  

^a SAITAMA UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c DAIICHI SANKYO CO   (Japan)

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ARTICLE;

EID: 0013388773     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol026804w     Document Type: Article

References (25)

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5. The convergent synthesis of the BCDE-ring of 1 was reported: Mori, Y.; Hayashi, H. Tetrahedron 2002, 58, 1789.
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7. The same strategy was reported independently by the groups of Murai and Mori at almost the same time: (a) Fujiwara, K.; Morishita, H.; Saka, K.; Murai, A. Tetrahedron Lett. 2000, 41, 507. (b) Mori, Y.; Mitsuoka, S.; Furukawa, H. Tetrahedron Lett. 2000, 41, 4161.
8. The same strategy was reported independently by the groups of Murai and Mori at almost the same time: (a) Fujiwara, K.; Morishita, H.; Saka, K.; Murai, A. Tetrahedron Lett. 2000, 41, 507. (b) Mori, Y.; Mitsuoka, S.; Furukawa, H. Tetrahedron Lett. 2000, 41, 4161.
9. The synthesis of 4 will be described in detail elsewhere. See Supporting Information for the synthetic scheme of 4.
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23. In a model study, we found that acetonide 17 was a more suitable coupling partner than the corresponding benzylidene and di-tert-butyl silylene derivatives and that use of t-BuLi gave the best result in generating acetylide. See Supporting Information for the model study.
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