DNA damage responses in cell cycle G2 phase and mitosis - Tracking and targeting

Anticancer Research

Volumn 26, Issue 3 A, 2006, Pages 1909-1916

  Ree, Anne Hansen ^a   Stokke, Trond ^a   Bratland, Åse ^a   Patzke, Sebastian ^a   Nome, Ragnhild V ^a   Folkvord, Sigurd ^a   Meza Zepeda, Leonardo A ^a   Flatmark, Kjersti ^a   Fodstad, Øystein ^a   Andersson, Yvonne ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cell cycle; Cervical carcinoma; G2 checkpoint; Mitosis; Molecular targeting

Indexed keywords

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL FRACTIONATION; CELL POPULATION; CLONOGENESIS; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DNA DAMAGE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; PRIORITY JOURNAL; RADIOSENSITIZATION;

CELL DIVISION; CELL GROWTH PROCESSES; DNA DAMAGE; FLOW CYTOMETRY; G2 PHASE; GENE TARGETING; HELA CELLS; HUMANS; MITOSIS;

EID: 33745610458     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Kastan MB and Bartek J: Cell-cycle checkpoints and cancer. Nature 452: 316-323, 2004.
2. Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R and Kroemer G: Cell death by mitotic catastrophe: a molecular definition, Oncogene 23: 2825-2837, 2004.
3. Brown JM and Attardi LD: The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 5: 231-237, 2005.
4. Zhou BBS and Bartek J: Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat Rev Cancer 4: 1-10, 2004.
5. Choy H: Taxanes in combined modality therapy for solid tumors. Crit Rev Oncol Hematol 37: 237-247, 2001.
6. zur Hausen H: Papillomavirus infections - a major cause of human cancers. Biochim Biophys Acta 1288: F55-F78, 1996.
7. Scheffner M, Werness BA, Huibregtse JM, Levine AJ and Howley PM: The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129-1136, 1990.
8. Hoppe-Seyler F and Butz K: Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53. J Virol 67: 3111-3117, 1993.
9. Kessis TD, Slebos RJ, Nelson WG, Kastan MB, Plunkett BS, Han SM, Lorincz AT, Hedrick L and Cho KR: Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc Natl Acad Sci USA 90: 3988-3992, 1993.
10. Ree AH, Bratland Å, Nome RV, Stokke T and Fodstad Ø: Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1. Oncogene 22: 8952-8955, 2003.
11. Larsen JK, Munch-Petersen B, Christiansen J and Jørgensen K: Flow cytometric discrimination of mitotic cells: resolution of M, as well as G1, S, and G2 phase nuclei with mithramycin, propidium iodide, and ethidium bromide after fixation with formaldehyde. Cytometry 7: 54-63, 1986.
12. de Toledo SM, Azzam EI, Dahlberg WK, Gooding TB and Little JB: ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation. Oncogene 19: 6185-6193, 2000.
13. Hovig E, Smith-Sørensen B, Brøgger A and Børresen AL: Constant denaturant gel electrophoresis, a modification of denaturing gradient gel electrophoresis in mutation detection. Mutat Res 262: 63-67, 1991.
14. Fei P and El-Deiry WS: p53 and radiation responses. Oncogene 22: 5774-5783, 2003.
15. Meek DW and Knippschild U: Posttranslational modification of MDM2. Mol Cancer Res 1: 1017-1026, 2003.
16. Xia L, Paik A and Li JJ: p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF. Cancer Res 64: 221-228, 2004.
17. Zhang R and Wang H: MDM2 oncogene as a novel target for human cancer therapy. Curr Pharm Des 6: 393-416, 2000.
18. Forus A, Flørenes VA, Maelandsmo GM, Meltzer PS, Fodstad Ø and Myklebost O: Mapping of amplification units in the q!3-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. Cell Growth Diff 4: 1065-1070, 1993.
19. Ree AH, Bratland Å, Nome RV, Stokke T, Fodstad Ø and Andersson Y: Inhibitory targeting of checkpoint kinase signaling impairs radiation-induced cell cycle gene regulation: a therapeutic strategy in tumor cell radiosensitization? Radiother Oncol 72: 305-310, 2004.
20. Nome RV, Bratland Å, Harman G, Fodstad Ø, Andersson Y and Ree AH: Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death. Mol Cancer Ther 4: 1231-1238, 2005.
21. Chen J, Marechal V and Levine AJ: Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol 13: 4107-4114, 1993.
22. Hietanen S, Lain S, Krausz E, Blattner C and Lane DP: Activation of p53 in cervical carcinoma cells by small molecules. Proc Natl Acad Sci USA 97: 8501-8506, 2000.
23. Wesierska-Gadek J, Schloffer D, Kotala V and Horky M: Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy. Int J Cancer 707: 128-136, 2002.
24. Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y and Shkedy D: Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci USA 96: 14973-14977, 1999.
25. Tian H, Faje AT, Lee SL and Jorgensen TJ: Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia 4: 171-180, 2002.
26. Koniaras K, Cuddihy AR, Christopoulos H, Hogg A and O'Connell MJ: Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene 20: 7453-7463, 2001.
27. Jordan MA, Toso RJ, Thrower D and Wilson L: Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci USA 90: 9552-9556, 1993.
28. Jordan MA, Ojima I, Rosas F, Distefano M, Wilson L, Scambia G and Ferlini C: Effects of novel taxanes SB-T-1213 and IDN5109 on tubulin polymerization and mitosis. Chem Biol 9: 93-101, 2002.
29. Yildiz F, Perez R and Redpath JL: Paclitaxel exposure time determines the nature of the interaction with radiation in HeLa cells: the role of apoptosis. Eur J Cancer 36: 1426-1432, 2000.
30. Einhorn N, Trope C, Ridderheim M, Boman K, Sorbe B and Cavallin-Stahl E: A systematic overview of radiation therapy effects in cervical cancer (cervix uteri). Acta Oncol 42: 546-556, 2003.
31. Loizzi V, Cormio G, Loverro G, Selvaggi L, Disaia PJ and Cappuccini F: Chemoradiation: a new approach for the treatment of cervical cancer. Int J Gynecol Cancer 13: 580-586, 2003.