Inhibitory targeting of checkpoint kinase signaling overrides radiation-induced cell cycle gene regulation: A therapeutic strategy in tumor cell radiosensitization?

Radiotherapy and Oncology

Volumn 72, Issue 3, 2004, Pages 305-310

  Ree, Anne Hansen ^a   Bratland, Åse ^a   Nome, Ragnhild V ^a   Stokke, Trond ^a   Fodstad, Øystein ^a   Andersson, Yvonne ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

BRCA1; Cell cycle; CHK; Gene expression; Molecular targeting; Radiotherapy

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 1; CYCLIN B1; ENZYME INHIBITOR; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE; CELL CYCLE G2 PHASE; CLONOGENESIS; CONFERENCE PAPER; CYTOTOXICITY; DNA DAMAGE; DOWN REGULATION; GENE CONTROL; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; RADIOSENSITIZATION; SIGNAL TRANSDUCTION; TUMOR CELL;

ANIMALS; CELL DEATH; CELL LINE, TUMOR; CYCLIN B; G2 PHASE; GENES, BRCA1; GENES, CDC; PROTEIN KINASES; RADIATION TOLERANCE; SIGNAL TRANSDUCTION;

EID: 4644224492     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.07.002     Document Type: Conference Paper

References (16)

1. J.M. Brown, and B.G. Wouters Apoptosis, p53, and tumor cell sensitivity to anticancer agents Cancer Res 59 1999 1391 1399
2. A.D. Colevas, J.M. Brown, S. Hahn, J. Mitchell, K. Camphausen, and C.N. Coleman Development of investigational radiation modifiers J Natl Cancer Inst 95 2003 646 651
3. 2 DNA damage checkpoint delays expression of genes encoding mitotic regulators J Biol Chem 276 2001 37166 37177
4. P. Fei, and W.S. El-Deiry P53 and radiation responses Oncogene 22 2003 5774 5783
5. G. Iliakis, Y. Wang, J. Guan, and H. Wang DNA damage checkpoint control in cells exposed to ionizing radiation Oncogene 22 2003 5834 5847
6. B.B.Y. Ma, R.G. Bristow, J. Kim, and L.L. Siu Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents J Clin Oncol 21 2003 2760 2776
7. T.K. MacLachlan, K. Somasundaram, and M. Sgagias BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression J Biol Chem 275 2000 2777 2785
8. S.N. Powell, and L.A. Kachnic Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation Oncogene 22 2003 5784 5791
9. A.H. Ree, Å. Bratland, R.V. Nome, T. Stokke, and Ø. Fodstad Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1 Oncogene 22 2003 8952 8955
10. I.B. Roninson, E.V. Broude, and B.D. Chang If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells Drug Resist Updates 4 2001 303 313
11. A.K. Roshak, E.A. Capper, C. Imburgia, J. Fornwald, G. Scott, and L.A. Marshall The human polo-like linase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase Cell Signal 12 2000 405 411
12. R. Scully, S. Ganesan, K. Vlasakova, J. Chen, M. Socolovsky, and D.M. Livingston Genetic analysis of BRCA1 function in a defined tumor cell line Mol Cell 4 1999 1093 1099
13. A.M. Senderowicz Small-molecule cyclin-dependent kinase modulators Oncogene 22 2003 6609 6620
14. V.A. Smits, R. Klompmaker, L. Arnaud, G. Rijksen, E.A. Nigg, and R.H. Medema Polo-like kinase-1 is a target of the DNA damage checkpoint Nat Cell Biol 2 2000 672 676
15. G.E. Tomlinson, T.T.L. Chen, and V.A. Stastny Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier Cancer Res 58 1998 3237 3242
16. B.B.S. Zhou, and J. Bartek Targeting the checkpoint kinases: chemosensitization versus chemoprotection Nat Rev Cancer 4 2004 1 10