Establishing direction during chemotaxis in eukaryotic cells

Biophysical Journal

Volumn 83, Issue 3, 2002, Pages 1361-1367

  Rappel, Wouter Jan ^a,b,c   Thomas, Peter J ^a,b   Levine, Herbert ^a,b   Loomis, William F ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; CYCLIC AMP; CYCLIC GMP;

ARTICLE; CELL ACTIVATION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHEMOTAXIS; CYTOSKELETON; DICTYOSTELIUM DISCOIDEUM; EUKARYOTIC CELL; MATHEMATICAL MODEL; NEUTROPHIL; NONHUMAN; PROTEIN DOMAIN; ANIMAL; BIOLOGICAL MODEL; BIOPHYSICS; CYTOLOGY; DICTYOSTELIUM; METABOLISM; MUTATION; PH; PROTEIN TERTIARY STRUCTURE; TIME;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; EUKARYOTA;

ANIMALS; BIOPHYSICS; CHEMOTAXIS; CYCLIC AMP; CYCLIC GMP; DICTYOSTELIUM; EUKARYOTIC CELLS; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; MUTATION; NEUTROPHILS; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS;

EID: 0036708448     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(02)73906-4     Document Type: Article

References (20)

1. Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization
2. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
3. Dictyostelium discoideum: A model system for cell-cell interactions in devel-opment
4. Dictyostelium: A model for regulated cell movement during mor-phogenesis
5. A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium
6. Orientation of chemotactic cells and growth cones: Models and mechanisms
7. A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics
8. G protein signaling events are activated at the leading edge of chemotactic cells
9. A cell's sense of direction
10. A diffusion-translocation model for gradient sensing by chemotactic cells
11. Real-time visual-ization of intracellular hydrodynamics in single living cells
12. The Dictyostclium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase
13. Behavioral responses of streamer F mutants of Dictyostelium discoideum: Effects of cyclic GMP on cell motility
14. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
15. Single-molecule analysis of chemotactic singaling in Dictyostelium cells
16. Molecular basis of localized responses during chemotaxis in amoebae and leukocytes
17. Excitation, adaptation, and deadaptation of the cAMP-mediated cGMP response in Dictyostelium discoideum
18. Chemoattraction and chemotaxis in Dictyostelium discoideum: Myxamoeba cannot read spatial gradients of cyclic adenosine monophosphate
19. The regulation of chemotaxis and chemokinesis in Dictyostelium amoebae by temporal signals and spatial gradients of cyclic AMP
20. Cyclic GMP in Dictyostelium discoideum, oscillations and pulses in response to folic acid and cyclic AMP signals